Hyperphosphatemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

351 genes co-occuring with the disease Hyperphosphatemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
FGF23 fibroblast growth factor 23 4.0
PTH parathyroid hormone 3.944
KL klotho 3.634
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 3.215
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 3.156
CASR calcium-sensing receptor 3.073
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 2.991
AHSG alpha-2-HS-glycoprotein 2.972
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.938
MGP matrix Gla protein 2.918
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.828
ALB albumin 2.825
PHEX phosphate regulating endopeptidase homolog, X-linked 2.805
FGFR1 fibroblast growth factor receptor 1 2.783
RUNX2 runt-related transcription factor 2 2.738
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 2.722
STX16 syntaxin 16 2.704
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.656
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.63
GNAS GNAS complex locus 2.621
BGLAP bone gamma-carboxyglutamate (gla) protein 2.608
FGFR4 fibroblast growth factor receptor 4 2.594
SPP1 secreted phosphoprotein 1 2.581
ALPL alkaline phosphatase, liver/bone/kidney 2.572
EPO erythropoietin 2.547
DMP1 dentin matrix acidic phosphoprotein 1 2.533
MSX2 msh homeobox 2 2.525
FGFR2 fibroblast growth factor receptor 2 2.515
GCM2 glial cells missing homolog 2 (Drosophila) 2.493
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.483
MEPE matrix extracellular phosphoglycoprotein 2.46
FGF7 fibroblast growth factor 7 2.457
FGF3 fibroblast growth factor 3 2.443
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.433
FGF6 fibroblast growth factor 6 2.431
FGF18 fibroblast growth factor 18 2.431
FGF16 fibroblast growth factor 16 2.43
FGF9 fibroblast growth factor 9 2.428
FGF17 fibroblast growth factor 17 2.428
FGF20 fibroblast growth factor 20 2.426
FGF22 fibroblast growth factor 22 2.426
FGF4 fibroblast growth factor 4 2.424
FGF5 fibroblast growth factor 5 2.422
FGF8 fibroblast growth factor 8 (androgen-induced) 2.421
REN renin 2.421
FGF10 fibroblast growth factor 10 2.419
FGFR3 fibroblast growth factor receptor 3 2.407
CHSY3 chondroitin sulfate synthase 3 2.401
SOST sclerostin 2.398
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2.364
BMP2 bone morphogenetic protein 2 2.334
PTH1R parathyroid hormone 1 receptor 2.323
SP7 Sp7 transcription factor 2.306
PTHLH parathyroid hormone-like hormone 2.297
CRP C-reactive protein, pentraxin-related 2.285
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.283
APOM apolipoprotein M 2.198
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 2.197
EMP1 epithelial membrane protein 1 2.18
GC group-specific component (vitamin D binding protein) 2.174
TAGLN transgelin 2.17
INS insulin 2.155
PLPPR3 phospholipid phosphatase related 3 2.14
ACE angiotensin I converting enzyme 2.136
IL6 interleukin 6 2.073
GHRH growth hormone releasing hormone 2.046
FAM20C family with sequence similarity 20, member C 2.025
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.004
MB myoglobin 1.982
IGF1 insulin-like growth factor 1 (somatomedin C) 1.967
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 1.95
SFRP4 secreted frizzled-related protein 4 1.941
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 1.928
CST3 cystatin C 1.927
ACP5 acid phosphatase 5, tartrate resistant 1.912
FGF19 fibroblast growth factor 19 1.893
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.881
TNF tumor necrosis factor 1.879
CKM creatine kinase, muscle 1.87
HAMP hepcidin antimicrobial peptide 1.868
KLB klotho beta 1.865
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.858
CKMT1B creatine kinase, mitochondrial 1B 1.857
CKB creatine kinase, brain 1.857
B2M beta-2-microglobulin 1.855
TGFB1 transforming growth factor, beta 1 1.855
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.854
FRS2 fibroblast growth factor receptor substrate 2 1.847
IL1B interleukin 1, beta 1.844
UCMA upper zone of growth plate and cartilage matrix associated 1.844
IBSP integrin-binding sialoprotein 1.841
TRPV6 transient receptor potential cation channel, subfamily V, member 6 1.838
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.836
BICC1 BicC family RNA binding protein 1 1.815
LRP2 low density lipoprotein receptor-related protein 2 1.803
ANKH ANKH inorganic pyrophosphate transport regulator 1.802
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.798
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 1.792
FURIN furin (paired basic amino acid cleaving enzyme) 1.764
BMP7 bone morphogenetic protein 7 1.762
PHOSPHO1 phosphatase, orphan 1 1.76
ELN elastin 1.755
LCN2 lipocalin 2 1.737
TACC3 transforming, acidic coiled-coil containing protein 3 1.736
SGK1 serum/glucocorticoid regulated kinase 1 1.732
FGF13 fibroblast growth factor 13 1.696
FGF21 fibroblast growth factor 21 1.696
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.695
LDLR low density lipoprotein receptor 1.692
APOE apolipoprotein E 1.682
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.672
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.666
MAPK3 mitogen-activated protein kinase 3 1.659
S100G S100 calcium binding protein G 1.651
SOX9 SRY (sex determining region Y)-box 9 1.638
ALPI alkaline phosphatase, intestinal 1.638
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.625
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 1.624
TRPC6 transient receptor potential cation channel, subfamily C, member 6 1.608
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.597
LRP5 low density lipoprotein receptor-related protein 5 1.596
CLDN16 claudin 16 1.595
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.595
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.593
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.591
AIRE autoimmune regulator 1.585
HAVCR1 hepatitis A virus cellular receptor 1 1.583
NOS3 nitric oxide synthase 3 (endothelial cell) 1.578
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.571
POMC proopiomelanocortin 1.567
FGFRL1 fibroblast growth factor receptor-like 1 1.56
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.557
F3 coagulation factor III (thromboplastin, tissue factor) 1.552
DNAH8 dynein, axonemal, heavy chain 8 1.55
LEP leptin 1.545
FGF2 fibroblast growth factor 2 (basic) 1.543
ALPG alkaline phosphatase, germ cell 1.538
AVP arginine vasopressin 1.535
ADAM17 ADAM metallopeptidase domain 17 1.533
BMP4 bone morphogenetic protein 4 1.533
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.532
PLPPR4 phospholipid phosphatase related 4 1.531
MRTFA myocardin related transcription factor A 1.526
GAS6 growth arrest-specific 6 1.525
EDN1 endothelin 1 1.523
ALPP alkaline phosphatase, placental 1.52
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.518
NPPB natriuretic peptide B 1.501
F2 coagulation factor II (thrombin) 1.498
TBCE tubulin folding cofactor E 1.494
CLDN19 claudin 19 1.492
SIRT1 sirtuin 1 1.48
XDH xanthine dehydrogenase 1.476
PXDN peroxidasin 1.473
PDE4D phosphodiesterase 4D, cAMP-specific 1.473
PXDNL peroxidasin-like 1.471
GPRC6A G protein-coupled receptor, class C, group 6, member A 1.469
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.468
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.463
TMEM174 transmembrane protein 174 1.461
CCL2 chemokine (C-C motif) ligand 2 1.459
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.457
IL1A interleukin 1, alpha 1.455
EGR1 early growth response 1 1.449
FGF1 fibroblast growth factor 1 (acidic) 1.447
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.445
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.439
FAM111A family with sequence similarity 111, member A 1.436
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.435
SAMD9 sterile alpha motif domain containing 9 1.433
CTSK cathepsin K 1.432
XPR1 xenotropic and polytropic retrovirus receptor 1 1.429
EGFR epidermal growth factor receptor 1.428
OR2D3 olfactory receptor, family 2, subfamily D, member 3 1.427
GGCX gamma-glutamyl carboxylase 1.426
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.422
NLRP5 NLR family, pyrin domain containing 5 1.421
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.409
ACTB actin, beta 1.407
TP53 tumor protein p53 1.406
EGLN2 egl-9 family hypoxia-inducible factor 2 1.404
MYH14 myosin, heavy chain 14, non-muscle 1.398
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.397
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.378
IFNG interferon, gamma 1.375
EGLN1 egl-9 family hypoxia-inducible factor 1 1.375
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.373
EGLN3 egl-9 family hypoxia-inducible factor 3 1.368
MMP9 matrix metallopeptidase 9 1.361
ADAM10 ADAM metallopeptidase domain 10 1.36
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.354
COL1A1 collagen, type I, alpha 1 1.352
ADIPOQ adiponectin, C1Q and collagen domain containing 1.349
AHCYL1 adenosylhomocysteinase-like 1 1.345
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.341
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.339
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.337
NPPA natriuretic peptide A 1.336
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.332
NFE2L2 nuclear factor, erythroid 2-like 2 1.332
VCAM1 vascular cell adhesion molecule 1 1.326
BAIAP2L1 BAI1-associated protein 2-like 1 1.323
PPARG peroxisome proliferator-activated receptor gamma 1.32
TRPM7 transient receptor potential cation channel, subfamily M, member 7 1.32
LRP6 low density lipoprotein receptor-related protein 6 1.319
PRL prolactin 1.315
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.315
OGA O-GlcNAcase 1.314
ARSJ arylsulfatase family, member J 1.311
IL10 interleukin 10 1.309
CALB1 calbindin 1, 28kDa 1.3
IRF6 interferon regulatory factor 6 1.297
PDE3A phosphodiesterase 3A, cGMP-inhibited 1.296
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 1.293
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.286
MSTN myostatin 1.285
ACVR2A activin A receptor, type IIA 1.284
FN1 fibronectin 1 1.281
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.281
PPHLN1 periphilin 1 1.281
IL18 interleukin 18 1.28
COL1A2 collagen, type I, alpha 2 1.269
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 1.268
CCN2 cellular communication network factor 2 1.266
MMP2 matrix metallopeptidase 2 1.266
ILK integrin-linked kinase 1.265
WNK4 WNK lysine deficient protein kinase 4 1.254
MYOCD myocardin 1.254
AXL AXL receptor tyrosine kinase 1.252
RET ret proto-oncogene 1.251
CLDN14 claudin 14 1.249
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.249
SMTN smoothelin 1.248
GCG glucagon 1.248
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 1.244
APOB apolipoprotein B 1.244
TPO thyroid peroxidase 1.239
ICAM1 intercellular adhesion molecule 1 1.238
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.235
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.233
KITLG KIT ligand 1.226
TLR4 toll-like receptor 4 1.218
FRZB frizzled-related protein 1.218
EGF epidermal growth factor 1.217
ERBB2 erb-b2 receptor tyrosine kinase 2 1.214
BMP1 bone morphogenetic protein 1 1.209
AQP2 aquaporin 2 (collecting duct) 1.208
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.205
MEMO1 mediator of cell motility 1 1.203
WNT3A wingless-type MMTV integration site family, member 3A 1.2
TBX1 T-box 1 1.199
CXCL8 chemokine (C-X-C motif) ligand 8 1.197
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.197
NOX4 NADPH oxidase 4 1.194
MYORG myogenesis regulating glycosidase (putative) 1.193
PGAP2 post-GPI attachment to proteins 2 1.188
CD4 CD4 molecule 1.186
ACE2 angiotensin I converting enzyme 2 1.185
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.168
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.167
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 1.166
UMOD uromodulin 1.166
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.166
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.163
GATA3 GATA binding protein 3 1.159
CDKN2A cyclin-dependent kinase inhibitor 2A 1.158
SELE selectin E 1.151
CA2 carbonic anhydrase II 1.144
TNNI3 troponin I type 3 (cardiac) 1.144
SMAD2 SMAD family member 2 1.143
MPO myeloperoxidase 1.141
TGFA transforming growth factor, alpha 1.137
GPX5 glutathione peroxidase 5 1.137
WNT10B wingless-type MMTV integration site family, member 10B 1.136
CD274 CD274 molecule 1.135
GPX7 glutathione peroxidase 7 1.134
GPX2 glutathione peroxidase 2 1.133
TTR transthyretin 1.133
KDR kinase insert domain receptor 1.132
GPX6 glutathione peroxidase 6 1.13
BCL2 B-cell CLL/lymphoma 2 1.13
GPX8 glutathione peroxidase 8 (putative) 1.128
ANXA2 annexin A2 1.128
ALK anaplastic lymphoma receptor tyrosine kinase 1.126
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 1.126
GPX3 glutathione peroxidase 3 1.124
GUSB glucuronidase, beta 1.121
ORAI1 ORAI calcium release-activated calcium modulator 1 1.121
IP6K1 inositol hexakisphosphate kinase 1 1.119
PCSK2 proprotein convertase subtilisin/kexin type 2 1.113
NT5E 5'-nucleotidase, ecto (CD73) 1.113
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.112
DSPP dentin sialophosphoprotein 1.111
GHR growth hormone receptor 1.108
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.108
APOA1 apolipoprotein A-I 1.107
SLC17A2 solute carrier family 17, member 2 1.104
CLDN2 claudin 2 1.094
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.091
VWF von Willebrand factor 1.09
GSK3B glycogen synthase kinase 3 beta 1.09
SMAD3 SMAD family member 3 1.087
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 1.085
CD8A CD8a molecule 1.084
BMP6 bone morphogenetic protein 6 1.084
SDF4 stromal cell derived factor 4 1.082
CCND1 cyclin D1 1.076
STC2 stanniocalcin 2 1.075
TG thyroglobulin 1.075
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.074
WNT7B wingless-type MMTV integration site family, member 7B 1.073
ERBB3 erb-b2 receptor tyrosine kinase 3 1.068
IL2 interleukin 2 1.068
FBXO32 F-box protein 32 1.063
ECE1 endothelin converting enzyme 1 1.062
CSF3 colony stimulating factor 3 (granulocyte) 1.057
ACVR1 activin A receptor, type I 1.051
CD19 CD19 molecule 1.049
GDF2 growth differentiation factor 2 1.049
CTSS cathepsin S 1.049
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.048
GPR39 G protein-coupled receptor 39 1.046
PLG plasminogen 1.046
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 1.045
HP haptoglobin 1.044
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.044
THBD thrombomodulin 1.044
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.042
AGER advanced glycosylation end product-specific receptor 1.036
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.035
AHR aryl hydrocarbon receptor 1.035
AGTR1 angiotensin II receptor, type 1 1.034
FABP1 fatty acid binding protein 1, liver 1.033
SMAD4 SMAD family member 4 1.032
ESR1 estrogen receptor 1 1.025
STIM1 stromal interaction molecule 1 1.022
BECN1 beclin 1, autophagy related 1.019
CD68 CD68 molecule 1.018
TACC1 transforming, acidic coiled-coil containing protein 1 1.011
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 1.011
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.01
CALML5 calmodulin-like 5 1.009
CALML3 calmodulin-like 3 1.009
ARID1A AT rich interactive domain 1A (SWI-like) 1.009
CDH5 cadherin 5, type 2 (vascular endothelium) 1.007
NPEPL1 aminopeptidase-like 1 1.007
PCSK9 proprotein convertase subtilisin/kexin type 9 1.006
FGF11 fibroblast growth factor 11 1.005
ANXA6 annexin A6 1.001
KEAP1 kelch-like ECH-associated protein 1 1.001
RCAN1 regulator of calcineurin 1 1.0