Hypertension Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. (Experimental Factor Ontology, EFO_0000537)
External Link https://www.disgenet.org/browser/0/1/0/C0745136
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Genes

157 genes associated with the disease Hypertension in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACR acrosin
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADRA1A adrenoceptor alpha 1A
ADRB1 adrenoceptor beta 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
ALMS1 Alstrom syndrome protein 1
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANO1 anoctamin 1, calcium activated chloride channel
APLN apelin
APOE apolipoprotein E
ATM ATM serine/threonine kinase
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL10 B-cell CLL/lymphoma 10
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like
BDNF brain-derived neurotrophic factor
CAPN1 calpain 1, (mu/I) large subunit
CAPN9 calpain 9
CCHCR1 coiled-coil alpha-helical rod protein 1
CCL2 chemokine (C-C motif) ligand 2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CHGA chromogranin A
CLIP2 CAP-GLY domain containing linker protein 2
COL17A1 collagen, type XVII, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
CRP C-reactive protein, pentraxin-related
CTF1 cardiotrophin 1
CTRL chymotrypsin-like
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR3 chemokine (C-X-C motif) receptor 3
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
DLD dihydrolipoamide dehydrogenase
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELN elastin
FBL fibrillarin
FGF21 fibroblast growth factor 21
FH fumarate hydratase
FIG4 FIG4 phosphoinositide 5-phosphatase
FN1 fibronectin 1
G6PD glucose-6-phosphate dehydrogenase
GCKR glucokinase (hexokinase 4) regulator
GDE1 glycerophosphodiester phosphodiesterase 1
GDNF glial cell derived neurotrophic factor
GJA1 gap junction protein, alpha 1, 43kDa
GJA5 gap junction protein, alpha 5, 40kDa
GRK2 G protein-coupled receptor kinase 2
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HCRT hypocretin (orexin) neuropeptide precursor
HDAC8 histone deacetylase 8
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMOX1 heme oxygenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL11 interleukin 11
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
JAK2 Janus kinase 2
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF1B kinesin family member 1B
KLK1 kallikrein 1
LAMA2 laminin, alpha 2
LEP leptin
LEPR leptin receptor
LIF leukemia inhibitory factor
LIMK1 LIM domain kinase 1
LOX lysyl oxidase
MAPK3 mitogen-activated protein kinase 3
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MAX MYC associated factor X
MBL2 mannose-binding lectin (protein C) 2, soluble
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MGAM maltase-glucoamylase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NPR1 natriuretic peptide receptor 1
NPR3 natriuretic peptide receptor 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
OGN osteoglycin
OR10A4 olfactory receptor, family 10, subfamily A, member 4
PDGFA platelet-derived growth factor alpha polypeptide
PKD1 polycystic kidney disease 1 (autosomal dominant)
PPARA peroxisome proliferator-activated receptor alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRL prolactin
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYY peptide YY
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RET ret proto-oncogene
RFC2 replication factor C (activator 1) 2, 40kDa
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
SCNN1B sodium channel, non voltage gated 1 beta subunit
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHAF2 succinate dehydrogenase complex assembly factor 2
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SELENBP1 selenium binding protein 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SHBG sex hormone-binding globulin
SI sucrase-isomaltase (alpha-glucosidase)
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SMAD3 SMAD family member 3
SOCS3 suppressor of cytokine signaling 3
SPP1 secreted phosphoprotein 1
SRI sorcin
STAT1 signal transducer and activator of transcription 1, 91kDa
SUCNR1 succinate receptor 1
TBL2 transducin (beta)-like 2
TGFB1 transforming growth factor, beta 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR4 toll-like receptor 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM127 transmembrane protein 127
TMSB4X thymosin beta 4, X-linked
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIP11 thyroid hormone receptor interactor 11
TRPM8 transient receptor potential cation channel, subfamily M, member 8
VAC14 Vac14 homolog (S. cerevisiae)
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
YY1AP1 YY1 associated protein 1
ZNF469 zinc finger protein 469