Hyperpituitarism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

272 genes co-occuring with the disease Hyperpituitarism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
IGF1 insulin-like growth factor 1 (somatomedin C) 4.0
SST somatostatin 3.935
GHR growth hormone receptor 3.676
PRL prolactin 3.459
GHRH growth hormone releasing hormone 3.452
POMC proopiomelanocortin 3.29
GH1 growth hormone 1 3.202
SSTR5 somatostatin receptor 5 3.191
AIP aryl hydrocarbon receptor interacting protein 3.142
SSTR2 somatostatin receptor 2 3.114
GH2 growth hormone 2 3.004
TRH thyrotropin-releasing hormone 3.001
INS insulin 2.99
SSTR1 somatostatin receptor 1 2.878
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.867
MEN1 multiple endocrine neoplasia I 2.854
CSH2 chorionic somatomammotropin hormone 2 2.851
GPR101 G protein-coupled receptor 101 2.823
IGFBP3 insulin-like growth factor binding protein 3 2.802
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.777
SSTR3 somatostatin receptor 3 2.606
GHRHR growth hormone releasing hormone receptor 2.598
GNAS GNAS complex locus 2.58
TBX19 T-box 19 2.536
SSTR4 somatostatin receptor 4 2.482
GCG glucagon 2.448
SNED1 sushi, nidogen and EGF-like domains 1 2.418
CRH corticotropin releasing hormone 2.417
IGF2 insulin-like growth factor 2 2.407
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.307
IGFBP1 insulin-like growth factor binding protein 1 2.24
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.199
PTH parathyroid hormone 2.194
IGF1R insulin-like growth factor 1 receptor 2.187
GHRL ghrelin/obestatin prepropeptide 2.182
VIP vasoactive intestinal peptide 2.181
POU1F1 POU class 1 homeobox 1 2.163
DRD2 dopamine receptor D2 2.161
GAST gastrin 2.16
GHSR growth hormone secretagogue receptor 2.155
USP8 ubiquitin specific peptidase 8 2.119
LEP leptin 2.073
INSR insulin receptor 2.066
PRKACB protein kinase, cAMP-dependent, catalytic, beta 2.053
BGLAP bone gamma-carboxyglutamate (gla) protein 2.032
CHGA chromogranin A 1.99
SHBG sex hormone-binding globulin 1.974
AVP arginine vasopressin 1.971
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.968
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.962
PPY pancreatic polypeptide 1.959
REN renin 1.955
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.931
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.928
TSHB thyroid stimulating hormone, beta 1.911
PROP1 PROP paired-like homeobox 1 1.904
SOCS2 suppressor of cytokine signaling 2 1.888
PRLR prolactin receptor 1.871
GHDC GH3 domain containing 1.869
GIP gastric inhibitory polypeptide 1.839
ADIPOQ adiponectin, C1Q and collagen domain containing 1.824
KL klotho 1.807
GIPR gastric inhibitory polypeptide receptor 1.803
CORT cortistatin 1.802
IRS1 insulin receptor substrate 1 1.791
USP48 ubiquitin specific peptidase 48 1.788
STAT5B signal transducer and activator of transcription 5B 1.788
TP53 tumor protein p53 1.784
SCT secretin 1.759
ESR1 estrogen receptor 1 1.758
ALB albumin 1.746
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.721
PDE11A phosphodiesterase 11A 1.717
RET ret proto-oncogene 1.716
SYP synaptophysin 1.707
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.707
FGF23 fibroblast growth factor 23 1.704
GLP1R glucagon-like peptide 1 receptor 1.672
IGFBP5 insulin-like growth factor binding protein 5 1.659
DPP4 dipeptidyl-peptidase 4 1.644
MLN motilin 1.643
IGFALS insulin-like growth factor binding protein, acid labile subunit 1.642
STAT5A signal transducer and activator of transcription 5A 1.642
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 1.617
GAL galanin/GMAP prepropeptide 1.603
ARRB1 arrestin, beta 1 1.599
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1.594
PTTG1 pituitary tumor-transforming 1 1.586
IL6 interleukin 6 1.582
JAK2 Janus kinase 2 1.581
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.58
ARRB2 arrestin, beta 2 1.573
CRP C-reactive protein, pentraxin-related 1.567
TG thyroglobulin 1.565
ACE angiotensin I converting enzyme 1.557
IGF2R insulin-like growth factor 2 receptor 1.544
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.53
PPARG peroxisome proliferator-activated receptor gamma 1.528
AHR aryl hydrocarbon receptor 1.527
CISH cytokine inducible SH2-containing protein 1.526
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1.52
FSHB follicle stimulating hormone, beta polypeptide 1.51
NTS neurotensin 1.509
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.507
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.504
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.502
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.497
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.497
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.494
HNF1A HNF1 homeobox A 1.493
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.491
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.488
CDC73 cell division cycle 73 1.478
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.476
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.474
OXT oxytocin/neurophysin I prepropeptide 1.474
EGF epidermal growth factor 1.473
TRHR thyrotropin-releasing hormone receptor 1.463
AVPR1B arginine vasopressin receptor 1B 1.447
TNF tumor necrosis factor 1.444
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.443
PDE8B phosphodiesterase 8B 1.424
IRS2 insulin receptor substrate 2 1.417
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.412
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.409
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.405
CCK cholecystokinin 1.402
NPY neuropeptide Y 1.398
SOST sclerostin 1.398
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.398
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.388
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.388
NF1 neurofibromin 1 1.387
RETN resistin 1.386
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.373
TSHR thyroid stimulating hormone receptor 1.369
TGFB1 transforming growth factor, beta 1 1.368
RETNLB resistin like beta 1.357
SHOX short stature homeobox 1.355
PTHLH parathyroid hormone-like hormone 1.349
FGF21 fibroblast growth factor 21 1.337
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.336
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.335
AGRP agouti related neuropeptide 1.331
PAPPA2 pappalysin 2 1.329
TAC1 tachykinin, precursor 1 1.323
CREB1 cAMP responsive element binding protein 1 1.323
CASR calcium-sensing receptor 1.319
EGFR epidermal growth factor receptor 1.315
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.311
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.309
CABLES1 Cdk5 and Abl enzyme substrate 1 1.308
LPL lipoprotein lipase 1.308
NPPA natriuretic peptide A 1.305
IGFBP4 insulin-like growth factor binding protein 4 1.304
NAMPT nicotinamide phosphoribosyltransferase 1.299
MSTN myostatin 1.297
PTEN phosphatase and tensin homolog 1.297
PLAGL1 pleiomorphic adenoma gene-like 1 1.295
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.294
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.294
FGF10 fibroblast growth factor 10 1.285
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.284
SDHAF2 succinate dehydrogenase complex assembly factor 2 1.284
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.283
FGF8 fibroblast growth factor 8 (androgen-induced) 1.282
FLNA filamin A, alpha 1.281
CIDEC cell death-inducing DFFA-like effector c 1.281
IL1B interleukin 1, beta 1.277
FGF2 fibroblast growth factor 2 (basic) 1.274
FGF4 fibroblast growth factor 4 1.274
TPO thyroid peroxidase 1.273
PXDNL peroxidasin-like 1.272
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.271
MGMT O-6-methylguanine-DNA methyltransferase 1.271
PXDN peroxidasin 1.271
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.269
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.265
APOA1 apolipoprotein A-I 1.265
KISS1 KiSS-1 metastasis-suppressor 1.263
IGFBP6 insulin-like growth factor binding protein 6 1.254
PAPPA pregnancy-associated plasma protein A, pappalysin 1 1.254
ESRP1 epithelial splicing regulatory protein 1 1.252
FGF18 fibroblast growth factor 18 1.244
CDKN2A cyclin-dependent kinase inhibitor 2A 1.239
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 1.237
LHX3 LIM homeobox 3 1.233
NPPB natriuretic peptide B 1.23
FGF22 fibroblast growth factor 22 1.23
FGF16 fibroblast growth factor 16 1.228
TMEM127 transmembrane protein 127 1.228
MAPK3 mitogen-activated protein kinase 3 1.225
FGF3 fibroblast growth factor 3 1.223
FGF17 fibroblast growth factor 17 1.223
AMH anti-Mullerian hormone 1.22
ENO2 enolase 2 (gamma, neuronal) 1.219
FGF6 fibroblast growth factor 6 1.219
FGFR4 fibroblast growth factor receptor 4 1.218
FGF20 fibroblast growth factor 20 1.217
FGF7 fibroblast growth factor 7 1.215
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.214
FGF5 fibroblast growth factor 5 1.212
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.212
HESX1 HESX homeobox 1 1.21
FGF9 fibroblast growth factor 9 1.21
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.208
MAX MYC associated factor X 1.207
LIPC lipase, hepatic 1.205
SCGB1D4 secretoglobin, family 1D, member 4 1.194
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 1.194
IGSF1 immunoglobulin superfamily, member 1 1.189
CCND1 cyclin D1 1.186
EPO erythropoietin 1.184
LEPR leptin receptor 1.183
LIPE lipase, hormone-sensitive 1.182
ZFAND3 zinc finger, AN1-type domain 3 1.173
RUNX2 runt-related transcription factor 2 1.162
ACTB actin, beta 1.155
APOB apolipoprotein B 1.153
HMGA2 high mobility group AT-hook 2 1.152
GRP gastrin-releasing peptide 1.149
GATA2 GATA binding protein 2 1.148
FOS FBJ murine osteosarcoma viral oncogene homolog 1.142
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.138
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.132
DRD5 dopamine receptor D5 1.128
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.116
FNDC5 fibronectin type III domain containing 5 1.108
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.107
CGA glycoprotein hormones, alpha polypeptide 1.1
SOCS1 suppressor of cytokine signaling 1 1.099
CDKN3 cyclin-dependent kinase inhibitor 3 1.095
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.095
GDNF glial cell derived neurotrophic factor 1.09
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.085
EDN1 endothelin 1 1.085
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.083
GC group-specific component (vitamin D binding protein) 1.076
AKNAD1 AKNA domain containing 1 1.073
DENND11 DENN domain containing 11 1.069
NKX2-1 NK2 homeobox 1 1.068
GFRA4 GDNF family receptor alpha 4 1.067
KLK3 kallikrein-related peptidase 3 1.063
GCK glucokinase (hexokinase 4) 1.063
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.053
DRD1 dopamine receptor D1 1.051
GNRHR gonadotropin-releasing hormone receptor 1.051
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.049
CRHR1 corticotropin releasing hormone receptor 1 1.046
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.045
JUN jun proto-oncogene 1.045
GATA3 GATA binding protein 3 1.042
CKB creatine kinase, brain 1.041
CKM creatine kinase, muscle 1.04
PEBP1 phosphatidylethanolamine binding protein 1 1.038
MYH14 myosin, heavy chain 14, non-muscle 1.036
ARMC5 armadillo repeat containing 5 1.035
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.035
CKMT1B creatine kinase, mitochondrial 1B 1.034
MMP9 matrix metallopeptidase 9 1.033
TSC2 tuberous sclerosis 2 1.033
MC4R melanocortin 4 receptor 1.031
ESR2 estrogen receptor 2 (ER beta) 1.031
NEUROD1 neuronal differentiation 1 1.03
L3HYPDH L-3-hydroxyproline dehydratase (trans-) 1.025
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.018
BMP4 bone morphogenetic protein 4 1.013
TTR transthyretin 1.011
CETP cholesteryl ester transfer protein, plasma 1.005
PDE2A phosphodiesterase 2A, cGMP-stimulated 1.004
BCL2 B-cell CLL/lymphoma 2 1.002
WWC3 WWC family member 3 1.0