Hypermethioninemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body. (Human Disease Ontology, DOID_0050544)
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Genes

93 genes co-occuring with the disease Hypermethioninemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
MAT1A methionine adenosyltransferase I, alpha 3.37
GNMT glycine N-methyltransferase 3.199
AHCY adenosylhomocysteinase 2.873
CBS cystathionine-beta-synthase 2.602
ADK adenosine kinase 2.502
MAT2A methionine adenosyltransferase II, alpha 2.453
BHMT betaine--homocysteine S-methyltransferase 2.371
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.11
CTH cystathionine gamma-lyase 2.037
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.006
MAT2B methionine adenosyltransferase II, beta 2.004
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 1.978
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 1.896
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.888
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 1.877
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 1.813
ACAD8 acyl-CoA dehydrogenase family, member 8 1.778
SARDH sarcosine dehydrogenase 1.73
PEMT phosphatidylethanolamine N-methyltransferase 1.708
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 1.682
OTC ornithine carbamoyltransferase 1.64
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 1.626
AHCYL2 adenosylhomocysteinase-like 2 1.611
LMBRD1 LMBR1 domain containing 1 1.598
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 1.587
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 1.583
ACADVL acyl-CoA dehydrogenase, very long chain 1.566
FTCD formimidoyltransferase cyclodeaminase 1.564
DGUOK deoxyguanosine kinase 1.558
ASS1 argininosuccinate synthase 1 1.547
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 1.545
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 1.523
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 1.513
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 1.485
ACADSB acyl-CoA dehydrogenase, short/branched chain 1.481
MPV17 MpV17 mitochondrial inner membrane protein 1.461
IVD isovaleryl-CoA dehydrogenase 1.455
HPD 4-hydroxyphenylpyruvate dioxygenase 1.433
LCMT1 leucine carboxyl methyltransferase 1 1.428
AHCYL1 adenosylhomocysteinase-like 1 1.415
MTAP methylthioadenosine phosphorylase 1.4
ALAS1 5'-aminolevulinate synthase 1 1.395
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 1.369
GCDH glutaryl-CoA dehydrogenase 1.366
PAH phenylalanine hydroxylase 1.357
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 1.346
NHLRC2 NHL repeat containing 2 1.319
SOCS2 suppressor of cytokine signaling 2 1.317
CD320 CD320 molecule 1.314
DMGDH dimethylglycine dehydrogenase 1.286
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 1.274
GAMT guanidinoacetate N-methyltransferase 1.259
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.249
CPT2 carnitine palmitoyltransferase 2 1.241
ARHGAP42 Rho GTPase activating protein 42 1.237
HIBADH 3-hydroxyisobutyrate dehydrogenase 1.23
BCKDK branched chain ketoacid dehydrogenase kinase 1.226
NAGS N-acetylglutamate synthase 1.222
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 1.213
MARS1 methionyl-tRNA synthetase 1 1.208
UNC80 unc-80 homolog (C. elegans) 1.205
NNMT nicotinamide N-methyltransferase 1.195
MARS2 methionyl-tRNA synthetase 2, mitochondrial 1.191
GPX6 glutathione peroxidase 6 1.184
GPX5 glutathione peroxidase 5 1.183
GPX8 glutathione peroxidase 8 (putative) 1.182
GPX7 glutathione peroxidase 7 1.179
MMUT methylmalonyl-CoA mutase 1.177
TYR tyrosinase 1.173
GPX2 glutathione peroxidase 2 1.17
NTPCR nucleoside-triphosphatase, cancer-related 1.165
GPX3 glutathione peroxidase 3 1.161
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 1.154
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.146
DEPTOR DEP domain containing MTOR-interacting protein 1.141
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 1.134
SHMT1 serine hydroxymethyltransferase 1 (soluble) 1.126
PLN phospholamban 1.122
MSRB2 methionine sulfoxide reductase B2 1.116
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.109
L2HGDH L-2-hydroxyglutarate dehydrogenase 1.099
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 1.076
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 1.069
OPLAH 5-oxoprolinase (ATP-hydrolysing) 1.064
ALAD aminolevulinate dehydratase 1.053
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 1.046
FBXL4 F-box and leucine-rich repeat protein 4 1.04
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 1.039
NAGLU N-acetylglucosaminidase, alpha 1.029
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 1.024
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.016
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 1.001
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 1.001