| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyurea perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Hydroxyurea_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPAG9 | sperm associated antigen 9 | 0.0876796 |
| ZNF292 | zinc finger protein 292 | 0.0669535 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0647435 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0618454 |
| WDR43 | WD repeat domain 43 | 0.0594934 |
| HMGA1 | high mobility group AT-hook 1 | 0.0579429 |
| ANXA5 | annexin A5 | 0.057918 |
| PFN1 | profilin 1 | 0.0525479 |
| RPL5 | ribosomal protein L5 | 0.051787 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0514928 |
| MED13L | mediator complex subunit 13-like | 0.046671 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0457765 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0388998 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0386201 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0384828 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0380008 |
| CALCR | calcitonin receptor | 0.0353464 |
| MB21D2 | Mab-21 domain containing 2 | 0.0340428 |
| MTF2 | metal response element binding transcription factor 2 | 0.0337597 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.0334537 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0330288 |
| FAM171B | family with sequence similarity 171, member B | 0.0328072 |
| FBXO11 | F-box protein 11 | 0.0328061 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0326391 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0326148 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0324806 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0323889 |
| UPP1 | uridine phosphorylase 1 | 0.0320528 |
| RHEB | Ras homolog enriched in brain | 0.0319268 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0313906 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0313532 |
| FN1 | fibronectin 1 | 0.031025 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0309052 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0306647 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0304804 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0302963 |
| RTN4 | reticulon 4 | 0.0300445 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0299051 |
| CCND1 | cyclin D1 | 0.0298026 |
| FOXO1 | forkhead box O1 | 0.0294973 |
| TMEM87A | transmembrane protein 87A | 0.0293545 |
| POU2F1 | POU class 2 homeobox 1 | 0.0291601 |
| NDRG1 | N-myc downstream regulated 1 | 0.0291046 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0288832 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0288816 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0286603 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0285851 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0284265 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0283487 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0283336 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.028237 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0281163 |
| RPL30 | ribosomal protein L30 | 0.0279516 |
| ZFP36 | ZFP36 ring finger protein | 0.0278087 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0276865 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0276275 |
| FTL | ferritin, light polypeptide | 0.0273761 |
| FAM133B | family with sequence similarity 133, member B | 0.0271752 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0271551 |
| GAB2 | GRB2-associated binding protein 2 | 0.0269151 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0268414 |
| ANK2 | ankyrin 2, neuronal | 0.0268142 |
| JMJD1C | jumonji domain containing 1C | 0.0266644 |
| ORC4 | origin recognition complex, subunit 4 | 0.026577 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0262041 |
| RPL28 | ribosomal protein L28 | 0.0260696 |
| SLC44A5 | solute carrier family 44, member 5 | 0.025652 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0255759 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0255591 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0252882 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0250137 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0249077 |
| RNASEH2A | ribonuclease H2, subunit A | 0.024803 |
| USP3 | ubiquitin specific peptidase 3 | 0.0247352 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0246514 |
| NOP58 | NOP58 ribonucleoprotein | 0.0246454 |
| RPS24 | ribosomal protein S24 | 0.0246373 |
| RYBP | RING1 and YY1 binding protein | 0.0241789 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0239709 |
| LRRN3 | leucine rich repeat neuronal 3 | 0.0238854 |
| TUSC3 | tumor suppressor candidate 3 | 0.0238561 |
| FLNB | filamin B, beta | 0.0238191 |
| KLHDC10 | kelch domain containing 10 | 0.0236647 |
| USP12 | ubiquitin specific peptidase 12 | 0.0233821 |
| RPLP1 | ribosomal protein, large, P1 | 0.0231467 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0230898 |
| TNPO1 | transportin 1 | 0.0229612 |
| RBM39 | RNA binding motif protein 39 | 0.022745 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0227282 |
| FAM168A | family with sequence similarity 168, member A | 0.0226659 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0225864 |
| S100A10 | S100 calcium binding protein A10 | 0.0225474 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0224863 |
| RPS12 | ribosomal protein S12 | 0.0223697 |
| RREB1 | ras responsive element binding protein 1 | 0.0220166 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0218485 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0217088 |
| NOCT | nocturnin | 0.021685 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0215014 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0214201 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | -0.222079 |
| VIM | vimentin | -0.157605 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.112136 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.110682 |
| COL5A2 | collagen, type V, alpha 2 | -0.0935159 |
| COL3A1 | collagen, type III, alpha 1 | -0.08715 |
| ITGAV | integrin, alpha V | -0.0867491 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.081062 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0753639 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0751039 |
| TMSB4X | thymosin beta 4, X-linked | -0.0746237 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0731128 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.071313 |
| SNX6 | sorting nexin 6 | -0.0690419 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0686949 |
| TMSB10 | thymosin beta 10 | -0.0677207 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0673526 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0670385 |
| MKI67 | marker of proliferation Ki-67 | -0.0669073 |
| NTM | neurotrimin | -0.0618899 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0606711 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0584296 |
| AHNAK | AHNAK nucleoprotein | -0.0549837 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0548278 |
| PHIP | pleckstrin homology domain interacting protein | -0.0547566 |
| CKAP5 | cytoskeleton associated protein 5 | -0.054726 |
| HMGB2 | high mobility group box 2 | -0.0541843 |
| RDX | radixin | -0.05397 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0527173 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0524751 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0517503 |
| ACTG1 | actin gamma 1 | -0.0509684 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0503936 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0486089 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0478635 |
| SMC4 | structural maintenance of chromosomes 4 | -0.047777 |
| STAG2 | stromal antigen 2 | -0.0476646 |
| CADM2 | cell adhesion molecule 2 | -0.0470238 |
| RPS2 | ribosomal protein S2 | -0.0444717 |
| PGK1 | phosphoglycerate kinase 1 | -0.0442717 |
| CENPF | centromere protein F, 350/400kDa | -0.0441454 |
| YBX1 | Y box binding protein 1 | -0.0438301 |
| PRKD1 | protein kinase D1 | -0.043606 |
| SET | SET nuclear proto-oncogene | -0.0435625 |
| APP | amyloid beta (A4) precursor protein | -0.043535 |
| MYL12B | myosin, light chain 12B, regulatory | -0.042586 |
| HDAC9 | histone deacetylase 9 | -0.0424554 |
| H1-4 | H1.4 linker histone, cluster member | -0.0423839 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0421948 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0421714 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0421675 |
| CANX | calnexin | -0.0419489 |
| CALR | calreticulin | -0.0417382 |
| THBS1 | thrombospondin 1 | -0.041259 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0412574 |
| UBC | ubiquitin C | -0.0405096 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0392828 |
| COL1A2 | collagen, type I, alpha 2 | -0.0392339 |
| STMN1 | stathmin 1 | -0.0390559 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0385147 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0384843 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0384543 |
| CLTC | clathrin, heavy chain (Hc) | -0.0384098 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0381544 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0375566 |
| GNAS | GNAS complex locus | -0.036275 |
| NKTR | natural killer cell triggering receptor | -0.0362477 |
| MEIS2 | Meis homeobox 2 | -0.03566 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0355815 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0347081 |
| TENM3 | teneurin transmembrane protein 3 | -0.034406 |
| TEX11 | testis expressed 11 | -0.0343093 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0342524 |
| CALU | calumenin | -0.0342047 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0341425 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0340632 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | -0.033558 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0334849 |
| TPM3 | tropomyosin 3 | -0.0328402 |
| POTEF | POTE ankyrin domain family, member F | -0.032487 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0323838 |
| CEP350 | centrosomal protein 350kDa | -0.0322757 |
| MAP4 | microtubule-associated protein 4 | -0.0319656 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0314146 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0311503 |
| GPC3 | glypican 3 | -0.0309035 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0306965 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.0304418 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0303649 |
| CDK12 | cyclin-dependent kinase 12 | -0.0303182 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0302607 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.0300304 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0299693 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0294751 |
| TPX2 | TPX2, microtubule-associated | -0.029239 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0291877 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.029024 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0289869 |
| TENM2 | teneurin transmembrane protein 2 | -0.0283872 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0283519 |
