Hyperhomocysteinemia Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood. (Human Disease Ontology, DOID_9279)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D020138
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Genes

182 genes/proteins associated with the disease Hyperhomocysteinemia from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
DES desmin 2.88009
CBS cystathionine-beta-synthase 2.88009
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.88009
GNMT glycine N-methyltransferase 2.88009
SLC46A1 solute carrier family 46 (folate transporter), member 1 2.88009
PON1 paraoxonase 1 2.88009
TNF tumor necrosis factor 2.88009
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.88009
PYCARD PYD and CARD domain containing 2.88009
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 2.88009
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.88009
CAT catalase 1.76131
APP amyloid beta (A4) precursor protein 1.67289
CCL2 chemokine (C-C motif) ligand 2 1.63788
GPX2 glutathione peroxidase 2 1.59054
NOS2 nitric oxide synthase 2, inducible 1.57474
FASN fatty acid synthase 1.56899
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.56337
BCL2 B-cell CLL/lymphoma 2 1.52914
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.52187
SOD2 superoxide dismutase 2, mitochondrial 1.492
MAPK3 mitogen-activated protein kinase 3 1.48993
MAPK1 mitogen-activated protein kinase 1 1.4817
BAX BCL2-associated X protein 1.4766
DUSP1 dual specificity phosphatase 1 1.45537
FOS FBJ murine osteosarcoma viral oncogene homolog 1.44517
IGF1 insulin-like growth factor 1 (somatomedin C) 1.42642
NCF1 neutrophil cytosolic factor 1 1.42508
TGFB1 transforming growth factor, beta 1 1.42047
ERN1 endoplasmic reticulum to nucleus signaling 1 1.4026
UNG uracil-DNA glycosylase 1.38696
HMOX1 heme oxygenase 1 1.38612
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.3759
CRP C-reactive protein, pentraxin-related 1.35962
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.35473
H2AFX H2A histone family, member X 1.34782
VCAM1 vascular cell adhesion molecule 1 1.34723
TLR4 toll-like receptor 4 1.3443
STAT1 signal transducer and activator of transcription 1, 91kDa 1.34198
S100A9 S100 calcium binding protein A9 1.3382
RARA retinoic acid receptor, alpha 1.31566
IL1B interleukin 1, beta 1.30696
FN1 fibronectin 1 1.28395
VEGFA vascular endothelial growth factor A 1.27751
E2F1 E2F transcription factor 1 1.27502
IL6 interleukin 6 1.27471
BDNF brain-derived neurotrophic factor 1.27347
CCND1 cyclin D1 1.27255
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.267
GPX1 glutathione peroxidase 1 1.267
CCL5 chemokine (C-C motif) ligand 5 1.26421
FLRT2 fibronectin leucine rich transmembrane protein 2 1.26421
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.25463
GSK3B glycogen synthase kinase 3 beta 1.25338
GATA3 GATA binding protein 3 1.25183
TIMP1 TIMP metallopeptidase inhibitor 1 1.2456
CTPS1 CTP synthase 1 1.24087
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.23712
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.22821
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.2279
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.2208
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.21759
ATF2 activating transcription factor 2 1.21567
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.21534
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.20784
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.20784
GSTM1 glutathione S-transferase mu 1 1.2059
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.20558
PLAT plasminogen activator, tissue 1.20558
STAT4 signal transducer and activator of transcription 4 1.20427
INSR insulin receptor 1.20196
SAFB2 scaffold attachment factor B2 1.2013
XDH xanthine dehydrogenase 1.19737
VIM vimentin 1.19737
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.19445
TFRC transferrin receptor 1.19279
IPO9 importin 9 1.19179
FAS Fas cell surface death receptor 1.19047
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.18359
ODC1 ornithine decarboxylase 1 1.18293
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.18093
AXIN2 axin 2 1.17926
PDGFB platelet-derived growth factor beta polypeptide 1.17134
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.16799
DDIT3 DNA-damage-inducible transcript 3 1.167
GLUL glutamate-ammonia ligase 1.16633
PPARA peroxisome proliferator-activated receptor alpha 1.165
S100A8 S100 calcium binding protein A8 1.16467
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.16434
TP53 tumor protein p53 1.16269
THBS1 thrombospondin 1 1.15967
MAPK9 mitogen-activated protein kinase 9 1.15933
NELFA negative elongation factor complex member A 1.15865
CCL3 chemokine (C-C motif) ligand 3 1.15729
CYBB cytochrome b-245, beta polypeptide 1.15661
JUN jun proto-oncogene 1.15526
MMP2 matrix metallopeptidase 2 1.1529
DLL4 delta-like 4 (Drosophila) 1.15122
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.15055
SOX3 SRY (sex determining region Y)-box 3 1.1437
PARP1 poly (ADP-ribose) polymerase 1 1.14234
GSR glutathione reductase 1.14098
MAPK8 mitogen-activated protein kinase 8 1.13895
COL3A1 collagen, type III, alpha 1 1.13758
MRPL33 mitochondrial ribosomal protein L33 1.13689
PNPLA2 patatin-like phospholipase domain containing 2 1.13621
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 1.13075
CREB1 cAMP responsive element binding protein 1 1.12805
VASP vasodilator-stimulated phosphoprotein 1.12805
MMP13 matrix metallopeptidase 13 1.12461
WNT5A wingless-type MMTV integration site family, member 5A 1.12288
XBP1 X-box binding protein 1 1.12185
IFNG interferon, gamma 1.12014
KRAS Kirsten rat sarcoma viral oncogene homolog 1.11741
SP1 Sp1 transcription factor 1.11606
TRIM13 tripartite motif containing 13 1.11151
TGIF2 TGFB-induced factor homeobox 2 1.11151
BCL2L1 BCL2-like 1 1.11081
LEP leptin 1.11046
SCARB1 scavenger receptor class B, member 1 1.10942
SOD1 superoxide dismutase 1, soluble 1.10872
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.10527
FASLG Fas ligand (TNF superfamily, member 6) 1.10033
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.09998
PHTF2 putative homeodomain transcription factor 2 1.09998
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.09716
ICAM1 intercellular adhesion molecule 1 1.09506
FADS1 fatty acid desaturase 1 1.09262
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.08797
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.08584
NFE2L2 nuclear factor, erythroid 2-like 2 1.08372
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.08337
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.07589
MMP9 matrix metallopeptidase 9 1.07057
TCF7 transcription factor 7 (T-cell specific, HMG-box) 1.06881
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.06844
FGF12 fibroblast growth factor 12 1.06442
ESPN espin 1.06406
MKI67 marker of proliferation Ki-67 1.06152
NQO1 NAD(P)H dehydrogenase, quinone 1 1.05972
PPARG peroxisome proliferator-activated receptor gamma 1.05936
LY6D lymphocyte antigen 6 complex, locus D 1.05936
MMP1 matrix metallopeptidase 1 1.05828
CTGF connective tissue growth factor 1.05793
CDC25B cell division cycle 25B 1.0561
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.05573
PITX2 paired-like homeodomain 2 1.05535
EGR1 early growth response 1 1.05274
AR androgen receptor 1.052
WISP1 WNT1 inducible signaling pathway protein 1 1.05089
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.05015
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.05015
APOE apolipoprotein E 1.04904
CCR2 chemokine (C-C motif) receptor 2 1.04757
IL2 interleukin 2 1.04538
CDC6 cell division cycle 6 1.04389
DAP3 death associated protein 3 1.04276
HRAS Harvey rat sarcoma viral oncogene homolog 1.04014
RAD9B RAD9 homolog B (S. pombe) 1.03864
DHCR7 7-dehydrocholesterol reductase 1.03827
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 1.03827
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 1.03789
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.03789
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 1.03419
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.03271
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.02708
FGFR1 fibroblast growth factor receptor 1 1.02671
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.02522
CASP12 caspase 12 (gene/pseudogene) 1.02373
LPL lipoprotein lipase 1.02077
HSPB1 heat shock 27kDa protein 1 1.02003
BMP4 bone morphogenetic protein 4 1.01966
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 1.01852
LHB luteinizing hormone beta polypeptide 1.01625
DHFR dihydrofolate reductase 1.01625
CXCL10 chemokine (C-X-C motif) ligand 10 1.01587
NOS3 nitric oxide synthase 3 (endothelial cell) 1.01512
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.01474
SP3 Sp3 transcription factor 1.01174
ACTA2 actin, alpha 2, smooth muscle, aorta 1.01099
G6PC glucose-6-phosphatase, catalytic subunit 1.01099
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.01062