IFIH1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description interferon induced with helicase C domain 1|DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012] (NCBI Entrez Gene Database, 64135)
Similar Terms
Downloads & Tools

Genes

318 genes differentially expressed following the IFIH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.36832
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.36832
LCNL1 lipocalin-like 1 2.36832
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.36832
OR4D2 olfactory receptor, family 4, subfamily D, member 2 2.36832
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.36832
NHLRC4 NHL repeat containing 4 2.36832
GCKR glucokinase (hexokinase 4) regulator 2.36832
TLR3 toll-like receptor 3 2.36832
TMEM40 transmembrane protein 40 2.36832
LACTB2 lactamase, beta 2 2.36832
CD8A CD8a molecule 2.36832
STARD6 StAR-related lipid transfer (START) domain containing 6 2.36832
NPFFR1 neuropeptide FF receptor 1 2.36832
FCMR Fc fragment of IgM receptor 2.36832
TPPP tubulin polymerization promoting protein 2.36832
LVRN laeverin 2.36832
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.36832
WNT2 wingless-type MMTV integration site family member 2 2.36832
GJA5 gap junction protein, alpha 5, 40kDa 2.36832
MSX1 msh homeobox 1 2.36832
ANKRD55 ankyrin repeat domain 55 2.36832
DNASE1L2 deoxyribonuclease I-like 2 2.31526
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.31526
CTRC chymotrypsin C (caldecrin) 2.31526
FBXL8 F-box and leucine-rich repeat protein 8 2.31526
PVRIG poliovirus receptor related immunoglobulin domain containing 2.31526
FPR3 formyl peptide receptor 3 2.31526
GUCA1C guanylate cyclase activator 1C 2.31526
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 2.31526
FAM90A26 family with sequence similarity 90, member A26, pseudogene 2.31526
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.31526
RP1L1 retinitis pigmentosa 1-like 1 2.31526
GPR55 G protein-coupled receptor 55 2.31526
MUC6 mucin 6, oligomeric mucus/gel-forming 2.31526
GAA glucosidase, alpha; acid 2.31526
TM4SF4 transmembrane 4 L six family member 4 2.31526
CELA1 chymotrypsin-like elastase family, member 1 2.31526
F2 coagulation factor II (thrombin) 2.31526
GTPBP4 GTP binding protein 4 2.31526
LONRF2 LON peptidase N-terminal domain and ring finger 2 2.31526
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.31526
TRPC5OS TRPC5 opposite strand 2.31526
LGALS2 lectin, galactoside-binding, soluble, 2 2.31526
MYO1A myosin IA 2.31526
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.31526
PSCA prostate stem cell antigen 2.31526
RGPD3 RANBP2-like and GRIP domain containing 3 2.31526
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.31526
TCHH trichohyalin 2.31526
ZNF185 zinc finger protein 185 (LIM domain) 2.31526
SSMEM1 serine-rich single-pass membrane protein 1 2.31526
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.31526
CIITA class II, major histocompatibility complex, transactivator 2.31526
ALPK2 alpha-kinase 2 2.31526
SP7 Sp7 transcription factor 2.31526
TRIM73 tripartite motif containing 73 2.31526
GYS2 glycogen synthase 2 (liver) 2.31526
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.31526
CCN5 cellular communication network factor 5 2.31526
PMIS2 PMIS2 transmembrane protein 2.31526
DOP1A DOP1 leucine zipper like protein A 2.31526
CFAP65 cilia and flagella associated protein 65 2.31526
GET3 guided entry of tail-anchored proteins factor 3, ATPase 2.31526
PHF24 PHD finger protein 24 2.31526
GBP3 guanylate binding protein 3 2.31526
VN1R2 vomeronasal 1 receptor 2 2.31526
CATSPERT catsper channel auxiliary subunit tau 2.31526
CCDC198 coiled-coil domain containing 198 2.31526
CBLIF cobalamin binding intrinsic factor 2.31526
LOC114841035 uncharacterized LOC114841035 2.31526
FAM240A family with sequence similarity 240 member A 2.31526
SERTM2 serine rich and transmembrane domain containing 2 2.31526
CIBAR2 CBY1 interacting BAR domain containing 2 2.31526
MEIOSIN meiosis initiator 2.31526
TERB2 telomere repeat binding bouquet formation protein 2 2.31526
NFILZ NFIL3 like basic leucine zipper 2.31526
GARIN1A golgi associated RAB2 interactor 1A 2.31526
DUSP29 dual specificity phosphatase 29 2.31526
DUSP8 dual specificity phosphatase 8 2.31526
C20ORF202 chromosome 20 open reading frame 202 2.31526
IQCF1 IQ motif containing F1 2.31526
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.31526
OVOL3 ovo-like zinc finger 3 2.31526
C1ORF162 chromosome 1 open reading frame 162 2.31526
DNASE2B deoxyribonuclease II beta 2.31526
MSANTD5 Myb/SANT DNA binding domain containing 5 2.31526
CCR6 chemokine (C-C motif) receptor 6 2.31526
RAB15 RAB15, member RAS oncogene family 2.31526
VIT vitrin 2.31526
OASL 2'-5'-oligoadenylate synthetase-like 2.31526
CFAP45 cilia and flagella associated protein 45 2.31526
CLDN22 claudin 22 2.31526
RDH8 retinol dehydrogenase 8 (all-trans) 2.31526
LY6K lymphocyte antigen 6 complex, locus K 2.31526
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.31526
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 2.31526
HNF1A HNF1 homeobox A 2.31526
GPR85 G protein-coupled receptor 85 2.31526
LRRC72 leucine rich repeat containing 72 2.31526
GINS1 GINS complex subunit 1 (Psf1 homolog) 2.31526
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.31526
REG3G regenerating islet-derived 3 gamma 2.31526
LDHC lactate dehydrogenase C 2.31526
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.31526
FNDC8 fibronectin type III domain containing 8 2.31526
PCDHGB2 protocadherin gamma subfamily B, 2 2.31526
SIGLEC15 sialic acid binding Ig-like lectin 15 2.31526
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.31526
LYZ lysozyme 2.31526
APOD apolipoprotein D 2.31526
PENK proenkephalin 2.31526
PRTN3 proteinase 3 2.31526
MAGEF1 melanoma antigen family F1 2.31526
DYTN dystrotelin 2.31526
KRT17 keratin 17, type I 2.31526
CA5A carbonic anhydrase VA, mitochondrial 2.31526
TSPAN32 tetraspanin 32 2.31526
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.31526
MOBP myelin-associated oligodendrocyte basic protein 2.31526
OR4D10 olfactory receptor, family 4, subfamily D, member 10 2.31526
LGALS12 lectin, galactoside-binding, soluble, 12 2.31526
GFRAL GDNF family receptor alpha like 2.31526
GAGE10 G antigen 10 2.31526
HIPK2 homeodomain interacting protein kinase 2 2.31526
SPINK9 serine peptidase inhibitor, Kazal type 9 2.31526
ADAM7 ADAM metallopeptidase domain 7 2.31526
FAM209A family with sequence similarity 209, member A 2.31526
WDR46 WD repeat domain 46 2.31526
C22ORF42 chromosome 22 open reading frame 42 2.31526
CRHR1 corticotropin releasing hormone receptor 1 2.31526
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.31526
NOX1 NADPH oxidase 1 2.31526
MUC13 mucin 13, cell surface associated 2.31526
GLOD5 glyoxalase domain containing 5 2.31526
CYSLTR1 cysteinyl leukotriene receptor 1 2.31526
OR9A4 olfactory receptor, family 9, subfamily A, member 4 2.31526
SLC36A3 solute carrier family 36, member 3 2.31526
CATIP ciliogenesis associated TTC17 interacting protein 2.31526
FBXO47 F-box protein 47 2.31526
ASTL astacin-like metallo-endopeptidase (M12 family) 2.31526
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 2.31526
ACKR2 atypical chemokine receptor 2 2.31526
PADI6 peptidyl arginine deiminase, type VI 2.31526
ZNF300 zinc finger protein 300 2.31526
ZNF831 zinc finger protein 831 2.31526
ANGPTL3 angiopoietin-like 3 2.31526
SEMG1 semenogelin I 2.31526
NLRP9 NLR family, pyrin domain containing 9 2.31526
NLRP8 NLR family, pyrin domain containing 8 2.31526
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.31526
BEX4 brain expressed, X-linked 4 2.31526
LKAAEAR1 LKAAEAR motif containing 1 2.31526
MRGPRX3 MAS-related GPR, member X3 2.31526
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.31526
KIAA1755 KIAA1755 2.31526
EVPL envoplakin 2.31526
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.31526
FOXS1 forkhead box S1 2.31526
SPNS3 spinster homolog 3 (Drosophila) 2.31526
CXORF58 chromosome X open reading frame 58 2.31526
PRRX1 paired related homeobox 1 2.31526
POU4F1 POU class 4 homeobox 1 2.31526
FITM1 fat storage-inducing transmembrane protein 1 2.31526
ZNF534 zinc finger protein 534 2.31526
RNF224 ring finger protein 224 2.31526
APOL1 apolipoprotein L, 1 2.31526
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.31526
TMEM86A transmembrane protein 86A 2.31526
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.31526
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.31526
GAS2L2 growth arrest-specific 2 like 2 2.31526
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.31526
BIN2 bridging integrator 2 2.31526
CHAF1A chromatin assembly factor 1, subunit A (p150) 2.31526
OPTN optineurin 2.30383
TSBP1 testis expressed basic protein 1 2.25095
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 2.23408
DORIP1 dopamine receptor interacting protein 1 2.23119
CD82 CD82 molecule 2.23119
IER3IP1 immediate early response 3 interacting protein 1 2.22133
LINC02798 long intergenic non-protein coding RNA 2798 2.21133
SLC35F3 solute carrier family 35, member F3 2.209
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.19579
PRKCD protein kinase C, delta 2.19294
C2CD2L C2CD2-like 2.19294
PCBP2 poly(rC) binding protein 2 2.19294
RAD51C RAD51 paralog C 2.19294
ARNT aryl hydrocarbon receptor nuclear translocator 2.18722
ZNF469 zinc finger protein 469 2.17768
IRF8 interferon regulatory factor 8 2.17768
ARHGAP15 Rho GTPase activating protein 15 2.17768
MED13L mediator complex subunit 13-like 2.15126
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.13033
PYGM phosphorylase, glycogen, muscle 2.12454
PRRX2 paired related homeobox 2 2.10127
RBM11 RNA binding motif protein 11 2.09851
MEIS3 Meis homeobox 3 2.09217
ZNF235 zinc finger protein 235 2.09109
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 2.09109
ATAT1 alpha tubulin acetyltransferase 1 2.08809
ACAA2 acetyl-CoA acyltransferase 2 2.07892
CDCA7L cell division cycle associated 7-like 2.05943
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.05928
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2.05928
DNA2 DNA replication helicase/nuclease 2 2.05827
NTN1 netrin 1 2.05451
ENDOD1 endonuclease domain containing 1 2.04975
SUSD6 sushi domain containing 6 2.04407
C19ORF33 chromosome 19 open reading frame 33 2.0337
C17ORF58 chromosome 17 open reading frame 58 2.02228
MRPS18B mitochondrial ribosomal protein S18B 2.01898
FOXO3B forkhead box O3B pseudogene 2.01047
MFAP3L microfibrillar-associated protein 3-like 2.01047
THSD4 thrombospondin, type I, domain containing 4 2.00711
CORO2B coronin, actin binding protein, 2B 2.00435

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.36832
CTSO cathepsin O -2.36832
SP140 SP140 nuclear body protein -2.36832
MTCL1 microtubule crosslinking factor 1 -2.36832
RASL11A RAS-like, family 11, member A -2.36832
GPR157 G protein-coupled receptor 157 -2.36832
DAGLA diacylglycerol lipase, alpha -2.36832
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -2.36832
RPS21-DT RPS21 divergent transcript -2.36832
SLC46A1 solute carrier family 46 (folate transporter), member 1 -2.36832
MOCS2 molybdenum cofactor synthesis 2 -2.31526
SCGN secretagogin, EF-hand calcium binding protein -2.31526
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -2.31526
KLHL35 kelch-like family member 35 -2.31526
TM4SF1 transmembrane 4 L six family member 1 -2.31526
PRB3 proline-rich protein BstNI subfamily 3 -2.31526
PZP pregnancy-zone protein -2.31526
NPSR1 neuropeptide S receptor 1 -2.31526
ASB16 ankyrin repeat and SOCS box containing 16 -2.31526
C11ORF87 chromosome 11 open reading frame 87 -2.31526
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.31526
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.31526
CLEC14A C-type lectin domain family 14, member A -2.31526
EFHB EF-hand domain family, member B -2.31526
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -2.31526
MISP3 MISP family member 3 -2.31526
PCDHGA9 protocadherin gamma subfamily A, 9 -2.31526
YPEL4 yippee-like 4 (Drosophila) -2.31526
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 -2.31526
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -2.31526
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -2.31526
TMEM43 transmembrane protein 43 -2.31526
IDS iduronate 2-sulfatase -2.31526
SPATA31H1 SPATA31 subfamily H member 1 -2.31526
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 -2.31526
TLR5 toll-like receptor 5 -2.31526
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.31526
C3ORF80 chromosome 3 open reading frame 80 -2.31526
AXDND1 axonemal dynein light chain domain containing 1 -2.31526
PEX12 peroxisomal biogenesis factor 12 -2.31526
FAM240C family with sequence similarity 240 member C -2.31526
APOH apolipoprotein H (beta-2-glycoprotein I) -2.31526
KRI1 KRI1 homolog (S. cerevisiae) -2.31526
LTB4R2 leukotriene B4 receptor 2 -2.31526
PRH2 proline-rich protein HaeIII subfamily 2 -2.31526
S100Z S100 calcium binding protein Z -2.31526
MRLN myoregulin -2.31526
CALB2 calbindin 2 -2.31526
SOSTDC1 sclerostin domain containing 1 -2.31526
DOC2B double C2-like domains, beta -2.31526
UBXN10 UBX domain protein 10 -2.31526
LPA lipoprotein, Lp(a) -2.31526
ETNPPL ethanolamine-phosphate phospho-lyase -2.31526
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 -2.31526
CLCNKA chloride channel, voltage-sensitive Ka -2.31526
SCUBE3 signal peptide, CUB domain, EGF-like 3 -2.25095
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.22412
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -2.21875
ADD3 adducin 3 (gamma) -2.21863
PDE4C phosphodiesterase 4C, cAMP-specific -2.21426
TMEM102 transmembrane protein 102 -2.19294
ZNF597 zinc finger protein 597 -2.19294
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.19294
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) -2.19294
RFX3 regulatory factor X, 3 (influences HLA class II expression) -2.18935
CSNK1G2 casein kinase 1, gamma 2 -2.18722
LARS1 leucyl-tRNA synthetase 1 -2.18401
CEP295 centrosomal protein 295kDa -2.17768
SLU7 SLU7 splicing factor homolog (S. cerevisiae) -2.17765
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -2.17684
STUM stum, mechanosensory transduction mediator homolog -2.14816
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 -2.14816
HAP1 huntingtin-associated protein 1 -2.14244
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.13033
SIAH1 siah E3 ubiquitin protein ligase 1 -2.13033
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.13033
APOLTP apolipoprotein lipid transfer particle homolog -2.13033
DCLK3 doublecortin-like kinase 3 -2.10683
ADAM15 ADAM metallopeptidase domain 15 -2.10294
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.09328
C10ORF90 chromosome 10 open reading frame 90 -2.09328
WDR93 WD repeat domain 93 -2.09328
TMX2 thioredoxin-related transmembrane protein 2 -2.08809
SYS1 Sys1 golgi trafficking protein -2.08809
NCOA4 nuclear receptor coactivator 4 -2.08809
PLA2G15 phospholipase A2, group XV -2.08159
HPSE heparanase -2.06849
S1PR1 sphingosine-1-phosphate receptor 1 -2.05943
GPC5 glypican 5 -2.05943
DCLK1 doublecortin-like kinase 1 -2.05827
MECR mitochondrial trans-2-enoyl-CoA reductase -2.05827
RIMS3 regulating synaptic membrane exocytosis 3 -2.05827
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -2.05713
PP2D1 protein phosphatase 2C-like domain containing 1 -2.04975
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.04755
KIAA0513 KIAA0513 -2.04755
AK7 adenylate kinase 7 -2.0337
INPP5J inositol polyphosphate-5-phosphatase J -2.02228
PPME1 protein phosphatase methylesterase 1 -2.01103
MSMO1 methylsterol monooxygenase 1 -2.01047
CLCN1 chloride channel, voltage-sensitive 1 -2.00862
ACSL3 acyl-CoA synthetase long-chain family member 3 -2.00711