Hypertension Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. (Experimental Factor Ontology, EFO_0000537)
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Genes

64 genes associated with the trait Hypertension in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.995026
UMOD uromodulin 0.973188
ARHGAP42 Rho GTPase activating protein 42 0.965948
BAG6 BCL2-associated athanogene 6 0.944178
HFE hemochromatosis 0.922056
PLCE1 phospholipase C, epsilon 1 0.769036
LRRC7 leucine rich repeat containing 7 0.711358
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.67572
MOV10 Mov10 RISC complex RNA helicase 0.585749
GSTCD glutathione S-transferase, C-terminal domain containing 0.552453
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.552134
FES FES proto-oncogene, tyrosine kinase 0.527821
ASPG asparaginase 0.521771
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.442769
CD36 CD36 molecule (thrombospondin receptor) 0.406869
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.388943
MSRA methionine sulfoxide reductase A 0.378873
KDM4A lysine (K)-specific demethylase 4A 0.378873
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.371757
CHD2 chromodomain helicase DNA binding protein 2 0.362262
MYO1D myosin ID 0.356676
BMPR1B bone morphogenetic protein receptor, type IB 0.323533
PRKCE protein kinase C, epsilon 0.323533
UBQLN1 ubiquilin 1 0.31704
WDR4 WD repeat domain 4 0.29163
UCN3 urocortin 3 0.269879
PVT1 Pvt1 oncogene (non-protein coding) 0.267772
IDNK idnK, gluconokinase homolog (E. coli) 0.261921
RHOBTB2 Rho-related BTB domain containing 2 0.250771
INTS12 integrator complex subunit 12 0.247645
MIR1-1HG MIR1-1 host gene 0.237262
ETV6 ets variant 6 0.215614
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.211758
LHFPL3 lipoma HMGIC fusion partner-like 3 0.149295
MYT1L myelin transcription factor 1-like 0.144401
MALRD1 MAM and LDL receptor class A domain containing 1 0.141504
AOAH acyloxyacyl hydrolase (neutrophil) 0.124932
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.122092
TRIM58 tripartite motif containing 58 0.121618
NRXN3 neurexin 3 0.109835
SP4 Sp4 transcription factor 0.107873
ANKRD55 ankyrin repeat domain 55 0.10463
MED12L mediator complex subunit 12-like 0.098926
DNAH8 dynein, axonemal, heavy chain 8 0.097407
RAP1GAP2 RAP1 GTPase activating protein 2 0.092429
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.09115
LPP LIM domain containing preferred translocation partner in lipoma 0.090882
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.087239
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase 0.086983
SYK spleen tyrosine kinase 0.085938
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.085853
MYO10 myosin X 0.081165
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.080597
NCKAP5 NCK-associated protein 5 0.075297
ASTN2 astrotactin 2 0.07505
FAM81B family with sequence similarity 81, member B 0.07319
UTRN utrophin 0.071524
PARK2 parkin RBR E3 ubiquitin protein ligase 0.071324
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.070984
ZFR2 zinc finger RNA binding protein 2 0.068247
KALRN kalirin, RhoGEF kinase 0.063638
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0632
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.061872
CREB5 cAMP responsive element binding protein 5 0.061629