Hyperkalemia Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An abnormally increased potassium concentration in the blood. (Human Phenotype Ontology, HP_0002153)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D006947
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Genes

173 genes/proteins associated with the disease Hyperkalemia from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.88009
INS insulin 2.88009
REN renin 2.47975
TNF tumor necrosis factor 2.38172
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.30861
NPPA natriuretic peptide A 2.30109
IL6 interleukin 6 2.29528
VEGFA vascular endothelial growth factor A 2.2925
IL1B interleukin 1, beta 2.26556
TGFB1 transforming growth factor, beta 1 2.25371
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.23936
FOS FBJ murine osteosarcoma viral oncogene homolog 2.21994
EDN1 endothelin 1 2.21524
CCL2 chemokine (C-C motif) ligand 2 2.21481
MAPK1 mitogen-activated protein kinase 1 2.21376
MAPK3 mitogen-activated protein kinase 3 2.18882
BCL2 B-cell CLL/lymphoma 2 2.11635
BAX BCL2-associated X protein 2.07985
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.06647
NOS2 nitric oxide synthase 2, inducible 2.03689
NOS3 nitric oxide synthase 3 (endothelial cell) 2.00898
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.98568
TP53 tumor protein p53 1.9551
ICAM1 intercellular adhesion molecule 1 1.94406
IFNG interferon, gamma 1.93813
SOD2 superoxide dismutase 2, mitochondrial 1.91284
IL10 interleukin 10 1.89407
NPPB natriuretic peptide B 1.88409
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.88159
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.86789
MPO myeloperoxidase 1.85169
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.81036
FAS Fas cell surface death receptor 1.80247
CXCL8 chemokine (C-X-C motif) ligand 8 1.78454
CAT catalase 1.78227
NGF nerve growth factor (beta polypeptide) 1.77686
FASLG Fas ligand (TNF superfamily, member 6) 1.75142
JUN jun proto-oncogene 1.73719
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.73639
EGR1 early growth response 1 1.73069
ADRB1 adrenoceptor beta 1 1.72322
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.71687
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.71441
IGF1 insulin-like growth factor 1 (somatomedin C) 1.70719
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.70368
DDIT3 DNA-damage-inducible transcript 3 1.6993
HMOX1 heme oxygenase 1 1.65864
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.65181
GSK3B glycogen synthase kinase 3 beta 1.64797
IL1A interleukin 1, alpha 1.64708
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.64573
SPP1 secreted phosphoprotein 1 1.63921
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.63272
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.63072
BCL2L1 BCL2-like 1 1.62713
GCG glucagon 1.6036
IL4 interleukin 4 1.60198
VCAM1 vascular cell adhesion molecule 1 1.60012
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.59638
PLAT plasminogen activator, tissue 1.58818
BAD BCL2-associated agonist of cell death 1.58678
FGF2 fibroblast growth factor 2 (basic) 1.57665
MMP9 matrix metallopeptidase 9 1.5745
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.57329
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.56459
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.56068
TIMP1 TIMP metallopeptidase inhibitor 1 1.55035
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.5311
CCL3 chemokine (C-C motif) ligand 3 1.52642
MMP2 matrix metallopeptidase 2 1.5181
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.51456
CALCA calcitonin-related polypeptide alpha 1.51355
MAPK8 mitogen-activated protein kinase 8 1.49992
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.49019
CLU clusterin 1.48042
PPARG peroxisome proliferator-activated receptor gamma 1.47864
IL2 interleukin 2 1.47167
CXCL2 chemokine (C-X-C motif) ligand 2 1.46146
SOD1 superoxide dismutase 1, soluble 1.46015
ACE angiotensin I converting enzyme 1.4567
PPARA peroxisome proliferator-activated receptor alpha 1.44572
CXCL10 chemokine (C-X-C motif) ligand 10 1.443
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.43482
NOS1 nitric oxide synthase 1 (neuronal) 1.42913
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.42428
ADRB2 adrenoceptor beta 2, surface 1.42266
CYBA cytochrome b-245, alpha polypeptide 1.41451
CYCS cytochrome c, somatic 1.40486
ALB albumin 1.40486
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.40401
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.3903
POMC proopiomelanocortin 1.38384
ACE2 angiotensin I converting enzyme 2 1.36961
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.3682
LEP leptin 1.36648
TAC1 tachykinin, precursor 1 1.34547
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.32816
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.32696
PRL prolactin 1.32162
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 1.30147
KNG1 kininogen 1 1.29348
BDNF brain-derived neurotrophic factor 1.29133
CTGF connective tissue growth factor 1.28303
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.28272
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.27255
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.27255
VIM vimentin 1.26545
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.25899
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.25899
SGK1 serum/glucocorticoid regulated kinase 1 1.254
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.24966
XBP1 X-box binding protein 1 1.24843
PARP1 poly (ADP-ribose) polymerase 1 1.24118
GADD45A growth arrest and DNA-damage-inducible, alpha 1.23868
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.21534
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 1.20816
AGTR1 angiotensin II receptor, type 1 1.20654
CDK2 cyclin-dependent kinase 2 1.19933
APP amyloid beta (A4) precursor protein 1.19574
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.19412
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.19345
LTA lymphotoxin alpha 1.18359
GSTT1 glutathione S-transferase theta 1 1.17728
THBS1 thrombospondin 1 1.17
CCL5 chemokine (C-C motif) ligand 5 1.169
BDKRB2 bradykinin receptor B2 1.16236
CCND1 cyclin D1 1.15933
CAPN2 calpain 2, (m/II) large subunit 1.15933
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 1.14781
SAT1 spermidine/spermine N1-acetyltransferase 1 1.14507
NFE2L2 nuclear factor, erythroid 2-like 2 1.14438
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.14234
EGFR epidermal growth factor receptor 1.13484
KLK1 kallikrein 1 1.13449
F3 coagulation factor III (thromboplastin, tissue factor) 1.12357
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.11707
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.11571
ATF4 activating transcription factor 4 1.1129
FOXO1 forkhead box O1 1.10562
ACTA2 actin, alpha 2, smooth muscle, aorta 1.10424
RB1 retinoblastoma 1 1.1014
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.09822
IFRD1 interferon-related developmental regulator 1 1.09822
EGF epidermal growth factor 1.09751
PCNA proliferating cell nuclear antigen 1.08549
GCLC glutamate-cysteine ligase, catalytic subunit 1.08266
IL12B interleukin 12B 1.07875
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.07768
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.07269
BIRC3 baculoviral IAP repeat containing 3 1.06297
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.06152
CREB1 cAMP responsive element binding protein 1 1.05864
JUND jun D proto-oncogene 1.05721
PPARD peroxisome proliferator-activated receptor delta 1.05721
AQP2 aquaporin 2 (collecting duct) 1.05498
HSPA8 heat shock 70kDa protein 8 1.04163
PENK proenkephalin 1.04014
PKM pyruvate kinase, muscle 1.04014
PTK2 protein tyrosine kinase 2 1.03382
SELL selectin L 1.03308
IL5 interleukin 5 1.03271
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.02971
CYBB cytochrome b-245, beta polypeptide 1.02971
TLR4 toll-like receptor 4 1.02821
BIRC5 baculoviral IAP repeat containing 5 1.02225
BIRC2 baculoviral IAP repeat containing 2 1.02188
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.02188
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.01966
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.01739
FKBP1B FK506 binding protein 1B, 12.6 kDa 1.01701
IRS1 insulin receptor substrate 1 1.01587
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.01399
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.01025