Hyperthyroidism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A thyroid gland disease that involves an over production of thyroid hormone. (Human Disease Ontology, DOID_7998)
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Genes

735 genes co-occuring with the disease Hyperthyroidism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TSHR thyroid stimulating hormone receptor 3.806
TG thyroglobulin 3.741
TPO thyroid peroxidase 3.491
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 3.077
TRH thyrotropin-releasing hormone 3.047
PTH parathyroid hormone 2.977
INS insulin 2.96
THRB thyroid hormone receptor, beta 2.945
DIO2 deiodinase, iodothyronine, type II 2.899
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.898
TSHB thyroid stimulating hormone, beta 2.721
ALB albumin 2.718
POMC proopiomelanocortin 2.71
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.701
PRL prolactin 2.695
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.691
CRP C-reactive protein, pentraxin-related 2.664
THRA thyroid hormone receptor, alpha 2.653
SHBG sex hormone-binding globulin 2.651
IGF1 insulin-like growth factor 1 (somatomedin C) 2.638
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.63
TXNRD2 thioredoxin reductase 2 2.597
BGLAP bone gamma-carboxyglutamate (gla) protein 2.572
REN renin 2.56
ACE angiotensin I converting enzyme 2.531
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 2.528
IL6 interleukin 6 2.526
SST somatostatin 2.491
CD274 CD274 molecule 2.49
ATP5PO ATP synthase peripheral stalk subunit OSCP 2.467
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.457
KCNJ18 potassium channel, inwardly rectifying subfamily J, member 18 2.454
LEP leptin 2.442
PDCD1 programmed cell death 1 2.416
TNF tumor necrosis factor 2.383
GNAS GNAS complex locus 2.376
NPPB natriuretic peptide B 2.342
PXDN peroxidasin 2.325
PXDNL peroxidasin-like 2.325
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.312
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 2.303
CD4 CD4 molecule 2.289
TTR transthyretin 2.269
MYH14 myosin, heavy chain 14, non-muscle 2.26
IL1B interleukin 1, beta 2.233
GCG glucagon 2.21
IFNG interferon, gamma 2.204
IFNA1 interferon, alpha 1 2.202
DIO3 deiodinase, iodothyronine, type III 2.198
CD8A CD8a molecule 2.184
DIO1 deiodinase, iodothyronine, type I 2.17
ESR1 estrogen receptor 1 2.168
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.151
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.132
IL2 interleukin 2 2.132
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.131
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.127
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.125
FGF23 fibroblast growth factor 23 2.121
ADIPOQ adiponectin, C1Q and collagen domain containing 2.118
CST3 cystatin C 2.114
F2 coagulation factor II (thrombin) 2.105
GHRL ghrelin/obestatin prepropeptide 2.098
CGA glycoprotein hormones, alpha polypeptide 2.09
CKB creatine kinase, brain 2.086
CKM creatine kinase, muscle 2.082
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.081
CKMT1B creatine kinase, mitochondrial 1B 2.078
FOXE1 forkhead box E1 2.078
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 2.076
APOB apolipoprotein B 2.074
IGF1R insulin-like growth factor 1 receptor 2.067
IFNA2 interferon, alpha 2 2.065
IL10 interleukin 10 2.061
PAX8 paired box 8 2.052
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.05
GPX3 glutathione peroxidase 3 2.048
NPPA natriuretic peptide A 2.046
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.039
CD40 CD40 molecule, TNF receptor superfamily member 5 2.038
VWF von Willebrand factor 2.035
IL1A interleukin 1, alpha 2.031
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.024
IFNA7 interferon, alpha 7 2.023
CRH corticotropin releasing hormone 2.023
IFNA6 interferon, alpha 6 2.023
IFNA10 interferon, alpha 10 2.021
IFNA16 interferon, alpha 16 2.02
IFNA13 interferon, alpha 13 2.02
IFNA21 interferon, alpha 21 2.019
IFNA4 interferon, alpha 4 2.019
IFNA14 interferon, alpha 14 2.019
IFNA8 interferon, alpha 8 2.018
IFNA5 interferon, alpha 5 2.017
IFNA17 interferon, alpha 17 2.016
TGFB1 transforming growth factor, beta 1 2.013
FCRL3 Fc receptor-like 3 2.007
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.995
GPX2 glutathione peroxidase 2 1.993
GPX7 glutathione peroxidase 7 1.992
GPX6 glutathione peroxidase 6 1.99
GPX5 glutathione peroxidase 5 1.989
GPX8 glutathione peroxidase 8 (putative) 1.988
GHRH growth hormone releasing hormone 1.986
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 1.977
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.976
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.961
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.958
F3 coagulation factor III (thromboplastin, tissue factor) 1.955
NPY neuropeptide Y 1.951
PDCD1LG2 programmed cell death 1 ligand 2 1.95
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 1.945
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 1.944
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.943
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.939
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.937
SOST sclerostin 1.933
PPARG peroxisome proliferator-activated receptor gamma 1.929
AVP arginine vasopressin 1.922
RET ret proto-oncogene 1.921
IL17A interleukin 17A 1.92
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.917
IL4 interleukin 4 1.911
DNAH8 dynein, axonemal, heavy chain 8 1.905
GHR growth hormone receptor 1.904
NKX2-1 NK2 homeobox 1 1.885
CXCL8 chemokine (C-X-C motif) ligand 8 1.876
AMH anti-Mullerian hormone 1.873
CASR calcium-sensing receptor 1.864
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.861
IYD iodotyrosine deiodinase 1.859
OXT oxytocin/neurophysin I prepropeptide 1.855
PTHLH parathyroid hormone-like hormone 1.853
MAOB monoamine oxidase B 1.85
TNNI3 troponin I type 3 (cardiac) 1.848
MAOA monoamine oxidase A 1.834
ACE2 angiotensin I converting enzyme 2 1.832
APOA1 apolipoprotein A-I 1.832
SCN4A sodium channel, voltage gated, type IV alpha subunit 1.826
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.822
FOXP3 forkhead box P3 1.822
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.821
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.82
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.82
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.816
THRSP thyroid hormone responsive 1.81
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.805
AGRP agouti related neuropeptide 1.804
CD28 CD28 molecule 1.785
GH1 growth hormone 1 1.784
DUOX2 dual oxidase 2 1.782
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.775
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1.768
EPO erythropoietin 1.762
MPO myeloperoxidase 1.755
DUOXA2 dual oxidase maturation factor 2 1.752
CD80 CD80 molecule 1.752
INSR insulin receptor 1.749
EDN1 endothelin 1 1.749
ADRB2 adrenoceptor beta 2, surface 1.743
GC group-specific component (vitamin D binding protein) 1.73
PDE8B phosphodiesterase 8B 1.728
GHSR growth hormone secretagogue receptor 1.719
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.716
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.714
PPARA peroxisome proliferator-activated receptor alpha 1.714
PTPRN protein tyrosine phosphatase, receptor type, N 1.712
ADRB3 adrenoceptor beta 3 1.701
MB myoglobin 1.699
ADRB1 adrenoceptor beta 1 1.698
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.695
FGF21 fibroblast growth factor 21 1.695
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.694
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.691
PRTN3 proteinase 3 1.69
TGM2 transglutaminase 2 1.689
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.689
AGTR1 angiotensin II receptor, type 1 1.688
IGFBP3 insulin-like growth factor binding protein 3 1.685
HLA-B major histocompatibility complex, class I, B 1.684
SLC30A10 solute carrier family 30, member 10 1.683
ICAM1 intercellular adhesion molecule 1 1.683
ACP5 acid phosphatase 5, tartrate resistant 1.682
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.681
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.68
SLC30A8 solute carrier family 30 (zinc transporter), member 8 1.677
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.673
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.673
TOR1A torsin family 1, member A (torsin A) 1.672
CCL2 chemokine (C-C motif) ligand 2 1.67
AIRE autoimmune regulator 1.667
CD40LG CD40 ligand 1.666
FSHR follicle stimulating hormone receptor 1.663
DPP4 dipeptidyl-peptidase 4 1.663
CD52 CD52 molecule 1.66
CSH2 chorionic somatomammotropin hormone 2 1.66
JUN jun proto-oncogene 1.658
CETP cholesteryl ester transfer protein, plasma 1.657
IFNB1 interferon, beta 1, fibroblast 1.653
LPL lipoprotein lipase 1.653
FNDC5 fibronectin type III domain containing 5 1.646
TP53 tumor protein p53 1.645
CXCL10 chemokine (C-X-C motif) ligand 10 1.643
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 1.641
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.639
RETN resistin 1.639
CD86 CD86 molecule 1.637
F8 coagulation factor VIII, procoagulant component 1.633
SSTR5 somatostatin receptor 5 1.627
SELENOP selenoprotein P 1.626
BCL2 B-cell CLL/lymphoma 2 1.623
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 1.621
RNF213 ring finger protein 213 1.62
BDNF brain-derived neurotrophic factor 1.619
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.618
RYR2 ryanodine receptor 2 (cardiac) 1.618
EGFR epidermal growth factor receptor 1.615
ACTB actin, beta 1.609
RETNLB resistin like beta 1.608
HP haptoglobin 1.608
TRHDE thyrotropin-releasing hormone degrading enzyme 1.604
AFP alpha-fetoprotein 1.602
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.6
CSF3 colony stimulating factor 3 (granulocyte) 1.594
SCN5A sodium channel, voltage gated, type V alpha subunit 1.589
MC4R melanocortin 4 receptor 1.587
SSTR2 somatostatin receptor 2 1.586
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.585
CREB1 cAMP responsive element binding protein 1 1.584
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 1.577
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 1.574
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.574
LHCGR luteinizing hormone/choriogonadotropin receptor 1.572
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.569
MUSK muscle, skeletal, receptor tyrosine kinase 1.567
GH2 growth hormone 2 1.566
NOS3 nitric oxide synthase 3 (endothelial cell) 1.563
GJA5 gap junction protein, alpha 5, 40kDa 1.563
DUOX1 dual oxidase 1 1.561
SECISBP2 SECIS binding protein 2 1.559
IL18 interleukin 18 1.559
GAST gastrin 1.558
GLP1R glucagon-like peptide 1 receptor 1.558
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.555
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.552
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.552
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.549
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.548
TRHR thyrotropin-releasing hormone receptor 1.543
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.542
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.542
TBX19 T-box 19 1.54
RNASET2 ribonuclease T2 1.537
SPP1 secreted phosphoprotein 1 1.535
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 1.535
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.534
CD19 CD19 molecule 1.533
TAAR1 trace amine associated receptor 1 1.533
NCOR1 nuclear receptor corepressor 1 1.533
CP ceruloplasmin (ferroxidase) 1.532
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.53
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.528
LAG3 lymphocyte-activation gene 3 1.527
LDLR low density lipoprotein receptor 1.525
B2M beta-2-microglobulin 1.524
TTN titin 1.523
HLA-A major histocompatibility complex, class I, A 1.521
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.52
BCHE butyrylcholinesterase 1.517
ALK anaplastic lymphoma receptor tyrosine kinase 1.517
PROP1 PROP paired-like homeobox 1 1.514
ESR2 estrogen receptor 2 (ER beta) 1.514
IL2RA interleukin 2 receptor, alpha 1.513
LGALS3 lectin, galactoside-binding, soluble, 3 1.512
GSR glutathione reductase 1.511
IL13 interleukin 13 1.508
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.506
FOS FBJ murine osteosarcoma viral oncogene homolog 1.498
APOE apolipoprotein E 1.498
IGF2 insulin-like growth factor 2 1.497
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.495
NCAM1 neural cell adhesion molecule 1 1.494
HLA-C major histocompatibility complex, class I, C 1.493
MEN1 multiple endocrine neoplasia I 1.492
IL5 interleukin 5 1.489
CRYM crystallin, mu 1.489
FGF7 fibroblast growth factor 7 1.488
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.486
LRP5 low density lipoprotein receptor-related protein 5 1.486
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.484
FSHB follicle stimulating hormone, beta polypeptide 1.482
LPA lipoprotein, Lp(a) 1.482
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.481
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.481
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.48
PLG plasminogen 1.479
EGF epidermal growth factor 1.477
FGF10 fibroblast growth factor 10 1.475
GJA1 gap junction protein, alpha 1, 43kDa 1.475
FGF8 fibroblast growth factor 8 (androgen-induced) 1.472
CHGA chromogranin A 1.466
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.465
MSTN myostatin 1.465
FGF18 fibroblast growth factor 18 1.464
NAMPT nicotinamide phosphoribosyltransferase 1.464
RUNX2 runt-related transcription factor 2 1.462
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.461
FGF4 fibroblast growth factor 4 1.46
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.46
ERBB2 erb-b2 receptor tyrosine kinase 2 1.46
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.458
FN1 fibronectin 1 1.453
PCSK9 proprotein convertase subtilisin/kexin type 9 1.452
TLR4 toll-like receptor 4 1.452
GLIS3 GLIS family zinc finger 3 1.451
FGF3 fibroblast growth factor 3 1.451
KLF9 Kruppel-like factor 9 1.449
EDNRA endothelin receptor type A 1.448
MAPK3 mitogen-activated protein kinase 3 1.447
FGF17 fibroblast growth factor 17 1.447
CYCS cytochrome c, somatic 1.446
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.445
VCAM1 vascular cell adhesion molecule 1 1.445
FGF16 fibroblast growth factor 16 1.444
ALPL alkaline phosphatase, liver/bone/kidney 1.443
TAC1 tachykinin, precursor 1 1.441
FGF6 fibroblast growth factor 6 1.439
LIPC lipase, hepatic 1.436
GPR174 G protein-coupled receptor 174 1.436
SREBF1 sterol regulatory element binding transcription factor 1 1.436
FGF2 fibroblast growth factor 2 (basic) 1.435
FGF20 fibroblast growth factor 20 1.433
AHSG alpha-2-HS-glycoprotein 1.433
FGF22 fibroblast growth factor 22 1.433
GPHRA golgi pH regulator A 1.43
CAPZB capping protein (actin filament) muscle Z-line, beta 1.43
CD34 CD34 molecule 1.428
FGF9 fibroblast growth factor 9 1.426
TAS2R42 taste receptor, type 2, member 42 1.425
CARTPT CART prepropeptide 1.424
IL16 interleukin 16 1.424
FGF5 fibroblast growth factor 5 1.423
MMP9 matrix metallopeptidase 9 1.421
CTSK cathepsin K 1.419
PDE10A phosphodiesterase 10A 1.418
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.415
AR androgen receptor 1.413
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.413
TNNT2 troponin T type 2 (cardiac) 1.413
G6PD glucose-6-phosphate dehydrogenase 1.409
CXCL9 chemokine (C-X-C motif) ligand 9 1.409
XDH xanthine dehydrogenase 1.406
MME membrane metallo-endopeptidase 1.403
SIRT1 sirtuin 1 1.403
CA1 carbonic anhydrase I 1.398
COL1A2 collagen, type I, alpha 2 1.397
NRG4 neuregulin 4 1.395
MBP myelin basic protein 1.394
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.394
SREBF2 sterol regulatory element binding transcription factor 2 1.393
PLAT plasminogen activator, tissue 1.389
LIPE lipase, hormone-sensitive 1.386
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 1.386
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.386
TMPRSS2 transmembrane protease, serine 2 1.382
PON1 paraoxonase 1 1.382
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.382
FASLG Fas ligand (TNF superfamily, member 6) 1.379
ARRB1 arrestin, beta 1 1.376
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.375
CCL5 chemokine (C-C motif) ligand 5 1.371
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.366
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.365
POU1F1 POU class 1 homeobox 1 1.361
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.361
KNG1 kininogen 1 1.361
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 1.361
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.358
JAK2 Janus kinase 2 1.358
NGF nerve growth factor (beta polypeptide) 1.357
PDE5A phosphodiesterase 5A, cGMP-specific 1.353
HAMP hepcidin antimicrobial peptide 1.351
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.351
CAPNS2 calpain, small subunit 2 1.351
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.35
PYY peptide YY 1.35
MMEL1 membrane metallo-endopeptidase-like 1 1.35
XPR1 xenotropic and polytropic retrovirus receptor 1 1.347
KISS1 KiSS-1 metastasis-suppressor 1.347
RBP4 retinol binding protein 4, plasma 1.346
IRS1 insulin receptor substrate 1 1.345
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.344
SCARB1 scavenger receptor class B, member 1 1.343
RHO rhodopsin 1.342
FLNB filamin B, beta 1.342
PTPRC protein tyrosine phosphatase, receptor type, C 1.342
ZFHX3 zinc finger homeobox 3 1.337
CCND1 cyclin D1 1.336
SI sucrase-isomaltase (alpha-glucosidase) 1.335
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.334
NUP155 nucleoporin 155kDa 1.334
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 1.333
PTEN phosphatase and tensin homolog 1.332
SLCO1A2 solute carrier organic anion transporter family, member 1A2 1.332
MCU mitochondrial calcium uniporter 1.332
ACHE acetylcholinesterase (Yt blood group) 1.331
NPPC natriuretic peptide C 1.33
GDF15 growth differentiation factor 15 1.33
RYR1 ryanodine receptor 1 (skeletal) 1.327
HCRT hypocretin (orexin) neuropeptide precursor 1.325
VIP vasoactive intestinal peptide 1.323
IL15 interleukin 15 1.323
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 1.322
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.319
SLCO4A1 solute carrier organic anion transporter family, member 4A1 1.319
HNF1A HNF1 homeobox A 1.316
FLT1 fms-related tyrosine kinase 1 1.316
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.316
C3 complement component 3 1.313
OGA O-GlcNAcase 1.313
MGAM maltase-glucoamylase 1.312
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 1.311
PITX2 paired-like homeodomain 2 1.311
PGR progesterone receptor 1.31
HAVCR2 hepatitis A virus cellular receptor 2 1.308
MYBPC3 myosin binding protein C, cardiac 1.307
ALPI alkaline phosphatase, intestinal 1.307
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.305
SYP synaptophysin 1.305
CCK cholecystokinin 1.304
NUCB2 nucleobindin 2 1.3
WSB1 WD repeat and SOCS box containing 1 1.3
MBIP MAP3K12 binding inhibitory protein 1 1.299
CALML3 calmodulin-like 3 1.299
CD36 CD36 molecule (thrombospondin receptor) 1.298
PLA1A phospholipase A1 member A 1.298
PNLIP pancreatic lipase 1.297
CALML4 calmodulin-like 4 1.296
CALML6 calmodulin-like 6 1.296
MLXIPL MLX interacting protein-like 1.295
APP amyloid beta (A4) precursor protein 1.294
PCNA proliferating cell nuclear antigen 1.293
CALML5 calmodulin-like 5 1.293
CXCR3 chemokine (C-X-C motif) receptor 3 1.291
LCN2 lipocalin 2 1.286
ADM adrenomedullin 1.285
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.283
CPB2 carboxypeptidase B2 (plasma) 1.283
CD68 CD68 molecule 1.282
CIDEA cell death-inducing DFFA-like effector a 1.281
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.278
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.277
SDF4 stromal cell derived factor 4 1.277
KLK3 kallikrein-related peptidase 3 1.276
ZSCAN23 zinc finger and SCAN domain containing 23 1.276
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 1.271
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.269
STAT1 signal transducer and activator of transcription 1, 91kDa 1.268
KDR kinase insert domain receptor 1.264
CD276 CD276 molecule 1.263
TH tyrosine hydroxylase 1.263
NFE2L2 nuclear factor, erythroid 2-like 2 1.262
DRD2 dopamine receptor D2 1.26
CXCL11 chemokine (C-X-C motif) ligand 11 1.258
HMOX1 heme oxygenase 1 1.258
COL1A1 collagen, type I, alpha 1 1.258
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 1.257
IL22 interleukin 22 1.256
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.255
BAX BCL2-associated X protein 1.254
KRAS Kirsten rat sarcoma viral oncogene homolog 1.25
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.248
ENO2 enolase 2 (gamma, neuronal) 1.248
F9 coagulation factor IX 1.246
FOXO1 forkhead box O1 1.246
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.245
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1.244
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 1.242
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.242
KL klotho 1.242
SELENOS selenoprotein S 1.238
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.235
NF1 neurofibromin 1 1.234
MLN motilin 1.233
LEPR leptin receptor 1.231
CTSH cathepsin H 1.23
MMP2 matrix metallopeptidase 2 1.228
GSK3B glycogen synthase kinase 3 beta 1.227
LRP2 low density lipoprotein receptor-related protein 2 1.226
SCGB3A2 secretoglobin, family 3A, member 2 1.223
KRT19 keratin 19, type I 1.22
LHX3 LIM homeobox 3 1.217
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.213
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 1.212
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 1.212
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.21
SELE selectin E 1.208
TIGIT T cell immunoreceptor with Ig and ITIM domains 1.207
ARRB2 arrestin, beta 2 1.207
PNPLA2 patatin-like phospholipase domain containing 2 1.206
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.205
CD27 CD27 molecule 1.203
NR2C2 nuclear receptor subfamily 2, group C, member 2 1.202
TERT telomerase reverse transcriptase 1.201
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1.201
BMP2 bone morphogenetic protein 2 1.201
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.199
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.199
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.199
IL7 interleukin 7 1.198
FGFR1 fibroblast growth factor receptor 1 1.197
IGFBP1 insulin-like growth factor binding protein 1 1.197
TXN thioredoxin 1.195
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.193
FCGRT Fc fragment of IgG, receptor, transporter, alpha 1.19
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.189
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.189
GPHB5 glycoprotein hormone beta 5 1.188
SP7 Sp7 transcription factor 1.187
NCOA1 nuclear receptor coactivator 1 1.185
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.185
SHH sonic hedgehog 1.183
IDO1 indoleamine 2,3-dioxygenase 1 1.181
GATA4 GATA binding protein 4 1.18
HNF4A hepatocyte nuclear factor 4, alpha 1.179
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.177
HRAS Harvey rat sarcoma viral oncogene homolog 1.174
NKX2-5 NK2 homeobox 5 1.172
SYNPO2L synaptopodin 2-like 1.171
GIP gastric inhibitory polypeptide 1.169
ITPK1 inositol-tetrakisphosphate 1-kinase 1.167
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.164
GATA3 GATA binding protein 3 1.163
SMTNL1 smoothelin-like 1 1.161
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.161
FABP1 fatty acid binding protein 1, liver 1.161
FABP4 fatty acid binding protein 4, adipocyte 1.16
CD5 CD5 molecule 1.16
ICOS inducible T-cell co-stimulator 1.159
TFAM transcription factor A, mitochondrial 1.159
RXRA retinoid X receptor, alpha 1.159
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.159
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 1.158
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 1.157
GPBAR1 G protein-coupled bile acid receptor 1 1.157
SH2B3 SH2B adaptor protein 3 1.156
THY1 Thy-1 cell surface antigen 1.153
GHRHR growth hormone releasing hormone receptor 1.15
MAPK1 mitogen-activated protein kinase 1 1.149
BMP8B bone morphogenetic protein 8b 1.147
BMP4 bone morphogenetic protein 4 1.146
NLRP3 NLR family, pyrin domain containing 3 1.145
MYOD1 myogenic differentiation 1 1.143
FBXO32 F-box protein 32 1.143
IGFBP5 insulin-like growth factor binding protein 5 1.142
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.141
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.141
PRF1 perforin 1 (pore forming protein) 1.14
ACTA1 actin, alpha 1, skeletal muscle 1.139
DNPEP aspartyl aminopeptidase 1.138
MUC1 mucin 1, cell surface associated 1.135
MOG myelin oligodendrocyte glycoprotein 1.129
IL2RB interleukin 2 receptor, beta 1.129
C6ORF15 chromosome 6 open reading frame 15 1.129
MGP matrix Gla protein 1.129
PPARD peroxisome proliferator-activated receptor delta 1.128
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.128
RAD51B RAD51 paralog B 1.128
SLN sarcolipin 1.127
SCARB2 scavenger receptor class B, member 2 1.127
CD38 CD38 molecule 1.125
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.125
AIP aryl hydrocarbon receptor interacting protein 1.125
ALPP alkaline phosphatase, placental 1.124
DUOXA1 dual oxidase maturation factor 1 1.121
FLYWCH2 FLYWCH family member 2 1.12
TIMP1 TIMP metallopeptidase inhibitor 1 1.119
SRL sarcalumenin 1.118
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 1.118
PGF placental growth factor 1.117
ALPG alkaline phosphatase, germ cell 1.115
SMAD2 SMAD family member 2 1.114
MYF5 myogenic factor 5 1.114
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 1.113
TAS2R38 taste receptor, type 2, member 38 1.111
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.111
MAP2K1 mitogen-activated protein kinase kinase 1 1.11
CCN2 cellular communication network factor 2 1.109
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.109
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.108
NOS1 nitric oxide synthase 1 (neuronal) 1.108
LTF lactotransferrin 1.106
GATA2 GATA binding protein 2 1.106
PPY pancreatic polypeptide 1.105
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.103
PPA1 pyrophosphatase (inorganic) 1 1.103
CCL3 chemokine (C-C motif) ligand 3 1.103
GNRHR gonadotropin-releasing hormone receptor 1.102
ENO1 enolase 1, (alpha) 1.101
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 1.1
PECAM1 platelet/endothelial cell adhesion molecule 1 1.099
PRDM11 PR domain containing 11 1.098
TBL1X transducin (beta)-like 1X-linked 1.098
SSTR1 somatostatin receptor 1 1.098
LGI1 leucine-rich, glioma inactivated 1 1.097
ADRA1B adrenoceptor alpha 1B 1.096
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A 1.096
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.095
STAR steroidogenic acute regulatory protein 1.094
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.094
CAV1 caveolin 1, caveolae protein, 22kDa 1.093
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 1.093
STAT4 signal transducer and activator of transcription 4 1.092
TYR tyrosinase 1.092
G6PC2 glucose-6-phosphatase, catalytic, 2 1.091
ELN elastin 1.09
MAPK8 mitogen-activated protein kinase 8 1.09
IL33 interleukin 33 1.09
TRIM21 tripartite motif containing 21 1.089
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.089
APOC3 apolipoprotein C-III 1.089
AHR aryl hydrocarbon receptor 1.088
KRT7 keratin 7, type II 1.087
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.084
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.084
CPT1A carnitine palmitoyltransferase 1A (liver) 1.082
APOA2 apolipoprotein A-II 1.081
TLR2 toll-like receptor 2 1.081
CXCR4 chemokine (C-X-C motif) receptor 4 1.08
VKORC1 vitamin K epoxide reductase complex, subunit 1 1.079
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.078
SDC1 syndecan 1 1.077
APLN apelin 1.077
SOX10 SRY (sex determining region Y)-box 10 1.076
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.075
HDAC9 histone deacetylase 9 1.074
PTH1R parathyroid hormone 1 receptor 1.074
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.069
PDK2 pyruvate dehydrogenase kinase, isozyme 2 1.068
CS citrate synthase 1.068
IAPP islet amyloid polypeptide 1.067
NELFCD negative elongation factor complex member C/D 1.066
IL11 interleukin 11 1.066
NTS neurotensin 1.065
CD1C CD1c molecule 1.064
NR1D1 nuclear receptor subfamily 1, group D, member 1 1.064
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.062
LOX lysyl oxidase 1.062
PRDM16 PR domain containing 16 1.062
CA6 carbonic anhydrase VI 1.061
CDC73 cell division cycle 73 1.06
LMNA lamin A/C 1.059
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.059
SLC44A4 solute carrier family 44, member 4 1.059
MED13 mediator complex subunit 13 1.059
FOXO3 forkhead box O3 1.055
MFN2 mitofusin 2 1.054
CALCR calcitonin receptor 1.054
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 1.052
TAC3 tachykinin 3 1.052
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.052
CA13 carbonic anhydrase XIII 1.051
HAVCR1 hepatitis A virus cellular receptor 1 1.051
FBN1 fibrillin 1 1.05
DPYSL5 dihydropyrimidinase-like 5 1.05
NCOA4 nuclear receptor coactivator 4 1.048
FGF19 fibroblast growth factor 19 1.048
PTCH1 patched 1 1.046
NRGN neurogranin (protein kinase C substrate, RC3) 1.045
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.045
KEAP1 kelch-like ECH-associated protein 1 1.044
MYD88 myeloid differentiation primary response 88 1.044
G6PC3 glucose 6 phosphatase, catalytic, 3 1.043
HSPA4 heat shock 70kDa protein 4 1.043
LRP4 low density lipoprotein receptor-related protein 4 1.042
APOH apolipoprotein H (beta-2-glycoprotein I) 1.041
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.04
GCK glucokinase (hexokinase 4) 1.04
CA5B carbonic anhydrase VB, mitochondrial 1.04
GCGR glucagon receptor 1.037
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 1.036
ORM2 orosomucoid 2 1.035
FGF13 fibroblast growth factor 13 1.034
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.034
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.034
DICER1 dicer 1, ribonuclease type III 1.033
CRHR1 corticotropin releasing hormone receptor 1 1.033
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.032
CA8 carbonic anhydrase VIII 1.032
ANGPTL8 angiopoietin like 8 1.03
CYBB cytochrome b-245, beta polypeptide 1.029
GRP gastrin-releasing peptide 1.027
PNMT phenylethanolamine N-methyltransferase 1.027
PMCH pro-melanin-concentrating hormone 1.026
COMT catechol-O-methyltransferase 1.026
SCT secretin 1.025
LCAT lecithin-cholesterol acyltransferase 1.025
GLB1 galactosidase, beta 1 1.025
GLIS1 GLIS family zinc finger 1 1.024
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.023
CASQ2 calsequestrin 2 (cardiac muscle) 1.021
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.021
APOA4 apolipoprotein A-IV 1.021
RXRG retinoid X receptor, gamma 1.02
MYH4 myosin, heavy chain 4, skeletal muscle 1.02
CA5A carbonic anhydrase VA, mitochondrial 1.02
TBP TATA box binding protein 1.02
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.019
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 1.018
HLA-G major histocompatibility complex, class I, G 1.018
IL3 interleukin 3 1.017
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.017
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 1.017
SOD1 superoxide dismutase 1, soluble 1.015
AADAT aminoadipate aminotransferase 1.015
FURIN furin (paired basic amino acid cleaving enzyme) 1.014
APOM apolipoprotein M 1.014
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.01
NOX4 NADPH oxidase 4 1.01
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.009
SMAD3 SMAD family member 3 1.009
MAG myelin associated glycoprotein 1.008
CD1D CD1d molecule 1.007
IL6R interleukin 6 receptor 1.007
ITM2A integral membrane protein 2A 1.007
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.006
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 1.006
SLC26A7 solute carrier family 26 (anion exchanger), member 7 1.006
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.004
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.002
FASN fatty acid synthase 1.002
PC pyruvate carboxylase 1.001
ORM1 orosomucoid 1 1.001
CFH complement factor H 1.001
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.0