IDH3B Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description isocitrate dehydrogenase 3 (NAD+) beta|Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3420)
External Link http://www.ncbi.nlm.nih.gov/gene/3420
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229 interacting proteins for IDH3B from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ACOT8 acyl-CoA thioesterase 8
ACTL6A actin-like 6A
ADRB2 adrenoceptor beta 2, surface
AKAP8 A kinase (PRKA) anchor protein 8
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL1 ADP-ribosylation factor-like 1
ASS1 argininosuccinate synthase 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATXN2 ataxin 2
BCR breakpoint cluster region
C1QBP complement component 1, q subcomponent binding protein
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDK1 cyclin-dependent kinase 1
CEPT1 choline/ethanolamine phosphotransferase 1
CHD4 chromodomain helicase DNA binding protein 4
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
COPG1 coatomer protein complex, subunit gamma 1
COPG2 coatomer protein complex, subunit gamma 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYR61 cysteine-rich, angiogenic inducer, 61
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
E2F1 E2F transcription factor 1
EEF1G eukaryotic translation elongation factor 1 gamma
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EP400 E1A binding protein p400
ERCC3 excision repair cross-complementation group 3
ETFA electron-transfer-flavoprotein, alpha polypeptide
FANCD2 Fanconi anemia, complementation group D2
FBL fibrillarin
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW8 F-box and WD repeat domain containing 8
GANAB glucosidase, alpha; neutral AB
GCDH glutaryl-CoA dehydrogenase
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GSG2 germ cell associated 2 (haspin)
GTF2I general transcription factor IIi
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HELLS helicase, lymphoid-specific
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H2BL histone cluster 1, H2bl
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ILVBL ilvB (bacterial acetolactate synthase)-like
IPO13 importin 13
IPO4 importin 4
IPO7 importin 7
IPO9 importin 9
IQGAP2 IQ motif containing GTPase activating protein 2
IQGAP3 IQ motif containing GTPase activating protein 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRS4 insulin receptor substrate 4
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KPNB1 karyopherin (importin) beta 1
LMNA lamin A/C
LONP1 lon peptidase 1, mitochondrial
LRPPRC leucine-rich pentatricopeptide repeat containing
MAPK6 mitogen-activated protein kinase 6
MAPKAP1 mitogen-activated protein kinase associated protein 1
MARS methionyl-tRNA synthetase
MAX MYC associated factor X
MCM7 minichromosome maintenance complex component 7
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MOGS mannosyl-oligosaccharide glucosidase
MRPS22 mitochondrial ribosomal protein S22
MRPS34 mitochondrial ribosomal protein S34
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MYBBP1A MYB binding protein (P160) 1a
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
MYO9A myosin IXA
MYO9B myosin IXB
NCL nucleolin
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NEK9 NIMA-related kinase 9
NONO non-POU domain containing, octamer-binding
NOP56 NOP56 ribonucleoprotein
NUP133 nucleoporin 133kDa
NUP153 nucleoporin 153kDa
OAT ornithine aminotransferase
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCBP1 poly(rC) binding protein 1
PELO pelota homolog (Drosophila)
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLK1 polo-like kinase 1
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP6C protein phosphatase 6, catalytic subunit
PPT1 palmitoyl-protein thioesterase 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT1 protein arginine methyltransferase 1
PRPF6 pre-mRNA processing factor 6
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSME4 proteasome (prosome, macropain) activator subunit 4
PTGES2 prostaglandin E synthase 2
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAB35 RAB35, member RAS oncogene family
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RANBP2 RAN binding protein 2
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNGTT RNA guanylyltransferase and 5'-phosphatase
RNH1 ribonuclease/angiogenin inhibitor 1
RPN1 ribophorin I
RPN2 ribophorin II
RPP30 ribonuclease P/MRP 30kDa subunit
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SARS seryl-tRNA synthetase
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SKP1 S-phase kinase-associated protein 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLIT2 slit homolog 2 (Drosophila)
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
SSR4 signal sequence receptor, delta
SUCLG1 succinate-CoA ligase, alpha subunit
SUMO2 small ubiquitin-like modifier 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TCP1 t-complex 1
TMPO thymopoietin
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRIM28 tripartite motif containing 28
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TRRAP transformation/transcription domain-associated protein
TTC27 tetratricopeptide repeat domain 27
TUBA4A tubulin, alpha 4a
TUBG1 tubulin, gamma 1
TUBGCP2 tubulin, gamma complex associated protein 2
U2SURP U2 snRNP-associated SURP domain containing
UBC ubiquitin C
UBE3C ubiquitin protein ligase E3C
UBR2 ubiquitin protein ligase E3 component n-recognin 2
WDR77 WD repeat domain 77
XPO1 exportin 1
XPO5 exportin 5
XPOT exportin, tRNA
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
XRN1 5'-3' exoribonuclease 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF121 zinc finger protein 121
ZNF281 zinc finger protein 281