| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyurea perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyurea_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.366192 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.158928 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.125709 |
| RPS16 | ribosomal protein S16 | 0.106324 |
| PGK1 | phosphoglycerate kinase 1 | 0.106087 |
| EGFR | epidermal growth factor receptor | 0.102396 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0913792 |
| NDRG1 | N-myc downstream regulated 1 | 0.0812373 |
| RPS6 | ribosomal protein S6 | 0.0790597 |
| RPL37A | ribosomal protein L37a | 0.0790586 |
| GOLGA4 | golgin A4 | 0.0752553 |
| JMJD1C | jumonji domain containing 1C | 0.0729162 |
| VIM | vimentin | 0.0727986 |
| B2M | beta-2-microglobulin | 0.0676591 |
| TXNRD1 | thioredoxin reductase 1 | 0.0650065 |
| PTMA | prothymosin, alpha | 0.0645503 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0610166 |
| RPS3 | ribosomal protein S3 | 0.0605236 |
| FTL | ferritin, light polypeptide | 0.0603675 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0595538 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0588011 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0573379 |
| TMSB10 | thymosin beta 10 | 0.0562819 |
| SETD5 | SET domain containing 5 | 0.0521667 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0517458 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0503203 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0499458 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0489803 |
| RPL12 | ribosomal protein L12 | 0.0487704 |
| NOP58 | NOP58 ribonucleoprotein | 0.0449372 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0432503 |
| RPS12 | ribosomal protein S12 | 0.0431207 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0428677 |
| PCBP2 | poly(rC) binding protein 2 | 0.0424157 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0417419 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0413501 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0412534 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0397866 |
| HM13 | histocompatibility (minor) 13 | 0.0388179 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0380911 |
| SPAG9 | sperm associated antigen 9 | 0.0379929 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0379475 |
| ENO1 | enolase 1, (alpha) | 0.0379425 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0378624 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0372007 |
| RPL34 | ribosomal protein L34 | 0.0370543 |
| NEK7 | NIMA-related kinase 7 | 0.0354607 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0341121 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0333438 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0327409 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0320297 |
| RNF145 | ring finger protein 145 | 0.0310957 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0307743 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0286038 |
| SUCO | SUN domain containing ossification factor | 0.0279519 |
| GNAS | GNAS complex locus | 0.0277466 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0277243 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0270797 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.026095 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.025098 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0239267 |
| MAP1B | microtubule-associated protein 1B | 0.0235704 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0234299 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0232288 |
| INSIG2 | insulin induced gene 2 | 0.022865 |
| ZRANB2 | zinc finger, RAN-binding domain containing 2 | 0.0212123 |
| RACK1 | receptor for activated C kinase 1 | 0.0209849 |
| RBM39 | RNA binding motif protein 39 | 0.0205595 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0205389 |
| ATP13A3 | ATPase type 13A3 | 0.0200039 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0187883 |
| LDHA | lactate dehydrogenase A | 0.0180431 |
| CD109 | CD109 molecule | 0.0177524 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0170869 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0167911 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0159989 |
| SEPTIN2 | septin 2 | 0.0159087 |
| CANX | calnexin | 0.0156481 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0151757 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0150166 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.014744 |
| FNBP1L | formin binding protein 1-like | 0.0147062 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0136862 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0130841 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0125099 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0120069 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0118423 |
| MYO6 | myosin VI | 0.0117263 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0106449 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.010444 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.00967746 |
| DENND4A | DENN/MADD domain containing 4A | 0.00911636 |
| AFF4 | AF4/FMR2 family, member 4 | 0.00837328 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.00777499 |
| ANKRD28 | ankyrin repeat domain 28 | 0.00776807 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.00740993 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.00696432 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.00687137 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.00627301 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.00573648 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.140122 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.113226 |
| PDE10A | phosphodiesterase 10A | -0.101782 |
| VCL | vinculin | -0.0842817 |
| EFNA5 | ephrin-A5 | -0.0832234 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0826683 |
| COL5A2 | collagen, type V, alpha 2 | -0.0723089 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0663593 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0642654 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0634701 |
| FOXP1 | forkhead box P1 | -0.0632654 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0608186 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0550331 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0525468 |
| SMYD3 | SET and MYND domain containing 3 | -0.0522784 |
| NABP1 | nucleic acid binding protein 1 | -0.0521861 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0490873 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0483784 |
| CUL3 | cullin 3 | -0.0463943 |
| USP34 | ubiquitin specific peptidase 34 | -0.0463371 |
| VMP1 | vacuole membrane protein 1 | -0.0456988 |
| ASPH | aspartate beta-hydroxylase | -0.0454933 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.045053 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0432354 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0425645 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0417801 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0401443 |
| POTEF | POTE ankyrin domain family, member F | -0.039595 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0389661 |
| CNKSR3 | CNKSR family member 3 | -0.0386452 |
| OGA | O-GlcNAcase | -0.038345 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0374734 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.036119 |
| PRKCA | protein kinase C, alpha | -0.0356631 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0356067 |
| LMO7 | LIM domain 7 | -0.0355545 |
| TNRC6A | trinucleotide repeat containing 6A | -0.0354112 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0350693 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0349332 |
| ANO6 | anoctamin 6 | -0.0336777 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0336355 |
| PHIP | pleckstrin homology domain interacting protein | -0.0334093 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0327503 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0319282 |
| PARD3 | par-3 family cell polarity regulator | -0.0316972 |
| FLNB | filamin B, beta | -0.0315327 |
| KIF1B | kinesin family member 1B | -0.0315162 |
| RAI14 | retinoic acid induced 14 | -0.0312724 |
| ACTG1 | actin gamma 1 | -0.0310353 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0308645 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0300727 |
| WDR43 | WD repeat domain 43 | -0.0294442 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0293305 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0292634 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0288674 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0288227 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0259621 |
| EXOC6B | exocyst complex component 6B | -0.025592 |
| USP53 | ubiquitin specific peptidase 53 | -0.025206 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.024532 |
| FMNL2 | formin-like 2 | -0.0243727 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0240657 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0238507 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0237099 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0234638 |
| CD2AP | CD2-associated protein | -0.0226356 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0222957 |
| FBXO11 | F-box protein 11 | -0.0220699 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0214935 |
| DENND4C | DENN/MADD domain containing 4C | -0.0212878 |
| MYOF | myoferlin | -0.0212538 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0211275 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0205451 |
| UBXN7 | UBX domain protein 7 | -0.0201982 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.020063 |
| KIF5B | kinesin family member 5B | -0.0197937 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | -0.0195113 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.019502 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0190644 |
| NUP153 | nucleoporin 153kDa | -0.0190552 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0179965 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0179455 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | -0.0178837 |
| MED13 | mediator complex subunit 13 | -0.0174415 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0171033 |
| BRD4 | bromodomain containing 4 | -0.0168624 |
| KIF21A | kinesin family member 21A | -0.0166228 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0165549 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0165015 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0161898 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0160272 |
| PRPF8 | pre-mRNA processing factor 8 | -0.0158239 |
| PRELID2 | PRELI domain containing 2 | -0.0157616 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0149616 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0146789 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0145368 |
| YAP1 | Yes-associated protein 1 | -0.0144806 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0144234 |
| NBAS | neuroblastoma amplified sequence | -0.0141965 |
| RIGI | RNA sensor RIG-I | -0.0138786 |
