IGF1R Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description insulin-like growth factor 1 receptor|This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 3480)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase IGF1R from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
N4BP3 NEDD4 binding protein 3 99.98
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 99.91
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 99.91
MRPS27 mitochondrial ribosomal protein S27 99.89
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.87
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.87
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 99.78
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 99.76
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 99.74
F5 coagulation factor V (proaccelerin, labile factor) 99.71
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 99.69
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 99.67
TRPC6 transient receptor potential cation channel, subfamily C, member 6 99.65
PDCD5 programmed cell death 5 99.65
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 99.61
ARHGAP30 Rho GTPase activating protein 30 99.59
GPATCH11 G patch domain containing 11 99.56
RCN2 reticulocalbin 2, EF-hand calcium binding domain 99.48
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 99.26
THEMIS2 thymocyte selection associated family member 2 99.15
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 99.12
ALOX5 arachidonate 5-lipoxygenase 99.08
VSTM4 V-set and transmembrane domain containing 4 99.04
IRS4 insulin receptor substrate 4 99.035
MCC mutated in colorectal cancers 98.97
PTPRA protein tyrosine phosphatase, receptor type, A 98.93
PDS5B PDS5 cohesin associated factor B 98.91
TLK1 tousled-like kinase 1 98.88
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 98.86
PTPN7 protein tyrosine phosphatase, non-receptor type 7 98.78
ZCCHC3 zinc finger, CCHC domain containing 3 98.77
PLXDC2 plexin domain containing 2 98.75
SON SON DNA binding protein 98.705
EIF3I eukaryotic translation initiation factor 3, subunit I 98.66
PDCD1 programmed cell death 1 98.655
PTPRE protein tyrosine phosphatase, receptor type, E 98.56
SIGLEC10 sialic acid binding Ig-like lectin 10 98.56
PARD6B par-6 family cell polarity regulator beta 98.55
CKS1B CDC28 protein kinase regulatory subunit 1B 98.51
TNN tenascin N 98.4
EIF1B eukaryotic translation initiation factor 1B 98.38
EIF1 eukaryotic translation initiation factor 1 98.38
KLRF2 killer cell lectin-like receptor subfamily F, member 2 98.31
LST1 leukocyte specific transcript 1 98.31
MFAP1 microfibrillar-associated protein 1 98.285
GRAMD4 GRAM domain containing 4 98.18
RABL6 RAB, member RAS oncogene family-like 6 98.16
TLK2 tousled-like kinase 2 98.14
ZNF598 zinc finger protein 598 98.05
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 98.01
HDAC3 histone deacetylase 3 97.97
LURAP1L leucine rich adaptor protein 1-like 97.97
SH2D1B SH2 domain containing 1B 97.94
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 97.92
CHRM2 cholinergic receptor, muscarinic 2 97.88
GCSAML germinal center-associated, signaling and motility-like 97.875
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 97.845
DLG2 discs, large homolog 2 (Drosophila) 97.64
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 97.635
KCTD12 potassium channel tetramerization domain containing 12 97.62
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 97.61
DLG3 discs, large homolog 3 (Drosophila) 97.53
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 97.5
CLEC12B C-type lectin domain family 12, member B 97.46
VWA5A von Willebrand factor A domain containing 5A 97.31
MX2 MX dynamin-like GTPase 2 97.29
DPF2 D4, zinc and double PHD fingers family 2 97.27
MYL12B myosin, light chain 12B, regulatory 97.24
TRIOBP TRIO and F-actin binding protein 97.24
ACE2 angiotensin I converting enzyme 2 97.15
CD300LB CD300 molecule-like family member b 97.09
PM20D2 peptidase M20 domain containing 2 97.04
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 97.02
PELP1 proline, glutamate and leucine rich protein 1 97.0
DCTN4 dynactin 4 (p62) 96.96
RNPS1 RNA binding protein S1, serine-rich domain 96.93
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 96.91
LRP4 low density lipoprotein receptor-related protein 4 96.8
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 96.74
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 96.72
TRPV2 transient receptor potential cation channel, subfamily V, member 2 96.7
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 96.69
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 96.58
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 96.56
MCEMP1 mast cell-expressed membrane protein 1 96.46
EML4 echinoderm microtubule associated protein like 4 96.43
SHROOM1 shroom family member 1 96.41
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 96.35
IL7R interleukin 7 receptor 96.34
MAGED2 melanoma antigen family D2 96.24
CEP43 centrosomal protein 43 96.23
STAMBPL1 STAM binding protein-like 1 96.13
IPO8 importin 8 96.11
ESYT2 extended synaptotagmin-like protein 2 96.1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 96.0
CEP170B centrosomal protein 170B 95.97
IKZF3 IKAROS family zinc finger 3 (Aiolos) 95.93
CNOT9 CCR4-NOT transcription complex subunit 9 95.91
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 95.82
PA2G4 proliferation-associated 2G4, 38kDa 95.8