| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2736690 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in IBC 293 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIM29 | tripartite motif containing 29 | 1.95 |
| COL1A1 | collagen, type I, alpha 1 | 1.83 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.76 |
| HMOX1 | heme oxygenase 1 | 1.25 |
| RINL | Ras and Rab interactor-like | 1.18 |
| GDF15 | growth differentiation factor 15 | 1.07 |
| SLC16A6 | solute carrier family 16, member 6 | 1.05 |
| ZFP36 | ZFP36 ring finger protein | 1.05 |
| TP53I3 | tumor protein p53 inducible protein 3 | 1.05 |
| C6ORF141 | chromosome 6 open reading frame 141 | 1.03 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.94 |
| TP53 | tumor protein p53 | 0.91 |
| TMC5 | transmembrane channel-like 5 | 0.88 |
| CCND1 | cyclin D1 | 0.84 |
| AEN | apoptosis enhancing nuclease | 0.82 |
| ZBTB7B | zinc finger and BTB domain containing 7B | 0.81 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.81 |
| FAS | Fas cell surface death receptor | 0.79 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.79 |
| BRSK2 | BR serine/threonine kinase 2 | 0.78 |
| TRNP1 | TMF1-regulated nuclear protein 1 | 0.75 |
| THAP9 | THAP domain containing 9 | 0.75 |
| SIRT7 | sirtuin 7 | 0.7 |
| TCAIM | T cell activation inhibitor, mitochondrial | 0.69 |
| RAB12 | RAB12, member RAS oncogene family | 0.68 |
| MTFMT | mitochondrial methionyl-tRNA formyltransferase | 0.68 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.66 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.65 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 0.64 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.64 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.63 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.61 |
| TDG | thymine-DNA glycosylase | 0.6 |
| RIOK3 | RIO kinase 3 | 0.59 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.59 |
| PRKX | protein kinase, X-linked | 0.58 |
| BMP8A | bone morphogenetic protein 8a | 0.58 |
| CAPN5 | calpain 5 | 0.58 |
| FDXR | ferredoxin reductase | 0.58 |
| PEX16 | peroxisomal biogenesis factor 16 | 0.58 |
| DUSP5 | dual specificity phosphatase 5 | 0.57 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.56 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | 0.56 |
| ZNF354B | zinc finger protein 354B | 0.54 |
| CCNE1 | cyclin E1 | 0.54 |
| ZNF564 | zinc finger protein 564 | 0.53 |
| SMOX | spermine oxidase | 0.53 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.52 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | 0.51 |
| ZNF624 | zinc finger protein 624 | 0.5 |
| CNTN1 | contactin 1 | 0.5 |
| EPS8L2 | EPS8-like 2 | 0.5 |
| PTGES | prostaglandin E synthase | 0.49 |
| KLF2 | Kruppel-like factor 2 | 0.49 |
| SRXN1 | sulfiredoxin 1 | 0.48 |
| DES | desmin | 0.48 |
| BHLHA15 | basic helix-loop-helix family, member a15 | 0.47 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | 0.47 |
| PARD6G | par-6 family cell polarity regulator gamma | 0.46 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.46 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.45 |
| BAX | BCL2-associated X protein | 0.45 |
| LZTR1 | leucine-zipper-like transcription regulator 1 | 0.45 |
| CUL7 | cullin 7 | 0.45 |
| TRAF4 | TNF receptor-associated factor 4 | 0.45 |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.44 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | 0.44 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.44 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.43 |
| LYST | lysosomal trafficking regulator | 0.43 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.43 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | 0.43 |
| FBXO22 | F-box protein 22 | 0.42 |
| VAV2 | vav 2 guanine nucleotide exchange factor | 0.42 |
| CCNT2 | cyclin T2 | 0.42 |
| MYO15B | myosin XVB | 0.42 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.42 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.41 |
| TGFB1 | transforming growth factor, beta 1 | 0.41 |
| NACC2 | NACC family member 2, BEN and BTB (POZ) domain containing | 0.4 |
| EPPK1 | epiplakin 1 | 0.4 |
| PLCD3 | phospholipase C, delta 3 | 0.39 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.39 |
| PUM2 | pumilio RNA-binding family member 2 | 0.39 |
| RGPD2 | RANBP2-like and GRIP domain containing 2 | 0.39 |
| CERS4 | ceramide synthase 4 | 0.39 |
| ARSD | arylsulfatase D | 0.39 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.39 |
| WDR74 | WD repeat domain 74 | 0.39 |
| TMEM63B | transmembrane protein 63B | 0.38 |
| SYTL2 | synaptotagmin-like 2 | 0.38 |
| RIOX1 | ribosomal oxygenase 1 | 0.38 |
| APOB | apolipoprotein B | 0.38 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.38 |
| DOLK | dolichol kinase | 0.38 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 0.38 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.38 |
| RARG | retinoic acid receptor, gamma | 0.38 |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | 0.38 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RIBC2 | RIB43A domain with coiled-coils 2 | -2.43 |
| SLC35A5 | solute carrier family 35, member A5 | -2.08 |
| AUNIP | aurora kinase A and ninein interacting protein | -2.03 |
| R3HDM4 | R3H domain containing 4 | -1.5 |
| CDC6 | cell division cycle 6 | -1.47 |
| PTTG1 | pituitary tumor-transforming 1 | -1.34 |
| LRP11 | low density lipoprotein receptor-related protein 11 | -1.28 |
| ZNF100 | zinc finger protein 100 | -1.2 |
| CDC20 | cell division cycle 20 | -1.19 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -1.18 |
| PCLAF | PCNA clamp associated factor | -1.17 |
| C9ORF40 | chromosome 9 open reading frame 40 | -1.15 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -1.14 |
| CKAP2L | cytoskeleton associated protein 2-like | -1.09 |
| DEPDC1 | DEP domain containing 1 | -1.08 |
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | -1.08 |
| CCNA2 | cyclin A2 | -1.06 |
| GMNN | geminin, DNA replication inhibitor | -1.06 |
| EXO1 | exonuclease 1 | -1.05 |
| ABHD13 | abhydrolase domain containing 13 | -1.04 |
| SGO1 | shugoshin 1 | -1.02 |
| GPSM2 | G-protein signaling modulator 2 | -1.02 |
| ARHGAP11A | Rho GTPase activating protein 11A | -0.93 |
| FBXO5 | F-box protein 5 | -0.93 |
| SGO2 | shugoshin 2 | -0.93 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.9 |
| PIMREG | PICALM interacting mitotic regulator | -0.89 |
| AURKA | aurora kinase A | -0.89 |
| PHF19 | PHD finger protein 19 | -0.87 |
| CLSPN | claspin | -0.87 |
| RGS3 | regulator of G-protein signaling 3 | -0.87 |
| CCNB1 | cyclin B1 | -0.87 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -0.87 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.87 |
| CCHCR1 | coiled-coil alpha-helical rod protein 1 | -0.87 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -0.86 |
| CDC25C | cell division cycle 25C | -0.86 |
| FOXM1 | forkhead box M1 | -0.86 |
| CDCA8 | cell division cycle associated 8 | -0.86 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | -0.85 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.85 |
| KIF18B | kinesin family member 18B | -0.84 |
| MT2A | metallothionein 2A | -0.84 |
| SYTL3 | synaptotagmin-like 3 | -0.84 |
| CENPF | centromere protein F, 350/400kDa | -0.83 |
| CDCA2 | cell division cycle associated 2 | -0.82 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -0.82 |
| ANLN | anillin, actin binding protein | -0.81 |
| CCNB2 | cyclin B2 | -0.81 |
| MASTL | microtubule associated serine/threonine kinase-like | -0.81 |
| TK1 | thymidine kinase 1, soluble | -0.81 |
| KIF22 | kinesin family member 22 | -0.8 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -0.79 |
| RRM2 | ribonucleotide reductase M2 | -0.79 |
| PLK1 | polo-like kinase 1 | -0.78 |
| TPX2 | TPX2, microtubule-associated | -0.77 |
| CCSAP | centriole, cilia and spindle-associated protein | -0.76 |
| CDCA7 | cell division cycle associated 7 | -0.76 |
| KIFC1 | kinesin family member C1 | -0.76 |
| MCM10 | minichromosome maintenance complex component 10 | -0.75 |
| MIS18BP1 | MIS18 binding protein 1 | -0.75 |
| C5ORF34 | chromosome 5 open reading frame 34 | -0.75 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.74 |
| ATAD5 | ATPase family, AAA domain containing 5 | -0.74 |
| RAD51AP1 | RAD51 associated protein 1 | -0.73 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.72 |
| KIF2C | kinesin family member 2C | -0.72 |
| MPHOSPH9 | M-phase phosphoprotein 9 | -0.72 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | -0.72 |
| BRCA1 | breast cancer 1, early onset | -0.72 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.72 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.71 |
| NET1 | neuroepithelial cell transforming 1 | -0.71 |
| CDC25B | cell division cycle 25B | -0.71 |
| PRC1 | protein regulator of cytokinesis 1 | -0.71 |
| E2F8 | E2F transcription factor 8 | -0.7 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.7 |
| WEE1 | WEE1 G2 checkpoint kinase | -0.7 |
| LRRC45 | leucine rich repeat containing 45 | -0.69 |
| FITM2 | fat storage-inducing transmembrane protein 2 | -0.69 |
| CEP55 | centrosomal protein 55kDa | -0.69 |
| CCNE2 | cyclin E2 | -0.68 |
| DIAPH3 | diaphanous-related formin 3 | -0.68 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.68 |
| KLK6 | kallikrein-related peptidase 6 | -0.68 |
| RAD54B | RAD54 homolog B (S. cerevisiae) | -0.67 |
| ATXN1 | ataxin 1 | -0.67 |
| CDCA5 | cell division cycle associated 5 | -0.67 |
| ECT2 | epithelial cell transforming 2 | -0.67 |
| BOD1 | biorientation of chromosomes in cell division 1 | -0.66 |
| TMEM51 | transmembrane protein 51 | -0.66 |
| SKA3 | spindle and kinetochore associated complex subunit 3 | -0.65 |
| ETAA1 | Ewing tumor-associated antigen 1 | -0.65 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | -0.65 |
| INCENP | inner centromere protein antigens 135/155kDa | -0.65 |
| AASS | aminoadipate-semialdehyde synthase | -0.64 |
| CEP152 | centrosomal protein 152kDa | -0.64 |
| CDC7 | cell division cycle 7 | -0.64 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | -0.64 |
| KMT5A | lysine methyltransferase 5A | -0.64 |
