Hypersplenism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

161 genes co-occuring with the disease Hypersplenism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
THPO thrombopoietin 3.075
F2 coagulation factor II (thrombin) 2.762
ALB albumin 2.568
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.538
AFP alpha-fetoprotein 2.217
EPO erythropoietin 2.205
F3 coagulation factor III (thromboplastin, tissue factor) 2.18
MPL MPL proto-oncogene, thrombopoietin receptor 2.108
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 2.05
HBE1 hemoglobin, epsilon 1 1.986
CSF3 colony stimulating factor 3 (granulocyte) 1.94
CRP C-reactive protein, pentraxin-related 1.935
CD4 CD4 molecule 1.93
VWF von Willebrand factor 1.918
HP haptoglobin 1.915
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.915
CHIT1 chitinase 1 (chitotriosidase) 1.91
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.909
HAMP hepcidin antimicrobial peptide 1.902
JAK2 Janus kinase 2 1.894
CD8A CD8a molecule 1.887
CP ceruloplasmin (ferroxidase) 1.843
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 1.806
IFNA1 interferon, alpha 1 1.745
IL6 interleukin 6 1.743
LCOR ligand dependent nuclear receptor corepressor 1.706
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 1.694
ATP7B ATPase, Cu++ transporting, beta polypeptide 1.693
TNF tumor necrosis factor 1.684
CD34 CD34 molecule 1.658
BCHE butyrylcholinesterase 1.658
CD68 CD68 molecule 1.632
IFNG interferon, gamma 1.623
ASXL1 additional sex combs like transcriptional regulator 1 1.618
IFNA2 interferon, alpha 2 1.614
UROS uroporphyrinogen III synthase 1.604
CD2 CD2 molecule 1.593
IFNA16 interferon, alpha 16 1.592
IFNA14 interferon, alpha 14 1.591
IFNA8 interferon, alpha 8 1.591
IFNA10 interferon, alpha 10 1.591
IFNA21 interferon, alpha 21 1.591
IFNA7 interferon, alpha 7 1.591
IFNA6 interferon, alpha 6 1.59
IFNA5 interferon, alpha 5 1.589
IFNA13 interferon, alpha 13 1.588
IFNA4 interferon, alpha 4 1.586
IFNA17 interferon, alpha 17 1.579
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.57
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.57
PF4 platelet factor 4 1.566
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.551
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.538
IL10 interleukin 10 1.531
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 1.52
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.518
CD19 CD19 molecule 1.493
ACE angiotensin I converting enzyme 1.484
TGFB1 transforming growth factor, beta 1 1.476
SST somatostatin 1.476
CD5 CD5 molecule 1.464
SRSF2 serine/arginine-rich splicing factor 2 1.431
HBB hemoglobin, beta 1.428
THBD thrombomodulin 1.427
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.425
IL1B interleukin 1, beta 1.42
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.405
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.4
PECAM1 platelet/endothelial cell adhesion molecule 1 1.393
IL2 interleukin 2 1.385
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.382
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.376
F8 coagulation factor VIII, procoagulant component 1.366
G6PD glucose-6-phosphate dehydrogenase 1.354
GP1BA glycoprotein Ib (platelet), alpha polypeptide 1.346
CD1E CD1e molecule 1.33
CD1D CD1d molecule 1.321
CALR calreticulin 1.32
CD1A CD1a molecule 1.32
TET2 tet methylcytosine dioxygenase 2 1.319
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.315
CD1B CD1b molecule 1.312
CD38 CD38 molecule 1.305
IL11 interleukin 11 1.296
PF4V1 platelet factor 4 variant 1 1.296
IL1A interleukin 1, alpha 1.281
TFRC transferrin receptor 1.262
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.25
NAAA N-acylethanolamine acid amidase 1.249
PLG plasminogen 1.249
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.248
CD59 CD59 molecule, complement regulatory protein 1.244
MME membrane metallo-endopeptidase 1.24
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.235
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.234
CD1C CD1c molecule 1.232
FIP1L1 factor interacting with PAPOLA and CPSF1 1.227
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.218
FBL fibrillarin 1.218
CD163 CD163 molecule 1.213
PSAP prosaposin 1.211
IL3 interleukin 3 1.207
CD22 CD22 molecule 1.207
IL3RA interleukin 3 receptor, alpha (low affinity) 1.203
NPHP3 nephronophthisis 3 (adolescent) 1.198
CD27 CD27 molecule 1.194
HFE hemochromatosis 1.189
RUNX1 runt-related transcription factor 1 1.189
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.181
INS insulin 1.181
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 1.181
NCAM1 neural cell adhesion molecule 1 1.18
PTPRC protein tyrosine phosphatase, receptor type, C 1.178
IL4 interleukin 4 1.174
TFR2 transferrin receptor 2 1.173
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 1.172
CD207 CD207 molecule, langerin 1.168
CD7 CD7 molecule 1.166
CPB2 carboxypeptidase B2 (plasma) 1.157
SPX spexin hormone 1.155
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.15
HJV hemojuvelin BMP co-receptor 1.144
TLR4 toll-like receptor 4 1.139
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.132
PLAT plasminogen activator, tissue 1.129
RHD Rh blood group, D antigen 1.127
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.125
U2AF1 U2 small nuclear RNA auxiliary factor 1 1.121
B3GAT1 beta-1,3-glucuronyltransferase 1 1.119
GATA1 GATA binding protein 1 (globin transcription factor 1) 1.116
EPB42 erythrocyte membrane protein band 4.2 1.111
KITLG KIT ligand 1.104
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.098
SPN sialophorin 1.097
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.091
IL17A interleukin 17A 1.089
MPO myeloperoxidase 1.088
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.081
ACP5 acid phosphatase 5, tartrate resistant 1.074
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.071
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.07
IL18 interleukin 18 1.069
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 1.068
GOLM1 golgi membrane protein 1 1.064
TMEM67 transmembrane protein 67 1.061
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.059
CXCL8 chemokine (C-X-C motif) ligand 8 1.057
B2M beta-2-microglobulin 1.051
IFNL3 interferon, lambda 3 1.038
EDN1 endothelin 1 1.033
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.031
EPOR erythropoietin receptor 1.026
DZIP1L DAZ interacting zinc finger protein 1-like 1.024
PTH parathyroid hormone 1.022
CCL2 chemokine (C-C motif) ligand 2 1.021
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.019
ETV6 ets variant 6 1.017
PKD2 polycystic kidney disease 2 (autosomal dominant) 1.016
ANPEP alanyl (membrane) aminopeptidase 1.005
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 1.003
SETBP1 SET binding protein 1 1.0