Hypercholesteremia_Hepatic Tissue_GSE3889 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE3889
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Genes

600 genes differentially expressed during Hypercholesteremia_Hepatic Tissue_GSE3889 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
EIF5A eukaryotic translation initiation factor 5A 3.58148
RPS24 ribosomal protein S24 3.4361
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.912
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 2.89699
RPS29 ribosomal protein S29 2.84027
RPL26 ribosomal protein L26 2.81359
RPS17 ribosomal protein S17 2.73799
MARK2 MAP/microtubule affinity-regulating kinase 2 2.70168
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.66174
ALB albumin 2.65931
LACC1 laccase (multicopper oxidoreductase) domain containing 1 2.6481
RPL4 ribosomal protein L4 2.59137
RPL3 ribosomal protein L3 2.57612
PRKCD protein kinase C, delta 2.5663
RPL38 ribosomal protein L38 2.55501
TF transferrin 2.55178
RPL10A ribosomal protein L10a 2.51418
RPL28 ribosomal protein L28 2.48609
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.43635
RAB31 RAB31, member RAS oncogene family 2.38594
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.36648
MYL12B myosin, light chain 12B, regulatory 2.35415
RPS15A ribosomal protein S15a 2.34879
RPL21 ribosomal protein L21 2.30937
GLRX5 glutaredoxin 5 2.308
TUBB4B tubulin, beta 4B class IVb 2.30552
PRDX3 peroxiredoxin 3 2.27164
TPD52 tumor protein D52 2.25782
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.25539
MELK maternal embryonic leucine zipper kinase 2.25119
RPL37A ribosomal protein L37a 2.24795
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.23989
GSS glutathione synthetase 2.21772
FTH1 ferritin, heavy polypeptide 1 2.19795
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 2.19487
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.17645
RHOG ras homolog family member G 2.1654
EIF4E2 eukaryotic translation initiation factor 4E family member 2 2.15421
MED13 mediator complex subunit 13 2.146
IQGAP1 IQ motif containing GTPase activating protein 1 2.13253
RPS5 ribosomal protein S5 2.13131
CSTB cystatin B (stefin B) 2.12968
SYS1 Sys1 golgi trafficking protein 2.11969
ASRGL1 asparaginase like 1 2.10439
PRELID1 PRELI domain containing 1 2.09366
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 2.0905
PGK1 phosphoglycerate kinase 1 2.0811
RPL13 ribosomal protein L13 2.05508
TUBB6 tubulin, beta 6 class V 2.05214
RPS10 ribosomal protein S10 2.0445
WSB2 WD repeat and SOCS box containing 2 2.0428
GLIPR1 GLI pathogenesis-related 1 2.02718
VAT1 vesicle amine transport 1 2.02433
PRKCI protein kinase C, iota 2.00966
CTSD cathepsin D 2.00916
RPL17 ribosomal protein L17 2.00519
LAMC1 laminin, gamma 1 (formerly LAMB2) 1.99376
NUP62 nucleoporin 62kDa 1.9899
CXADR coxsackie virus and adenovirus receptor 1.98762
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 1.96744
ADRBK2 adrenergic, beta, receptor kinase 2 1.95679
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.93256
EXOC1 exocyst complex component 1 1.9188
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 1.88318
UBE2M ubiquitin-conjugating enzyme E2M 1.87106
RPS15 ribosomal protein S15 1.85549
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.8534
SRSF11 serine/arginine-rich splicing factor 11 1.85156
DDR1 discoidin domain receptor tyrosine kinase 1 1.84439
SGSH N-sulfoglucosamine sulfohydrolase 1.84294
NCAPH2 non-SMC condensin II complex, subunit H2 1.83587
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 1.82306
UBC ubiquitin C 1.81672
RPS14 ribosomal protein S14 1.81298
PPT2 palmitoyl-protein thioesterase 2 1.81037
IGF2R insulin-like growth factor 2 receptor 1.80357
MTF1 metal-regulatory transcription factor 1 1.80169
ANXA2 annexin A2 1.79029
EIF6 eukaryotic translation initiation factor 6 1.78752
RPL19 ribosomal protein L19 1.78613
PBX3 pre-B-cell leukemia homeobox 3 1.78347
TKT transketolase 1.78217
RPS11 ribosomal protein S11 1.77737
MAPK6 mitogen-activated protein kinase 6 1.77525
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 1.77194
RPS13 ribosomal protein S13 1.76743
RNH1 ribonuclease/angiogenin inhibitor 1 1.76482
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 1.73721
CAPG capping protein (actin filament), gelsolin-like 1.73714
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 1.73199
KLHDC10 kelch domain containing 10 1.71569
GLA galactosidase, alpha 1.71561
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 1.71526
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 1.7125
SDCBP syndecan binding protein (syntenin) 1.70718
CIAPIN1 cytokine induced apoptosis inhibitor 1 1.70361
RPS28 ribosomal protein S28 1.69596
ANXA5 annexin A5 1.6856
KCTD14 potassium channel tetramerization domain containing 14 1.67943
SCCPDH saccharopine dehydrogenase (putative) 1.67655
NLGN2 neuroligin 2 1.66111
TMPO thymopoietin 1.65995
RPS8 ribosomal protein S8 1.6595
TRIP13 thyroid hormone receptor interactor 13 1.6459
RPS7 ribosomal protein S7 1.63757
RPS2 ribosomal protein S2 1.63634
ARF1 ADP-ribosylation factor 1 1.63573
TFRC transferrin receptor 1.62817
RPS23 ribosomal protein S23 1.6279
RPL18A ribosomal protein L18a 1.61526
KIF3B kinesin family member 3B 1.61428
S1PR2 sphingosine-1-phosphate receptor 2 1.61371
DOK2 docking protein 2, 56kDa 1.61281
RRAGD Ras-related GTP binding D 1.60949
KCTD3 potassium channel tetramerization domain containing 3 1.59271
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 1.5852
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 1.57926
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 1.57696
LNPEP leucyl/cystinyl aminopeptidase 1.57565
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.56627
LPIN3 lipin 3 1.56314
RPS3 ribosomal protein S3 1.56265
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 1.56106
CHEK1 checkpoint kinase 1 1.55771
GSTP1 glutathione S-transferase pi 1 1.54229
ANO6 anoctamin 6 1.54113
VANGL1 VANGL planar cell polarity protein 1 1.53906
RPL18 ribosomal protein L18 1.53623
KIF20B kinesin family member 20B 1.53388
RPS26 ribosomal protein S26 1.52917
RPL7A ribosomal protein L7a 1.52839
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 1.4983
PYCR2 pyrroline-5-carboxylate reductase family, member 2 1.49572
CLMP CXADR-like membrane protein 1.49572
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 1.4931
TJP2 tight junction protein 2 1.48709
CELF2 CUGBP, Elav-like family member 2 1.48696
RPL6 ribosomal protein L6 1.48571
MYO5A myosin VA (heavy chain 12, myoxin) 1.48547
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.48445
AUNIP aurora kinase A and ninein interacting protein 1.48251
CLASP1 cytoplasmic linker associated protein 1 1.47695
FAM105A family with sequence similarity 105, member A 1.47676
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 1.4694
KIAA0513 KIAA0513 1.46521
TMOD3 tropomodulin 3 (ubiquitous) 1.46229
WDFY3 WD repeat and FYVE domain containing 3 1.4576
RPS18 ribosomal protein S18 1.45544
RPL35A ribosomal protein L35a 1.45232
PLEC plectin 1.44991
C3ORF70 chromosome 3 open reading frame 70 1.43512
RPS25 ribosomal protein S25 1.43308
SGOL1 shugoshin-like 1 (S. pombe) 1.42832
DERL3 derlin 3 1.42806
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 1.42695
SMC2 structural maintenance of chromosomes 2 1.42636
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 1.42554
APP amyloid beta (A4) precursor protein 1.42062
EEF1G eukaryotic translation elongation factor 1 gamma 1.42034
RPLP0 ribosomal protein, large, P0 1.41702
RPS27A ribosomal protein S27a 1.41365
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 1.41293
TRAPPC3 trafficking protein particle complex 3 1.41087
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 1.40811
CTSA cathepsin A 1.40782
PDE7A phosphodiesterase 7A 1.40603
CD93 CD93 molecule 1.39749
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.39507
RPS12 ribosomal protein S12 1.39482
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 1.38649
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 1.38617
ARHGAP39 Rho GTPase activating protein 39 1.38175
ITGAV integrin, alpha V 1.38069
PGAM1 phosphoglycerate mutase 1 (brain) 1.37976
KLF6 Kruppel-like factor 6 1.37895
CORO1C coronin, actin binding protein, 1C 1.37879
FAM124A family with sequence similarity 124A 1.37179
NME2 NME/NM23 nucleoside diphosphate kinase 2 1.36934
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 1.36778
MAEA macrophage erythroblast attacher 1.36106
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) 1.35943
SLC38A1 solute carrier family 38, member 1 1.35549
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 1.35519
C1QBP complement component 1, q subcomponent binding protein 1.35143
FRMD4B FERM domain containing 4B 1.34717
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 1.34618
YBX1 Y box binding protein 1 1.34402
PCM1 pericentriolar material 1 1.34268
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 1.33845
SETX senataxin 1.33541
NUP93 nucleoporin 93kDa 1.32759
ANKRD10 ankyrin repeat domain 10 1.32586
JUND jun D proto-oncogene 1.32567
ACTB actin, beta 1.325
SPC25 SPC25, NDC80 kinetochore complex component 1.32479
LRRTM4 leucine rich repeat transmembrane neuronal 4 1.31867
TUBB2A tubulin, beta 2A class IIa 1.31813
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 1.31218
NRIP1 nuclear receptor interacting protein 1 1.31061
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 1.30939
SELPLG selectin P ligand 1.30735
NKTR natural killer cell triggering receptor 1.30409
CTPS2 CTP synthase 2 1.3038
ERMP1 endoplasmic reticulum metallopeptidase 1 1.30189
RPL8 ribosomal protein L8 1.29026
ENAH enabled homolog (Drosophila) 1.28668
RPL35 ribosomal protein L35 1.28611
MEF2D myocyte enhancer factor 2D 1.28375
KIF23 kinesin family member 23 1.27834
RRM1 ribonucleotide reductase M1 1.27727
VDAC2 voltage-dependent anion channel 2 1.27257
MED14 mediator complex subunit 14 1.27111
LAMP1 lysosomal-associated membrane protein 1 1.26706
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 1.26595
GPR85 G protein-coupled receptor 85 1.26362
TREM2 triggering receptor expressed on myeloid cells 2 1.26224
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 1.26089
HEXA hexosaminidase A (alpha polypeptide) 1.25894
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 1.25544
HAUS7 HAUS augmin-like complex, subunit 7 1.25488
CDC25A cell division cycle 25A 1.25076
CNTN6 contactin 6 1.2487
FUCA2 fucosidase, alpha-L- 2, plasma 1.24846
RENBP renin binding protein 1.2479
RAB3D RAB3D, member RAS oncogene family 1.24154
IPO5 importin 5 1.24091
GPX4 glutathione peroxidase 4 1.24063
CD200R1L CD200 receptor 1-like 1.24007
TAGLN2 transgelin 2 1.23587
FKBP1A FK506 binding protein 1A, 12kDa 1.22909
CENPT centromere protein T 1.22839
HINT1 histidine triad nucleotide binding protein 1 1.22751
PHC2 polyhomeotic homolog 2 (Drosophila) 1.225
ATPIF1 ATPase inhibitory factor 1 1.22294
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 1.22191
WDFY2 WD repeat and FYVE domain containing 2 1.22011
PDLIM7 PDZ and LIM domain 7 (enigma) 1.21817
PPL periplakin 1.21668
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 1.21651
REEP3 receptor accessory protein 3 1.21606
SAE1 SUMO1 activating enzyme subunit 1 1.21533
PRKCB protein kinase C, beta 1.21468
KRT8 keratin 8, type II 1.21442
FKBP11 FK506 binding protein 11, 19 kDa 1.21414
HIP1 huntingtin interacting protein 1 1.21273
RCSD1 RCSD domain containing 1 1.21179
FRRS1 ferric-chelate reductase 1 1.20949
RLIM ring finger protein, LIM domain interacting 1.20935
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 1.20859
SHKBP1 SH3KBP1 binding protein 1 1.20595
FEN1 flap structure-specific endonuclease 1 1.20125
RPSA ribosomal protein SA 1.19898
USP20 ubiquitin specific peptidase 20 1.19799
FAM133B family with sequence similarity 133, member B 1.19553
SSR4 signal sequence receptor, delta 1.19544
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 1.19403
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 1.19394
SMAP1 small ArfGAP 1 1.19362
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 1.18796
C16ORF62 chromosome 16 open reading frame 62 1.18677
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.18647
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 1.18455
TUBB tubulin, beta class I 1.18015
BAZ2A bromodomain adjacent to zinc finger domain, 2A 1.1764
ANKRD17 ankyrin repeat domain 17 1.17451
GSTM5 glutathione S-transferase mu 5 1.17382
PSAT1 phosphoserine aminotransferase 1 1.17158
RIOK1 RIO kinase 1 1.17145
BAK1 BCL2-antagonist/killer 1 1.16613
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 1.16507
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 1.16492
ZBTB49 zinc finger and BTB domain containing 49 1.16302
MARK4 MAP/microtubule affinity-regulating kinase 4 1.16273
CLEC4D C-type lectin domain family 4, member D 1.16168
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 1.16147
SLPI secretory leukocyte peptidase inhibitor 1.16061
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.15861
PARVB parvin, beta 1.15591
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 1.15286
CLTA clathrin, light chain A 1.15204
IMPACT impact RWD domain protein 1.1513
RPL37 ribosomal protein L37 1.15045
NT5C2 5'-nucleotidase, cytosolic II 1.14986
RAB11B RAB11B, member RAS oncogene family 1.14849
NANS N-acetylneuraminic acid synthase 1.14815
RPL30 ribosomal protein L30 1.14617
SAMM50 SAMM50 sorting and assembly machinery component 1.14545
EDNRA endothelin receptor type A 1.145
STOM stomatin 1.14452
UBE2S ubiquitin-conjugating enzyme E2S 1.14435
FOXP4 forkhead box P4 1.14058
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 1.14011
F13A1 coagulation factor XIII, A1 polypeptide 1.13795
VASP vasodilator-stimulated phosphoprotein 1.13786
CBR3 carbonyl reductase 3 1.1376
STRN striatin, calmodulin binding protein 1.13554
EHD2 EH-domain containing 2 1.13365
BRD8 bromodomain containing 8 1.13313
CSRP2BP CSRP2 binding protein 1.13251
PPP1R13B protein phosphatase 1, regulatory subunit 13B 1.13168

decreased expression

Symbol Name Standardized Value
SYNE2 spectrin repeat containing, nuclear envelope 2 -4.47286
NAT8B N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene) -3.81957
UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 -3.69508
ACBD4 acyl-CoA binding domain containing 4 -3.38166
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -3.37757
TMEM205 transmembrane protein 205 -3.31743
ETFA electron-transfer-flavoprotein, alpha polypeptide -3.27632
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase -3.03056
NPR2 natriuretic peptide receptor 2 -3.02964
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -3.00489
SOD2 superoxide dismutase 2, mitochondrial -2.92034
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.91999
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 -2.90012
SCRN2 secernin 2 -2.89897
COG4 component of oligomeric golgi complex 4 -2.8772
PTPRF protein tyrosine phosphatase, receptor type, F -2.82389
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -2.79246
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 -2.75041
GCDH glutaryl-CoA dehydrogenase -2.72832
C8G complement component 8, gamma polypeptide -2.72531
CLMN calmin (calponin-like, transmembrane) -2.70405
TMIE transmembrane inner ear -2.6815
MCEE methylmalonyl CoA epimerase -2.6457
PTN pleiotrophin -2.63497
FBXO3 F-box protein 3 -2.61768
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.60703
PHYH phytanoyl-CoA 2-hydroxylase -2.6065
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.60295
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -2.57297
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.57215
ATP5SL ATP5S-like -2.56778
DDRGK1 DDRGK domain containing 1 -2.52159
TSC1 tuberous sclerosis 1 -2.51302
IGSF10 immunoglobulin superfamily, member 10 -2.46359
GAA glucosidase, alpha; acid -2.43747
DEPTOR DEP domain containing MTOR-interacting protein -2.43742
GPX1 glutathione peroxidase 1 -2.43403
TEX264 testis expressed 264 -2.42695
FBXL20 F-box and leucine-rich repeat protein 20 -2.40972
BCL9L B-cell CLL/lymphoma 9-like -2.40937
SPP2 secreted phosphoprotein 2, 24kDa -2.40679
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa -2.40032
SSBP1 single-stranded DNA binding protein 1, mitochondrial -2.37918
OAZ1 ornithine decarboxylase antizyme 1 -2.35407
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.34604
DCPS decapping enzyme, scavenger -2.31857
PM20D1 peptidase M20 domain containing 1 -2.31039
ASPDH aspartate dehydrogenase domain containing -2.30937
GABARAPL1 GABA(A) receptor-associated protein like 1 -2.30505
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.30106
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.30076
FXYD1 FXYD domain containing ion transport regulator 1 -2.29711
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -2.29681
FECH ferrochelatase -2.29552
KYNU kynureninase -2.27734
AAGAB alpha- and gamma-adaptin binding protein -2.26507
TMPRSS6 transmembrane protease, serine 6 -2.24806
RAB23 RAB23, member RAS oncogene family -2.24272
F5 coagulation factor V (proaccelerin, labile factor) -2.2426
PLG plasminogen -2.24211
ZNF358 zinc finger protein 358 -2.22423
FBXW4 F-box and WD repeat domain containing 4 -2.21947
ATRN attractin -2.18479
UBE2H ubiquitin-conjugating enzyme E2H -2.1795
C16ORF13 chromosome 16 open reading frame 13 -2.17303
RHBDD3 rhomboid domain containing 3 -2.15537
LAP3 leucine aminopeptidase 3 -2.15225
LMO7 LIM domain 7 -2.14726
MPDZ multiple PDZ domain protein -2.14551
GPN3 GPN-loop GTPase 3 -2.14386
ECI1 enoyl-CoA delta isomerase 1 -2.13895
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.13401
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.12649
FGGY FGGY carbohydrate kinase domain containing -2.12446
LRRC61 leucine rich repeat containing 61 -2.11966
ACAD11 acyl-CoA dehydrogenase family, member 11 -2.11683
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.11467
NADK NAD kinase -2.1097
CISD1 CDGSH iron sulfur domain 1 -2.10862
BCAS3 breast carcinoma amplified sequence 3 -2.10078
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -2.08852
CFHR1 complement factor H-related 1 -2.07202
GLO1 glyoxalase I -2.06905
ZNF14 zinc finger protein 14 -2.06556
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.04708
BCL2L12 BCL2-like 12 (proline rich) -2.04352
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.02852
NIT2 nitrilase family, member 2 -2.0239
ODF3 outer dense fiber of sperm tails 3 -2.0193
PTGR2 prostaglandin reductase 2 -2.01381
FRG1 FSHD region gene 1 -2.01177
PDK2 pyruvate dehydrogenase kinase, isozyme 2 -2.00875
NBR1 neighbor of BRCA1 gene 1 -2.00528
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -2.00085
SLC31A1 solute carrier family 31 (copper transporter), member 1 -1.99891
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -1.98463
FAM134A family with sequence similarity 134, member A -1.97278
MCC mutated in colorectal cancers -1.95641
ACAD8 acyl-CoA dehydrogenase family, member 8 -1.93819
HRSP12 heat-responsive protein 12 -1.93682
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -1.93589
PDZK1 PDZ domain containing 1 -1.92899
PCCB propionyl CoA carboxylase, beta polypeptide -1.92369
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -1.91262
MRPL14 mitochondrial ribosomal protein L14 -1.8971
GALT galactose-1-phosphate uridylyltransferase -1.89708
GSTA3 glutathione S-transferase alpha 3 -1.8917
FAM149A family with sequence similarity 149, member A -1.8897
ATG9A autophagy related 9A -1.88746
MYCT1 myc target 1 -1.88706
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -1.8867
F2 coagulation factor II (thrombin) -1.88194
SLC17A2 solute carrier family 17, member 2 -1.88186
LMAN2 lectin, mannose-binding 2 -1.87928
ACAA1 acetyl-CoA acyltransferase 1 -1.87642
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -1.87471
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -1.87193
EPPIN-WFDC6 EPPIN-WFDC6 readthrough -1.86755
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -1.86086
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -1.86016
PHF2 PHD finger protein 2 -1.85838
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -1.85165
NIT1 nitrilase 1 -1.84814
KIAA1467 KIAA1467 -1.84786
PRODH2 proline dehydrogenase (oxidase) 2 -1.84696
OXSM 3-oxoacyl-ACP synthase, mitochondrial -1.84303
TRAP1 TNF receptor-associated protein 1 -1.83846
CREBL2 cAMP responsive element binding protein-like 2 -1.82919
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -1.81981
CASP6 caspase 6, apoptosis-related cysteine peptidase -1.81742
PFKM phosphofructokinase, muscle -1.81703
SURF1 surfeit 1 -1.81347
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -1.81185
MRPL39 mitochondrial ribosomal protein L39 -1.80727
MACROD1 MACRO domain containing 1 -1.80507
ZHX1 zinc fingers and homeoboxes 1 -1.80421
MAP3K10 mitogen-activated protein kinase kinase kinase 10 -1.80267
PVRL3 poliovirus receptor-related 3 -1.79954
PROC protein C (inactivator of coagulation factors Va and VIIIa) -1.79774
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -1.79699
PITPNB phosphatidylinositol transfer protein, beta -1.79043
CHDH choline dehydrogenase -1.79026
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) -1.78784
C12ORF50 chromosome 12 open reading frame 50 -1.78241
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -1.78159
D2HGDH D-2-hydroxyglutarate dehydrogenase -1.77863
CNOT2 CCR4-NOT transcription complex, subunit 2 -1.77812
HPN hepsin -1.77541
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -1.77123
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -1.76943
MUT methylmalonyl CoA mutase -1.76624
GNPAT glyceronephosphate O-acyltransferase -1.76389
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -1.76095
TST thiosulfate sulfurtransferase (rhodanese) -1.75627
CNPY2 canopy FGF signaling regulator 2 -1.75627
SYNJ2BP synaptojanin 2 binding protein -1.75221
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide -1.74748
SLC38A3 solute carrier family 38, member 3 -1.746
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -1.74412
HAGH hydroxyacylglutathione hydrolase -1.74128
FAM134C family with sequence similarity 134, member C -1.74027
GSTK1 glutathione S-transferase kappa 1 -1.72797
HIST1H2BI histone cluster 1, H2bi -1.72395
APOA2 apolipoprotein A-II -1.72282
CCDC102A coiled-coil domain containing 102A -1.72101
F13B coagulation factor XIII, B polypeptide -1.71781
FOXK1 forkhead box K1 -1.71502
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -1.71333
STRADB STE20-related kinase adaptor beta -1.70822
SQRDL sulfide quinone reductase-like (yeast) -1.70469
TARSL2 threonyl-tRNA synthetase-like 2 -1.70202
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7 -1.69823
ABHD14A abhydrolase domain containing 14A -1.69778
SARDH sarcosine dehydrogenase -1.69408
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -1.68671
C7ORF55 chromosome 7 open reading frame 55 -1.68573
LIMA1 LIM domain and actin binding 1 -1.68511
KALRN kalirin, RhoGEF kinase -1.68457
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -1.67688
GHR growth hormone receptor -1.67445
HEBP1 heme binding protein 1 -1.67015
AES amino-terminal enhancer of split -1.6701
VKORC1 vitamin K epoxide reductase complex, subunit 1 -1.66866
CDC14B cell division cycle 14B -1.66677
HGFAC HGF activator -1.66433
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -1.65697
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -1.64778
RNF114 ring finger protein 114 -1.64758
TOM1L2 target of myb1-like 2 (chicken) -1.64755
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -1.64395
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -1.64302
C22ORF15 chromosome 22 open reading frame 15 -1.64269
NCALD neurocalcin delta -1.64097
ARHGAP31 Rho GTPase activating protein 31 -1.64052
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 -1.63966
C3 complement component 3 -1.635
GID4 GID complex subunit 4 -1.63447
FYCO1 FYVE and coiled-coil domain containing 1 -1.63422
DLG1 discs, large homolog 1 (Drosophila) -1.63262
SUCLG1 succinate-CoA ligase, alpha subunit -1.63127
ECH1 enoyl CoA hydratase 1, peroxisomal -1.62937
MAT1A methionine adenosyltransferase I, alpha -1.62892
ROR1 receptor tyrosine kinase-like orphan receptor 1 -1.62829
IL1RAP interleukin 1 receptor accessory protein -1.62443
COASY CoA synthase -1.62295
GCGR glucagon receptor -1.61522
AGMAT agmatine ureohydrolase (agmatinase) -1.61385
AK3 adenylate kinase 3 -1.61361
GCH1 GTP cyclohydrolase 1 -1.61207
ULK2 unc-51 like autophagy activating kinase 2 -1.60907
MET MET proto-oncogene, receptor tyrosine kinase -1.60852
KIAA1919 KIAA1919 -1.60566
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -1.60459
IRF2BPL interferon regulatory factor 2 binding protein-like -1.59939
EMC2 ER membrane protein complex subunit 2 -1.59798
FCGRT Fc fragment of IgG, receptor, transporter, alpha -1.59514
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa -1.59337
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 -1.58856
R3HDM2 R3H domain containing 2 -1.58773
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 -1.58642
UPB1 ureidopropionase, beta -1.58185
ASPG asparaginase -1.57987
GCAT glycine C-acetyltransferase -1.57548
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 -1.57513
PRKACB protein kinase, cAMP-dependent, catalytic, beta -1.57472
C14ORF93 chromosome 14 open reading frame 93 -1.56809
NDFIP1 Nedd4 family interacting protein 1 -1.56645
GRAMD3 GRAM domain containing 3 -1.5634
LACTB lactamase, beta -1.55675
C17ORF89 chromosome 17 open reading frame 89 -1.54247
PRICKLE1 prickle homolog 1 (Drosophila) -1.54001
KLF1 Kruppel-like factor 1 (erythroid) -1.53556
OTC ornithine carbamoyltransferase -1.53378
CFI complement factor I -1.53373
CPSF4L cleavage and polyadenylation specific factor 4-like -1.53122
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -1.53106
S100A13 S100 calcium binding protein A13 -1.53077
UQCRB ubiquinol-cytochrome c reductase binding protein -1.53057
IFT172 intraflagellar transport 172 -1.52995
GFM2 G elongation factor, mitochondrial 2 -1.52648
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -1.52585
ZCCHC24 zinc finger, CCHC domain containing 24 -1.51927
C2ORF69 chromosome 2 open reading frame 69 -1.51801
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -1.51794
TCEA3 transcription elongation factor A (SII), 3 -1.51166
FAAH fatty acid amide hydrolase -1.5103
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -1.50791
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled -1.50703
MASP2 mannan-binding lectin serine peptidase 2 -1.5048
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -1.50478
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 -1.50431
DCXR dicarbonyl/L-xylulose reductase -1.50195
YPEL3 yippee-like 3 (Drosophila) -1.49531
CCS copper chaperone for superoxide dismutase -1.49354
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa -1.4935
SNCAIP synuclein, alpha interacting protein -1.49287
IGFBP4 insulin-like growth factor binding protein 4 -1.48979
STK38 serine/threonine kinase 38 -1.4843
DHRS4 dehydrogenase/reductase (SDR family) member 4 -1.48338
DHRS7 dehydrogenase/reductase (SDR family) member 7 -1.48289
FAM73B family with sequence similarity 73, member B -1.48257
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 -1.47985
CTAGE5 CTAGE family, member 5 -1.47973
PEX1 peroxisomal biogenesis factor 1 -1.47751
FBP1 fructose-1,6-bisphosphatase 1 -1.47678
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -1.47578
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -1.47534
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 -1.47334
SELENBP1 selenium binding protein 1 -1.47215
USP8 ubiquitin specific peptidase 8 -1.47105
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -1.47052
DGCR2 DiGeorge syndrome critical region gene 2 -1.46876
ACSM3 acyl-CoA synthetase medium-chain family member 3 -1.46583
GTPBP8 GTP-binding protein 8 (putative) -1.46243
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -1.46177
CDC26 cell division cycle 26 -1.45901
GTF2I general transcription factor IIi -1.45684
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -1.45363
IL16 interleukin 16 -1.45166
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 -1.45146
RDH16 retinol dehydrogenase 16 (all-trans) -1.45141
PYGL phosphorylase, glycogen, liver -1.45027
SPZ1 spermatogenic leucine zipper 1 -1.44816
INSR insulin receptor -1.44502
NMRK1 nicotinamide riboside kinase 1 -1.44398
PEX11B peroxisomal biogenesis factor 11 beta -1.44395
LAMP2 lysosomal-associated membrane protein 2 -1.44179
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) -1.43924
MDK midkine (neurite growth-promoting factor 2) -1.43269
AUH AU RNA binding protein/enoyl-CoA hydratase -1.42722
MYLK myosin light chain kinase -1.42711
SLC35E2B solute carrier family 35, member E2B -1.42695
NR1H4 nuclear receptor subfamily 1, group H, member 4 -1.42683
RABGGTA Rab geranylgeranyltransferase, alpha subunit -1.42491
PNPO pyridoxamine 5'-phosphate oxidase -1.42322
PHYHD1 phytanoyl-CoA dioxygenase domain containing 1 -1.42235
STARD5 StAR-related lipid transfer (START) domain containing 5 -1.42227
MPC2 mitochondrial pyruvate carrier 2 -1.42195
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -1.42121
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -1.42063
Funding