| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyurea perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyurea_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.131539 |
| FLNB | filamin B, beta | 0.117569 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0854696 |
| EGFR | epidermal growth factor receptor | 0.0814072 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0728474 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0662333 |
| HDAC9 | histone deacetylase 9 | 0.0659001 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0644061 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0605321 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.059328 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0586251 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0579586 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0566814 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0517112 |
| PYGB | phosphorylase, glycogen; brain | 0.0473394 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0471848 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 0.0462571 |
| EVI5 | ecotropic viral integration site 5 | 0.0461712 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0458378 |
| TJP1 | tight junction protein 1 | 0.0456671 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0451877 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0443324 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0433279 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0422381 |
| SETD5 | SET domain containing 5 | 0.0422187 |
| NUP58 | nucleoporin 58 | 0.0420035 |
| ZNF292 | zinc finger protein 292 | 0.0417771 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.040669 |
| TXNRD1 | thioredoxin reductase 1 | 0.038954 |
| NBEA | neurobeachin | 0.0373002 |
| RPL5 | ribosomal protein L5 | 0.0370402 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0369401 |
| SMYD3 | SET and MYND domain containing 3 | 0.0368045 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0360769 |
| MED13L | mediator complex subunit 13-like | 0.0359917 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 0.035844 |
| JMJD1C | jumonji domain containing 1C | 0.0354578 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0348929 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0338994 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0338814 |
| RPS12 | ribosomal protein S12 | 0.033521 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0331642 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0329996 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0322091 |
| SBF2 | SET binding factor 2 | 0.032142 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0320689 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0320358 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0310194 |
| RTN4 | reticulon 4 | 0.0307676 |
| NGLY1 | N-glycanase 1 | 0.0306931 |
| EZR | ezrin | 0.0304505 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0302319 |
| TMEM41B | transmembrane protein 41B | 0.0299225 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0298898 |
| GLI2 | GLI family zinc finger 2 | 0.0294251 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0294018 |
| NBEAL1 | neurobeachin-like 1 | 0.0293175 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0292162 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0289668 |
| PCBP2 | poly(rC) binding protein 2 | 0.0289128 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0288433 |
| VMP1 | vacuole membrane protein 1 | 0.028753 |
| HMGA1 | high mobility group AT-hook 1 | 0.0287377 |
| RPS2 | ribosomal protein S2 | 0.0287178 |
| NF1 | neurofibromin 1 | 0.0284497 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0283528 |
| TMEM65 | transmembrane protein 65 | 0.028219 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.028142 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0280294 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0279573 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0278628 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0277577 |
| ANXA1 | annexin A1 | 0.0276148 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0274846 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0269485 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0267684 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0266204 |
| RAB10 | RAB10, member RAS oncogene family | 0.0266153 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0265342 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0263701 |
| CCND1 | cyclin D1 | 0.0261385 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0259833 |
| PDGFC | platelet derived growth factor C | 0.0259344 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0258585 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0255083 |
| YAP1 | Yes-associated protein 1 | 0.0253747 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.02533 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0251853 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0250198 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0249509 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0248588 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0248531 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0244831 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.024453 |
| RPS8 | ribosomal protein S8 | 0.0244202 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0240393 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.023989 |
| NCKAP1 | NCK-associated protein 1 | 0.0239363 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0238717 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0238271 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.156062 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.123137 |
| AHNAK | AHNAK nucleoprotein | -0.117221 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0919661 |
| TMSB4X | thymosin beta 4, X-linked | -0.0830881 |
| PTMA | prothymosin, alpha | -0.0804855 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0778736 |
| ACTG1 | actin gamma 1 | -0.0630975 |
| RPL35A | ribosomal protein L35a | -0.0589178 |
| RPS19 | ribosomal protein S19 | -0.0525364 |
| PKM | pyruvate kinase, muscle | -0.0476994 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0474613 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0439177 |
| RPLP1 | ribosomal protein, large, P1 | -0.0421764 |
| CANX | calnexin | -0.0412648 |
| S100A6 | S100 calcium binding protein A6 | -0.0410002 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0385555 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.037913 |
| HDLBP | high density lipoprotein binding protein | -0.0378446 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0376685 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0374644 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0347461 |
| TMSB10 | thymosin beta 10 | -0.0326835 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0316609 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0314859 |
| MKI67 | marker of proliferation Ki-67 | -0.0310438 |
| RRBP1 | ribosome binding protein 1 | -0.0306679 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0295873 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0291945 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0280743 |
| JUN | jun proto-oncogene | -0.0270275 |
| RPS14 | ribosomal protein S14 | -0.0263254 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0261491 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0256347 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0255467 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0254603 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0251 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | -0.0248866 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0247484 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0247104 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0245311 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0243224 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0243036 |
| B2M | beta-2-microglobulin | -0.0242679 |
| RPL34 | ribosomal protein L34 | -0.024038 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0238718 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0237722 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0233624 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0232737 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.0227862 |
| NOP58 | NOP58 ribonucleoprotein | -0.0226599 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0225879 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0222257 |
| ARF1 | ADP-ribosylation factor 1 | -0.0222017 |
| LDHA | lactate dehydrogenase A | -0.0221858 |
| FTL | ferritin, light polypeptide | -0.0219407 |
| HMGB1 | high mobility group box 1 | -0.021901 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0218754 |
| PGK1 | phosphoglycerate kinase 1 | -0.0218107 |
| VIM | vimentin | -0.0213199 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.021144 |
| TUBB | tubulin, beta class I | -0.021021 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.02097 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0207925 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.020674 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0202762 |
| YBX1 | Y box binding protein 1 | -0.020196 |
| TPM4 | tropomyosin 4 | -0.0201959 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0201376 |
| RPS6 | ribosomal protein S6 | -0.0199287 |
| RPL14 | ribosomal protein L14 | -0.0199038 |
| CUL4B | cullin 4B | -0.0195512 |
| S100A4 | S100 calcium binding protein A4 | -0.0194136 |
| SEC61G | Sec61 gamma subunit | -0.0193179 |
| ABI1 | abl-interactor 1 | -0.0192412 |
| FN1 | fibronectin 1 | -0.0190953 |
| HMGB2 | high mobility group box 2 | -0.0189979 |
| RPL4 | ribosomal protein L4 | -0.0189018 |
| IPO7 | importin 7 | -0.0187531 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0184714 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0184152 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0183878 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0182991 |
| BPTF | bromodomain PHD finger transcription factor | -0.0177987 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0175749 |
| RPS11 | ribosomal protein S11 | -0.0175653 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.01755 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0174951 |
| RPLP0 | ribosomal protein, large, P0 | -0.0174134 |
| H3-3B | H3.3 histone B | -0.0172841 |
| RPS27A | ribosomal protein S27a | -0.0172828 |
| RPS24 | ribosomal protein S24 | -0.0172313 |
| RPS4X | ribosomal protein S4, X-linked | -0.017147 |
| DEK | DEK proto-oncogene | -0.0170756 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0168527 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | -0.0166177 |
| NAV2 | neuron navigator 2 | -0.0165683 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0165486 |
| BMP10 | bone morphogenetic protein 10 | -0.0164539 |
| VDAC1 | voltage-dependent anion channel 1 | -0.016404 |
