Hydroxyurea_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyurea perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyurea_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.158013
EFNA5 ephrin-A5 0.0871454
CXCL8 chemokine (C-X-C motif) ligand 8 0.0806597
TRIO trio Rho guanine nucleotide exchange factor 0.0770751
NEK7 NIMA-related kinase 7 0.0651223
RTN4 reticulon 4 0.0599598
ELL2 elongation factor, RNA polymerase II, 2 0.0588319
AGFG1 ArfGAP with FG repeats 1 0.0579001
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.057497
SPAG9 sperm associated antigen 9 0.0563956
GDA guanine deaminase 0.0517072
TXNRD1 thioredoxin reductase 1 0.0503857
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0503553
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0485573
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0475225
ATP13A3 ATPase type 13A3 0.0459954
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0429287
ESYT2 extended synaptotagmin-like protein 2 0.0421157
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0414167
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0404917
BIRC6 baculoviral IAP repeat containing 6 0.0403625
FNDC3B fibronectin type III domain containing 3B 0.0378534
TM4SF1 transmembrane 4 L six family member 1 0.03734
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.036785
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0362195
NUP58 nucleoporin 58 0.0360523
ZEB2 zinc finger E-box binding homeobox 2 0.035858
USP3 ubiquitin specific peptidase 3 0.0355487
OGA O-GlcNAcase 0.034717
FLNB filamin B, beta 0.0343037
UBA6 ubiquitin-like modifier activating enzyme 6 0.0337854
ERRFI1 ERBB receptor feedback inhibitor 1 0.0337481
NBAS neuroblastoma amplified sequence 0.0336295
FAM13A family with sequence similarity 13, member A 0.0334483
KMT2E lysine (K)-specific methyltransferase 2E 0.0329375
PTEN phosphatase and tensin homolog 0.032814
PUM2 pumilio RNA-binding family member 2 0.0326515
ZNF292 zinc finger protein 292 0.0324926
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0323548
NCKAP1 NCK-associated protein 1 0.0320044
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.031917
KDM6A lysine (K)-specific demethylase 6A 0.0314969
LIMCH1 LIM and calponin homology domains 1 0.0312447
RICTOR RPTOR independent companion of MTOR, complex 2 0.0311989
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0309467
CARD16 caspase recruitment domain family, member 16 0.0305843
ITPRID2 ITPR interacting domain containing 2 0.0302485
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0302133
AVL9 AVL9 homolog (S. cerevisiase) 0.0299381
TNPO1 transportin 1 0.0298886
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.029804
GOLGA4 golgin A4 0.0289191
KMT2C lysine (K)-specific methyltransferase 2C 0.0288021
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0287206
WDR43 WD repeat domain 43 0.0285773
ANXA5 annexin A5 0.0285579
HELZ helicase with zinc finger 0.0279408
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0274097
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.027077
RNF145 ring finger protein 145 0.0270714
USP9X ubiquitin specific peptidase 9, X-linked 0.0267306
COG5 component of oligomeric golgi complex 5 0.0266566
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0265101
SAMD4A sterile alpha motif domain containing 4A 0.0260965
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0259866
ENAH enabled homolog (Drosophila) 0.025858
WAC WW domain containing adaptor with coiled-coil 0.025556
CDC73 cell division cycle 73 0.0255173
CTSC cathepsin C 0.0253443
ANKRD28 ankyrin repeat domain 28 0.0251965
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0245777
COL4A6 collagen, type IV, alpha 6 0.0243372
CD109 CD109 molecule 0.0243356
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0241422
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0239008
USP34 ubiquitin specific peptidase 34 0.0234847
BRWD3 bromodomain and WD repeat domain containing 3 0.0234093
ADAM17 ADAM metallopeptidase domain 17 0.0226192
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0223086
DPY19L1 dpy-19-like 1 (C. elegans) 0.0222081
ADAM9 ADAM metallopeptidase domain 9 0.0221894
ARRDC3 arrestin domain containing 3 0.0221535
PTK2 protein tyrosine kinase 2 0.0216993
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0216681
RUNX1 runt-related transcription factor 1 0.0216271
SUCO SUN domain containing ossification factor 0.0215365
RBM39 RNA binding motif protein 39 0.0215133
RAP1B RAP1B, member of RAS oncogene family 0.0214763
ECPAS Ecm29 proteasome adaptor and scaffold 0.0213721
TSC22D2 TSC22 domain family, member 2 0.0213596
BMERB1 bMERB domain containing 1 0.0212238
AHCTF1 AT hook containing transcription factor 1 0.020806
ANKRD17 ankyrin repeat domain 17 0.0207918
OLA1 Obg-like ATPase 1 0.0206896
PICALM phosphatidylinositol binding clathrin assembly protein 0.0205079
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0203609
TCERG1 transcription elongation regulator 1 0.0203255
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0202499
NGLY1 N-glycanase 1 0.0202363
BZW1 basic leucine zipper and W2 domains 1 0.0202115

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.344801
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.273938
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.120665
PDE10A phosphodiesterase 10A -0.11344
TMSB10 thymosin beta 10 -0.109186
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0923297
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.090238
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0841996
COL5A2 collagen, type V, alpha 2 -0.0764049
NALF1 NALCN channel auxiliary factor 1 -0.0714446
FN1 fibronectin 1 -0.0690498
P3H2 prolyl 3-hydroxylase 2 -0.0685962
PRKN parkin RBR E3 ubiquitin protein ligase -0.0677502
VIM vimentin -0.0647458
TPT1 tumor protein, translationally-controlled 1 -0.0633148
PSD3 pleckstrin and Sec7 domain containing 3 -0.0600577
LSAMP limbic system-associated membrane protein -0.0588807
CDH13 cadherin 13 -0.058571
FTL ferritin, light polypeptide -0.0580981
RPLP1 ribosomal protein, large, P1 -0.0580958
RPS6 ribosomal protein S6 -0.055754
DST dystonin -0.0542698
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0534584
MAML3 mastermind-like 3 (Drosophila) -0.0463444
ADGRD1 adhesion G protein-coupled receptor D1 -0.0462192
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0456713
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0434379
BASP1 brain abundant, membrane attached signal protein 1 -0.0433638
PM20D1 peptidase M20 domain containing 1 -0.041898
RPL31 ribosomal protein L31 -0.0416922
PTMA prothymosin, alpha -0.039752
RPS19 ribosomal protein S19 -0.0393564
MT2A metallothionein 2A -0.0382872
RPL37A ribosomal protein L37a -0.0378341
RPL35A ribosomal protein L35a -0.0369127
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0368589
KIAA0825 KIAA0825 -0.0364343
VCL vinculin -0.0359353
PTPRM protein tyrosine phosphatase, receptor type, M -0.0357453
PCBP3 poly(rC) binding protein 3 -0.0353532
ANTXR1 anthrax toxin receptor 1 -0.0350953
RPL12 ribosomal protein L12 -0.0343525
PRELID2 PRELI domain containing 2 -0.0342187
ACTG1 actin gamma 1 -0.0338651
RPS8 ribosomal protein S8 -0.0337356
RAD51B RAD51 paralog B -0.0334966
PCDH15 protocadherin-related 15 -0.033083
RPL26 ribosomal protein L26 -0.0328911
RPL19 ribosomal protein L19 -0.0319796
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0316939
CADM2 cell adhesion molecule 2 -0.0311811
PDE7B phosphodiesterase 7B -0.0311561
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0310109
SMYD3 SET and MYND domain containing 3 -0.0307636
RPS24 ribosomal protein S24 -0.0306631
WARS1 tryptophanyl-tRNA synthetase 1 -0.0306579
RPS23 ribosomal protein S23 -0.0302792
NCKAP5 NCK-associated protein 5 -0.0300687
RPS27A ribosomal protein S27a -0.0299749
RPH3AL rabphilin 3A-like (without C2 domains) -0.0299636
GNAS GNAS complex locus -0.0286517
RPL9 ribosomal protein L9 -0.0282672
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0278539
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0278489
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0277877
SOX4 SRY (sex determining region Y)-box 4 -0.0275677
RPLP2 ribosomal protein, large, P2 -0.0271455
RPS29 ribosomal protein S29 -0.0263207
INTS6 integrator complex subunit 6 -0.0262717
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0261317
RPS4X ribosomal protein S4, X-linked -0.0259647
DOCK5 dedicator of cytokinesis 5 -0.0256496
CHL1 cell adhesion molecule L1-like -0.0256316
RPL37 ribosomal protein L37 -0.0254677
RPL36 ribosomal protein L36 -0.0254661
RPS21 ribosomal protein S21 -0.0251234
MAP7 microtubule-associated protein 7 -0.0249317
RPL23 ribosomal protein L23 -0.0248812
RPL34 ribosomal protein L34 -0.0244952
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0244826
RPS3 ribosomal protein S3 -0.0244603
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0241978
RPL7A ribosomal protein L7a -0.0241621
RPL11 ribosomal protein L11 -0.0239553
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0237471
RTN1 reticulon 1 -0.0233931
SQSTM1 sequestosome 1 -0.0232476
RIGI RNA sensor RIG-I -0.02304
SMOC1 SPARC related modular calcium binding 1 -0.0230042
ITPK1 inositol-tetrakisphosphate 1-kinase -0.0229634
RPS14 ribosomal protein S14 -0.0229161
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0228963
RPS12 ribosomal protein S12 -0.0228954
AUTS2 autism susceptibility candidate 2 -0.022885
EPHA4 EPH receptor A4 -0.0227694
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0227285
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0227237
CUX1 cut-like homeobox 1 -0.0225112
AEBP2 AE binding protein 2 -0.0223823
AGTPBP1 ATP/GTP binding protein 1 -0.0216611