IC-86621-7513 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the IC-86621-7513 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADAM15 ADAM metallopeptidase domain 15
ADARB1 adenosine deaminase, RNA-specific, B1
AK2 adenylate kinase 2
AKR1C1 aldo-keto reductase family 1, member C1
ALPK1 alpha-kinase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AR androgen receptor
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
B9D2 B9 protein domain 2
BGN biglycan
C11ORF16 chromosome 11 open reading frame 16
CAPN7 calpain 7
CD47 CD47 molecule
CHST10 carbohydrate sulfotransferase 10
CLIC4 chloride intracellular channel 4
CLSPN claspin
CRIP1 cysteine-rich protein 1 (intestinal)
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF4 DDB1 and CUL4 associated factor 4
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DGCR8 DGCR8 microprocessor complex subunit
DPP4 dipeptidyl-peptidase 4
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EFNB3 ephrin-B3
EGFL7 EGF-like-domain, multiple 7
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHA2 EPH receptor A2
ERN2 endoplasmic reticulum to nucleus signaling 2
ESR1 estrogen receptor 1
FER fer (fps/fes related) tyrosine kinase
GALT galactose-1-phosphate uridylyltransferase
GLS2 glutaminase 2 (liver, mitochondrial)
GPR1 G protein-coupled receptor 1
HLA-J major histocompatibility complex, class I, J (pseudogene)
HRASLS2 HRAS-like suppressor 2
IFI35 interferon-induced protein 35
INO80B INO80 complex subunit B
ITGA6 integrin, alpha 6
JMJD4 jumonji domain containing 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK12 potassium channel, two pore domain subfamily K, member 12
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LY9 lymphocyte antigen 9
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK7 mitogen-activated protein kinase 7
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MRPL44 mitochondrial ribosomal protein L44
MSL3 male-specific lethal 3 homolog (Drosophila)
MST1R macrophage stimulating 1 receptor
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NLRX1 NLR family member X1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OCRL oculocerebrorenal syndrome of Lowe
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PCGF3 polycomb group ring finger 3
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POT1 protection of telomeres 1
PQLC2 PQ loop repeat containing 2
PRDX2 peroxiredoxin 2
RAD51D RAD51 paralog D
RARS arginyl-tRNA synthetase
RHOQ ras homolog family member Q
RPAIN RPA interacting protein
RRP1B ribosomal RNA processing 1B
SAMD4A sterile alpha motif domain containing 4A
SCNN1B sodium channel, non voltage gated 1 beta subunit
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC38A7 solute carrier family 38, member 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SOCS7 suppressor of cytokine signaling 7
SPPL2B signal peptide peptidase like 2B
STX6 syntaxin 6
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFG TRK-fused gene
THBS3 thrombospondin 3
THY1 Thy-1 cell surface antigen
TJAP1 tight junction associated protein 1 (peripheral)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBA4B tubulin, alpha 4b
ULK2 unc-51 like autophagy activating kinase 2
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WDFY3 WD repeat and FYVE domain containing 3
ZNF205 zinc finger protein 205
ZNF419 zinc finger protein 419
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AFAP1 actin filament associated protein 1
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ARRB2 arrestin, beta 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AZI2 5-azacytidine induced 2
BEGAIN brain-enriched guanylate kinase-associated
BIRC7 baculoviral IAP repeat containing 7
C11ORF80 chromosome 11 open reading frame 80
CCDC69 coiled-coil domain containing 69
CEL carboxyl ester lipase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COPZ2 coatomer protein complex, subunit zeta 2
CORT cortistatin
CRELD1 cysteine-rich with EGF-like domains 1
CRYBG3 beta-gamma crystallin domain containing 3
CRYL1 crystallin, lambda 1
CST4 cystatin S
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGAT1 diacylglycerol O-acyltransferase 1
DMBT1 deleted in malignant brain tumors 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFNA3 ephrin-A3
ELP3 elongator acetyltransferase complex subunit 3
FADS2 fatty acid desaturase 2
FAP fibroblast activation protein, alpha
FBXO31 F-box protein 31
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGD1 FYVE, RhoGEF and PH domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
GLB1L galactosidase, beta 1-like
GPR68 G protein-coupled receptor 68
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC7 histone deacetylase 7
HIST1H4A histone cluster 1, H4a
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFT81 intraflagellar transport 81
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KLK8 kallikrein-related peptidase 8
LAMP5 lysosomal-associated membrane protein family, member 5
LHX6 LIM homeobox 6
LIN7B lin-7 homolog B (C. elegans)
LNPEP leucyl/cystinyl aminopeptidase
LTBP2 latent transforming growth factor beta binding protein 2
LTC4S leukotriene C4 synthase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MT3 metallothionein 3
NOL10 nucleolar protein 10
NRSN2 neurensin 2
PADI1 peptidyl arginine deiminase, type I
PEX26 peroxisomal biogenesis factor 26
PKD2L1 polycystic kidney disease 2-like 1
PLCD1 phospholipase C, delta 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLXNB3 plexin B3
PODNL1 podocan-like 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PTPRM protein tyrosine phosphatase, receptor type, M
RNF208 ring finger protein 208
RNF25 ring finger protein 25
RUSC2 RUN and SH3 domain containing 2
S100A9 S100 calcium binding protein A9
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D4A SH2 domain containing 4A
SIPA1 signal-induced proliferation-associated 1
SLC12A9 solute carrier family 12, member 9
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMA4 glucuronidase, beta pseudogene
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNHG3 small nucleolar RNA host gene 3
SPAG4 sperm associated antigen 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD3 StAR-related lipid transfer (START) domain containing 3
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TCP10 t-complex 10
TCTN2 tectonic family member 2
TFF2 trefoil factor 2
TMEM209 transmembrane protein 209
TMPRSS4 transmembrane protease, serine 4
TPSG1 tryptase gamma 1
TTC23 tetratricopeptide repeat domain 23
TTLL1 tubulin tyrosine ligase-like family member 1
TUBG2 tubulin, gamma 2
USP36 ubiquitin specific peptidase 36
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC14 zinc finger, DHHC-type containing 14
ZFP69B ZFP69 zinc finger protein B
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF211 zinc finger protein 211
ZNF250 zinc finger protein 250
ZNF76 zinc finger protein 76