Hyperthyroidism Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A thyroid gland disease that involves an over production of thyroid hormone. (Human Disease Ontology, DOID_7998)
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Genes

55 genes associated with the disease Hyperthyroidism in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CEP128 centrosomal protein 128kDa 1.85
TSHR thyroid stimulating hormone receptor 1.85
PDE8B phosphodiesterase 8B 1.826
FAM227B family with sequence similarity 227, member B 1.762
GALK2 galactokinase 2 1.762
FGF7 fibroblast growth factor 7 1.762
RSBN1 round spermatid basic protein 1 1.741
HIPK1 homeodomain interacting protein kinase 1 1.741
AP4B1 adaptor-related protein complex 4, beta 1 subunit 1.741
PHTF1 putative homeodomain transcription factor 1 1.741
DCLRE1B DNA cross-link repair 1B 1.741
BCL2L15 BCL2-like 15 1.741
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.741
SYT13 synaptotagmin XIII 1.644
PRDM11 PR domain containing 11 1.644
TMEM71 transmembrane protein 71 1.529
PHF20L1 PHD finger protein 20-like 1 1.529
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.49
PDE10A phosphodiesterase 10A 1.29
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 1.277
NBL1 neuroblastoma 1, DAN family BMP antagonist 1.277
CAPZB capping protein (actin filament) muscle Z-line, beta 1.277
DTWD1 DTW domain containing 1 1.217
LPP LIM domain containing preferred translocation partner in lipoma 1.146
BTNL2 butyrophilin-like 2 1.112
TSBP1 testis expressed basic protein 1 1.112
XPA xeroderma pigmentosum, complementation group A 1.105
FOXE1 forkhead box E1 1.105
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.032
ICOS inducible T-cell co-stimulator 1.032
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.988
IL2RA interleukin 2 receptor, alpha 0.988
RBM17 RNA binding motif protein 17 0.988
IL15RA interleukin 15 receptor, alpha 0.988
POLR1C polymerase (RNA) I polypeptide C, 30kDa 0.987
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.961
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.961
TSLIG3B tRNA splicing ligase complex subunit 3B 0.961
TAPBP TAP binding protein (tapasin) 0.847
WDR46 WD repeat domain 46 0.847
RING1 ring finger protein 1 0.847
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 0.847
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 0.847
RPS18 ribosomal protein S18 0.847
ZBTB22 zinc finger and BTB domain containing 22 0.847
COL11A2 collagen, type XI, alpha 2 0.847
RXRB retinoid X receptor, beta 0.847
DAXX death-domain associated protein 0.847
PFDN6 prefoldin subunit 6 0.847
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 0.847
RGL2 ral guanine nucleotide dissociation stimulator-like 2 0.847
SLC39A7 solute carrier family 39 (zinc transporter), member 7 0.847
TRIM27 tripartite motif containing 27 0.778
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 0.547
PTPRC protein tyrosine phosphatase, receptor type, C 0.547