IGF1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description insulin-like growth factor 1 (somatomedin C)|The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 3479)
External Link http://www.ncbi.nlm.nih.gov/gene/3479
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67 interacting proteins for IGF1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BCAR1 breast cancer anti-estrogen resistance 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTSB cathepsin B
CTSG cathepsin G
E2F1 E2F transcription factor 1
ESR1 estrogen receptor 1
F2 coagulation factor II (thrombin)
FN1 fibronectin 1
GHRL ghrelin/obestatin prepropeptide
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HNF4A hepatocyte nuclear factor 4, alpha
HRAS Harvey rat sarcoma viral oncogene homolog
IDE insulin-degrading enzyme
IGF1R insulin-like growth factor 1 receptor
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IGSF1 immunoglobulin superfamily, member 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUP junction plakoglobin
KLK1 kallikrein 1
KLK13 kallikrein-related peptidase 13
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KLKB1 kallikrein B, plasma (Fletcher factor) 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
NOV nephroblastoma overexpressed
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PELP1 proline, glutamate and leucine rich protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLG plasminogen
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKD1 protein kinase D1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PXN paxillin
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TF transferrin
VTN vitronectin
WISP2 WNT1 inducible signaling pathway protein 2