IFIH1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interferon induced with helicase C domain 1|DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012] (NCBI Entrez Gene Database, 64135)
External Link http://www.ncbi.nlm.nih.gov/gene/64135
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275 interacting proteins for IFIH1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACOT8 acyl-CoA thioesterase 8
ADRM1 adhesion regulating molecule 1
AGK acylglycerol kinase
AKAP8L A kinase (PRKA) anchor protein 8-like
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
APP amyloid beta (A4) precursor protein
ASPH aspartate beta-hydroxylase
ATG12 autophagy related 12
ATG5 autophagy related 5
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
ATXN10 ataxin 10
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BSG basigin (Ok blood group)
C19ORF70 chromosome 19 open reading frame 70
C2ORF47 chromosome 2 open reading frame 47
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CANX calnexin
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CEPT1 choline/ethanolamine phosphotransferase 1
CFL1 cofilin 1 (non-muscle)
CHD4 chromodomain helicase DNA binding protein 4
CHUK conserved helix-loop-helix ubiquitous kinase
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COPA coatomer protein complex, subunit alpha
COPB1 coatomer protein complex, subunit beta 1
COPG2 coatomer protein complex, subunit gamma 2
CYB5R3 cytochrome b5 reductase 3
DARS aspartyl-tRNA synthetase
DDB1 damage-specific DNA binding protein 1, 127kDa
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3I eukaryotic translation initiation factor 3, subunit I
EMD emerin
EPRS glutamyl-prolyl-tRNA synthetase
ERP44 endoplasmic reticulum protein 44
ESYT2 extended synaptotagmin-like protein 2
FAF2 Fas associated factor family member 2
FANCI Fanconi anemia, complementation group I
FAR1 fatty acyl CoA reductase 1
FKBP8 FK506 binding protein 8, 38kDa
FOXK1 forkhead box K1
FOXK2 forkhead box K2
GANAB glucosidase, alpha; neutral AB
GATAD2A GATA zinc finger domain containing 2A
GCDH glutaryl-CoA dehydrogenase
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GLUD1 glutamate dehydrogenase 1
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa
HACD3 3-hydroxyacyl-CoA dehydratase 3
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HAX1 HCLS1 associated protein X-1
HEATR1 HEAT repeat containing 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H1A histone cluster 1, H1a
HIST1H1T histone cluster 1, H1t
HIST1H4F histone cluster 1, H4f
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPM heterogeneous nuclear ribonucleoprotein M
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HSPH1 heat shock 105kDa/110kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IDE insulin-degrading enzyme
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IMMT inner membrane protein, mitochondrial
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO7 importin 7
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
IRS4 insulin receptor substrate 4
ISYNA1 inositol-3-phosphate synthase 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0368 KIAA0368
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAGE3 L antigen family, member 3
LARS leucyl-tRNA synthetase
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LYPLAL1 lysophospholipase-like 1
LZTR1 leucine-zipper-like transcription regulator 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MARS methionyl-tRNA synthetase
MAT2A methionine adenosyltransferase II, alpha
MAVS mitochondrial antiviral signaling protein
MBD3 methyl-CpG binding domain protein 3
MGME1 mitochondrial genome maintenance exonuclease 1
MLF2 myeloid leukemia factor 2
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDUFA4 NDUFA4, mitochondrial complex associated
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
NLRC5 NLR family, CARD domain containing 5
NLRX1 NLR family member X1
NUCLEOLIN nucleolin multifunctional protein
NUP205 nucleoporin 205kDa
NUP93 nucleoporin 93kDa
OSBPL8 oxysterol binding protein-like 8
OSGEP O-sialoglycoprotein endopeptidase
OTUD5 OTU deubiquitinase 5
PCBP2 poly(rC) binding protein 2
PELO pelota homolog (Drosophila)
PGRMC1 progesterone receptor membrane component 1
PHB prohibitin
PHB2 prohibitin 2
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIAS2 protein inhibitor of activated STAT, 2
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PPP6C protein phosphatase 6, catalytic subunit
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF8 pre-mRNA processing factor 8
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
RAB1B RAB1B, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RARS arginyl-tRNA synthetase
RBBP7 retinoblastoma binding protein 7
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RFC3 replication factor C (activator 1) 3, 38kDa
RHBDD2 rhomboid domain containing 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL13 ribosomal protein L13
RPL18 ribosomal protein L18
RPL21 ribosomal protein L21
RPL23 ribosomal protein L23
RPL24 ribosomal protein L24
RPL29 ribosomal protein L29
RPL3 ribosomal protein L3
RPL31 ribosomal protein L31
RPL5 ribosomal protein L5
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPLP0 ribosomal protein, large, P0
RPLP1 ribosomal protein, large, P1
RPN1 ribophorin I
RPN2 ribophorin II
RPS27 ribosomal protein S27
RPS27A ribosomal protein S27a
RPS7 ribosomal protein S7
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
S100A11 S100 calcium binding protein A11
SCO2 SCO2 cytochrome c oxidase assembly protein
SDF2L1 stromal cell-derived factor 2-like 1
SDF4 stromal cell derived factor 4
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEC61B Sec61 beta subunit
SF3B3 splicing factor 3b, subunit 3, 130kDa
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SNRPF small nuclear ribonucleoprotein polypeptide F
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SSR4 signal sequence receptor, delta
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIP1 stress-induced phosphoprotein 1
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCP1 t-complex 1
TECR trans-2,3-enoyl-CoA reductase
THOC2 THO complex 2
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1
TKFC triokinase/FMN cyclase
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM33 transmembrane protein 33
TMPO thymopoietin
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TP53 tumor protein p53
TRAFD1 TRAF-type zinc finger domain containing 1
TRAP1 TNF receptor-associated protein 1
TRIM28 tripartite motif containing 28
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
UBC ubiquitin C
UBE2S ubiquitin-conjugating enzyme E2S
USMG5 up-regulated during skeletal muscle growth 5 homolog (mouse)
USP21 ubiquitin specific peptidase 21
USP3 ubiquitin specific peptidase 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VIM vimentin
WDR6 WD repeat domain 6
XPO1 exportin 1
XPO5 exportin 5
XPOT exportin, tRNA
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6