Hypospadias Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum. (Human Disease Ontology, DOID_10892)
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Genes

48 genes associated with the disease Hypospadias in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
SHROOM4 shroom family member 4 2.042
DGKK diacylglycerol kinase, kappa 2.042
CCNB3 cyclin B3 2.042
MTA3 metastasis associated 1 family, member 3 1.897
OXER1 oxoeicosanoid (OXE) receptor 1 1.897
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 1.897
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 1.857
DNAJB8 DnaJ (Hsp40) homolog, subfamily B, member 8 1.857
RUVBL1 RuvB-like AAA ATPase 1 1.857
ZFHX3 zinc finger homeobox 3 1.77
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 1.456
HIBADH 3-hydroxyisobutyrate dehydrogenase 1.456
JAZF1 JAZF zinc finger 1 1.456
HOXA9 homeobox A9 1.447
HOXA6 homeobox A6 1.447
HOXA10 homeobox A10 1.447
HOXA11 homeobox A11 1.447
HOXA5 homeobox A5 1.447
HOXA4 homeobox A4 1.447
HOXA3 homeobox A3 1.447
HOXA13 homeobox A13 1.447
HOXA2 homeobox A2 1.447
HOXA1 homeobox A1 1.447
HOXA7 homeobox A7 1.447
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.336
SCG5 secretogranin V 1.266
ARHGAP11A Rho GTPase activating protein 11A 1.266
GREM1 gremlin 1, DAN family BMP antagonist 1.266
FMN1 formin 1 1.266
SUCLG1 succinate-CoA ligase, alpha subunit 1.159
DNAH6 dynein, axonemal, heavy chain 6 1.159
EXOC3 exocyst complex component 3 1.099
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.099
KIF6 kinesin family member 6 1.089
DAAM2 dishevelled associated activator of morphogenesis 2 1.089
XKR9 XK, Kell blood group complex subunit-related family, member 9 0.716
EYA1 EYA transcriptional coactivator and phosphatase 1 0.716
PKDCC protein kinase domain containing, cytoplasmic 0.688
PRR13 proline rich 13 0.587
PCBP2 poly(rC) binding protein 2 0.587
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.587
SP1 Sp1 transcription factor 0.587
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.587
AMHR2 anti-Mullerian hormone receptor, type II 0.587
SP7 Sp7 transcription factor 0.587
PFDN5 prefoldin subunit 5 0.587
MMP2 matrix metallopeptidase 2 0.558
IRX6 iroquois homeobox 6 0.558