Hyponatremia Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An abnormally decreased sodium concentration in the blood. (Human Phenotype Ontology, HP_0002902)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D007010
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Genes

330 genes/proteins associated with the disease Hyponatremia from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.88009
OXT oxytocin/neurophysin I prepropeptide 2.88009
IFNG interferon, gamma 2.88009
AVP arginine vasopressin 2.88009
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.38948
FOS FBJ murine osteosarcoma viral oncogene homolog 2.37068
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.33001
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.3122
CAT catalase 2.28655
TNF tumor necrosis factor 2.26455
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.17168
BCL2 B-cell CLL/lymphoma 2 2.14934
VEGFA vascular endothelial growth factor A 2.12472
IL6 interleukin 6 2.06015
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 2.05583
REN renin 2.04905
GSTP1 glutathione S-transferase pi 1 2.02142
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.02101
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.99365
BDNF brain-derived neurotrophic factor 1.99179
MAPK3 mitogen-activated protein kinase 3 1.9877
MAPK1 mitogen-activated protein kinase 1 1.93152
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.92721
BCL2L1 BCL2-like 1 1.92297
POMC proopiomelanocortin 1.92009
CCL2 chemokine (C-C motif) ligand 2 1.91684
FAS Fas cell surface death receptor 1.89682
BAX BCL2-associated X protein 1.89185
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.88704
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.88409
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.88008
NPPA natriuretic peptide A 1.87344
IL1B interleukin 1, beta 1.86515
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.85729
TP53 tumor protein p53 1.8545
EGR1 early growth response 1 1.83449
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.82411
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.81036
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.80737
CXCL8 chemokine (C-X-C motif) ligand 8 1.79808
SOD1 superoxide dismutase 1, soluble 1.7977
VCAM1 vascular cell adhesion molecule 1 1.79522
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.7755
MAPK8 mitogen-activated protein kinase 8 1.76849
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.75301
PRL prolactin 1.74701
NUPR1 nuclear protein, transcriptional regulator, 1 1.74079
TGFB1 transforming growth factor, beta 1 1.72717
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.71647
INHBE inhibin, beta E 1.71461
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.71399
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.69701
GSK3B glycogen synthase kinase 3 beta 1.69232
SOD2 superoxide dismutase 2, mitochondrial 1.67955
EDN1 endothelin 1 1.67526
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.66663
GADD45A growth arrest and DNA-damage-inducible, alpha 1.66598
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.66274
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.66081
NOS2 nitric oxide synthase 2, inducible 1.65643
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.6491
F3 coagulation factor III (thromboplastin, tissue factor) 1.64752
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.62176
JUN jun proto-oncogene 1.6206
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.61851
C10ORF10 chromosome 10 open reading frame 10 1.61295
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.61154
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.60897
HMOX1 heme oxygenase 1 1.60617
PARP1 poly (ADP-ribose) polymerase 1 1.60291
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.60151
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.59708
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.58444
DDIT3 DNA-damage-inducible transcript 3 1.57924
HSPA8 heat shock 70kDa protein 8 1.56263
ICAM1 intercellular adhesion molecule 1 1.5619
EGFR epidermal growth factor receptor 1.56166
MAPK14 mitogen-activated protein kinase 14 1.56117
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.55946
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.55378
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.55231
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.5501
GJA1 gap junction protein, alpha 1, 43kDa 1.54572
TAGLN transgelin 1.54378
FGF2 fibroblast growth factor 2 (basic) 1.54135
GPX1 glutathione peroxidase 1 1.54014
CCND1 cyclin D1 1.54014
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.5254
FNDC4 fibronectin type III domain containing 4 1.52036
PPARG peroxisome proliferator-activated receptor gamma 1.5133
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.507
MPO myeloperoxidase 1.50549
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.50043
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.48608
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.48376
CRH corticotropin releasing hormone 1.47915
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.46674
BAD BCL2-associated agonist of cell death 1.45458
SGK1 serum/glucocorticoid regulated kinase 1 1.45141
MMP9 matrix metallopeptidase 9 1.44763
ALB albumin 1.44409
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.43946
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.43809
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.43564
IL1A interleukin 1, alpha 1.43455
GNAS GNAS complex locus 1.43103
DDIT4 DNA-damage-inducible transcript 4 1.42508
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.42374
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.42101
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.41911
POR P450 (cytochrome) oxidoreductase 1.40787
IL10 interleukin 10 1.4076
ZNF45 zinc finger protein 45 1.4076
ARC activity-regulated cytoskeleton-associated protein 1.40541
PLAU plasminogen activator, urokinase 1.40401
TRIM2 tripartite motif containing 2 1.40401
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 1.39924
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.3903
THBS1 thrombospondin 1 1.38527
CCNB1 cyclin B1 1.38355
FABP1 fatty acid binding protein 1, liver 1.37475
BTG3 BTG family, member 3 1.37332
MAP2K2 mitogen-activated protein kinase kinase 2 1.37246
CCND3 cyclin D3 1.36218
CDKN2A cyclin-dependent kinase inhibitor 2A 1.36104
CCNG2 cyclin G2 1.35849
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.35849
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 1.35734
EDNRB endothelin receptor type B 1.35415
INS insulin 1.35184
PLAT plasminogen activator, tissue 1.35184
GDF15 growth differentiation factor 15 1.35184
FASLG Fas ligand (TNF superfamily, member 6) 1.3382
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.33464
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.33022
MGMT O-6-methylguanine-DNA methyltransferase 1.32726
ZBTB24 zinc finger and BTB domain containing 24 1.32547
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.32339
IGF1 insulin-like growth factor 1 (somatomedin C) 1.32162
DUSP1 dual specificity phosphatase 1 1.32074
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 1.31208
TAC1 tachykinin, precursor 1 1.30941
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.30941
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.30177
PRC1 protein regulator of cytokinesis 1 1.29905
S100A9 S100 calcium binding protein A9 1.29533
NOS3 nitric oxide synthase 3 (endothelial cell) 1.29502
NFE2L2 nuclear factor, erythroid 2-like 2 1.29103
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.2895
ZNF544 zinc finger protein 544 1.28858
NOS1 nitric oxide synthase 1 (neuronal) 1.28425
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.2772
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.27626
RB1 retinoblastoma 1 1.27502
CDK2 cyclin-dependent kinase 2 1.27255
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.26763
CDK5 cyclin-dependent kinase 5 1.26732
GSTM1 glutathione S-transferase mu 1 1.26669
PCNA proliferating cell nuclear antigen 1.25868
NBN nibrin 1.25838
GCLC glutamate-cysteine ligase, catalytic subunit 1.25557
NGF nerve growth factor (beta polypeptide) 1.25494
BLM Bloom syndrome, RecQ helicase-like 1.25369
TOR1A torsin family 1, member A (torsin A) 1.24935
DCAF8 DDB1 and CUL4 associated factor 8 1.24905
RRM2 ribonucleotide reductase M2 1.2475
EPRS glutamyl-prolyl-tRNA synthetase 1.24181
TPI1 triosephosphate isomerase 1 1.23584
NPY neuropeptide Y 1.23552
BAK1 BCL2-antagonist/killer 1 1.23169
DRD1 dopamine receptor D1 1.23169
MAOA monoamine oxidase A 1.22979
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.22758
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.22469
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.21727
XBP1 X-box binding protein 1 1.21631
E2F1 E2F transcription factor 1 1.21435
ERBB2 erb-b2 receptor tyrosine kinase 2 1.21435
ATF2 activating transcription factor 2 1.21173
BIRC5 baculoviral IAP repeat containing 5 1.20978
BTG2 BTG family, member 2 1.20881
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.20848
AQP2 aquaporin 2 (collecting duct) 1.20262
LHX2 LIM homeobox 2 1.20229
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.199
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.19868
TNNI3 troponin I type 3 (cardiac) 1.1977
PELO pelota homolog (Drosophila) 1.19639
MMP2 matrix metallopeptidase 2 1.19477
MBP myelin basic protein 1.19146
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.18685
STBD1 starch binding domain 1 1.18456
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.18424
EGF epidermal growth factor 1.17827
EGR2 early growth response 2 1.17268
KLF6 Kruppel-like factor 6 1.17034
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.17034
RGS16 regulator of G-protein signaling 16 1.17
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.16799
GCLM glutamate-cysteine ligase, modifier subunit 1.16799
DRD2 dopamine receptor D2 1.16666
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.16633
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.16533
PLXND1 plexin D1 1.15899
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.15763
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 1.15022
VWF von Willebrand factor 1.15022
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.15022
PROC protein C (inactivator of coagulation factors Va and VIIIa) 1.15022
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.14885
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.14816
CALCA calcitonin-related polypeptide alpha 1.14678
S100A8 S100 calcium binding protein A8 1.14575
EIF4B eukaryotic translation initiation factor 4B 1.14234
EPO erythropoietin 1.14166
APAF1 apoptotic peptidase activating factor 1 1.14166
NTS neurotensin 1.14098
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 1.1403
C7ORF26 chromosome 7 open reading frame 26 1.1403
CCDC51 coiled-coil domain containing 51 1.1403
PTK2 protein tyrosine kinase 2 1.13963
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.13793
CREB1 cAMP responsive element binding protein 1 1.13758
ARF1 ADP-ribosylation factor 1 1.13724
MAP2K1 mitogen-activated protein kinase kinase 1 1.13724
FANCG Fanconi anemia, complementation group G 1.13724
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.13586
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.13518
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.13245
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.12906
NPPB natriuretic peptide B 1.12906
ABHD4 abhydrolase domain containing 4 1.12771
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.12703
CDC25A cell division cycle 25A 1.12599
FOSL2 FOS-like antigen 2 1.12599
CFLAR CASP8 and FADD-like apoptosis regulator 1.12288
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 1.12014
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.11911
HPN hepsin 1.11911
CDA cytidine deaminase 1.11877
SAT1 spermidine/spermine N1-acetyltransferase 1 1.11741
INHA inhibin, alpha 1.11431
RRAS2 related RAS viral (r-ras) oncogene homolog 2 1.10977
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.10907
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.10907
PPARA peroxisome proliferator-activated receptor alpha 1.10838
SPP1 secreted phosphoprotein 1 1.10838
TIMP1 TIMP metallopeptidase inhibitor 1 1.10734
TGFB2 transforming growth factor, beta 2 1.10734
RBM17 RNA binding motif protein 17 1.10665
TRIM38 tripartite motif containing 38 1.10665
SREBF1 sterol regulatory element binding transcription factor 1 1.10459
ZNF232 zinc finger protein 232 1.1014
HPSE heparanase 1.1014
ZNF202 zinc finger protein 202 1.10033
RAB8A RAB8A, member RAS oncogene family 1.09857
ANG angiogenin, ribonuclease, RNase A family, 5 1.09716
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.09681
KIF20A kinesin family member 20A 1.09541
UNG uracil-DNA glycosylase 1.09262
PUS3 pseudouridylate synthase 3 1.09119
AKR1C2 aldo-keto reductase family 1, member C2 1.08833
TRIB3 tribbles pseudokinase 3 1.08655
TUBA4A tubulin, alpha 4a 1.08478
CDK4 cyclin-dependent kinase 4 1.08478
TH tyrosine hydroxylase 1.08337
ACKR3 atypical chemokine receptor 3 1.08055
TRAF2 TNF receptor-associated factor 2 1.08055
CREM cAMP responsive element modulator 1.07983
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.07983
EFNA5 ephrin-A5 1.07732
CAMK2D calcium/calmodulin-dependent protein kinase II delta 1.0766
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 1.0766
CDC6 cell division cycle 6 1.07447
IL7 interleukin 7 1.07305
NINJ1 ninjurin 1 1.07269
CD44 CD44 molecule (Indian blood group) 1.07199
ACTA2 actin, alpha 2, smooth muscle, aorta 1.06881
ZNF200 zinc finger protein 200 1.06808
FAM212B family with sequence similarity 212, member B 1.06808
NRP1 neuropilin 1 1.06734
BID BH3 interacting domain death agonist 1.06588
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.06552
DPYD dihydropyrimidine dehydrogenase 1.06479
MAPK9 mitogen-activated protein kinase 9 1.06333
SIVA1 SIVA1, apoptosis-inducing factor 1.06297
AKR1C1 aldo-keto reductase family 1, member C1 1.05828
GEM GTP binding protein overexpressed in skeletal muscle 1.05793
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.05793
CP ceruloplasmin (ferroxidase) 1.05461
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.05089
FLT1 fms-related tyrosine kinase 1 1.05015
MED13L mediator complex subunit 13-like 1.05015
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.04794
S1PR1 sphingosine-1-phosphate receptor 1 1.04684
THNSL2 threonine synthase-like 2 (S. cerevisiae) 1.04389
KDM4B lysine (K)-specific demethylase 4B 1.04389
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.04352
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 1.04126
FOXJ2 forkhead box J2 1.04088
SREBF2 sterol regulatory element binding transcription factor 2 1.03976
TMEM80 transmembrane protein 80 1.03939
GRIK2 glutamate receptor, ionotropic, kainate 2 1.03827
ADORA1 adenosine A1 receptor 1.03641
MCM10 minichromosome maintenance complex component 10 1.03641
MAP3K8 mitogen-activated protein kinase kinase kinase 8 1.03604
IGFBP5 insulin-like growth factor binding protein 5 1.03419
GADD45G growth arrest and DNA-damage-inducible, gamma 1.03382
BPTF bromodomain PHD finger transcription factor 1.03197
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 1.03159
EDNRA endothelin receptor type A 1.02971
BIRC3 baculoviral IAP repeat containing 3 1.02971
ZBED1 zinc finger, BED-type containing 1 1.02783
CES2 carboxylesterase 2 1.02746
LDLR low density lipoprotein receptor 1.02671
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.02299
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 1.02262
GSTM2 glutathione S-transferase mu 2 (muscle) 1.02188
SYP synaptophysin 1.01928
GSTT1 glutathione S-transferase theta 1 1.0189
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.01852
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.01625
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.01625
TMEM185B transmembrane protein 185B 1.01587
MAP7 microtubule-associated protein 7 1.01474
NREP neuronal regeneration related protein 1.01286
PRKCB protein kinase C, beta 1.01025
PENK proenkephalin 1.01025
CA2 carbonic anhydrase II 1.01025
STMN1 stathmin 1 1.01025