Hyperuricemia Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood. (Human Disease Ontology, DOID_1920)
External Link https://www.disgenet.org/browser/0/1/0/C0740394
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Genes

205 genes associated with the disease Hyperuricemia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAT1 acetyl-CoA acetyltransferase 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADRB3 adrenoceptor beta 3
AFP alpha-fetoprotein
ALB albumin
ALDH16A1 aldehyde dehydrogenase 16 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOB aldolase B, fructose-bisphosphate
ALMS1 Alstrom syndrome protein 1
APLN apelin
APOA1 apolipoprotein A-I
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AR androgen receptor
ATN1 atrophin 1
B2M beta-2-microglobulin
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCAS1 breast carcinoma amplified sequence 1
BPIFA2 BPI fold containing family A, member 2
CAPN1 calpain 1, (mu/I) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CCHCR1 coiled-coil alpha-helical rod protein 1
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
CLDN16 claudin 16
CLTC clathrin, heavy chain (Hc)
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CRP C-reactive protein, pentraxin-related
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CSH2 chorionic somatomammotropin hormone 2
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DBP D site of albumin promoter (albumin D-box) binding protein
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DPEP1 dipeptidase 1 (renal)
EDN1 endothelin 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERCC8 excision repair cross-complementation group 8
ETFA electron-transfer-flavoprotein, alpha polypeptide
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP2 fatty acid binding protein 2, intestinal
FAM35A family with sequence similarity 35, member A
FBL fibrillarin
FBP1 fructose-1,6-bisphosphatase 1
FN1 fibronectin 1
FOXO3 forkhead box O3
FUZ fuzzy planar cell polarity protein
G6PC glucose-6-phosphatase, catalytic subunit
GCKR glucokinase (hexokinase 4) regulator
GH1 growth hormone 1
GJA4 gap junction protein, alpha 4, 37kDa
GLI2 GLI family zinc finger 2
GNAS GNAS complex locus
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GORASP1 golgi reassembly stacking protein 1, 65kDa
GPATCH8 G patch domain containing 8
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
HAS2 hyaluronan synthase 2
HAVCR1 hepatitis A virus cellular receptor 1
HBG1 hemoglobin, gamma A
HBG2 hemoglobin, gamma G
HFE hemochromatosis
HLA-B major histocompatibility complex, class I, B
HMBS hydroxymethylbilane synthase
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HNF4G hepatocyte nuclear factor 4, gamma
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFNL3 interferon, lambda 3
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL6 interleukin 6
JAK2 Janus kinase 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KHK ketohexokinase (fructokinase)
KLF2 Kruppel-like factor 2
KLRC4-KLRK1 KLRC4-KLRK1 readthrough
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LCN2 lipocalin 2
LOC105371045 uncharacterized LOC105371045
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP2 low density lipoprotein receptor-related protein 2
MAOA monoamine oxidase A
MAPK3 mitogen-activated protein kinase 3
MEFV Mediterranean fever
MMP3 matrix metallopeptidase 3
MPRIP myosin phosphatase Rho interacting protein
MSMB microseminoprotein, beta-
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NLRP3 NLR family, pyrin domain containing 3
NR3C2 nuclear receptor subfamily 3, group C, member 2
OIT3 oncoprotein induced transcript 3
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PC pyruvate carboxylase
PFKM phosphofructokinase, muscle
PHKA2 phosphorylase kinase, alpha 2 (liver)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PNP purine nucleoside phosphorylase
PON1 paraoxonase 1
POU2F2 POU class 2 homeobox 2
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRKG2 protein kinase, cGMP-dependent, type II
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PSPH phosphoserine phosphatase
PSPN persephin
PYCARD PYD and CARD domain containing
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1A regenerating islet-derived 1 alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RIDA reactive intermediate imine deaminase A homolog
RIPK3 receptor-interacting serine-threonine kinase 3
RRBP1 ribosome binding protein 1
RREB1 ras responsive element binding protein 1
SAA1 serum amyloid A1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SELENBP1 selenium binding protein 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFMBT1 Scm-like with four mbt domains 1
SH2B1 SH2B adaptor protein 1
SHBG sex hormone-binding globulin
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIRT1 sirtuin 1
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC17A4 solute carrier family 17, member 4
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SMAD3 SMAD family member 3
SMN1 survival of motor neuron 1, telomeric
SMN2 survival of motor neuron 2, centromeric
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STS steroid sulfatase (microsomal), isozyme S
STXBP3 syntaxin binding protein 3
SYT1 synaptotagmin I
TCTA T-cell leukemia translocation altered
THBD thrombomodulin
TMEM171 transmembrane protein 171
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UMOD uromodulin
VEGFA vascular endothelial growth factor A
WDR72 WD repeat domain 72
WNK1 WNK lysine deficient protein kinase 1
WNT3A wingless-type MMTV integration site family, member 3A
XDH xanthine dehydrogenase
ZNF365 zinc finger protein 365
ZPBP2 zona pellucida binding protein 2