Hyperandrogenism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

370 genes co-occuring with the disease Hyperandrogenism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
SHBG sex hormone-binding globulin 3.869
AMH anti-Mullerian hormone 3.563
INS insulin 3.493
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 3.141
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 3.128
PRL prolactin 3.058
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.03
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.979
DENND1A DENN/MADD domain containing 1A 2.972
POMC proopiomelanocortin 2.97
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.871
INSR insulin receptor 2.826
FSHR follicle stimulating hormone receptor 2.773
LHCGR luteinizing hormone/choriogonadotropin receptor 2.765
AR androgen receptor 2.751
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.708
LEP leptin 2.695
IGF1 insulin-like growth factor 1 (somatomedin C) 2.694
KISS1 KiSS-1 metastasis-suppressor 2.683
ADIPOQ adiponectin, C1Q and collagen domain containing 2.645
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 2.591
STAR steroidogenic acute regulatory protein 2.493
IGFBP1 insulin-like growth factor binding protein 1 2.436
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 2.419
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 2.413
IRS1 insulin receptor substrate 1 2.371
FSHB follicle stimulating hormone, beta polypeptide 2.357
AMHR2 anti-Mullerian hormone receptor, type II 2.356
AOPEP aminopeptidase O (putative) 2.332
GDF9 growth differentiation factor 9 2.324
TAC3 tachykinin 3 2.311
FBN3 fibrillin 3 2.303
AKR1C3 aldo-keto reductase family 1, member C3 2.298
ESR1 estrogen receptor 1 2.29
PPARG peroxisome proliferator-activated receptor gamma 2.252
CRP C-reactive protein, pentraxin-related 2.237
RAB5B RAB5B, member RAS oncogene family 2.233
IL6 interleukin 6 2.233
BMP15 bone morphogenetic protein 15 2.233
WNT4 wingless-type MMTV integration site family, member 4 2.216
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.201
TNF tumor necrosis factor 2.165
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.126
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.121
GNRHR gonadotropin-releasing hormone receptor 2.111
ESR2 estrogen receptor 2 (ER beta) 2.101
TOX3 TOX high mobility group box family member 3 2.097
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.093
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.081
THADA thyroid adenoma associated 2.076
RETN resistin 2.062
CAPN10 calpain 10 2.056
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 2.053
GCG glucagon 2.05
REN renin 2.044
GHRL ghrelin/obestatin prepropeptide 2.042
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.034
RETNLB resistin like beta 2.028
CRH corticotropin releasing hormone 2.015
KISS1R KISS1 receptor 2.014
NAMPT nicotinamide phosphoribosyltransferase 1.978
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.969
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.968
TACR3 tachykinin receptor 3 1.956
FOXL2 forkhead box L2 1.949
HOXA10 homeobox A10 1.942
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 1.936
FST follistatin 1.926
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 1.91
INSL3 insulin-like 3 (Leydig cell) 1.909
IL1B interleukin 1, beta 1.902
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.901
PDYN prodynorphin 1.889
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 1.88
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.875
GLP1R glucagon-like peptide 1 receptor 1.866
IRS2 insulin receptor substrate 2 1.864
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.852
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.852
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.846
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.842
IL18 interleukin 18 1.842
ALB albumin 1.826
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.822
PGR progesterone receptor 1.812
APOB apolipoprotein B 1.808
IGF2 insulin-like growth factor 2 1.788
TGFB1 transforming growth factor, beta 1 1.757
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.753
ARL14EP ADP-ribosylation factor-like 14 effector protein 1.746
NPY neuropeptide Y 1.74
ITLN1 intelectin 1 (galactofuranose binding) 1.73
FTO fat mass and obesity associated 1.72
TBC1D4 TBC1 domain family, member 4 1.715
FNDC5 fibronectin type III domain containing 5 1.709
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.708
MC4R melanocortin 4 receptor 1.698
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.697
CYB5A cytochrome b5 type A (microsomal) 1.691
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.687
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.683
IGFBP3 insulin-like growth factor binding protein 3 1.68
APOA1 apolipoprotein A-I 1.677
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 1.677
FOXO1 forkhead box O1 1.67
CMKLR1 chemerin chemokine-like receptor 1 1.656
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.656
CCL2 chemokine (C-C motif) ligand 2 1.653
SUOX sulfite oxidase 1.647
LHX1 LIM homeobox 1 1.641
YAP1 Yes-associated protein 1 1.635
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.634
ACTB actin, beta 1.621
IL1A interleukin 1, alpha 1.621
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.62
ALMS1 Alstrom syndrome protein 1 1.617
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1.617
LEPR leptin receptor 1.615
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.612
IGF1R insulin-like growth factor 1 receptor 1.609
NEIL2 nei endonuclease VIII-like 2 (E. coli) 1.599
RHCG Rh family, C glycoprotein 1.598
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.595
LIPE lipase, hormone-sensitive 1.591
MTNR1A melatonin receptor 1A 1.583
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.583
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 1.582
SIRT1 sirtuin 1 1.575
HMGA2 high mobility group AT-hook 2 1.575
TBX6 T-box 6 1.571
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.566
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.561
LPL lipoprotein lipase 1.558
AGRP agouti related neuropeptide 1.556
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 1.553
LMNA lamin A/C 1.546
PYY peptide YY 1.543
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.539
GATA4 GATA binding protein 4 1.528
TRH thyrotropin-releasing hormone 1.528
SRY sex determining region Y 1.523
ADIPOR2 adiponectin receptor 2 1.518
ADIPOR1 adiponectin receptor 1 1.517
RBP4 retinol binding protein 4, plasma 1.515
DPP4 dipeptidyl-peptidase 4 1.503
GPX3 glutathione peroxidase 3 1.502
PPARA peroxisome proliferator-activated receptor alpha 1.499
GPER1 G protein-coupled estrogen receptor 1 1.495
PON1 paraoxonase 1 1.494
IL10 interleukin 10 1.49
GPX5 glutathione peroxidase 5 1.485
GPX8 glutathione peroxidase 8 (putative) 1.48
GPX2 glutathione peroxidase 2 1.478
GPX6 glutathione peroxidase 6 1.477
POR P450 (cytochrome) oxidoreductase 1.477
MTNR1B melatonin receptor 1B 1.475
ACE angiotensin I converting enzyme 1.475
GPX7 glutathione peroxidase 7 1.472
APLN apelin 1.47
PXDN peroxidasin 1.466
PXDNL peroxidasin-like 1.464
SREBF1 sterol regulatory element binding transcription factor 1 1.458
GHR growth hormone receptor 1.45
STS steroid sulfatase (microsomal), isozyme S 1.447
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.444
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.438
FEM1A fem-1 homolog a (C. elegans) 1.427
NGF nerve growth factor (beta polypeptide) 1.425
PLIN1 perilipin 1 1.421
PAEP progestagen-associated endometrial protein 1.417
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.414
EDN1 endothelin 1 1.403
TPO thyroid peroxidase 1.403
LIPC lipase, hepatic 1.402
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.4
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 1.4
FOXO3 forkhead box O3 1.4
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 1.394
FEM1C fem-1 homolog c (C. elegans) 1.393
PTH parathyroid hormone 1.392
WNT9B wingless-type MMTV integration site family, member 9B 1.391
BCL2 B-cell CLL/lymphoma 2 1.388
CXCL8 chemokine (C-X-C motif) ligand 8 1.386
PLG plasminogen 1.379
HOXA11 homeobox A11 1.375
WNT7A wingless-type MMTV integration site family, member 7A 1.373
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 1.372
TMPRSS2 transmembrane protease, serine 2 1.37
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 1.362
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.36
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 1.358
MAPK3 mitogen-activated protein kinase 3 1.358
CCK cholecystokinin 1.353
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.349
IL22 interleukin 22 1.344
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.343
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.342
TLR4 toll-like receptor 4 1.341
LIF leukemia inhibitory factor 1.34
SST somatostatin 1.335
MADD MAP-kinase activating death domain 1.331
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 1.328
HOXA13 homeobox A13 1.323
CSH2 chorionic somatomammotropin hormone 2 1.317
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.316
AKR1C2 aldo-keto reductase family 1, member C2 1.316
DMRT1 doublesex and mab-3 related transcription factor 1 1.313
FOS FBJ murine osteosarcoma viral oncogene homolog 1.313
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.302
TP53 tumor protein p53 1.299
GHRH growth hormone releasing hormone 1.298
SHOX short stature homeobox 1.295
LHB luteinizing hormone beta polypeptide 1.29
TNXB tenascin XB 1.285
ZP4 zona pellucida glycoprotein 4 1.281
IL17A interleukin 17A 1.281
DHRS9 dehydrogenase/reductase (SDR family) member 9 1.279
IFNG interferon, gamma 1.278
NPVF neuropeptide VF precursor 1.272
EGF epidermal growth factor 1.269
BAX BCL2-associated X protein 1.267
PTEN phosphatase and tensin homolog 1.267
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.265
FKBP5 FK506 binding protein 5 1.264
LDLR low density lipoprotein receptor 1.262
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.257
FIGLA folliculogenesis specific basic helix-loop-helix 1.253
JUN jun proto-oncogene 1.252
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.252
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.249
PGRMC1 progesterone receptor membrane component 1 1.249
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.249
FGF21 fibroblast growth factor 21 1.248
ERBB4 erb-b2 receptor tyrosine kinase 4 1.245
OXT oxytocin/neurophysin I prepropeptide 1.245
TG thyroglobulin 1.244
WT1 Wilms tumor 1 1.243
NOBOX NOBOX oogenesis homeobox 1.241
CALB2 calbindin 2 1.236
CAVIN1 caveolae associated protein 1 1.235
ZNF217 zinc finger protein 217 1.234
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.234
INHBB inhibin, beta B 1.234
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 1.23
LBR lamin B receptor 1.223
BGLAP bone gamma-carboxyglutamate (gla) protein 1.217
PRLR prolactin receptor 1.217
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.217
GREB1L growth regulation by estrogen in breast cancer-like 1.214
VCAM1 vascular cell adhesion molecule 1 1.212
CREB1 cAMP responsive element binding protein 1 1.212
GATA6 GATA binding protein 6 1.211
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.21
SORBS1 sorbin and SH3 domain containing 1 1.206
PTX3 pentraxin 3, long 1.205
ACE2 angiotensin I converting enzyme 2 1.205
AHSG alpha-2-HS-glycoprotein 1.196
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.195
LPA lipoprotein, Lp(a) 1.194
ANGPTL8 angiopoietin like 8 1.191
SCARB1 scavenger receptor class B, member 1 1.191
NOS3 nitric oxide synthase 3 (endothelial cell) 1.186
SIRT3 sirtuin 3 1.185
GC group-specific component (vitamin D binding protein) 1.18
PER2 period circadian clock 2 1.178
SOX9 SRY (sex determining region Y)-box 9 1.175
CRHR1 corticotropin releasing hormone receptor 1 1.175
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.175
UNK unkempt family zinc finger 1.17
MMP9 matrix metallopeptidase 9 1.161
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1.16
WNT5A wingless-type MMTV integration site family, member 5A 1.154
KITLG KIT ligand 1.154
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 1.154
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.153
METRNL meteorin, glial cell differentiation regulator-like 1.152
EMX2 empty spiracles homeobox 2 1.149
PAX2 paired box 2 1.148
GIP gastric inhibitory polypeptide 1.144
ADRA1B adrenoceptor alpha 1B 1.143
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.143
BDNF brain-derived neurotrophic factor 1.142
FKBP4 FK506 binding protein 4, 59kDa 1.137
BMPR1B bone morphogenetic protein receptor, type IB 1.135
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.132
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 1.132
ARMC5 armadillo repeat containing 5 1.13
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.128
PCNA proliferating cell nuclear antigen 1.127
RAD50 RAD50 homolog (S. cerevisiae) 1.126
ALG6 ALG6, alpha-1,3-glucosyltransferase 1.125
HP haptoglobin 1.122
ZMPSTE24 zinc metallopeptidase STE24 1.121
GCK glucokinase (hexokinase 4) 1.12
ANOS1 anosmin 1 1.116
MEN1 multiple endocrine neoplasia I 1.109
BMP4 bone morphogenetic protein 4 1.108
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.104
STK11 serine/threonine kinase 11 1.103
FEM1B fem-1 homolog b (C. elegans) 1.102
GH1 growth hormone 1 1.101
SOCS3 suppressor of cytokine signaling 3 1.101
CIDEC cell death-inducing DFFA-like effector c 1.1
FGF8 fibroblast growth factor 8 (androgen-induced) 1.097
USP34 ubiquitin specific peptidase 34 1.096
SPDYE16 speedy/RINGO cell cycle regulator family member E16 1.094
INHBA inhibin, beta A 1.093
CCN2 cellular communication network factor 2 1.093
NUCB2 nucleobindin 2 1.088
NCOR1 nuclear receptor corepressor 1 1.088
TFAM transcription factor A, mitochondrial 1.088
FGF9 fibroblast growth factor 9 1.083
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.083
ZBTB16 zinc finger and BTB domain containing 16 1.082
MIGA2 mitoguardin 2 1.08
SOD2 superoxide dismutase 2, mitochondrial 1.078
FMR1 fragile X mental retardation 1 1.078
FBN1 fibrillin 1 1.076
GNAS GNAS complex locus 1.074
PBX1 pre-B-cell leukemia homeobox 1 1.074
FABP4 fatty acid binding protein 4, adipocyte 1.073
MAPRE1 microtubule-associated protein, RP/EB family, member 1 1.07
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.069
MIGA1 mitoguardin 1 1.068
ZNF518A zinc finger protein 518A 1.068
GH2 growth hormone 2 1.066
GAL galanin/GMAP prepropeptide 1.066
EDN2 endothelin 2 1.063
NFE2L2 nuclear factor, erythroid 2-like 2 1.063
AFP alpha-fetoprotein 1.062
ADRB2 adrenoceptor beta 2, surface 1.062
FGF7 fibroblast growth factor 7 1.058
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.056
CD4 CD4 molecule 1.055
ICAM1 intercellular adhesion molecule 1 1.05
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 1.05
BCLAF3 BCLAF1 and THRAP3 family member 3 1.049
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.049
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.044
LOX lysyl oxidase 1.043
PDE8B phosphodiesterase 8B 1.043
RSPO1 R-spondin 1 1.042
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.041
MSTN myostatin 1.037
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 1.036
SMAD4 SMAD family member 4 1.035
UCN urocortin 1.034
BMP6 bone morphogenetic protein 6 1.032
KLF15 Kruppel-like factor 15 1.032
IL4 interleukin 4 1.03
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 1.03
PDE11A phosphodiesterase 11A 1.024
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 1.024
ZNF423 zinc finger protein 423 1.023
FGF10 fibroblast growth factor 10 1.022
IL2 interleukin 2 1.02
CARTPT CART prepropeptide 1.019
TLR2 toll-like receptor 2 1.018
FSBP fibrinogen silencer binding protein 1.018
SREBF2 sterol regulatory element binding transcription factor 2 1.017
AKR1C1 aldo-keto reductase family 1, member C1 1.015
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.013
ACTL8 actin-like 8 1.011
FGF5 fibroblast growth factor 5 1.008
FGF18 fibroblast growth factor 18 1.008
MMP2 matrix metallopeptidase 2 1.003
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 1.003
HNF4A hepatocyte nuclear factor 4, alpha 1.002
FGF17 fibroblast growth factor 17 1.0
PPARD peroxisome proliferator-activated receptor delta 1.0