Hydroxyurea_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyurea perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyurea_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.131981
FNDC3B fibronectin type III domain containing 3B 0.130414
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.124476
NAMPT nicotinamide phosphoribosyltransferase 0.122002
TSC22D2 TSC22 domain family, member 2 0.103226
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0952664
FXR1 fragile X mental retardation, autosomal homolog 1 0.0822809
HMGA1 high mobility group AT-hook 1 0.0806237
FAM13A family with sequence similarity 13, member A 0.080293
UBA6 ubiquitin-like modifier activating enzyme 6 0.0800197
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0761864
RNF145 ring finger protein 145 0.0750679
FN1 fibronectin 1 0.0726803
ZNF292 zinc finger protein 292 0.0706318
TFG TRK-fused gene 0.0691178
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0647166
GRB10 growth factor receptor-bound protein 10 0.0631869
KMT2E lysine (K)-specific methyltransferase 2E 0.0613301
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0600896
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0585585
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0579095
ANXA5 annexin A5 0.0562934
SLMAP sarcolemma associated protein 0.0543916
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.054048
TOP1 topoisomerase (DNA) I 0.0539925
ZFAND3 zinc finger, AN1-type domain 3 0.0538758
NUP58 nucleoporin 58 0.0518597
ARRDC3 arrestin domain containing 3 0.0515521
USP3 ubiquitin specific peptidase 3 0.0515232
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.050149
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.047193
MYO6 myosin VI 0.0463786
WAC WW domain containing adaptor with coiled-coil 0.0463564
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0458813
ADAM9 ADAM metallopeptidase domain 9 0.0447163
CDC73 cell division cycle 73 0.0438045
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0437463
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0433092
SETD5 SET domain containing 5 0.0430916
NCKAP1 NCK-associated protein 1 0.0426933
MXD1 MAX dimerization protein 1 0.0422274
PTK2 protein tyrosine kinase 2 0.0418044
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0416338
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0415603
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0408366
MSN moesin 0.0402393
TRIO trio Rho guanine nucleotide exchange factor 0.0400411
SEC23A Sec23 homolog A (S. cerevisiae) 0.0391491
MATR3 matrin 3 0.0388937
RPL5 ribosomal protein L5 0.0386078
ATP13A3 ATPase type 13A3 0.0383852
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0383457
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0382267
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0375714
QKI QKI, KH domain containing, RNA binding 0.0365213
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0364901
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.036159
CCNL1 cyclin L1 0.0358948
KDM6A lysine (K)-specific demethylase 6A 0.0358869
RYBP RING1 and YY1 binding protein 0.0354373
MBNL1 muscleblind-like splicing regulator 1 0.0344342
ITCH itchy E3 ubiquitin protein ligase 0.0340148
NPEPPS aminopeptidase puromycin sensitive 0.0335024
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0330592
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0325843
HSPA8 heat shock 70kDa protein 8 0.0324687
TXNRD1 thioredoxin reductase 1 0.0324094
GARS1 glycyl-tRNA synthetase 1 0.0321748
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0318228
SPAG9 sperm associated antigen 9 0.0316798
PCBP2 poly(rC) binding protein 2 0.031617
RHEB Ras homolog enriched in brain 0.0314811
TPM3 tropomyosin 3 0.0312646
ENO1 enolase 1, (alpha) 0.0312132
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0306703
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0306588
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0303884
MEF2A myocyte enhancer factor 2A 0.0303127
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0302188
BHLHE40 basic helix-loop-helix family, member e40 0.0301318
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0297193
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0295451
CLINT1 clathrin interactor 1 0.0294524
DSTN destrin (actin depolymerizing factor) 0.0291183
PAPOLA poly(A) polymerase alpha 0.0290973
PDIA6 protein disulfide isomerase family A, member 6 0.0290003
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0289317
CDK17 cyclin-dependent kinase 17 0.0289187
SSBP2 single-stranded DNA binding protein 2 0.0288762
PARD3 par-3 family cell polarity regulator 0.0282005
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0280777
RYK receptor-like tyrosine kinase 0.0278903
AGFG1 ArfGAP with FG repeats 1 0.027771
TRA2B transformer 2 beta homolog (Drosophila) 0.027768
SMC4 structural maintenance of chromosomes 4 0.0276673
FAM162A family with sequence similarity 162, member A 0.0276318
RIOK3 RIO kinase 3 0.0275487
RLF rearranged L-myc fusion 0.0274798
MTMR3 myotubularin related protein 3 0.0273723
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0273346

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.140418
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1392
ACTG1 actin gamma 1 -0.130424
TMSB10 thymosin beta 10 -0.127379
FTL ferritin, light polypeptide -0.118227
EXT1 exostosin glycosyltransferase 1 -0.0768439
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0729309
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0723959
SAMD4A sterile alpha motif domain containing 4A -0.0705385
LMO7 LIM domain 7 -0.0704516
RPL35A ribosomal protein L35a -0.0623852
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0618943
IGFBP3 insulin-like growth factor binding protein 3 -0.0612097
TPT1 tumor protein, translationally-controlled 1 -0.0600254
AHNAK AHNAK nucleoprotein -0.0574563
CANX calnexin -0.0546553
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0538501
EIF1 eukaryotic translation initiation factor 1 -0.0517095
ARHGAP5 Rho GTPase activating protein 5 -0.0482266
IFI6 interferon, alpha-inducible protein 6 -0.0471063
EFNA5 ephrin-A5 -0.0462396
LAMB3 laminin, beta 3 -0.0444245
SOX4 SRY (sex determining region Y)-box 4 -0.0441656
LOC112694756 uncharaterized LOC112694756 -0.0434937
FTH1 ferritin, heavy polypeptide 1 -0.0421496
MYO1E myosin IE -0.0420221
SDC4 syndecan 4 -0.0413332
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0402325
VCL vinculin -0.0391922
PLEC plectin -0.0387832
RPS19 ribosomal protein S19 -0.0380583
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0375604
RPL34 ribosomal protein L34 -0.0365046
FBXO32 F-box protein 32 -0.0357518
RPLP1 ribosomal protein, large, P1 -0.0349487
IFITM3 interferon induced transmembrane protein 3 -0.0347431
IFI27 interferon, alpha-inducible protein 27 -0.0346874
PALLD palladin, cytoskeletal associated protein -0.0336973
GOLGB1 golgin B1 -0.0322521
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0315966
LAMC2 laminin, gamma 2 -0.0315444
PGBD5 piggyBac transposable element derived 5 -0.0296329
ARHGAP20 Rho GTPase activating protein 20 -0.0286992
SH3RF1 SH3 domain containing ring finger 1 -0.0281844
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0278365
HLA-A major histocompatibility complex, class I, A -0.0274717
ETV6 ets variant 6 -0.0273429
SMAD3 SMAD family member 3 -0.0271607
RPL8 ribosomal protein L8 -0.0270096
ARF1 ADP-ribosylation factor 1 -0.0269648
KDM2A lysine (K)-specific demethylase 2A -0.0269472
SVIL supervillin -0.0269223
CSTB cystatin B (stefin B) -0.0269024
FNIP1 folliculin interacting protein 1 -0.0267381
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0261988
EGFR epidermal growth factor receptor -0.0260472
PTMA prothymosin, alpha -0.0257799
OSMR oncostatin M receptor -0.0257783
C15ORF48 chromosome 15 open reading frame 48 -0.0257757
CEP350 centrosomal protein 350kDa -0.0256345
ERBIN erbb2 interacting protein -0.0250986
CDK13 cyclin-dependent kinase 13 -0.0249721
HLA-E major histocompatibility complex, class I, E -0.0249203
HLA-B major histocompatibility complex, class I, B -0.0249026
H1-0 H1.0 linker histone -0.0248796
FBXL2 F-box and leucine-rich repeat protein 2 -0.0248006
SP100 SP100 nuclear antigen -0.0247619
RNF213 ring finger protein 213 -0.0246795
RRBP1 ribosome binding protein 1 -0.0245622
TJP1 tight junction protein 1 -0.024364
TPM4 tropomyosin 4 -0.0243572
LIMCH1 LIM and calponin homology domains 1 -0.0239675
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0237702
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0234315
RIGI RNA sensor RIG-I -0.0233065
BLZF1 basic leucine zipper nuclear factor 1 -0.0232587
S100A10 S100 calcium binding protein A10 -0.0230132
CTSB cathepsin B -0.0227511
RPS27A ribosomal protein S27a -0.0226334
MX2 MX dynamin-like GTPase 2 -0.0224626
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0223332
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0223274
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0222559
GNAS GNAS complex locus -0.0221822
IFITM1 interferon induced transmembrane protein 1 -0.0217789
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0217615
IFI16 interferon, gamma-inducible protein 16 -0.0215917
NPC1 Niemann-Pick disease, type C1 -0.0215844
RPS14 ribosomal protein S14 -0.0215097
VGLL3 vestigial-like family member 3 -0.0213634
RASAL2 RAS protein activator like 2 -0.0212751
CD44 CD44 molecule (Indian blood group) -0.0211578
BASP1 brain abundant, membrane attached signal protein 1 -0.0208908
MT2A metallothionein 2A -0.0207939
PLSCR1 phospholipid scramblase 1 -0.0202301
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0198883
VIM vimentin -0.0198786
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.0198356
CRABP2 cellular retinoic acid binding protein 2 -0.0198034
SH3KBP1 SH3-domain kinase binding protein 1 -0.019772