Hyperuricemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood. (Human Disease Ontology, DOID_1920)
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Genes

656 genes co-occuring with the disease Hyperuricemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 3.852
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 3.838
XDH xanthine dehydrogenase 3.787
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 3.157
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.152
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 3.108
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.074
REN renin 3.055
INS insulin 2.981
UMOD uromodulin 2.957
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.945
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.944
ALB albumin 2.887
CRP C-reactive protein, pentraxin-related 2.883
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.784
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.774
IL1B interleukin 1, beta 2.757
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.676
IL6 interleukin 6 2.661
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.645
KHK ketohexokinase (fructokinase) 2.641
ACE angiotensin I converting enzyme 2.639
PDZK1 PDZ domain containing 1 2.636
SLC16A9 solute carrier family 16, member 9 2.624
NLRP3 NLR family, pyrin domain containing 3 2.595
TNF tumor necrosis factor 2.513
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.507
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.46
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.451
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.408
IL18 interleukin 18 2.367
AMPD2 adenosine monophosphate deaminase 2 2.366
ADIPOQ adiponectin, C1Q and collagen domain containing 2.363
AMPD3 adenosine monophosphate deaminase 3 2.333
CST3 cystatin C 2.319
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.311
LEP leptin 2.31
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.287
APOB apolipoprotein B 2.277
PNP purine nucleoside phosphorylase 2.274
CCL2 chemokine (C-C motif) ligand 2 2.263
AMPD1 adenosine monophosphate deaminase 1 2.254
PTH parathyroid hormone 2.221
TLR4 toll-like receptor 4 2.219
PRPS1 phosphoribosyl pyrophosphate synthetase 1 2.208
HNF1B HNF1 homeobox B 2.192
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.181
SLC17A4 solute carrier family 17, member 4 2.167
HLA-B major histocompatibility complex, class I, B 2.154
TGFB1 transforming growth factor, beta 1 2.131
GDA guanine deaminase 2.13
G6PC3 glucose 6 phosphatase, catalytic, 3 2.124
NPPB natriuretic peptide B 2.122
GCG glucagon 2.11
ADA adenosine deaminase 2.104
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.1
CARMIL1 capping protein regulator and myosin 1 linker 1 2.091
NOS3 nitric oxide synthase 3 (endothelial cell) 2.084
PPARG peroxisome proliferator-activated receptor gamma 2.084
EDN1 endothelin 1 2.084
HAVCR1 hepatitis A virus cellular receptor 1 2.06
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.043
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 2.036
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.019
CXCL8 chemokine (C-X-C motif) ligand 8 2.014
APOA1 apolipoprotein A-I 2.009
SARS2 seryl-tRNA synthetase 2, mitochondrial 1.996
G6PC2 glucose-6-phosphatase, catalytic, 2 1.995
IL1A interleukin 1, alpha 1.987
A1CF APOBEC1 complementation factor 1.984
PPARA peroxisome proliferator-activated receptor alpha 1.969
CKM creatine kinase, muscle 1.964
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.962
CKMT1B creatine kinase, mitochondrial 1B 1.961
CKB creatine kinase, brain 1.96
IL10 interleukin 10 1.943
EPO erythropoietin 1.941
DPP4 dipeptidyl-peptidase 4 1.934
APOM apolipoprotein M 1.926
LCN2 lipocalin 2 1.925
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 1.913
NOX4 NADPH oxidase 4 1.913
ICAM1 intercellular adhesion molecule 1 1.904
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 1.901
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.895
APOE apolipoprotein E 1.895
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 1.893
SIRT1 sirtuin 1 1.886
B2M beta-2-microglobulin 1.883
APRT adenine phosphoribosyltransferase 1.879
MYD88 myeloid differentiation primary response 88 1.878
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 1.87
MLXIPL MLX interacting protein-like 1.863
GPX3 glutathione peroxidase 3 1.861
GLP1R glucagon-like peptide 1 receptor 1.853
MB myoglobin 1.853
GPX5 glutathione peroxidase 5 1.852
GPX8 glutathione peroxidase 8 (putative) 1.852
GPX6 glutathione peroxidase 6 1.851
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.85
GPX7 glutathione peroxidase 7 1.849
GPX2 glutathione peroxidase 2 1.846
PXDNL peroxidasin-like 1.845
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.843
PXDN peroxidasin 1.843
FGF23 fibroblast growth factor 23 1.839
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.839
HMOX1 heme oxygenase 1 1.838
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.835
SREBF1 sterol regulatory element binding transcription factor 1 1.831
IL17A interleukin 17A 1.828
BCAS3 breast carcinoma amplified sequence 3 1.822
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 1.821
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.819
SARS1 seryl-tRNA synthetase 1 1.819
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.813
HNF4G hepatocyte nuclear factor 4, gamma 1.813
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.811
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.81
IRS1 insulin receptor substrate 1 1.808
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.808
SI sucrase-isomaltase (alpha-glucosidase) 1.802
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.799
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.795
IFNG interferon, gamma 1.794
GSDMD gasdermin D 1.793
F2 coagulation factor II (thrombin) 1.792
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.79
PRPS2 phosphoribosyl pyrophosphate synthetase 2 1.79
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.785
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.777
AOX1 aldehyde oxidase 1 1.776
VCAM1 vascular cell adhesion molecule 1 1.773
INHBC inhibin, beta C 1.772
MGAM maltase-glucoamylase 1.772
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.771
GCKR glucokinase (hexokinase 4) regulator 1.764
CLDN16 claudin 16 1.763
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.759
TXNIP thioredoxin interacting protein 1.756
TLR2 toll-like receptor 2 1.754
AVP arginine vasopressin 1.751
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.751
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.743
F3 coagulation factor III (thromboplastin, tissue factor) 1.74
FGF21 fibroblast growth factor 21 1.738
GCK glucokinase (hexokinase 4) 1.732
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 1.729
CD4 CD4 molecule 1.728
APOC3 apolipoprotein C-III 1.728
INSR insulin receptor 1.726
CLDN19 claudin 19 1.726
LPL lipoprotein lipase 1.723
MPO myeloperoxidase 1.721
TRIM46 tripartite motif containing 46 1.721
CSF3 colony stimulating factor 3 (granulocyte) 1.714
IGF1 insulin-like growth factor 1 (somatomedin C) 1.708
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.7
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 1.698
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.693
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.689
ACTB actin, beta 1.685
PNPLA3 patatin-like phospholipase domain containing 3 1.682
TMEM171 transmembrane protein 171 1.67
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.67
RETN resistin 1.657
SHLD2 shieldin complex subunit 2 1.654
DNAH8 dynein, axonemal, heavy chain 8 1.654
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1.653
JUN jun proto-oncogene 1.652
MSMB microseminoprotein, beta- 1.652
NFE2L2 nuclear factor, erythroid 2-like 2 1.651
RETNLB resistin like beta 1.648
OGA O-GlcNAcase 1.648
FABP1 fatty acid binding protein 1, liver 1.644
PCSK9 proprotein convertase subtilisin/kexin type 9 1.644
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 1.641
MUC1 mucin 1, cell surface associated 1.639
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.637
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.633
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.631
FXYD2 FXYD domain containing ion transport regulator 2 1.631
RFX3 regulatory factor X, 3 (influences HLA class II expression) 1.627
MME membrane metallo-endopeptidase 1.617
G6PD glucose-6-phosphate dehydrogenase 1.615
JAK2 Janus kinase 2 1.614
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 1.613
FN1 fibronectin 1 1.611
GHRL ghrelin/obestatin prepropeptide 1.609
DUOX2 dual oxidase 2 1.606
ALDOB aldolase B, fructose-bisphosphate 1.606
DUOX1 dual oxidase 1 1.605
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.605
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 1.601
KL klotho 1.598
BCL2 B-cell CLL/lymphoma 2 1.587
ALPK1 alpha-kinase 1 1.586
IL2 interleukin 2 1.585
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.585
SLCO1B1 solute carrier organic anion transporter family, member 1B1 1.582
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.577
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.575
AGTR1 angiotensin II receptor, type 1 1.572
LRP2 low density lipoprotein receptor-related protein 2 1.57
POMC proopiomelanocortin 1.568
ACAD10 acyl-CoA dehydrogenase family, member 10 1.562
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.56
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.558
CD8A CD8a molecule 1.558
NLRP1 NLR family, pyrin domain containing 1 1.549
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.549
CUX2 cut-like homeobox 2 1.545
HNF1A HNF1 homeobox A 1.543
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.543
ACLY ATP citrate lyase 1.541
PPAT phosphoribosyl pyrophosphate amidotransferase 1.535
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 1.529
ADSL adenylosuccinate lyase 1.525
SELE selectin E 1.525
MAPK3 mitogen-activated protein kinase 3 1.521
CYBB cytochrome b-245, beta polypeptide 1.515
CYCS cytochrome c, somatic 1.51
SMAD3 SMAD family member 3 1.489
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.485
MMP9 matrix metallopeptidase 9 1.484
OR52E4 olfactory receptor, family 52, subfamily E, member 4 1.483
MTTP microsomal triglyceride transfer protein 1.477
RBP4 retinol binding protein 4, plasma 1.477
SLC22A10 solute carrier family 22, member 10 1.474
LDLR low density lipoprotein receptor 1.474
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 1.473
OR4F6 olfactory receptor, family 4, subfamily F, member 6 1.473
MMEL1 membrane metallo-endopeptidase-like 1 1.465
OCLN occludin 1.464
PANX1 pannexin 1 1.462
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.462
AIM2 absent in melanoma 2 1.46
C3 complement component 3 1.459
ACE2 angiotensin I converting enzyme 2 1.457
NLRC4 NLR family, CARD domain containing 4 1.452
CD68 CD68 molecule 1.452
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.447
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.444
TNNI3 troponin I type 3 (cardiac) 1.44
IL4 interleukin 4 1.435
INHBB inhibin, beta B 1.435
PNLIP pancreatic lipase 1.429
TP53 tumor protein p53 1.427
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 1.419
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 1.419
ZNF724 zinc finger protein 724 1.416
NEK7 NIMA-related kinase 7 1.416
BAX BCL2-associated X protein 1.415
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.415
CNIH2 cornichon family AMPA receptor auxiliary protein 2 1.415
NPHP1 nephronophthisis 1 (juvenile) 1.413
MOCOS molybdenum cofactor sulfurase 1.413
SCARB1 scavenger receptor class B, member 1 1.408
PRTN3 proteinase 3 1.408
SHBG sex hormone-binding globulin 1.405
PYGL phosphorylase, glycogen, liver 1.405
CD36 CD36 molecule (thrombospondin receptor) 1.404
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 1.402
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.401
KEAP1 kelch-like ECH-associated protein 1 1.397
TJP1 tight junction protein 1 1.393
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 1.393
SORD sorbitol dehydrogenase 1.391
SLC26A6 solute carrier family 26 (anion exchanger), member 6 1.388
SPP1 secreted phosphoprotein 1 1.387
CETP cholesteryl ester transfer protein, plasma 1.386
CCDC63 coiled-coil domain containing 63 1.385
NPPA natriuretic peptide A 1.383
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.382
IL1R1 interleukin 1 receptor, type I 1.38
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 1.379
PYCARD PYD and CARD domain containing 1.377
AHSG alpha-2-HS-glycoprotein 1.374
AFP alpha-fetoprotein 1.373
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 1.368
LOX lysyl oxidase 1.368
LPA lipoprotein, Lp(a) 1.367
GGTLC3 gamma-glutamyltransferase light chain 3 1.366
TKFC triokinase/FMN cyclase 1.364
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 1.36
AMY2A amylase, alpha 2A (pancreatic) 1.36
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.359
AGER advanced glycosylation end product-specific receptor 1.359
FFAR2 free fatty acid receptor 2 1.359
SCARB2 scavenger receptor class B, member 2 1.356
NIPAL1 NIPA-like domain containing 1 1.353
FOXO3 forkhead box O3 1.352
ADRB3 adrenoceptor beta 3 1.35
BAZ1B bromodomain adjacent to zinc finger domain, 1B 1.349
MAPK8 mitogen-activated protein kinase 8 1.341
CD19 CD19 molecule 1.34
CCN2 cellular communication network factor 2 1.34
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 1.339
LEPR leptin receptor 1.339
AMY2B amylase, alpha 2B (pancreatic) 1.338
KNG1 kininogen 1 1.333
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.331
TXN thioredoxin 1.331
PYY peptide YY 1.33
PLG plasminogen 1.329
SIRT3 sirtuin 3 1.327
HP haptoglobin 1.326
PYGM phosphorylase, glycogen, muscle 1.324
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 1.323
AMY1B amylase, alpha 1B (salivary) 1.322
NOX1 NADPH oxidase 1 1.32
NRBP1 nuclear receptor binding protein 1 1.316
BGLAP bone gamma-carboxyglutamate (gla) protein 1.314
GGT1 gamma-glutamyltransferase 1 1.313
TTR transthyretin 1.313
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 1.311
R3HDM2 R3H domain containing 2 1.311
GSR glutathione reductase 1.311
HAMP hepcidin antimicrobial peptide 1.309
NAMPT nicotinamide phosphoribosyltransferase 1.308
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.306
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.304
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.301
SOCS3 suppressor of cytokine signaling 3 1.3
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.3
ESR1 estrogen receptor 1 1.299
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.298
AQP2 aquaporin 2 (collecting duct) 1.297
PPARD peroxisome proliferator-activated receptor delta 1.296
EGF epidermal growth factor 1.296
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.295
HMGB1 high mobility group box 1 1.295
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.294
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 1.294
APOA5 apolipoprotein A-V 1.294
SREBF2 sterol regulatory element binding transcription factor 2 1.293
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.293
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 1.292
CASR calcium-sensing receptor 1.291
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 1.29
FOXO1 forkhead box O1 1.289
LIPC lipase, hepatic 1.285
TM6SF2 transmembrane 6 superfamily member 2 1.285
NCF1 neutrophil cytosolic factor 1 1.284
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 1.284
SLCO4C1 solute carrier organic anion transporter family, member 4C1 1.283
CAPN1 calpain 1, (mu/I) large subunit 1.273
CARD8 caspase recruitment domain family, member 8 1.271
WDR1 WD repeat domain 1 1.267
MMP2 matrix metallopeptidase 2 1.266
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.265
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.265
CCK cholecystokinin 1.263
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 1.262
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.261
EGFR epidermal growth factor receptor 1.259
CD34 CD34 molecule 1.259
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 1.258
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 1.258
NPY neuropeptide Y 1.258
PGGT1B protein geranylgeranyltransferase type I, beta subunit 1.257
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.257
PHKA2 phosphorylase kinase, alpha 2 (liver) 1.257
TRPV5 transient receptor potential cation channel, subfamily V, member 5 1.255
RARS2 arginyl-tRNA synthetase 2, mitochondrial 1.254
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.253
CTSB cathepsin B 1.253
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.251
SLC26A3 solute carrier family 26 (anion exchanger), member 3 1.251
VWF von Willebrand factor 1.25
ZNF518B zinc finger protein 518B 1.249
IFNA1 interferon, alpha 1 1.249
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 1.248
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.247
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.247
ACO2 aconitase 2, mitochondrial 1.242
FNDC5 fibronectin type III domain containing 5 1.24
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.233
CD38 CD38 molecule 1.231
PGF placental growth factor 1.23
CD5 CD5 molecule 1.228
SDC1 syndecan 1 1.228
PFKM phosphofructokinase, muscle 1.227
GIP gastric inhibitory polypeptide 1.226
UMPS uridine monophosphate synthetase 1.225
PKM pyruvate kinase, muscle 1.225
AVPR2 arginine vasopressin receptor 2 1.223
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.222
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 1.221
LARS2 leucyl-tRNA synthetase 2, mitochondrial 1.22
SFMBT1 Scm-like with four mbt domains 1 1.22
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.219
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.218
CPT1A carnitine palmitoyltransferase 1A (liver) 1.218
CREB1 cAMP responsive element binding protein 1 1.217
PTPRC protein tyrosine phosphatase, receptor type, C 1.216
CCL5 chemokine (C-C motif) ligand 5 1.216
GSK3B glycogen synthase kinase 3 beta 1.215
FGF5 fibroblast growth factor 5 1.214
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.214
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 1.211
IL1RN interleukin 1 receptor antagonist 1.211
LGALS3 lectin, galactoside-binding, soluble, 3 1.211
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.21
NOS1 nitric oxide synthase 1 (neuronal) 1.209
GRHPR glyoxylate reductase/hydroxypyruvate reductase 1.209
NPHP3 nephronophthisis 3 (adolescent) 1.209
IL37 interleukin 37 1.207
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.206
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 1.206
APOL1 apolipoprotein L, 1 1.204
SUOX sulfite oxidase 1.204
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.203
AMBP alpha-1-microglobulin/bikunin precursor 1.203
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.202
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 1.202
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.202
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.201
PAX2 paired box 2 1.201
FGF4 fibroblast growth factor 4 1.197
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 1.195
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.194
NQO1 NAD(P)H dehydrogenase, quinone 1 1.193
NCAM1 neural cell adhesion molecule 1 1.193
FTO fat mass and obesity associated 1.192
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 1.192
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.191
FGF20 fibroblast growth factor 20 1.19
AGXT alanine-glyoxylate aminotransferase 1.19
SMAD2 SMAD family member 2 1.189
IRS2 insulin receptor substrate 2 1.188
FGF7 fibroblast growth factor 7 1.188
FGF22 fibroblast growth factor 22 1.187
FGF6 fibroblast growth factor 6 1.186
FGF16 fibroblast growth factor 16 1.186
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.185
PRKG2 protein kinase, cGMP-dependent, type II 1.183
GBE1 glucan (1,4-alpha-), branching enzyme 1 1.183
MC4R melanocortin 4 receptor 1.183
GDF15 growth differentiation factor 15 1.183
FGF17 fibroblast growth factor 17 1.181
IGF1R insulin-like growth factor 1 receptor 1.18
RREB1 ras responsive element binding protein 1 1.18
FGF18 fibroblast growth factor 18 1.178
THBD thrombomodulin 1.177
BECN1 beclin 1, autophagy related 1.177
AHR aryl hydrocarbon receptor 1.176
FGF9 fibroblast growth factor 9 1.175
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 1.174
FABP4 fatty acid binding protein 4, adipocyte 1.174
FGF3 fibroblast growth factor 3 1.172
FBP1 fructose-1,6-bisphosphatase 1 1.171
NPC1L1 NPC1-like 1 1.171
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.171
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 1.17
FGF8 fibroblast growth factor 8 (androgen-induced) 1.17
GALP galanin-like peptide 1.169
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 1.169
LIPE lipase, hormone-sensitive 1.169
FGF10 fibroblast growth factor 10 1.165
CLCN5 chloride channel, voltage-sensitive 5 1.164
TFAM transcription factor A, mitochondrial 1.163
MEST mesoderm specific transcript 1.162
CLDN14 claudin 14 1.161
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.161
PYGB phosphorylase, glycogen; brain 1.16
CYBA cytochrome b-245, alpha polypeptide 1.16
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 1.159
EDNRA endothelin receptor type A 1.159
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.159
LDHD lactate dehydrogenase D 1.158
ARG1 arginase 1 1.158
ATXN2 ataxin 2 1.156
OIT3 oncoprotein induced transcript 3 1.156
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 1.156
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 1.155
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.154
ARG2 arginase 2 1.154
HNF4A hepatocyte nuclear factor 4, alpha 1.153
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.152
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.151
MMP3 matrix metallopeptidase 3 1.151
CLDN7 claudin 7 1.15
CLDN1 claudin 1 1.15
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.147
SLCO1A2 solute carrier organic anion transporter family, member 1A2 1.147
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.146
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.146
IL33 interleukin 33 1.145
IL22 interleukin 22 1.145
AARS2 alanyl-tRNA synthetase 2, mitochondrial 1.145
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.145
SOD2 superoxide dismutase 2, mitochondrial 1.143
ELN elastin 1.143
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10 1.142
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 1.142
TIMP1 TIMP metallopeptidase inhibitor 1 1.142
CLCNKB chloride channel, voltage-sensitive Kb 1.14
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.14
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 1.137
XPR1 xenotropic and polytropic retrovirus receptor 1 1.136
MLKL mixed lineage kinase domain-like 1.135
IFNA2 interferon, alpha 2 1.134
NLRP12 NLR family, pyrin domain containing 12 1.133
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 1.132
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.132
COX18 COX18 cytochrome c oxidase assembly factor 1.131
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.131
BCHE butyrylcholinesterase 1.13
SST somatostatin 1.13
HDAC9 histone deacetylase 9 1.129
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 1.128
MARS2 methionyl-tRNA synthetase 2, mitochondrial 1.127
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.126
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.123
SYK spleen tyrosine kinase 1.123
MAOA monoamine oxidase A 1.123
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.122
APOC2 apolipoprotein C-II 1.118
ACP5 acid phosphatase 5, tartrate resistant 1.118
SOD1 superoxide dismutase 1, soluble 1.118
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.118
CA3 carbonic anhydrase III 1.117
KDR kinase insert domain receptor 1.115
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.114
SLCO1B3 solute carrier organic anion transporter family, member 1B3 1.112
PLA2R1 phospholipase A2 receptor 1, 180kDa 1.111
NRXN2 neurexin 2 1.111
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.11
PON1 paraoxonase 1 1.106
CNTN5 contactin 5 1.106
ULK1 unc-51 like autophagy activating kinase 1 1.103
CNIH4 cornichon family AMPA receptor auxiliary protein 4 1.103
GPKOW G patch domain and KOW motifs 1.102
PKD1 polycystic kidney disease 1 (autosomal dominant) 1.102
ADIPOR1 adiponectin receptor 1 1.1
CALML4 calmodulin-like 4 1.1
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 1.099
CALML6 calmodulin-like 6 1.099
CALML3 calmodulin-like 3 1.097
GPX4 glutathione peroxidase 4 1.097
CALML5 calmodulin-like 5 1.097
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.097
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.094
HLA-A major histocompatibility complex, class I, A 1.093
APP amyloid beta (A4) precursor protein 1.092
SOD3 superoxide dismutase 3, extracellular 1.091
CLNK cytokine-dependent hematopoietic cell linker 1.09
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 1.088
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.088
BDNF brain-derived neurotrophic factor 1.088
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.087
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.085
ACHE acetylcholinesterase (Yt blood group) 1.084
HSPB3 heat shock 27kDa protein 3 1.082
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 1.081
CXCL10 chemokine (C-X-C motif) ligand 10 1.081
ACACA acetyl-CoA carboxylase alpha 1.08
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.079
CTSS cathepsin S 1.079
PLAT plasminogen activator, tissue 1.078
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 1.076
ANGPTL3 angiopoietin-like 3 1.075
XBP1 X-box binding protein 1 1.075
ALPL alkaline phosphatase, liver/bone/kidney 1.075
IFNB1 interferon, beta 1, fibroblast 1.075
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.075
GSDMA gasdermin A 1.074
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 1.074
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.074
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.073
MAOB monoamine oxidase B 1.072
SMLR1 small leucine-rich protein 1 1.071
MYOM2 myomesin 2 1.069
SLC22A25 solute carrier family 22, member 25 1.069
MRPS7 mitochondrial ribosomal protein S7 1.066
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 1.064
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 1.064
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 1.064
FOS FBJ murine osteosarcoma viral oncogene homolog 1.062
SLCO2B1 solute carrier organic anion transporter family, member 2B1 1.062
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 1.06
HCAR2 hydroxycarboxylic acid receptor 2 1.057
PKD2 polycystic kidney disease 2 (autosomal dominant) 1.057
MFN2 mitofusin 2 1.057
TG thyroglobulin 1.055
SLC22A15 solute carrier family 22, member 15 1.053
DDAH2 dimethylarginine dimethylaminohydrolase 2 1.052
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.051
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.051
KLK3 kallikrein-related peptidase 3 1.051
YARS1 tyrosyl-tRNA synthetase 1 1.05
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 1.05
PHKG2 phosphorylase kinase, gamma 2 (testis) 1.049
CCR2 chemokine (C-C motif) receptor 2 1.047
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 1.047
TBL1X transducin (beta)-like 1X-linked 1.046
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 1.042
GPBAR1 G protein-coupled bile acid receptor 1 1.042
RIPK3 receptor-interacting serine-threonine kinase 3 1.041
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 1.038
PNPLA2 patatin-like phospholipase domain containing 2 1.037
NT5C2 5'-nucleotidase, cytosolic II 1.037
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.036
IFNA17 interferon, alpha 17 1.036
NLRP6 NLR family, pyrin domain containing 6 1.036
UBAP1 ubiquitin associated protein 1 1.034
MYH14 myosin, heavy chain 14, non-muscle 1.033
SGK1 serum/glucocorticoid regulated kinase 1 1.031
IFNL3 interferon, lambda 3 1.031
TTF2 transcription termination factor, RNA polymerase II 1.031
CA5B carbonic anhydrase VB, mitochondrial 1.03
SMAD9 SMAD family member 9 1.03
GANAB glucosidase, alpha; neutral AB 1.029
FMC1-LUC7L2 FMC1-LUC7L2 readthrough 1.029
STC1 stanniocalcin 1 1.028
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.028
MMP13 matrix metallopeptidase 13 1.026
MBOAT7 membrane bound O-acyltransferase domain containing 7 1.025
PTHLH parathyroid hormone-like hormone 1.025
PHKA1 phosphorylase kinase, alpha 1 (muscle) 1.023
IFNA13 interferon, alpha 13 1.022
LUC7L2 LUC7-like 2 (S. cerevisiae) 1.021
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.02
EDNRB endothelin receptor type B 1.02
TPMT thiopurine S-methyltransferase 1.019
ZNF860 zinc finger protein 860 1.019
ANKRD17 ankyrin repeat domain 17 1.018
TNNT2 troponin T type 2 (cardiac) 1.018
TAC1 tachykinin, precursor 1 1.017
IFNA16 interferon, alpha 16 1.016
IFNA10 interferon, alpha 10 1.015
IFNA21 interferon, alpha 21 1.015
IAPP islet amyloid polypeptide 1.015
IFNA7 interferon, alpha 7 1.015
IFNA8 interferon, alpha 8 1.015
IFNA14 interferon, alpha 14 1.015
TYR tyrosinase 1.014
ZNF324 zinc finger protein 324 1.014
IFNA6 interferon, alpha 6 1.014
IFNA5 interferon, alpha 5 1.013
MMP1 matrix metallopeptidase 1 1.011
PINK1 PTEN induced putative kinase 1 1.011
IFNA4 interferon, alpha 4 1.01
ERN1 endoplasmic reticulum to nucleus signaling 1 1.009
SELENOP selenoprotein P 1.008
PARD3B par-3 family cell polarity regulator beta 1.007
MEPE matrix extracellular phosphoglycoprotein 1.007
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.005
APOA2 apolipoprotein A-II 1.005
CD40 CD40 molecule, TNF receptor superfamily member 5 1.004
ERBB2 erb-b2 receptor tyrosine kinase 2 1.004
FFAR3 free fatty acid receptor 3 1.003
NOS2 nitric oxide synthase 2, inducible 1.003
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.003
HSPA4 heat shock 70kDa protein 4 1.001