IGF1R Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description insulin-like growth factor 1 receptor|This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 3480)
External Link http://www.ncbi.nlm.nih.gov/gene/3480
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5 substrates of the kinase IGF1R from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
CRK v-crk avian sarcoma virus CT10 oncogene homolog
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
PDPK1 3-phosphoinositide dependent protein kinase 1
SIRPA signal-regulatory protein alpha