Hyperthyroidism Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A thyroid gland disease that involves an over production of thyroid hormone. (Human Disease Ontology, DOID_7998)
External Link https://www.disgenet.org/browser/0/1/0/C0020550
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Genes

265 genes associated with the disease Hyperthyroidism in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACP3 acid phosphatase 3
ACTB actin, beta
ADA adenosine deaminase
ADCY1 adenylate cyclase 1 (brain)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ANGPT1 angiopoietin 1
ANXA1 annexin A1
ANXA2 annexin A2
ANXA5 annexin A5
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOD apolipoprotein D
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG5 autophagy related 5
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAAT bile acid CoA:amino acid N-acyltransferase
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BRCA1 breast cancer 1, early onset
BTNL2 butyrophilin-like 2
C6 complement component 6
CA1 carbonic anhydrase I
CAB39 calcium binding protein 39
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CALCA calcitonin-related polypeptide alpha
CARTPT CART prepropeptide
CAT catalase
CBS cystathionine-beta-synthase
CD274 CD274 molecule
CD34 CD34 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CETP cholesteryl ester transfer protein, plasma
CGA glycoprotein hormones, alpha polypeptide
CGB chorionic gonadotropin, beta polypeptide
CGB5 chorionic gonadotropin, beta polypeptide 5
CGB8 chorionic gonadotropin, beta polypeptide 8
CLOCK clock circadian regulator
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
COMT catechol-O-methyltransferase
COQ9 coenzyme Q9
COX1
COX2
COX3
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CP ceruloplasmin (ferroxidase)
CPB2 carboxypeptidase B2 (plasma)
CPQ carboxypeptidase Q
CS citrate synthase
CST3 cystatin C
CTH cystathionine gamma-lyase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DIO1 deiodinase, iodothyronine, type I
DIO2 deiodinase, iodothyronine, type II
DIO3 deiodinase, iodothyronine, type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DMP1 dentin matrix acidic phosphoprotein 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELANE elastase, neutrophil expressed
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM227B family with sequence similarity 227, member B
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FLNB filamin B, beta
FN1 fibronectin 1
FOXP3 forkhead box P3
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GCG glucagon
GDF1 growth differentiation factor 1
GDF15 growth differentiation factor 15
GH1 growth hormone 1
GIP gastric inhibitory polypeptide
GJA1 gap junction protein, alpha 1, 43kDa
GLP1R glucagon-like peptide 1 receptor
GNAS GNAS complex locus
GORASP1 golgi reassembly stacking protein 1, 65kDa
GP1BB glycoprotein Ib (platelet), beta polypeptide
GPR174 G protein-coupled receptor 174
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GSK3B glycogen synthase kinase 3 beta
GSR glutathione reductase
GUSB glucuronidase, beta
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIRA histone cell cycle regulator
HLA-A major histocompatibility complex, class I, A
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HOXD13 homeobox D13
HSPA4 heat shock 70kDa protein 4
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
KCNJ18 potassium channel, inwardly rectifying subfamily J, member 18
KNG1 kininogen 1
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LEP leptin
LHB luteinizing hormone beta polypeptide
LIPE lipase, hormone-sensitive
LMOD1 leiomodin 1 (smooth muscle)
LOC102724560 cystathionine beta-synthase
LPA lipoprotein, Lp(a)
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAT2B methionine adenosyltransferase II, beta
MBL2 mannose-binding lectin (protein C) 2, soluble
MCM7 minichromosome maintenance complex component 7
MEN1 multiple endocrine neoplasia I
MINOS1 mitochondrial inner membrane organizing system 1
MOK MOK protein kinase
MPST mercaptopyruvate sulfurtransferase
MSTO1 misato 1, mitochondrial distribution and morphology regulator
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MT-ND6 NADH dehydrogenase, subunit 6 (complex I)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYD88 myeloid differentiation primary response 88
NAMPT nicotinamide phosphoribosyltransferase
ND1
NFE2L2 nuclear factor, erythroid 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY neuropeptide Y
NR1D1 nuclear receptor subfamily 1, group D, member 1
NRG4 neuregulin 4
NT5E 5'-nucleotidase, ecto (CD73)
PAX8 paired box 8
PC pyruvate carboxylase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDCD1 programmed cell death 1
PDE10A phosphodiesterase 10A
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE8B phosphodiesterase 8B
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PITX2 paired-like homeodomain 2
POLG polymerase (DNA directed), gamma
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
PON1 paraoxonase 1
POTEF POTE ankyrin domain family, member F
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRDM11 PR domain containing 11
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRL prolactin
PTEN phosphatase and tensin homolog
PTH parathyroid hormone
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RNASET2 ribonuclease T2
RNF213 ring finger protein 213
RNH1 ribonuclease/angiogenin inhibitor 1
RPS19 ribosomal protein S19
RREB1 ras responsive element binding protein 1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SEC24C SEC24 family member C
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETD2 SET domain containing 2
SHBG sex hormone-binding globulin
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOST sclerostin
SST somatostatin
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK11 serine/threonine kinase 11
STS steroid sulfatase (microsomal), isozyme S
SYT1 synaptotagmin I
TBX1 T-box 1
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TM7SF2 transmembrane 7 superfamily member 2
TMEM71 transmembrane protein 71
TNF tumor necrosis factor
TPO thyroid peroxidase
TRH thyrotropin-releasing hormone
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSHB thyroid stimulating hormone, beta
TSHR thyroid stimulating hormone receptor
TTN titin
TWNK twinkle mtDNA helicase
TXNRD2 thioredoxin reductase 2
TXNRD3 thioredoxin reductase 3
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UFD1 ubiquitin recognition factor in ER associated degradation 1
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
VKORC1 vitamin K epoxide reductase complex, subunit 1
VWF von Willebrand factor
WNK1 WNK lysine deficient protein kinase 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZGLP1 zinc finger, GATA-like protein 1