IGF1R Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description insulin-like growth factor 1 receptor|This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 3480)
Similar Terms
Downloads & Tools

Genes

287 genes differentially expressed following the IGF1R gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KDM3B lysine (K)-specific demethylase 3B 2.53277
CLEC19A C-type lectin domain family 19, member A 2.53277
GJB5 gap junction protein, beta 5, 31.1kDa 2.53277
PAX7 paired box 7 2.53277
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.53277
FETUB fetuin B 2.53277
TYRP1 tyrosinase-related protein 1 2.53277
FAM156B family with sequence similarity 156, member B 2.53277
SSTR5 somatostatin receptor 5 2.53277
ASPA aspartoacylase 2.53277
HGD homogentisate 1,2-dioxygenase 2.53277
ZNF469 zinc finger protein 469 2.53277
ZFP57 ZFP57 zinc finger protein 2.53277
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.53277
FBXL2 F-box and leucine-rich repeat protein 2 2.53277
KNG1 kininogen 1 2.53277
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.53277
PLIN4 perilipin 4 2.53277
NUP50 nucleoporin 50kDa 2.53277
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.53277
TMEM176B transmembrane protein 176B 2.53277
CAMP cathelicidin antimicrobial peptide 2.53277
NUGGC nuclear GTPase, germinal center associated 2.53277
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.53277
SOWAHB sosondowah ankyrin repeat domain family member B 2.53277
ATOH7 atonal homolog 7 (Drosophila) 2.53277
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.53277
HMX3 H6 family homeobox 3 2.53277
SPACA3 sperm acrosome associated 3 2.53277
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.53277
IL18R1 interleukin 18 receptor 1 2.53277
BOLA2 bolA family member 2 2.53277
ERAP2 endoplasmic reticulum aminopeptidase 2 2.53277
SKOR1 SKI family transcriptional corepressor 1 2.53277
CRX cone-rod homeobox 2.53277
SHISA7 shisa family member 7 2.53277
KCNRG potassium channel regulator 2.53277
LYZL6 lysozyme-like 6 2.53277
BIRC3 baculoviral IAP repeat containing 3 2.53277
PTGFR prostaglandin F receptor (FP) 2.53277
CXCL2 chemokine (C-X-C motif) ligand 2 2.53277
ADAMTSL5 ADAMTS-like 5 2.53277
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.53277
RPL3L ribosomal protein L3-like 2.53277
C1ORF146 chromosome 1 open reading frame 146 2.53277
RNASE6 ribonuclease, RNase A family, k6 2.53277
SPATA31H1 SPATA31 subfamily H member 1 2.53277
FMOD fibromodulin 2.53277
PLCZ1 phospholipase C, zeta 1 2.53277
IQCF1 IQ motif containing F1 2.53277
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.53277
TSPAN8 tetraspanin 8 2.53277
TBX10 T-box 10 2.53277
GATA5 GATA binding protein 5 2.53277
RNF183 ring finger protein 183 2.53277
COX8C cytochrome c oxidase subunit VIIIC 2.53277
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.53277
TCERG1L transcription elongation regulator 1-like 2.53277
PTH1R parathyroid hormone 1 receptor 2.53277
GREP1 glycine rich extracellular protein 1 2.53277
H4C14 H4 clustered histone 14 2.53277
MYMK myomaker, myoblast fusion factor 2.53277
IHO1 interactor of HORMAD1 1 2.53277
CFAP107 cilia and flagella associated protein 107 2.53277
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.53277
DYNLT4 dynein light chain Tctex-type 4 2.53277
PLAAT4 phospholipase A and acyltransferase 4 2.53277
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.53277
PGA5 pepsinogen 5, group I (pepsinogen A) 2.53277
C7ORF57 chromosome 7 open reading frame 57 2.53277
LIPK lipase, family member K 2.53277
CPED1 cadherin-like and PC-esterase domain containing 1 2.53277
TBX20 T-box 20 2.53277
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.53277
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.53277
SYCP1 synaptonemal complex protein 1 2.53277
SYCP2 synaptonemal complex protein 2 2.53277
GPR6 G protein-coupled receptor 6 2.53277
PIGR polymeric immunoglobulin receptor 2.53277
PCDHA8 protocadherin alpha 8 2.53277
OASL 2'-5'-oligoadenylate synthetase-like 2.53277
PTPRH protein tyrosine phosphatase, receptor type, H 2.53277
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.53277
MYOG myogenin (myogenic factor 4) 2.53277
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.53277
KLRF2 killer cell lectin-like receptor subfamily F, member 2 2.53277
TBX3 T-box 3 2.53277
TLR4 toll-like receptor 4 2.53277
CATSPERD catsper channel auxiliary subunit delta 2.53277
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.53277
TRIM67 tripartite motif containing 67 2.53277
FOXL1 forkhead box L1 2.53277
KISS1 KiSS-1 metastasis-suppressor 2.53277
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.53277
SIGLEC11 sialic acid binding Ig-like lectin 11 2.53277
PRSS38 protease, serine, 38 2.53277
GCOM1 GRINL1A complex locus 1 2.53277
OTOP1 otopetrin 1 2.53277
AQP3 aquaporin 3 (Gill blood group) 2.53277
IDI2 isopentenyl-diphosphate delta isomerase 2 2.53277
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.53277
ANKRD6 ankyrin repeat domain 6 2.53277
RNF111 ring finger protein 111 2.53277
KRTAP19-6 keratin associated protein 19-6 2.53277
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.53277
PAGE4 P antigen family, member 4 (prostate associated) 2.53277
TMEM242 transmembrane protein 242 2.53277
PSG8 pregnancy specific beta-1-glycoprotein 8 2.53277
TRIM7 tripartite motif containing 7 2.53277
PALMD palmdelphin 2.53277
PRM1 protamine 1 2.53277
OR1M1 olfactory receptor, family 1, subfamily M, member 1 2.53277
ISL2 ISL LIM homeobox 2 2.53277
VWA3B von Willebrand factor A domain containing 3B 2.53277
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.53277
TTC16 tetratricopeptide repeat domain 16 2.53277
EVPLL envoplakin-like 2.53277
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 2.53277
PCDHGA2 protocadherin gamma subfamily A, 2 2.53277
DRD1 dopamine receptor D1 2.53277
FAM135B family with sequence similarity 135, member B 2.53277
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.53277
BSPH1 binder of sperm protein homolog 1 2.53277
C16ORF78 chromosome 16 open reading frame 78 2.53277
BAIAP2L2 BAI1-associated protein 2-like 2 2.53277
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 2.53277
TPSB2 tryptase beta 2 (gene/pseudogene) 2.53277
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.53277
OR2AK2 olfactory receptor, family 2, subfamily AK, member 2 2.53277
SPTBN5 spectrin, beta, non-erythrocytic 5 2.53277
LRCOL1 leucine rich colipase-like 1 2.53277
PCDHGB1 protocadherin gamma subfamily B, 1 2.53277
PLA2G2C phospholipase A2, group IIC 2.53277
SLFN12L schlafen family member 12-like 2.53277
ECM1 extracellular matrix protein 1 2.53277
TEX35 testis expressed 35 2.53277
SUN5 Sad1 and UNC84 domain containing 5 2.53277
CCDC170 coiled-coil domain containing 170 2.53277
C22ORF31 chromosome 22 open reading frame 31 2.53277
POTEF POTE ankyrin domain family, member F 2.53277
STMND1 stathmin domain containing 1 2.53277
PCSK2 proprotein convertase subtilisin/kexin type 2 2.53277
MEPE matrix extracellular phosphoglycoprotein 2.53277
FOXP3 forkhead box P3 2.53277
ETV3L ets variant 3-like 2.53277
PRSS58 protease, serine, 58 2.53277
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.53277
PRSS57 protease, serine, 57 2.53277
PCDHGB5 protocadherin gamma subfamily B, 5 2.53277
CABP7 calcium binding protein 7 2.53277
KRTAP10-2 keratin associated protein 10-2 2.53277
CYBB cytochrome b-245, beta polypeptide 2.53277
KLHL10 kelch-like family member 10 2.53277
FOXG1 forkhead box G1 2.53277
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.53277
NPR3 natriuretic peptide receptor 3 2.53277
POU4F1 POU class 4 homeobox 1 2.53277
FXYD2 FXYD domain containing ion transport regulator 2 2.53277
ANKRD30B ankyrin repeat domain 30B 2.53277
GHRH growth hormone releasing hormone 2.53277
GPR179 G protein-coupled receptor 179 2.53277
TEX38 testis expressed 38 2.53277
ELP6 elongator acetyltransferase complex subunit 6 2.46876
CHL1 cell adhesion molecule L1-like 2.40112
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.40112
IGFL4 IGF-like family member 4 2.40112
CD5 CD5 molecule 2.38996
TMED8 transmembrane emp24 protein transport domain containing 8 2.33955
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 2.3218
SV2C synaptic vesicle glycoprotein 2C 2.29915
CCL25 chemokine (C-C motif) ligand 25 2.29915
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.28952
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.27169
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.26622
CSPG4 chondroitin sulfate proteoglycan 4 2.26622
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.26622
KLF12 Kruppel-like factor 12 2.26622
GOLGA6L10 golgin A6 family-like 10 2.26206
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2.25992
RUBCNL rubicon like autophagy enhancer 2.24365
ZNF354B zinc finger protein 354B 2.24365
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.24365
ZNF577 zinc finger protein 577 2.21768
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 2.21682
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 2.21426
KLRD1 killer cell lectin-like receptor subfamily D, member 1 2.20799
LRRC36 leucine rich repeat containing 36 2.19691
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.16943
C12ORF56 chromosome 12 open reading frame 56 2.16484
BCLAF1 BCL2-associated transcription factor 1 2.1483
RNFT1 ring finger protein, transmembrane 1 2.13992
THOC6 THO complex 6 2.13267
ERC2 ELKS/RAB6-interacting/CAST family member 2 2.11779
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 2.11779
VSIG10L V-set and immunoglobulin domain containing 10 like 2.11463
ESYT2 extended synaptotagmin-like protein 2 2.11004
ADAT2 adenosine deaminase, tRNA-specific 2 2.10558
CAT catalase 2.08735
EFNA4 ephrin-A4 2.08282
DUSP14 dual specificity phosphatase 14 2.0782
HTATSF1 HIV-1 Tat specific factor 1 2.07606
MED11 mediator complex subunit 11 2.07451
GRK2 G protein-coupled receptor kinase 2 2.06803
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.06732
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 2.05677
CDK14 cyclin-dependent kinase 14 2.0157
MTMR2 myotubularin related protein 2 2.0157
RAB40B RAB40B, member RAS oncogene family 2.01394
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.00963
TRPC3 transient receptor potential cation channel, subfamily C, member 3 2.00905
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2.00411
RBBP6 retinoblastoma binding protein 6 2.00347
ULK3 unc-51 like kinase 3 2.00172
ZNRD2 zinc ribbon domain containing 2 2.00141

decreased expression

Symbol Name Standardized Value
ZFR2 zinc finger RNA binding protein 2 -2.53277
COG4 component of oligomeric golgi complex 4 -2.53277
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.53277
GAL3ST2 galactose-3-O-sulfotransferase 2 -2.53277
BMX BMX non-receptor tyrosine kinase -2.53277
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.53277
DNAI2 dynein, axonemal, intermediate chain 2 -2.53277
UPK3A uroplakin 3A -2.53277
SOX6 SRY (sex determining region Y)-box 6 -2.53277
FRMPD1 FERM and PDZ domain containing 1 -2.53277
SEZ6 seizure related 6 homolog (mouse) -2.53277
MCM9 minichromosome maintenance complex component 9 -2.53277
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -2.53277
CAPS calcyphosine -2.53277
ATP8B4 ATPase, class I, type 8B, member 4 -2.53277
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -2.53277
MYOT myotilin -2.53277
IQCN IQ motif containing N -2.53277
MYLK4 myosin light chain kinase family, member 4 -2.53277
DENND2D DENN/MADD domain containing 2D -2.53277
UBXN10 UBX domain protein 10 -2.53277
SCNN1D sodium channel, non voltage gated 1 delta subunit -2.53277
ALOX12 arachidonate 12-lipoxygenase -2.53277
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.53277
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.53277
POU2F2 POU class 2 homeobox 2 -2.53277
CLEC4D C-type lectin domain family 4, member D -2.53277
GDF6 growth differentiation factor 6 -2.53277
LRRC26 leucine rich repeat containing 26 -2.53277
LOC122526780 uncharacterized LOC122526780 -2.53277
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.52231
TRDN triadin -2.42542
CCDC127 coiled-coil domain containing 127 -2.40605
IGF1R insulin-like growth factor 1 receptor -2.37747
ZNF501 zinc finger protein 501 -2.35317
CHLSN cholesin -2.3218
TAPBP TAP binding protein (tapasin) -2.32103
KLF9 Kruppel-like factor 9 -2.32103
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.30586
PTCH2 patched 2 -2.29959
TFDP1 transcription factor Dp-1 -2.27901
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 -2.27253
COQ10A coenzyme Q10 homolog A (S. cerevisiae) -2.26297
TVP23C trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) -2.25955
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.24651
DHRS11 dehydrogenase/reductase (SDR family) member 11 -2.24106
LRRN3 leucine rich repeat neuronal 3 -2.22452
DGCR2 DiGeorge syndrome critical region gene 2 -2.22155
SCLY selenocysteine lyase -2.19102
LETMD1 LETM1 domain containing 1 -2.17798
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 -2.14537
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 -2.13572
ECI2 enoyl-CoA delta isomerase 2 -2.13572
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.13572
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -2.13572
ZFAND5 zinc finger, AN1-type domain 5 -2.13572
ITPRIPL1 inositol 1,4,5-trisphosphate receptor interacting protein-like 1 -2.13572
IFI27 interferon, alpha-inducible protein 27 -2.13572
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.13554
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -2.12769
HEXA hexosaminidase A (alpha polypeptide) -2.09382
ABHD14A abhydrolase domain containing 14A -2.06803
TBP TATA box binding protein -2.06294
PRAM1 PML-RARA regulated adaptor molecule 1 -2.06294
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -2.06294
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -2.06294
E2F6 E2F transcription factor 6 -2.05078
EIF3M eukaryotic translation initiation factor 3, subunit M -2.04822
SESN2 sestrin 2 -2.02958
SLC26A5 solute carrier family 26 (anion exchanger), member 5 -2.02526
ASXL2 additional sex combs like transcriptional regulator 2 -2.01972
SENP5 SUMO1/sentrin specific peptidase 5 -2.0157
LAMC2 laminin, gamma 2 -2.0091