Hyperthyroidism Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A thyroid gland disease that involves an over production of thyroid hormone. (Human Disease Ontology, DOID_7998)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D006980
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Genes

184 genes/proteins associated with the disease Hyperthyroidism from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
GSR glutathione reductase 2.88009
TSHR thyroid stimulating hormone receptor 2.88009
GPX1 glutathione peroxidase 1 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
SOD1 superoxide dismutase 1, soluble 2.88009
AQP1 aquaporin 1 (Colton blood group) 2.88009
CARTPT CART prepropeptide 2.88009
PON1 paraoxonase 1 2.88009
CAT catalase 2.88009
TSHB thyroid stimulating hormone, beta 1.71789
TNF tumor necrosis factor 1.71379
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.67955
BAX BCL2-associated X protein 1.66188
ODC1 ornithine decarboxylase 1 1.62736
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.52667
JUN jun proto-oncogene 1.52061
DIO1 deiodinase, iodothyronine, type I 1.51961
IL1B interleukin 1, beta 1.50599
IL10 interleukin 10 1.50095
PCNA proliferating cell nuclear antigen 1.49686
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 1.49019
IL2 interleukin 2 1.48119
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.46304
MMP2 matrix metallopeptidase 2 1.44763
IL4 interleukin 4 1.44763
BCL2 B-cell CLL/lymphoma 2 1.43428
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.42696
BCL3 B-cell CLL/lymphoma 3 1.42508
VEGFA vascular endothelial growth factor A 1.41992
APP amyloid beta (A4) precursor protein 1.38469
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.3827
IL6 interleukin 6 1.3793
EGR1 early growth response 1 1.3759
FOS FBJ murine osteosarcoma viral oncogene homolog 1.36047
ALB albumin 1.35647
NCOA2 nuclear receptor coactivator 2 1.35502
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.34343
S100A6 S100 calcium binding protein A6 1.32993
THRA thyroid hormone receptor, alpha 1.31119
CCND1 cyclin D1 1.30758
BIRC5 baculoviral IAP repeat containing 5 1.30604
AQP3 aquaporin 3 (Gill blood group) 1.29905
MAPK3 mitogen-activated protein kinase 3 1.29379
THRB thyroid hormone receptor, beta 1.28919
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.28549
NOS2 nitric oxide synthase 2, inducible 1.28364
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.27875
SFTPB surfactant protein B 1.27689
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.27533
IFNG interferon, gamma 1.27409
AP2M1 adaptor-related protein complex 2, mu 1 subunit 1.26329
DUSP1 dual specificity phosphatase 1 1.26329
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 1.26298
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.26267
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.25028
CFLAR CASP8 and FADD-like apoptosis regulator 1.24843
PCSK2 proprotein convertase subtilisin/kexin type 2 1.24623
CCL2 chemokine (C-C motif) ligand 2 1.24591
CXCL8 chemokine (C-X-C motif) ligand 8 1.24087
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.23993
STAT5A signal transducer and activator of transcription 5A 1.2393
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.23899
MPO myeloperoxidase 1.23648
FOXD1 forkhead box D1 1.23488
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.23265
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.23201
NCOR1 nuclear receptor corepressor 1 1.22884
TGFB1 transforming growth factor, beta 1 1.22821
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.22371
F3 coagulation factor III (thromboplastin, tissue factor) 1.22339
ATF3 activating transcription factor 3 1.22177
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.21727
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.2137
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.21271
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.21141
ZNF676 zinc finger protein 676 1.21076
IGFBP4 insulin-like growth factor binding protein 4 1.21076
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.20394
NR1D1 nuclear receptor subfamily 1, group D, member 1 1.20361
CCL5 chemokine (C-C motif) ligand 5 1.20097
PRKCD protein kinase C, delta 1.19279
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.19213
RET ret proto-oncogene 1.18981
HMOX1 heme oxygenase 1 1.18948
NKX2-2 NK2 homeobox 2 1.18751
MAPK1 mitogen-activated protein kinase 1 1.18259
KLF9 Kruppel-like factor 9 1.1786
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.17629
SIRT1 sirtuin 1 1.17399
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.16866
CRYBA1 crystallin, beta A1 1.16666
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.165
POU2F1 POU class 2 homeobox 1 1.15865
NGF nerve growth factor (beta polypeptide) 1.15865
CRIP1 cysteine-rich protein 1 (intestinal) 1.15831
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.15729
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.15627
TG thyroglobulin 1.15156
MBP myelin basic protein 1.15022
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.14644
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.14404
GNAS GNAS complex locus 1.14404
STAT1 signal transducer and activator of transcription 1, 91kDa 1.14166
GJA1 gap junction protein, alpha 1, 43kDa 1.14166
LOX lysyl oxidase 1.13279
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.13245
PRPF3 pre-mRNA processing factor 3 1.13109
UBE2Z ubiquitin-conjugating enzyme E2Z 1.13109
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.13041
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.12906
MMP9 matrix metallopeptidase 9 1.1253
COL2A1 collagen, type II, alpha 1 1.12391
AMY1A amylase, alpha 1A (salivary) 1.12357
CSNK1A1 casein kinase 1, alpha 1 1.12323
PPDPF pancreatic progenitor cell differentiation and proliferation factor 1.12288
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 1.12254
PCSK9 proprotein convertase subtilisin/kexin type 9 1.11673
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.11466
HSPB1 heat shock 27kDa protein 1 1.1136
ADRB1 adrenoceptor beta 1 1.10699
IGF1 insulin-like growth factor 1 (somatomedin C) 1.10631
HTRA1 HtrA serine peptidase 1 1.1014
ING2 inhibitor of growth family, member 2 1.1014
CA3 carbonic anhydrase III 1.1014
TACC3 transforming, acidic coiled-coil containing protein 3 1.09822
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.09681
CCNA2 cyclin A2 1.09681
PRL prolactin 1.09576
RELN reelin 1.09541
BMP6 bone morphogenetic protein 6 1.09506
THY1 Thy-1 cell surface antigen 1.09226
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 1.08868
SPDEF SAM pointed domain containing ETS transcription factor 1.08762
MRPL9 mitochondrial ribosomal protein L9 1.08726
EGFR epidermal growth factor receptor 1.08619
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.08372
ECI1 enoyl-CoA delta isomerase 1 1.08091
FBXO17 F-box protein 17 1.07732
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 1.07553
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.06917
CCND2 cyclin D2 1.06917
ENO1 enolase 1, (alpha) 1.06881
CREB1 cAMP responsive element binding protein 1 1.06734
REST RE1-silencing transcription factor 1.06406
PCSK1 proprotein convertase subtilisin/kexin type 1 1.0637
SELK selenoprotein K 1.06188
CPT1A carnitine palmitoyltransferase 1A (liver) 1.05864
HDC histidine decarboxylase 1.05757
SOX4 SRY (sex determining region Y)-box 4 1.05721
TF transferrin 1.0561
ELK1 ELK1, member of ETS oncogene family 1.05498
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.05461
EPC1 enhancer of polycomb homolog 1 (Drosophila) 1.05237
CORO1C coronin, actin binding protein, 1C 1.05237
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.04941
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.04721
GHRH growth hormone releasing hormone 1.04684
COL1A2 collagen, type I, alpha 2 1.04465
C1S complement component 1, s subcomponent 1.04239
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 1.04051
ALDOC aldolase C, fructose-bisphosphate 1.04014
CD86 CD86 molecule 1.03939
GFAP glial fibrillary acidic protein 1.03641
PTK2B protein tyrosine kinase 2 beta 1.03567
GSTA4 glutathione S-transferase alpha 4 1.03271
GSTP1 glutathione S-transferase pi 1 1.03159
GADD45A growth arrest and DNA-damage-inducible, alpha 1.03009
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.02858
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.02634
ECH1 enoyl CoA hydratase 1, peroxisomal 1.02634
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 1.02559
ADRB2 adrenoceptor beta 2, surface 1.02522
IGFBP3 insulin-like growth factor binding protein 3 1.02485
LDHAL6B lactate dehydrogenase A-like 6B 1.02262
GAP43 growth associated protein 43 1.02188
LDLR low density lipoprotein receptor 1.01814
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.01739
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.01739
TGOLN2 trans-golgi network protein 2 1.01701
STAG2 stromal antigen 2 1.01663
GSTT1 glutathione S-transferase theta 1 1.01212
RAI14 retinoic acid induced 14 1.01174
ACOT4 acyl-CoA thioesterase 4 1.01137
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.01099