Hyperprolactinemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood. (Human Disease Ontology, DOID_12700)
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Genes

303 genes co-occuring with the disease Hyperprolactinemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PRL prolactin 4.0
TRH thyrotropin-releasing hormone 3.24
POMC proopiomelanocortin 3.163
PRLR prolactin receptor 3.161
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 3.09
SHBG sex hormone-binding globulin 3.059
DRD2 dopamine receptor D2 3.049
AMH anti-Mullerian hormone 2.932
IGF1 insulin-like growth factor 1 (somatomedin C) 2.911
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.79
INS insulin 2.766
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.698
KISS1 KiSS-1 metastasis-suppressor 2.614
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.564
GHRH growth hormone releasing hormone 2.498
SST somatostatin 2.451
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.361
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.31
MEN1 multiple endocrine neoplasia I 2.304
TRIM32 tripartite motif containing 32 2.291
CSH2 chorionic somatomammotropin hormone 2 2.286
TBX19 T-box 19 2.236
LEP leptin 2.236
OXT oxytocin/neurophysin I prepropeptide 2.211
GH1 growth hormone 1 2.182
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.172
AVP arginine vasopressin 2.155
GHR growth hormone receptor 2.141
DRD3 dopamine receptor D3 2.133
ESR1 estrogen receptor 1 2.133
CRH corticotropin releasing hormone 2.123
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.121
GPR101 G protein-coupled receptor 101 2.107
PTH parathyroid hormone 2.071
GH2 growth hormone 2 2.059
AIP aryl hydrocarbon receptor interacting protein 2.047
TH tyrosine hydroxylase 2.021
GNRHR gonadotropin-releasing hormone receptor 2.004
FSHR follicle stimulating hormone receptor 1.972
VIP vasoactive intestinal peptide 1.953
FSHB follicle stimulating hormone, beta polypeptide 1.938
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.931
ADIPOQ adiponectin, C1Q and collagen domain containing 1.925
TPO thyroid peroxidase 1.917
STAT5B signal transducer and activator of transcription 5B 1.916
POU1F1 POU class 1 homeobox 1 1.908
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.885
STAT5A signal transducer and activator of transcription 5A 1.878
NPY neuropeptide Y 1.877
IL6 interleukin 6 1.86
CRP C-reactive protein, pentraxin-related 1.856
GCG glucagon 1.855
TAC3 tachykinin 3 1.843
GHRL ghrelin/obestatin prepropeptide 1.834
SSTR5 somatostatin receptor 5 1.831
TG thyroglobulin 1.809
BGLAP bone gamma-carboxyglutamate (gla) protein 1.808
ALB albumin 1.803
GNAS GNAS complex locus 1.801
KISS1R KISS1 receptor 1.786
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.777
MAOB monoamine oxidase B 1.755
TSHB thyroid stimulating hormone, beta 1.745
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.742
PRLH prolactin releasing hormone 1.741
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.734
JAK2 Janus kinase 2 1.73
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.729
MAOA monoamine oxidase A 1.727
PROP1 PROP paired-like homeobox 1 1.725
TNF tumor necrosis factor 1.722
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.718
ESR2 estrogen receptor 2 (ER beta) 1.713
INSR insulin receptor 1.713
IGFBP3 insulin-like growth factor binding protein 3 1.709
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.708
LHCGR luteinizing hormone/choriogonadotropin receptor 1.706
IL1B interleukin 1, beta 1.699
GAST gastrin 1.697
FGA fibrinogen alpha chain 1.696
DENND1A DENN/MADD domain containing 1A 1.695
DRD4 dopamine receptor D4 1.675
AR androgen receptor 1.674
SSTR2 somatostatin receptor 2 1.668
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.668
COMT catechol-O-methyltransferase 1.659
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.654
DRD1 dopamine receptor D1 1.646
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.635
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.633
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.621
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.619
GAL galanin/GMAP prepropeptide 1.612
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.609
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.6
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.585
PDYN prodynorphin 1.572
TGFB1 transforming growth factor, beta 1 1.567
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.567
PGR progesterone receptor 1.566
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.565
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1.561
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.559
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.558
PDE5A phosphodiesterase 5A, cGMP-specific 1.556
GHRHR growth hormone releasing hormone receptor 1.553
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.552
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.546
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.534
IGFBP1 insulin-like growth factor binding protein 1 1.531
ANKK1 ankyrin repeat and kinase domain containing 1 1.527
IFNG interferon, gamma 1.514
IL2 interleukin 2 1.509
OMA1 OMA1 zinc metallopeptidase 1.487
HRH1 histamine receptor H1 1.484
ARRB2 arrestin, beta 2 1.484
BDNF brain-derived neurotrophic factor 1.483
ACE angiotensin I converting enzyme 1.48
LEPR leptin receptor 1.475
PXDNL peroxidasin-like 1.475
REN renin 1.471
PXDN peroxidasin 1.47
HESX1 HESX homeobox 1 1.469
GHSR growth hormone secretagogue receptor 1.468
TP53 tumor protein p53 1.462
IGSF1 immunoglobulin superfamily, member 1 1.46
SYP synaptophysin 1.454
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.451
CHGA chromogranin A 1.448
PPARG peroxisome proliferator-activated receptor gamma 1.446
GDF9 growth differentiation factor 9 1.444
STAR steroidogenic acute regulatory protein 1.425
RHCG Rh family, C glycoprotein 1.425
PROKR2 prokineticin receptor 2 1.423
TAC1 tachykinin, precursor 1 1.422
FOS FBJ murine osteosarcoma viral oncogene homolog 1.421
HCRT hypocretin (orexin) neuropeptide precursor 1.412
IL10 interleukin 10 1.407
BMP15 bone morphogenetic protein 15 1.405
PHOX2B paired-like homeobox 2b 1.4
SSTR1 somatostatin receptor 1 1.4
CD4 CD4 molecule 1.398
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.396
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1.396
HRH2 histamine receptor H2 1.391
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.386
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.382
PPY pancreatic polypeptide 1.378
USP8 ubiquitin specific peptidase 8 1.371
IRS1 insulin receptor substrate 1 1.371
F2 coagulation factor II (thrombin) 1.369
ESX1 ESX homeobox 1 1.369
IL1A interleukin 1, alpha 1.364
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 1.36
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.359
AOPEP aminopeptidase O (putative) 1.358
ACTB actin, beta 1.356
IGF2 insulin-like growth factor 2 1.349
CD1A CD1a molecule 1.34
EGF epidermal growth factor 1.336
BCL2 B-cell CLL/lymphoma 2 1.335
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.334
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.332
GRM2 glutamate receptor, metabotropic 2 1.331
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.328
MEA1 male-enhanced antigen 1 1.325
AGRP agouti related neuropeptide 1.324
MC4R melanocortin 4 receptor 1.32
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.315
DHRS11 dehydrogenase/reductase (SDR family) member 11 1.315
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.314
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.312
ANOS1 anosmin 1 1.307
TACR3 tachykinin receptor 3 1.307
LALBA lactalbumin, alpha- 1.3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 1.296
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.295
RAMP2 receptor (G protein-coupled) activity modifying protein 2 1.292
PTHLH parathyroid hormone-like hormone 1.286
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.285
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.284
DRD5 dopamine receptor D5 1.284
TAAR1 trace amine associated receptor 1 1.281
LGALS1 lectin, galactoside-binding, soluble, 1 1.275
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.275
FST follistatin 1.273
TRHR thyrotropin-releasing hormone receptor 1.27
CD1E CD1e molecule 1.264
PDE10A phosphodiesterase 10A 1.264
LHX3 LIM homeobox 3 1.26
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.259
CD8A CD8a molecule 1.258
NTS neurotensin 1.256
ADRA2A adrenoceptor alpha 2A 1.252
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.251
CD1B CD1b molecule 1.246
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.239
FGF2 fibroblast growth factor 2 (basic) 1.235
HNF1A HNF1 homeobox A 1.234
ATP5PO ATP synthase peripheral stalk subunit OSCP 1.226
RETN resistin 1.226
SMR3A submaxillary gland androgen regulated protein 3A 1.226
MAPK3 mitogen-activated protein kinase 3 1.222
LHX4 LIM homeobox 4 1.221
MLN motilin 1.215
CISH cytokine inducible SH2-containing protein 1.214
RETNLB resistin like beta 1.213
CSN2 casein beta 1.207
UNK unkempt family zinc finger 1.199
CD68 CD68 molecule 1.197
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.194
ARRB1 arrestin, beta 1 1.194
AMHR2 anti-Mullerian hormone receptor, type II 1.193
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.193
CCL2 chemokine (C-C motif) ligand 2 1.193
SSTR3 somatostatin receptor 3 1.192
LPL lipoprotein lipase 1.191
KLK3 kallikrein-related peptidase 3 1.185
RAB5B RAB5B, member RAS oncogene family 1.184
TSHR thyroid stimulating hormone receptor 1.179
HOXA10 homeobox A10 1.178
CD1C CD1c molecule 1.178
APOB apolipoprotein B 1.175
OXTR oxytocin receptor 1.175
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.171
LHB luteinizing hormone beta polypeptide 1.166
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.165
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.163
CD1D CD1d molecule 1.157
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.156
CREB1 cAMP responsive element binding protein 1 1.154
IL4 interleukin 4 1.154
NKX2-1 NK2 homeobox 1 1.154
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.148
GPER1 G protein-coupled estrogen receptor 1 1.146
NCAM1 neural cell adhesion molecule 1 1.144
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 1.139
CCK cholecystokinin 1.139
NAMPT nicotinamide phosphoribosyltransferase 1.133
TRHDE thyrotropin-releasing hormone degrading enzyme 1.128
TGFA transforming growth factor, alpha 1.126
AFP alpha-fetoprotein 1.116
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.115
USP48 ubiquitin specific peptidase 48 1.105
FGF8 fibroblast growth factor 8 (androgen-induced) 1.103
ADRB2 adrenoceptor beta 2, surface 1.102
SNED1 sushi, nidogen and EGF-like domains 1 1.1
GLP1R glucagon-like peptide 1 receptor 1.097
GRM3 glutamate receptor, metabotropic 3 1.096
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.095
IL17A interleukin 17A 1.09
HMGA2 high mobility group AT-hook 2 1.086
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.086
MGMT O-6-methylguanine-DNA methyltransferase 1.085
IGF1R insulin-like growth factor 1 receptor 1.083
IRF1 interferon regulatory factor 1 1.082
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.082
EPO erythropoietin 1.081
PNMT phenylethanolamine N-methyltransferase 1.08
FGF4 fibroblast growth factor 4 1.08
DISC1 disrupted in schizophrenia 1 1.078
CTSD cathepsin D 1.078
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.078
FBN3 fibrillin 3 1.075
NGF nerve growth factor (beta polypeptide) 1.072
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.072
RRAD Ras-related associated with diabetes 1.072
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.07
TOX3 TOX high mobility group box family member 3 1.068
PTTG1 pituitary tumor-transforming 1 1.067
SOX3 SRY (sex determining region Y)-box 3 1.065
F3 coagulation factor III (thromboplastin, tissue factor) 1.063
FGF23 fibroblast growth factor 23 1.061
CDC73 cell division cycle 73 1.061
PAEP progestagen-associated endometrial protein 1.061
GDNF glial cell derived neurotrophic factor 1.058
ERBB2 erb-b2 receptor tyrosine kinase 2 1.057
PVALB parvalbumin 1.057
PCNA proliferating cell nuclear antigen 1.055
CXCL8 chemokine (C-X-C motif) ligand 8 1.055
LIF leukemia inhibitory factor 1.053
IFNA1 interferon, alpha 1 1.053
NPFFR1 neuropeptide FF receptor 1 1.05
PLG plasminogen 1.05
CD40LG CD40 ligand 1.045
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 1.044
FOXO1 forkhead box O1 1.042
NOS3 nitric oxide synthase 3 (endothelial cell) 1.039
OPRM1 opioid receptor, mu 1 1.037
FGF17 fibroblast growth factor 17 1.029
GATA3 GATA binding protein 3 1.028
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.027
TPH1 tryptophan hydroxylase 1 1.017
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 1.017
TNP1 transition protein 1 (during histone to protamine replacement) 1.016
FGF9 fibroblast growth factor 9 1.016
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.016
FGF18 fibroblast growth factor 18 1.013
GPX3 glutathione peroxidase 3 1.01
FGF10 fibroblast growth factor 10 1.006
QDPR quinoid dihydropteridine reductase 1.006
FAM90A1 family with sequence similarity 90, member A1 1.005
FMR1 fragile X mental retardation 1 1.005