Hypertension Gene Set

Dataset	DISEASES Curated Gene-Disease Association Evidence Scores 2025
Category	disease or phenotype associations
Type	disease
Description	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. (Experimental Factor Ontology, EFO_0000537)
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Genes

10 genes involed in the disease Hypertension from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.

Symbol	Name	Standardized Value
PTGIS	prostaglandin I2 (prostacyclin) synthase	5.0
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	5.0
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	5.0
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	5.0
EIF2AK4	eukaryotic translation initiation factor 2 alpha kinase 4	5.0
AGTR1	angiotensin II receptor, type 1	5.0
NOS3	nitric oxide synthase 3 (endothelial cell)	5.0
NOS2	nitric oxide synthase 2, inducible	5.0
EDNRA	endothelin receptor type A	5.0
SELE	selectin E	5.0