Hyperostosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A bone remodeling disease that results in an abnormal growth of located_in bone. (Human Disease Ontology, DOID_205)
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Genes

566 genes co-occuring with the disease Hyperostosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
SOST sclerostin 3.547
EXT2 exostosin glycosyltransferase 2 3.507
EXT1 exostosin glycosyltransferase 1 3.499
VCP valosin containing protein 3.167
LRP5 low density lipoprotein receptor-related protein 5 3.028
SQSTM1 sequestosome 1 3.009
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 2.927
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.779
BGLAP bone gamma-carboxyglutamate (gla) protein 2.748
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.738
PTH parathyroid hormone 2.674
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.644
ZNF687 zinc finger protein 687 2.587
LRP6 low density lipoprotein receptor-related protein 6 2.581
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2.562
ACP5 acid phosphatase 5, tartrate resistant 2.512
RUNX2 runt-related transcription factor 2 2.478
CTSK cathepsin K 2.443
SP7 Sp7 transcription factor 2.433
FGF23 fibroblast growth factor 23 2.425
EXTL1 exostosin-like glycosyltransferase 1 2.418
EXTL2 exostosin-like glycosyltransferase 2 2.401
OPTN optineurin 2.383
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.382
PHEX phosphate regulating endopeptidase homolog, X-linked 2.359
TARDBP TAR DNA binding protein 2.357
LEMD3 LEM domain containing 3 2.294
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.29
EXTL3 exostosin-like glycosyltransferase 3 2.282
LPIN2 lipin 2 2.246
DCSTAMP dendrocyte expressed seven transmembrane protein 2.245
CRP C-reactive protein, pentraxin-related 2.238
ANKH ANKH inorganic pyrophosphate transport regulator 2.237
TNF tumor necrosis factor 2.23
BMP2 bone morphogenetic protein 2 2.224
DMP1 dentin matrix acidic phosphoprotein 1 2.222
ACAN aggrecan 2.175
IHH indian hedgehog 2.175
IL1B interleukin 1, beta 2.156
RIN3 Ras and Rab interactor 3 2.151
IBSP integrin-binding sialoprotein 2.141
COL1A1 collagen, type I, alpha 1 2.139
TGFB1 transforming growth factor, beta 1 2.136
UBQLN2 ubiquilin 2 2.13
ALPL alkaline phosphatase, liver/bone/kidney 2.129
MMP13 matrix metallopeptidase 13 2.127
PTHLH parathyroid hormone-like hormone 2.12
MEPE matrix extracellular phosphoglycoprotein 2.109
CLCN7 chloride channel, voltage-sensitive 7 2.108
COL2A1 collagen, type II, alpha 1 2.079
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 2.078
IGF1 insulin-like growth factor 1 (somatomedin C) 2.077
IL6 interleukin 6 2.066
COL1A2 collagen, type I, alpha 2 2.062
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2.052
CHMP2B charged multivesicular body protein 2B 2.048
C9ORF72 chromosome 9 open reading frame 72 2.029
FDPS farnesyl diphosphate synthase 2.029
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2.026
WNT1 wingless-type MMTV integration site family, member 1 2.017
WNT10B wingless-type MMTV integration site family, member 10B 2.011
WNT16 wingless-type MMTV integration site family, member 16 2.01
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.006
PTH1R parathyroid hormone 1 receptor 2.0
IL1A interleukin 1, alpha 1.995
WNT3A wingless-type MMTV integration site family, member 3A 1.984
CSF1 colony stimulating factor 1 (macrophage) 1.957
GDF5 growth differentiation factor 5 1.946
DNAH8 dynein, axonemal, heavy chain 8 1.943
SPP1 secreted phosphoprotein 1 1.934
CHSY3 chondroitin sulfate synthase 3 1.927
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.923
FUS FUS RNA binding protein 1.918
DKK4 dickkopf WNT signaling pathway inhibitor 4 1.917
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.916
SOX9 SRY (sex determining region Y)-box 9 1.912
KL klotho 1.897
IL1RN interleukin 1 receptor antagonist 1.873
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 1.872
IL17A interleukin 17A 1.87
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.865
MATR3 matrin 3 1.858
UFD1 ubiquitin recognition factor in ER associated degradation 1 1.839
SFRP4 secreted frizzled-related protein 4 1.837
FGF18 fibroblast growth factor 18 1.835
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.832
BMP4 bone morphogenetic protein 4 1.825
FRZB frizzled-related protein 1.82
PTDSS1 phosphatidylserine synthase 1 1.82
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.817
KREMEN1 kringle containing transmembrane protein 1 1.81
SFRP1 secreted frizzled-related protein 1 1.809
FBLIM1 filamin binding LIM protein 1 1.802
CD300C CD300c molecule 1.796
FGF7 fibroblast growth factor 7 1.79
OSTM1 osteopetrosis associated transmembrane protein 1 1.79
FGF9 fibroblast growth factor 9 1.778
AXIN1 axin 1 1.777
ACVR1 activin A receptor, type I 1.776
BMP7 bone morphogenetic protein 7 1.775
TBK1 TANK-binding kinase 1 1.768
BMP6 bone morphogenetic protein 6 1.767
FGF8 fibroblast growth factor 8 (androgen-induced) 1.766
NOG noggin 1.765
WNT5A wingless-type MMTV integration site family, member 5A 1.759
HSPG2 heparan sulfate proteoglycan 2 1.755
GRN granulin 1.753
NUP205 nucleoporin 205kDa 1.751
FGF10 fibroblast growth factor 10 1.748
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 1.747
FGF5 fibroblast growth factor 5 1.747
MEF2C myocyte enhancer factor 2C 1.745
FGF6 fibroblast growth factor 6 1.744
FGF17 fibroblast growth factor 17 1.743
FGF16 fibroblast growth factor 16 1.741
FGF3 fibroblast growth factor 3 1.741
FGF22 fibroblast growth factor 22 1.739
FGF20 fibroblast growth factor 20 1.738
FGF4 fibroblast growth factor 4 1.731
NBR1 neighbor of BRCA1 gene 1 1.729
MMP3 matrix metallopeptidase 3 1.718
POLR3GL polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like 1.717
FAM20B family with sequence similarity 20, member B 1.71
SOD1 superoxide dismutase 1, soluble 1.705
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.703
CRTAP cartilage associated protein 1.697
UBXN6 UBX domain protein 6 1.697
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 1.688
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 1.687
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 1.683
GJA1 gap junction protein, alpha 1, 43kDa 1.682
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.674
MEOX1 mesenchyme homeobox 1 1.658
FOS FBJ murine osteosarcoma viral oncogene homolog 1.657
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 1.65
NF2 neurofibromin 2 (merlin) 1.649
GREM2 gremlin 2, DAN family BMP antagonist 1.645
PFN1 profilin 1 1.64
IFITM5 interferon induced transmembrane protein 5 1.64
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.636
IL36RN interleukin 36 receptor antagonist 1.632
SOSTDC1 sclerostin domain containing 1 1.623
MESD mesoderm development LRP chaperone 1.617
HNF4A hepatocyte nuclear factor 4, alpha 1.614
AMER1 APC membrane recruitment protein 1 1.601
ALB albumin 1.599
AXIN2 axin 2 1.598
WDFY3 WD repeat and FYVE domain containing 3 1.596
ATAD1 ATPase family, AAA domain containing 1 1.595
FGFR3 fibroblast growth factor receptor 3 1.582
MEFV Mediterranean fever 1.582
UBE4A ubiquitination factor E4A 1.581
FGF2 fibroblast growth factor 2 (basic) 1.579
OCSTAMP osteoclast stimulatory transmembrane protein 1.575
INS insulin 1.571
WNT7B wingless-type MMTV integration site family, member 7B 1.571
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.568
MGP matrix Gla protein 1.566
UBE4B ubiquitination factor E4B 1.565
CXCL8 chemokine (C-X-C motif) ligand 8 1.553
FLNA filamin A, alpha 1.552
KREMEN2 kringle containing transmembrane protein 2 1.55
WIF1 WNT inhibitory factor 1 1.549
MAPT microtubule-associated protein tau 1.547
ACTB actin, beta 1.546
DLX5 distal-less homeobox 5 1.541
AGGF1 angiogenic factor with G patch and FHA domains 1 1.537
CARD14 caspase recruitment domain family, member 14 1.535
GOLGA6A golgin A6 family, member A 1.528
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.526
ATXN2 ataxin 2 1.526
ESR1 estrogen receptor 1 1.523
CALCR calcitonin receptor 1.523
LRP4 low density lipoprotein receptor-related protein 4 1.52
SNX10 sorting nexin 10 1.519
XYLT1 xylosyltransferase I 1.519
PRG4 proteoglycan 4 1.518
NLRP3 NLR family, pyrin domain containing 3 1.512
AGRN agrin 1.511
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.509
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 1.502
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.502
TMEM53 transmembrane protein 53 1.502
ATG7 autophagy related 7 1.501
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.501
MMP9 matrix metallopeptidase 9 1.496
GSK3B glycogen synthase kinase 3 beta 1.494
RSPO2 R-spondin 2 1.494
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 1.493
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 1.492
IL36R interleukin 36 receptor 1.491
CKB creatine kinase, brain 1.491
FGFR1 fibroblast growth factor receptor 1 1.491
PLS3 plastin 3 1.489
COMP cartilage oligomeric matrix protein 1.487
SMAD9 SMAD family member 9 1.486
LEP leptin 1.483
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.481
COL10A1 collagen, type X, alpha 1 1.481
CKM creatine kinase, muscle 1.481
CKMT1B creatine kinase, mitochondrial 1B 1.48
JUN jun proto-oncogene 1.48
ATG5 autophagy related 5 1.479
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 1.47
UNC45B unc-45 homolog B (C. elegans) 1.468
UBQLN1 ubiquilin 1 1.467
COL11A2 collagen, type XI, alpha 2 1.466
CALCOCO2 calcium binding and coiled-coil domain 2 1.466
DCTN1 dynactin 1 1.466
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 1.461
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 1.46
TP53 tumor protein p53 1.459
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 1.455
NOD2 nucleotide-binding oligomerization domain containing 2 1.453
WNT4 wingless-type MMTV integration site family, member 4 1.452
WNT9A wingless-type MMTV integration site family, member 9A 1.451
EGF epidermal growth factor 1.446
IFNG interferon, gamma 1.443
IRS4 insulin receptor substrate 4 1.44
EWSR1 EWS RNA-binding protein 1 1.439
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.439
GDF2 growth differentiation factor 2 1.438
GNAS GNAS complex locus 1.435
FGF13 fibroblast growth factor 13 1.435
PXDNL peroxidasin-like 1.432
PXDN peroxidasin 1.431
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 1.431
DLX3 distal-less homeobox 3 1.43
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.428
IL10 interleukin 10 1.425
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.425
DVL1 dishevelled segment polarity protein 1 1.425
IL18 interleukin 18 1.424
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 1.424
GABARAPL1 GABA(A) receptor-associated protein like 1 1.423
BMP5 bone morphogenetic protein 5 1.421
RARG retinoic acid receptor, gamma 1.42
CHRD chordin 1.42
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 1.419
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 1.414
CYLD cylindromatosis (turban tumor syndrome) 1.414
BGN biglycan 1.413
FAM20C family with sequence similarity 20, member C 1.409
P3H1 prolyl 3-hydroxylase 1 1.408
SULF1 sulfatase 1 1.402
DCN decorin 1.4
ASPN asporin 1.397
CASR calcium-sensing receptor 1.397
CA2 carbonic anhydrase II 1.397
WNT11 wingless-type MMTV integration site family, member 11 1.393
HTT huntingtin 1.391
ALPP alkaline phosphatase, placental 1.388
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 1.388
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 1.387
USP17L13 ubiquitin specific peptidase 17-like family member 13 1.387
ATG12 autophagy related 12 1.386
PRRX1 paired related homeobox 1 1.384
B3GAT3 beta-1,3-glucuronyltransferase 3 1.384
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.382
TGFB3 transforming growth factor, beta 3 1.381
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.373
SMAD3 SMAD family member 3 1.372
WNT5B wingless-type MMTV integration site family, member 5B 1.369
FN1 fibronectin 1 1.367
ALPG alkaline phosphatase, germ cell 1.362
DSPP dentin sialophosphoprotein 1.359
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.356
KEAP1 kelch-like ECH-associated protein 1 1.352
FZD9 frizzled class receptor 9 1.351
ZBTB40 zinc finger and BTB domain containing 40 1.349
EMP1 epithelial membrane protein 1 1.348
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.344
GREM1 gremlin 1, DAN family BMP antagonist 1.342
MSX2 msh homeobox 2 1.337
POSTN periostin, osteoblast specific factor 1.337
UCMA upper zone of growth plate and cartilage matrix associated 1.334
WASHC5 WASH complex subunit 5 1.334
SH3BP2 SH3-domain binding protein 2 1.333
CSF1R colony stimulating factor 1 receptor 1.332
MMP2 matrix metallopeptidase 2 1.33
LDLR low density lipoprotein receptor 1.327
MAPK3 mitogen-activated protein kinase 3 1.327
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 1.325
CD4 CD4 molecule 1.324
ALPI alkaline phosphatase, intestinal 1.323
CD44 CD44 molecule (Indian blood group) 1.323
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.32
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 1.315
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.315
CD34 CD34 molecule 1.314
XYLT2 xylosyltransferase II 1.313
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.313
LEF1 lymphoid enhancer-binding factor 1 1.312
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 1.311
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.31
ANXA11 annexin A11 1.308
NSFL1C NSFL1 (p97) cofactor (p47) 1.308
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 1.307
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.305
PHOSPHO1 phosphatase, orphan 1 1.303
TYROBP TYRO protein tyrosine kinase binding protein 1.303
TRPS1 trichorhinophalangeal syndrome I 1.301
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.3
IL11 interleukin 11 1.3
EPHB4 EPH receptor B4 1.3
BECN1 beclin 1, autophagy related 1.298
FKBP10 FK506 binding protein 10, 65 kDa 1.295
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 1.293
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.293
OSCAR osteoclast associated, immunoglobulin-like receptor 1.292
BMP3 bone morphogenetic protein 3 1.29
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.29
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.29
BMP1 bone morphogenetic protein 1 1.281
ATXN3 ataxin 3 1.28
NF1 neurofibromin 1 1.28
SDC1 syndecan 1 1.279
MUSK muscle, skeletal, receptor tyrosine kinase 1.278
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.277
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 1.276
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 1.276
CCN4 cellular communication network factor 4 1.275
PTEN phosphatase and tensin homolog 1.274
WNT3 wingless-type MMTV integration site family, member 3 1.274
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.268
GGPS1 geranylgeranyl diphosphate synthase 1 1.264
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.262
WLS wntless Wnt ligand secretion mediator 1.261
HDAC4 histone deacetylase 4 1.259
COL11A1 collagen, type XI, alpha 1 1.259
UXS1 UDP-glucuronate decarboxylase 1 1.258
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.255
CHSY1 chondroitin sulfate synthase 1 1.254
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.254
IL19 interleukin 19 1.251
RYK receptor-like tyrosine kinase 1.251
MVK mevalonate kinase 1.246
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.245
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.243
NLRP12 NLR family, pyrin domain containing 12 1.242
COL9A1 collagen, type IX, alpha 1 1.24
SULF2 sulfatase 2 1.24
PTPRC protein tyrosine phosphatase, receptor type, C 1.238
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.237
PINK1 PTEN induced putative kinase 1 1.237
EFNB2 ephrin-B2 1.236
FIG4 FIG4 phosphoinositide 5-phosphatase 1.235
RSPO3 R-spondin 3 1.235
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.233
RSPO1 R-spondin 1 1.23
ANO5 anoctamin 5 1.226
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 1.222
CREB1 cAMP responsive element binding protein 1 1.222
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 1.221
CCDC91 coiled-coil domain containing 91 1.221
ROR2 receptor tyrosine kinase-like orphan receptor 2 1.219
MAP2K1 mitogen-activated protein kinase kinase 1 1.217
UBQLN4 ubiquilin 4 1.216
SMAD5 SMAD family member 5 1.216
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.216
ULK1 unc-51 like autophagy activating kinase 1 1.215
ELN elastin 1.214
WNT7A wingless-type MMTV integration site family, member 7A 1.213
H3-3B H3.3 histone B 1.21
IL4 interleukin 4 1.209
TFEB transcription factor EB 1.209
SHH sonic hedgehog 1.209
SLC39A14 solute carrier family 39 (zinc transporter), member 14 1.208
H3-3A H3.3 histone A 1.207
CCN6 cellular communication network factor 6 1.207
SVIP small VCP/p97-interacting protein 1.205
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 1.204
PPARG peroxisome proliferator-activated receptor gamma 1.203
RB1CC1 RB1-inducible coiled-coil 1 1.202
RHOA ras homolog family member A 1.202
HGD homogentisate 1,2-dioxygenase 1.201
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.201
NDP Norrie disease (pseudoglioma) 1.198
WNT10A wingless-type MMTV integration site family, member 10A 1.197
SMAD4 SMAD family member 4 1.197
TGFBR1 transforming growth factor, beta receptor 1 1.196
BCL2 B-cell CLL/lymphoma 2 1.195
IL22 interleukin 22 1.194
FURIN furin (paired basic amino acid cleaving enzyme) 1.194
SETX senataxin 1.192
PSEN1 presenilin 1 1.191
BMPR1A bone morphogenetic protein receptor, type IA 1.191
FERMT3 fermitin family member 3 1.19
WNT6 wingless-type MMTV integration site family, member 6 1.189
TWIST2 twist family bHLH transcription factor 2 1.184
MSTN myostatin 1.184
GPC1 glypican 1 1.184
SMAD2 SMAD family member 2 1.183
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 1.182
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 1.177
SCUBE3 signal peptide, CUB domain, EGF-like 3 1.175
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.172
MAP3K3 mitogen-activated protein kinase kinase kinase 3 1.171
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 1.171
CTSS cathepsin S 1.171
ATG10 autophagy related 10 1.168
TGFB2 transforming growth factor, beta 2 1.167
TREM2 triggering receptor expressed on myeloid cells 2 1.167
SOX5 SRY (sex determining region Y)-box 5 1.165
PRKN parkin RBR E3 ubiquitin protein ligase 1.164
ENG endoglin 1.163
HDAC6 histone deacetylase 6 1.163
ALX4 ALX homeobox 4 1.163
CCNF cyclin F 1.162
COL12A1 collagen, type XII, alpha 1 1.162
NGF nerve growth factor (beta polypeptide) 1.161
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.159
BMPR1B bone morphogenetic protein receptor, type IB 1.159
IL1R1 interleukin 1 receptor, type I 1.158
DKK3 dickkopf WNT signaling pathway inhibitor 3 1.158
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.157
TRPV4 transient receptor potential cation channel, subfamily V, member 4 1.154
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 1.154
PLAA phospholipase A2-activating protein 1.15
CD68 CD68 molecule 1.15
PRL prolactin 1.148
JAG1 jagged 1 1.148
CDKN2A cyclin-dependent kinase inhibitor 2A 1.147
STMP1 short transmembrane mitochondrial protein 1 1.144
CCL2 chemokine (C-C motif) ligand 2 1.143
CCND1 cyclin D1 1.143
NFAM1 NFAT activating protein with ITAM motif 1 1.141
OSM oncostatin M 1.14
LOX lysyl oxidase 1.14
ATG101 autophagy related 101 1.139
RAB8A RAB8A, member RAS oncogene family 1.139
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.137
COL6A1 collagen, type VI, alpha 1 1.137
APP amyloid beta (A4) precursor protein 1.137
THY1 Thy-1 cell surface antigen 1.136
BTBD8 BTB (POZ) domain containing 8 1.136
MYOD1 myogenic differentiation 1 1.132
FZD4 frizzled class receptor 4 1.131
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.131
TRABD2A TraB domain containing 2A 1.13
FBN1 fibrillin 1 1.13
HPSE heparanase 1.13
MAP1A microtubule-associated protein 1A 1.129
UBQLN3 ubiquilin 3 1.128
SFRP2 secreted frizzled-related protein 2 1.127
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 1.125
MMP1 matrix metallopeptidase 1 1.125
GPHA2 glycoprotein hormone alpha 2 1.123
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.12
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.12
RECQL4 RecQ protein-like 4 1.12
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 1.119
RAB5A RAB5A, member RAS oncogene family 1.118
TBC1D25 TBC1 domain family, member 25 1.116
CXCL12 chemokine (C-X-C motif) ligand 12 1.114
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 1.113
FGFR2 fibroblast growth factor receptor 2 1.113
CD1A CD1a molecule 1.112
CD8A CD8a molecule 1.111
SUFU suppressor of fused homolog (Drosophila) 1.105
RBM8A RNA binding motif protein 8A 1.105
HDAC5 histone deacetylase 5 1.1
SMAD6 SMAD family member 6 1.098
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1.095
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.095
POMC proopiomelanocortin 1.093
FZD8 frizzled class receptor 8 1.092
FZD1 frizzled class receptor 1 1.091
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 1.09
APOE apolipoprotein E 1.088
TMEM106B transmembrane protein 106B 1.087
TNPO1 transportin 1 1.087
MAP1S microtubule-associated protein 1S 1.086
PTCH1 patched 1 1.085
ATG14 autophagy related 14 1.085
CD99 CD99 molecule 1.085
NBL1 neuroblastoma 1, DAN family BMP antagonist 1.083
HLA-B major histocompatibility complex, class I, B 1.083
SIRPB1 signal-regulatory protein beta 1 1.082
FGF1 fibroblast growth factor 1 (acidic) 1.081
HSPB8 heat shock 22kDa protein 8 1.08
MYH14 myosin, heavy chain 14, non-muscle 1.078
COL9A2 collagen, type IX, alpha 2 1.076
CD1B CD1b molecule 1.074
FNDC5 fibronectin type III domain containing 5 1.073
PRTN3 proteinase 3 1.071
RASA1 RAS p21 protein activator (GTPase activating protein) 1 1.071
ACVR2A activin A receptor, type IIA 1.071
SYNGAP1 synaptic Ras GTPase activating protein 1 1.07
ATF4 activating transcription factor 4 1.07
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 1.07
SDC4 syndecan 4 1.067
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 1.066
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.065
IL23R interleukin 23 receptor 1.063
TLR4 toll-like receptor 4 1.063
SST somatostatin 1.061
CD1E CD1e molecule 1.059
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 1.058
SDC2 syndecan 2 1.056
FLNC filamin C, gamma 1.054
GLB1 galactosidase, beta 1 1.054
FST follistatin 1.054
TAC1 tachykinin, precursor 1 1.053
BAG3 BCL2-associated athanogene 3 1.052
CHRDL1 chordin-like 1 1.051
DVL2 dishevelled segment polarity protein 2 1.05
GABARAP GABA(A) receptor-associated protein 1.05
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.048
PHGDH phosphoglycerate dehydrogenase 1.047
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.046
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 1.046
LEPR leptin receptor 1.046
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 1.046
MAP1B microtubule-associated protein 1B 1.045
ADIPOQ adiponectin, C1Q and collagen domain containing 1.044
ERAP1 endoplasmic reticulum aminopeptidase 1 1.043
EDN1 endothelin 1 1.043
GPC4 glypican 4 1.042
NKX3-2 NK3 homeobox 2 1.041
SPG11 spastic paraplegia 11 (autosomal recessive) 1.041
ATG13 autophagy related 13 1.04
DMD dystrophin 1.038
IFNB1 interferon, beta 1, fibroblast 1.035
NCSTN nicastrin 1.034
SERINC4 serine incorporator 4 1.034
AHSG alpha-2-HS-glycoprotein 1.034
ZNRF3 zinc and ring finger 3 1.034
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 1.033
B2M beta-2-microglobulin 1.032
FOXO1 forkhead box O1 1.032
SIRT1 sirtuin 1 1.032
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 1.03
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.029
TMEM38B transmembrane protein 38B 1.026
HSPA4 heat shock 70kDa protein 4 1.026
WNT9B wingless-type MMTV integration site family, member 9B 1.026
CD99L2 CD99 molecule-like 2 1.025
PECAM1 platelet/endothelial cell adhesion molecule 1 1.024
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 1.024
CD1C CD1c molecule 1.024
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 1.022
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.022
PRKCZ protein kinase C, zeta 1.021
IL2 interleukin 2 1.02
SDC3 syndecan 3 1.02
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 1.018
MRAP melanocortin 2 receptor accessory protein 1.018
GCG glucagon 1.016
LAMP2 lysosomal-associated membrane protein 2 1.015
YOD1 YOD1 deubiquitinase 1.015
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1.011
PSENEN presenilin enhancer gamma secretase subunit 1.011
TIMP1 TIMP metallopeptidase inhibitor 1 1.011
ACE angiotensin I converting enzyme 1.01
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 1.01
IL17F interleukin 17F 1.01
RUBCN rubicon autophagy regulator 1.008
SEC24D SEC24 family member D 1.006
CCN2 cellular communication network factor 2 1.005
GPC6 glypican 6 1.002
FZD2 frizzled class receptor 2 1.002
WNT2B wingless-type MMTV integration site family, member 2B 1.001
LTN1 listerin E3 ubiquitin protein ligase 1 1.001
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.001
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 1.0