Hypophosphatemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

377 genes co-occuring with the disease Hypophosphatemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
FGF23 fibroblast growth factor 23 4.0
PHEX phosphate regulating endopeptidase homolog, X-linked 3.742
PTH parathyroid hormone 3.65
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 3.517
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 3.26
DMP1 dentin matrix acidic phosphoprotein 1 3.143
KL klotho 3.12
MEPE matrix extracellular phosphoglycoprotein 3.112
EMP1 epithelial membrane protein 1 3.108
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.946
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2.887
FAM20C family with sequence similarity 20, member C 2.793
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2.751
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.741
CLCN5 chloride channel, voltage-sensitive 5 2.717
CASR calcium-sensing receptor 2.673
FGFR1 fibroblast growth factor receptor 1 2.672
ALB albumin 2.522
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.477
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 2.475
BGLAP bone gamma-carboxyglutamate (gla) protein 2.457
FGF7 fibroblast growth factor 7 2.456
PTHLH parathyroid hormone-like hormone 2.447
ALPL alkaline phosphatase, liver/bone/kidney 2.443
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.401
SFRP4 secreted frizzled-related protein 4 2.375
SOST sclerostin 2.363
OCRL oculocerebrorenal syndrome of Lowe 2.351
INS insulin 2.325
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 2.324
FGF6 fibroblast growth factor 6 2.318
FGF16 fibroblast growth factor 16 2.315
FGF3 fibroblast growth factor 3 2.313
FGF5 fibroblast growth factor 5 2.313
FGF22 fibroblast growth factor 22 2.313
FGF20 fibroblast growth factor 20 2.311
FGF9 fibroblast growth factor 9 2.31
FGF17 fibroblast growth factor 17 2.308
FGF18 fibroblast growth factor 18 2.307
FGF4 fibroblast growth factor 4 2.304
FGF8 fibroblast growth factor 8 (androgen-induced) 2.303
FGF10 fibroblast growth factor 10 2.297
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.297
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.281
PTH1R parathyroid hormone 1 receptor 2.233
SPP1 secreted phosphoprotein 1 2.19
FGFR4 fibroblast growth factor receptor 4 2.184
FGFR3 fibroblast growth factor receptor 3 2.134
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.093
GC group-specific component (vitamin D binding protein) 2.082
B2M beta-2-microglobulin 2.081
GNAS GNAS complex locus 2.058
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.052
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.047
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.028
EPO erythropoietin 1.983
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.98
CKMT1B creatine kinase, mitochondrial 1B 1.979
CKB creatine kinase, brain 1.978
CKM creatine kinase, muscle 1.976
IGF1 insulin-like growth factor 1 (somatomedin C) 1.976
TRPV6 transient receptor potential cation channel, subfamily V, member 6 1.971
RET ret proto-oncogene 1.971
CRP C-reactive protein, pentraxin-related 1.969
IBSP integrin-binding sialoprotein 1.969
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.948
FGFR2 fibroblast growth factor receptor 2 1.947
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.947
FURIN furin (paired basic amino acid cleaving enzyme) 1.939
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.931
AVP arginine vasopressin 1.926
DSPP dentin sialophosphoprotein 1.921
MB myoglobin 1.919
FAM20A family with sequence similarity 20, member A 1.903
REN renin 1.902
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 1.9
CHSY3 chondroitin sulfate synthase 3 1.894
ACP5 acid phosphatase 5, tartrate resistant 1.893
KCNJ18 potassium channel, inwardly rectifying subfamily J, member 18 1.889
CTNS cystinosin, lysosomal cystine transporter 1.875
FGF1 fibroblast growth factor 1 (acidic) 1.867
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 1.864
IL6 interleukin 6 1.851
GCM2 glial cells missing homolog 2 (Drosophila) 1.845
RUNX2 runt-related transcription factor 2 1.821
S100G S100 calcium binding protein G 1.816
CLDN16 claudin 16 1.812
SST somatostatin 1.805
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.803
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.801
FGF19 fibroblast growth factor 19 1.797
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.797
KDR kinase insert domain receptor 1.791
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.79
HAMP hepcidin antimicrobial peptide 1.787
ANKH ANKH inorganic pyrophosphate transport regulator 1.787
AMBP alpha-1-microglobulin/bikunin precursor 1.786
LRP2 low density lipoprotein receptor-related protein 2 1.782
FGF13 fibroblast growth factor 13 1.766
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.765
FAM20B family with sequence similarity 20, member B 1.758
MGP matrix Gla protein 1.755
FLT3 fms-related tyrosine kinase 3 1.753
DNAH8 dynein, axonemal, heavy chain 8 1.741
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.74
FLT1 fms-related tyrosine kinase 1 1.737
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.731
MEN1 multiple endocrine neoplasia I 1.724
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.71
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.709
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.705
SP7 Sp7 transcription factor 1.7
EGFR epidermal growth factor receptor 1.69
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.673
LRP5 low density lipoprotein receptor-related protein 5 1.673
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.673
TNF tumor necrosis factor 1.673
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.67
COL1A1 collagen, type I, alpha 1 1.669
FGF2 fibroblast growth factor 2 (basic) 1.669
IL2 interleukin 2 1.666
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.666
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.659
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.65
CD274 CD274 molecule 1.647
ARSJ arylsulfatase family, member J 1.643
FRZB frizzled-related protein 1.639
CDC73 cell division cycle 73 1.632
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.622
PHOSPHO1 phosphatase, orphan 1 1.613
POMC proopiomelanocortin 1.612
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.61
F2 coagulation factor II (thrombin) 1.606
KLB klotho beta 1.605
ALK anaplastic lymphoma receptor tyrosine kinase 1.603
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.603
CLDN19 claudin 19 1.6
CD4 CD4 molecule 1.599
AHSG alpha-2-HS-glycoprotein 1.589
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.584
GCG glucagon 1.584
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.58
ACE angiotensin I converting enzyme 1.579
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.575
CST3 cystatin C 1.573
IL1B interleukin 1, beta 1.572
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.567
ERBB2 erb-b2 receptor tyrosine kinase 2 1.551
KRAS Kirsten rat sarcoma viral oncogene homolog 1.544
CTSK cathepsin K 1.539
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.539
MAPK3 mitogen-activated protein kinase 3 1.536
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 1.531
ALPI alkaline phosphatase, intestinal 1.531
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.53
COL1A2 collagen, type I, alpha 2 1.519
CSF1R colony stimulating factor 1 receptor 1.518
FLT4 fms-related tyrosine kinase 4 1.517
F3 coagulation factor III (thromboplastin, tissue factor) 1.511
LCN2 lipocalin 2 1.508
CSF3 colony stimulating factor 3 (granulocyte) 1.491
BSND barttin CLCNK-type chloride channel accessory beta subunit 1.487
HRAS Harvey rat sarcoma viral oncogene homolog 1.486
ALPG alkaline phosphatase, germ cell 1.486
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.485
FGF21 fibroblast growth factor 21 1.482
AXL AXL receptor tyrosine kinase 1.482
FRS2 fibroblast growth factor receptor substrate 2 1.478
CD8A CD8a molecule 1.478
OGA O-GlcNAcase 1.477
SSTR2 somatostatin receptor 2 1.476
FN1 fibronectin 1 1.471
SKA1 spindle and kinetochore associated complex subunit 1 1.47
TGFB1 transforming growth factor, beta 1 1.467
TP53 tumor protein p53 1.464
MET MET proto-oncogene, receptor tyrosine kinase 1.463
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.461
PTEN phosphatase and tensin homolog 1.448
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.445
EGR1 early growth response 1 1.445
LEP leptin 1.439
KIF5B kinesin family member 5B 1.439
ESR1 estrogen receptor 1 1.438
CA2 carbonic anhydrase II 1.435
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.434
TEK TEK tyrosine kinase, endothelial 1.431
IFNG interferon, gamma 1.429
PCSK2 proprotein convertase subtilisin/kexin type 2 1.423
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.42
ALPP alkaline phosphatase, placental 1.419
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 1.413
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.411
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.406
HDAC9 histone deacetylase 9 1.406
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.405
TTR transthyretin 1.385
PRL prolactin 1.378
PDCD1 programmed cell death 1 1.368
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.366
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.362
CLCNKB chloride channel, voltage-sensitive Kb 1.359
IFNA1 interferon, alpha 1 1.357
CLCN7 chloride channel, voltage-sensitive 7 1.351
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 1.346
IL1A interleukin 1, alpha 1.34
CD19 CD19 molecule 1.338
CALB1 calbindin 1, 28kDa 1.328
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.326
AQP2 aquaporin 2 (collecting duct) 1.324
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.323
BCR breakpoint cluster region 1.321
AFP alpha-fetoprotein 1.32
BMP1 bone morphogenetic protein 1 1.32
HAVCR1 hepatitis A virus cellular receptor 1 1.317
CD34 CD34 molecule 1.316
BMP2 bone morphogenetic protein 2 1.31
STATH statherin 1.31
COL10A1 collagen, type X, alpha 1 1.308
EGF epidermal growth factor 1.307
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.3
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.291
CCDC6 coiled-coil domain containing 6 1.285
NF1 neurofibromin 1 1.282
CD38 CD38 molecule 1.282
CRTAP cartilage associated protein 1.276
LRP6 low density lipoprotein receptor-related protein 6 1.272
BCL2 B-cell CLL/lymphoma 2 1.27
IGF1R insulin-like growth factor 1 receptor 1.264
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.259
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 1.254
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.254
SLC17A2 solute carrier family 17, member 2 1.254
BICC1 BicC family RNA binding protein 1 1.243
ACTB actin, beta 1.242
APOM apolipoprotein M 1.242
AMBN ameloblastin (enamel matrix protein) 1.239
TACSTD2 tumor-associated calcium signal transducer 2 1.238
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.233
NPPA natriuretic peptide A 1.23
NCAM1 neural cell adhesion molecule 1 1.23
CCND1 cyclin D1 1.227
CXCL8 chemokine (C-X-C motif) ligand 8 1.227
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.227
IL10 interleukin 10 1.222
ACE2 angiotensin I converting enzyme 2 1.221
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.22
CTSB cathepsin B 1.217
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.212
ENAM enamelin 1.21
SATB2 SATB homeobox 2 1.205
EZR ezrin 1.195
TFRC transferrin receptor 1.194
IFNA2 interferon, alpha 2 1.193
AGXT alanine-glyoxylate aminotransferase 1.189
IL15 interleukin 15 1.189
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.189
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 1.189
ARSL arylsulfatase L 1.187
XPR1 xenotropic and polytropic retrovirus receptor 1 1.186
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.184
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.184
STX16 syntaxin 16 1.179
WNK4 WNK lysine deficient protein kinase 4 1.173
IFNA13 interferon, alpha 13 1.17
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.17
FGFRL1 fibroblast growth factor receptor-like 1 1.17
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.168
IFNA16 interferon, alpha 16 1.164
SGK1 serum/glucocorticoid regulated kinase 1 1.164
IFNA10 interferon, alpha 10 1.163
IFNA7 interferon, alpha 7 1.163
IFNA14 interferon, alpha 14 1.163
IFNA21 interferon, alpha 21 1.163
IFNA6 interferon, alpha 6 1.162
IFNA8 interferon, alpha 8 1.162
IFNA5 interferon, alpha 5 1.161
CSDE1 cold shock domain containing E1, RNA-binding 1.159
GAST gastrin 1.158
IFNA4 interferon, alpha 4 1.157
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.156
IFNA17 interferon, alpha 17 1.154
IHH indian hedgehog 1.152
EEF1AKMT3 EEF1A lysine methyltransferase 3 1.152
SOX9 SRY (sex determining region Y)-box 9 1.152
MSX2 msh homeobox 2 1.151
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.151
CSF1 colony stimulating factor 1 (macrophage) 1.148
PXDNL peroxidasin-like 1.147
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.147
PXDN peroxidasin 1.146
CBLL2 Cbl proto-oncogene like 2 1.141
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.139
FKBP1A FK506 binding protein 1A, 12kDa 1.128
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 1.125
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.124
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.124
MRTFA myocardin related transcription factor A 1.124
TSC2 tuberous sclerosis 2 1.122
MAP2K1 mitogen-activated protein kinase kinase 1 1.12
CDKN2A cyclin-dependent kinase inhibitor 2A 1.119
INSR insulin receptor 1.119
SSTR1 somatostatin receptor 1 1.119
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.118
OSTM1 osteopetrosis associated transmembrane protein 1 1.118
NPPB natriuretic peptide B 1.116
CD28 CD28 molecule 1.115
TACC3 transforming, acidic coiled-coil containing protein 3 1.114
GPRC6A G protein-coupled receptor, class C, group 6, member A 1.114
MSLN mesothelin 1.103
CALCR calcitonin receptor 1.102
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.1
CREB1 cAMP responsive element binding protein 1 1.1
ASPG asparaginase 1.093
WNT1 wingless-type MMTV integration site family, member 1 1.092
GASK1A golgi associated kinase 1A 1.092
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 1.09
CHGA chromogranin A 1.089
PTH2R parathyroid hormone 2 receptor 1.088
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.087
FDPS farnesyl diphosphate synthase 1.084
MCL1 myeloid cell leukemia 1 1.082
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.081
CDK4 cyclin-dependent kinase 4 1.079
RNLS renalase, FAD-dependent amine oxidase 1.073
PDCD1LG2 programmed cell death 1 ligand 2 1.071
NECTIN4 nectin cell adhesion molecule 4 1.071
ERBB3 erb-b2 receptor tyrosine kinase 3 1.07
SMAD9 SMAD family member 9 1.069
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.068
TG thyroglobulin 1.067
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.066
CLDN14 claudin 14 1.064
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.062
HES4 hes family bHLH transcription factor 4 1.061
CLDN2 claudin 2 1.061
FOLR1 folate receptor 1 (adult) 1.06
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 1.06
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.06
SHROOM4 shroom family member 4 1.057
PLS3 plastin 3 1.056
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.055
TMEM174 transmembrane protein 174 1.052
MYH14 myosin, heavy chain 14, non-muscle 1.052
KITLG KIT ligand 1.052
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.052
KLK3 kallikrein-related peptidase 3 1.047
GRHPR glyoxylate reductase/hydroxypyruvate reductase 1.044
IFITM5 interferon induced transmembrane protein 5 1.04
SMS spermine synthase 1.038
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.038
CP ceruloplasmin (ferroxidase) 1.036
H3-3B H3.3 histone B 1.03
BMP4 bone morphogenetic protein 4 1.029
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.026
NCOA4 nuclear receptor coactivator 4 1.026
BTK Bruton agammaglobulinemia tyrosine kinase 1.024
IL17A interleukin 17A 1.024
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.019
PPHLN1 periphilin 1 1.019
MYOM2 myomesin 2 1.016
ADIPOQ adiponectin, C1Q and collagen domain containing 1.015
COL2A1 collagen, type II, alpha 1 1.013
ENO2 enolase 2 (gamma, neuronal) 1.012
IP6K1 inositol hexakisphosphate kinase 1 1.011
AMTN amelotin 1.011
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.009
AR androgen receptor 1.007
EML4 echinoderm microtubule associated protein like 4 1.006
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1.005
MMP13 matrix metallopeptidase 13 1.004
IL4 interleukin 4 1.003
MSTN myostatin 1.003
NPPC natriuretic peptide C 1.002
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.001
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.001
CRH corticotropin releasing hormone 1.001
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 1.0