IGF1R Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description insulin-like growth factor 1 receptor|This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 3480)
External Link http://www.ncbi.nlm.nih.gov/gene/3480
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Genes

186 interacting proteins for IGF1R from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AMY2A amylase, alpha 2A (pancreatic)
APP amyloid beta (A4) precursor protein
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATM ATM serine/threonine kinase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
BCAR1 breast cancer anti-estrogen resistance 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BMP2K BMP2 inducible kinase
BRD3 bromodomain containing 3
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAMP cathelicidin antimicrobial peptide
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CDK12 cyclin-dependent kinase 12
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDK5 cyclin-dependent kinase 5
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK1A1L casein kinase 1, alpha 1-like
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G1 casein kinase 1, gamma 1
CSNK1G2 casein kinase 1, gamma 2
CSNK1G3 casein kinase 1, gamma 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
DOK4 docking protein 4
DOK5 docking protein 5
EEA1 early endosome antigen 1
EGFR epidermal growth factor receptor
EHD1 EH-domain containing 1
EPHA2 EPH receptor A2
EPHA5 EPH receptor A5
EPHA7 EPH receptor A7
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
FBXO6 F-box protein 6
FER fer (fps/fes related) tyrosine kinase
FES FES proto-oncogene, tyrosine kinase
FFAR2 free fatty acid receptor 2
FGR FGR proto-oncogene, Src family tyrosine kinase
FN1 fibronectin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAK cyclin G associated kinase
GIGYF1 GRB10 interacting GYF protein 1
GIPC1 GIPC PDZ domain containing family, member 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HNF1A HNF1 homeobox A
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUP junction plakoglobin
KL klotho
KRT27 keratin 27, type I
LEF1 lymphoid enhancer-binding factor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MELK maternal embryonic leucine zipper kinase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NAMPT nicotinamide phosphoribosyltransferase
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEK9 NIMA-related kinase 9
NLK nemo-like kinase
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDPK1 3-phosphoinositide dependent protein kinase 1
PELP1 proline, glutamate and leucine rich protein 1
PHB2 prohibitin 2
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCD protein kinase C, delta
PRKCG protein kinase C, gamma
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PXN paxillin
RASA1 RAS p21 protein activator (GTPase activating protein) 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL11 ribosomal protein L11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUVBL1 RuvB-like AAA ATPase 1
SGK1 serum/glucocorticoid regulated kinase 1
SH2B1 SH2B adaptor protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK3 SIK family kinase 3
SLC23A3 solute carrier family 23, member 3
SLK STE20-like kinase
SNAP29 synaptosomal-associated protein, 29kDa
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SPEG SPEG complex locus
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK16 serine/threonine kinase 16
SUMO1 small ubiquitin-like modifier 1
TAGLN transgelin
TBK1 TANK-binding kinase 1
TEC tec protein tyrosine kinase
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TRIM28 tripartite motif containing 28
TYK2 tyrosine kinase 2
UBC ubiquitin C
ULK3 unc-51 like kinase 3
VAV3 vav 3 guanine nucleotide exchange factor
WEE1 WEE1 G2 checkpoint kinase
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta