IGF1R_knockdown_52_GSE16684 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16684
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Genes

600 genes differentially expressed following the IGF1R_knockdown_52_GSE16684 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
GBP7 guanylate binding protein 7 4.53525
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 4.33792
GBP2 guanylate binding protein 2, interferon-inducible 3.90909
NMI N-myc (and STAT) interactor 3.8328
BCAR3 breast cancer anti-estrogen resistance 3 3.80574
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 3.78584
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 3.76537
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 3.6985
PRMT2 protein arginine methyltransferase 2 3.57943
GDF3 growth differentiation factor 3 3.53762
SLFN5 schlafen family member 5 3.47129
GEMIN5 gem (nuclear organelle) associated protein 5 3.44119
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 3.33868
TRAPPC2L trafficking protein particle complex 2-like 3.28969
WSB2 WD repeat and SOCS box containing 2 3.24501
TMEM180 transmembrane protein 180 3.2047
LDAH lipid droplet associated hydrolase 3.2047
IFITM3 interferon induced transmembrane protein 3 3.18117
MRPL30 mitochondrial ribosomal protein L30 3.14802
OASL 2'-5'-oligoadenylate synthetase-like 3.13476
FCF1 FCF1 rRNA-processing protein 3.11433
IRF1 interferon regulatory factor 1 3.10318
CHMP4B charged multivesicular body protein 4B 3.07562
PHF11 PHD finger protein 11 3.01487
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.96455
CD274 CD274 molecule 2.9557
SLFN13 schlafen family member 13 2.93381
SETDB2 SET domain, bifurcated 2 2.89959
GBP6 guanylate binding protein family, member 6 2.89455
ABHD11 abhydrolase domain containing 11 2.89366
DTX3L deltex 3 like, E3 ubiquitin ligase 2.85075
TTC4 tetratricopeptide repeat domain 4 2.84344
UBC ubiquitin C 2.79139
SAMD9L sterile alpha motif domain containing 9-like 2.7721
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 2.77036
TRIM25 tripartite motif containing 25 2.76854
EDF1 endothelial differentiation-related factor 1 2.76843
C14ORF1 chromosome 14 open reading frame 1 2.76792
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2.7398
RSPH3 radial spoke 3 homolog (Chlamydomonas) 2.73593
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.71683
RPS27A ribosomal protein S27a 2.71598
ATF5 activating transcription factor 5 2.66773
IFI35 interferon-induced protein 35 2.65382
DUSP13 dual specificity phosphatase 13 2.65344
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 2.62074
PPP1R3E protein phosphatase 1, regulatory subunit 3E 2.55488
LGALS8 lectin, galactoside-binding, soluble, 8 2.55287
FAM46A family with sequence similarity 46, member A 2.53195
NME1 NME/NM23 nucleoside diphosphate kinase 1 2.52762
RANGRF RAN guanine nucleotide release factor 2.52229
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.50984
SDHAF2 succinate dehydrogenase complex assembly factor 2 2.47019
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 2.44295
EMC1 ER membrane protein complex subunit 1 2.43344
ZNHIT2 zinc finger, HIT-type containing 2 2.42549
ARMCX5 armadillo repeat containing, X-linked 5 2.39214
TEK TEK tyrosine kinase, endothelial 2.35687
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.35167
IRGM immunity-related GTPase family, M 2.34814
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.33701
PLIN2 perilipin 2 2.33461
C18ORF32 chromosome 18 open reading frame 32 2.31983
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.31237
C14ORF166 chromosome 14 open reading frame 166 2.29693
PCDHB2 protocadherin beta 2 2.29354
NT5C 5', 3'-nucleotidase, cytosolic 2.29023
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.28761
SHCBP1L SHC SH2-domain binding protein 1-like 2.26285
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.25293
APOBR apolipoprotein B receptor 2.24836
PLAC8 placenta-specific 8 2.22912
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 2.2229
B2M beta-2-microglobulin 2.21933
METTL21A methyltransferase like 21A 2.19959
GSTO1 glutathione S-transferase omega 1 2.19447
SUMO1 small ubiquitin-like modifier 1 2.18998
C10ORF105 chromosome 10 open reading frame 105 2.18608
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.17181
EXOC8 exocyst complex component 8 2.15806
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.14997
FAM129A family with sequence similarity 129, member A 2.14707
APLN apelin 2.13724
GRN granulin 2.12843
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 2.12813
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.11446
PHAX phosphorylated adaptor for RNA export 2.11308
RPL27 ribosomal protein L27 2.11241
LHX1 LIM homeobox 1 2.11031
HERPUD2 HERPUD family member 2 2.10086
NHP2 NHP2 ribonucleoprotein 2.09982
RSAD2 radical S-adenosyl methionine domain containing 2 2.0977
CUTA cutA divalent cation tolerance homolog (E. coli) 2.0811
ATG5 autophagy related 5 2.06725
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.06116
TMEM160 transmembrane protein 160 2.04658
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.03804
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.03744
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 2.03043
IRF7 interferon regulatory factor 7 2.02713
TMEM106A transmembrane protein 106A 2.02624
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 2.02415
RPS9 ribosomal protein S9 2.02084
HLA-G major histocompatibility complex, class I, G 2.01366
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.01251
MRPS34 mitochondrial ribosomal protein S34 2.00707
SNF8 SNF8, ESCRT-II complex subunit 2.00451
HELZ2 helicase with zinc finger 2, transcriptional coactivator 1.99749
STAT1 signal transducer and activator of transcription 1, 91kDa 1.98992
RNF19B ring finger protein 19B 1.98055
TEX2 testis expressed 2 1.97619
ZNHIT1 zinc finger, HIT-type containing 1 1.96406
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 1.95554
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 1.95396
CALML4 calmodulin-like 4 1.94498
DCPS decapping enzyme, scavenger 1.94201
PARP14 poly (ADP-ribose) polymerase family, member 14 1.92976
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.91946
TPP1 tripeptidyl peptidase I 1.91246
RASAL3 RAS protein activator like 3 1.9054
TMEM102 transmembrane protein 102 1.89273
FLAD1 flavin adenine dinucleotide synthetase 1 1.88895
GCH1 GTP cyclohydrolase 1 1.88603
TMEM14C transmembrane protein 14C 1.86354
GBA glucosidase, beta, acid 1.86072
NLRC5 NLR family, CARD domain containing 5 1.85617
CSTB cystatin B (stefin B) 1.85249
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 1.8457
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 1.84367
RPS19BP1 ribosomal protein S19 binding protein 1 1.84105
XDH xanthine dehydrogenase 1.83554
VDAC2 voltage-dependent anion channel 2 1.82892
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 1.82722
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 1.82536
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.81451
DCTN3 dynactin 3 (p22) 1.8114
NMUR2 neuromedin U receptor 2 1.81062
IL2RA interleukin 2 receptor, alpha 1.81028
SMIM7 small integral membrane protein 7 1.80924
ZBP1 Z-DNA binding protein 1 1.80816
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 1.80798
ISG20 interferon stimulated exonuclease gene 20kDa 1.80477
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1.79763
PARP12 poly (ADP-ribose) polymerase family, member 12 1.79162
CCDC107 coiled-coil domain containing 107 1.79159
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 1.78914
RIPK2 receptor-interacting serine-threonine kinase 2 1.78784
WDR6 WD repeat domain 6 1.77081
MITD1 MIT, microtubule interacting and transport, domain containing 1 1.77074
CRBN cereblon 1.75772
CCL5 chemokine (C-C motif) ligand 5 1.75351
CMC4 C-x(9)-C motif containing 4 1.7524
XAF1 XIAP associated factor 1 1.75123
COX15 cytochrome c oxidase assembly homolog 15 (yeast) 1.74944
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 1.74848
ECSIT ECSIT signalling integrator 1.74769
USP18 ubiquitin specific peptidase 18 1.74657
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.74069
TBRG1 transforming growth factor beta regulator 1 1.73371
FBXO7 F-box protein 7 1.7337
GNG2 guanine nucleotide binding protein (G protein), gamma 2 1.71716
MYL1 myosin, light chain 1, alkali; skeletal, fast 1.70806
RINL Ras and Rab interactor-like 1.7059
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 1.70428
RGS2 regulator of G-protein signaling 2 1.70256
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 1.70143
CXCL10 chemokine (C-X-C motif) ligand 10 1.68972
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 1.68812
VAMP8 vesicle-associated membrane protein 8 1.68734
AACS acetoacetyl-CoA synthetase 1.67802
SEPW1 selenoprotein W, 1 1.66309
CYB5A cytochrome b5 type A (microsomal) 1.65066
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 1.64522
TEX36 testis expressed 36 1.63689
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 1.63538
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 1.62496
MRPL24 mitochondrial ribosomal protein L24 1.62386
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 1.62357
GTPBP10 GTP-binding protein 10 (putative) 1.61396
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 1.61154
TATDN1 TatD DNase domain containing 1 1.60993
IFI44 interferon-induced protein 44 1.60989
RTP4 receptor (chemosensory) transporter protein 4 1.6007
SAMHD1 SAM domain and HD domain 1 1.59965
URM1 ubiquitin related modifier 1 1.58931
VCPKMT valosin containing protein lysine (K) methyltransferase 1.58776
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 1.5849
TAPBPL TAP binding protein-like 1.58471
DCTN6 dynactin 6 1.58384
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 1.58342
CYFIP1 cytoplasmic FMR1 interacting protein 1 1.58248
EIF4E2 eukaryotic translation initiation factor 4E family member 2 1.58232
GSPT2 G1 to S phase transition 2 1.58065
MRPL27 mitochondrial ribosomal protein L27 1.58044
BRI3 brain protein I3 1.5764
RBKS ribokinase 1.57514
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 1.56647
USB1 U6 snRNA biogenesis 1 1.56243
TSTA3 tissue specific transplantation antigen P35B 1.56191
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.55831
TEX19 testis expressed 19 1.55716
KIF1B kinesin family member 1B 1.55576
N6AMT2 N-6 adenine-specific DNA methyltransferase 2 (putative) 1.55469
TMEM208 transmembrane protein 208 1.54728
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.53881
TRIM21 tripartite motif containing 21 1.53683
PSENEN presenilin enhancer gamma secretase subunit 1.52534
TDRD7 tudor domain containing 7 1.51764
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 1.51403
ELOVL1 ELOVL fatty acid elongase 1 1.5125
IL18 interleukin 18 1.51222
ECI1 enoyl-CoA delta isomerase 1 1.51121
CCL22 chemokine (C-C motif) ligand 22 1.50451
SAR1B secretion associated, Ras related GTPase 1B 1.50376
GAA glucosidase, alpha; acid 1.5032
CCDC71L coiled-coil domain containing 71-like 1.50182
HEXA hexosaminidase A (alpha polypeptide) 1.49561
WDFY2 WD repeat and FYVE domain containing 2 1.49458
SF3A3 splicing factor 3a, subunit 3, 60kDa 1.49415
MIEN1 migration and invasion enhancer 1 1.49266
IFI16 interferon, gamma-inducible protein 16 1.48563
RENBP renin binding protein 1.48556
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.48131
MEX3A mex-3 RNA binding family member A 1.47404
RPS19 ribosomal protein S19 1.47156
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 1.46682
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 1.46568
TMEM176B transmembrane protein 176B 1.46432
CWC15 CWC15 spliceosome-associated protein 1.46296
PARP9 poly (ADP-ribose) polymerase family, member 9 1.4605
MSTO1 misato 1, mitochondrial distribution and morphology regulator 1.45836
FAM84B family with sequence similarity 84, member B 1.45421
SZRD1 SUZ RNA binding domain containing 1 1.45345
RPL27A ribosomal protein L27a 1.45021
MCTS1 malignant T cell amplified sequence 1 1.45007
RAB22A RAB22A, member RAS oncogene family 1.4398
VTI1B vesicle transport through interaction with t-SNAREs 1B 1.43851
PDDC1 Parkinson disease 7 domain containing 1 1.4339
ARRB2 arrestin, beta 2 1.43334
SEC61G Sec61 gamma subunit 1.43022
TSPO translocator protein (18kDa) 1.42679
GBP4 guanylate binding protein 4 1.41897
LIMD2 LIM domain containing 2 1.4155
COX18 COX18 cytochrome c oxidase assembly factor 1.41153
SHISA5 shisa family member 5 1.41024
NR2C1 nuclear receptor subfamily 2, group C, member 1 1.40551
UBASH3B ubiquitin associated and SH3 domain containing B 1.40034
ADAR adenosine deaminase, RNA-specific 1.39937
PDCD1LG2 programmed cell death 1 ligand 2 1.39796
PQBP1 polyglutamine binding protein 1 1.39774
TMEM71 transmembrane protein 71 1.39724
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 1.39638
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 1.39526
WDR81 WD repeat domain 81 1.39476
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 1.39128
ATF3 activating transcription factor 3 1.39051
MRPL36 mitochondrial ribosomal protein L36 1.38981
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 1.38721
CD300LB CD300 molecule-like family member b 1.38556
PLSCR1 phospholipid scramblase 1 1.38556
SIX4 SIX homeobox 4 1.37814
HLA-A major histocompatibility complex, class I, A 1.37793
ELOF1 elongation factor 1 homolog (S. cerevisiae) 1.37246
POLM polymerase (DNA directed), mu 1.37203
MRPL16 mitochondrial ribosomal protein L16 1.37075
COMMD4 COMM domain containing 4 1.3661
RNF213 ring finger protein 213 1.35598
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 1.3553
IFT22 intraflagellar transport 22 1.35375
VIMP VCP-interacting membrane selenoprotein 1.35172
UCKL1 uridine-cytidine kinase 1-like 1 1.34444
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 1.34375
MCOLN1 mucolipin 1 1.34267
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 1.33406
STAP1 signal transducing adaptor family member 1 1.3337
TMEM173 transmembrane protein 173 1.32922
HNRNPM heterogeneous nuclear ribonucleoprotein M 1.32575
TMEM147 transmembrane protein 147 1.32551
ZNF414 zinc finger protein 414 1.32532
TOR1AIP1 torsin A interacting protein 1 1.31442
GUCD1 guanylyl cyclase domain containing 1 1.31114
GMFG glia maturation factor, gamma 1.30892
IFIH1 interferon induced with helicase C domain 1 1.30734
RPS12 ribosomal protein S12 1.30457
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) 1.3017
SMIM19 small integral membrane protein 19 1.30101
USP34 ubiquitin specific peptidase 34 1.29898
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.29637
MEA1 male-enhanced antigen 1 1.29446
SMIM14 small integral membrane protein 14 1.29282
MED11 mediator complex subunit 11 1.2921
GMPPB GDP-mannose pyrophosphorylase B 1.29014
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1.2815
RNF215 ring finger protein 215 1.28006
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 1.27511
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 1.27238
METTL17 methyltransferase like 17 1.27188
ASPH aspartate beta-hydroxylase 1.27039
CDC73 cell division cycle 73 1.27006
SUSD6 sushi domain containing 6 1.269

decreased expression

Symbol Name Standardized Value
OPRK1 opioid receptor, kappa 1 -3.64652
S100A1 S100 calcium binding protein A1 -3.42998
PPDPF pancreatic progenitor cell differentiation and proliferation factor -3.39902
SPOP speckle-type POZ protein -3.12563
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.08198
GP9 glycoprotein IX (platelet) -2.98735
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.86586
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific -2.79371
AGBL5 ATP/GTP binding protein-like 5 -2.76663
TRRAP transformation/transcription domain-associated protein -2.67011
G6PC3 glucose 6 phosphatase, catalytic, 3 -2.61596
SLC51B solute carrier family 51, beta subunit -2.59288
PDZK1IP1 PDZK1 interacting protein 1 -2.57825
RAD18 RAD18 E3 ubiquitin protein ligase -2.55213
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -2.54815
SUN1 Sad1 and UNC84 domain containing 1 -2.54054
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -2.51972
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.49376
HELB helicase (DNA) B -2.46265
OPTN optineurin -2.3584
HN1 hematological and neurological expressed 1 -2.34024
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta -2.33685
PGP phosphoglycolate phosphatase -2.3325
PBK PDZ binding kinase -2.28347
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.26632
LCOR ligand dependent nuclear receptor corepressor -2.25106
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.21587
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.20894
RPS11 ribosomal protein S11 -2.20873
SKA1 spindle and kinetochore associated complex subunit 1 -2.20244
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 -2.19577
KLF1 Kruppel-like factor 1 (erythroid) -2.17645
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.16672
SFRP4 secreted frizzled-related protein 4 -2.15589
GFM1 G elongation factor, mitochondrial 1 -2.1504
SRRT serrate, RNA effector molecule -2.13279
MAPK1 mitogen-activated protein kinase 1 -2.10665
TACC3 transforming, acidic coiled-coil containing protein 3 -2.1038
ZNF511 zinc finger protein 511 -2.09754
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 -2.0702
RANBP1 RAN binding protein 1 -2.04272
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -2.00136
SMIM5 small integral membrane protein 5 -1.97825
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -1.96283
RECQL RecQ helicase-like -1.9477
ERP27 endoplasmic reticulum protein 27 -1.94368
TRIO trio Rho guanine nucleotide exchange factor -1.91691
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -1.90082
SRSF6 serine/arginine-rich splicing factor 6 -1.88868
BIRC5 baculoviral IAP repeat containing 5 -1.88774
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -1.886
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -1.85957
CENPF centromere protein F, 350/400kDa -1.84483
DDB2 damage-specific DNA binding protein 2, 48kDa -1.83516
KIF2A kinesin heavy chain member 2A -1.82232
ADCY6 adenylate cyclase 6 -1.81961
ALDOC aldolase C, fructose-bisphosphate -1.8144
GADD45A growth arrest and DNA-damage-inducible, alpha -1.79765
NXT1 nuclear transport factor 2-like export factor 1 -1.79764
TMPO thymopoietin -1.79508
TANGO2 transport and golgi organization 2 homolog (Drosophila) -1.79069
NCOR2 nuclear receptor corepressor 2 -1.78056
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -1.78021
SIAH1 siah E3 ubiquitin protein ligase 1 -1.7795
GM2A GM2 ganglioside activator -1.77318
ZMYM1 zinc finger, MYM-type 1 -1.76639
RPS8 ribosomal protein S8 -1.76526
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -1.76351
ORAI1 ORAI calcium release-activated calcium modulator 1 -1.76147
DCTPP1 dCTP pyrophosphatase 1 -1.75061
GABPA GA binding protein transcription factor, alpha subunit 60kDa -1.72614
UBE2C ubiquitin-conjugating enzyme E2C -1.72609
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -1.71672
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -1.71648
GABPB1 GA binding protein transcription factor, beta subunit 1 -1.71638
RETN resistin -1.71245
C15ORF43 chromosome 15 open reading frame 43 -1.70602
PFKP phosphofructokinase, platelet -1.70587
TFR2 transferrin receptor 2 -1.70011
NCAPH2 non-SMC condensin II complex, subunit H2 -1.69403
USP39 ubiquitin specific peptidase 39 -1.6926
ECI2 enoyl-CoA delta isomerase 2 -1.68774
CERCAM cerebral endothelial cell adhesion molecule -1.6841
WHSC1 Wolf-Hirschhorn syndrome candidate 1 -1.68359
RNF26 ring finger protein 26 -1.67916
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -1.66375
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -1.65732
SMC1A structural maintenance of chromosomes 1A -1.65726
JADE1 jade family PHD finger 1 -1.64527
LBR lamin B receptor -1.64292
PTEN phosphatase and tensin homolog -1.63728
ACSF2 acyl-CoA synthetase family member 2 -1.63323
ASNS asparagine synthetase (glutamine-hydrolyzing) -1.62715
TUSC1 tumor suppressor candidate 1 -1.62641
BLVRB biliverdin reductase B -1.62519
RALBP1 ralA binding protein 1 -1.62262
RAD51AP1 RAD51 associated protein 1 -1.62013
GLUL glutamate-ammonia ligase -1.61615
ECM1 extracellular matrix protein 1 -1.61007
ATXN2L ataxin 2-like -1.60519
SLA2 Src-like-adaptor 2 -1.60072
GSTM3 glutathione S-transferase mu 3 (brain) -1.59686
CKS1B CDC28 protein kinase regulatory subunit 1B -1.59101
TRIP13 thyroid hormone receptor interactor 13 -1.57754
PGK1 phosphoglycerate kinase 1 -1.57528
NCAPH non-SMC condensin I complex, subunit H -1.56992
S100A6 S100 calcium binding protein A6 -1.56776
SLAIN2 SLAIN motif family, member 2 -1.56468
ITM2A integral membrane protein 2A -1.55024
CDCA8 cell division cycle associated 8 -1.54743
TACC1 transforming, acidic coiled-coil containing protein 1 -1.54453
SYCE2 synaptonemal complex central element protein 2 -1.54149
RDM1 RAD52 motif containing 1 -1.53646
CCNA2 cyclin A2 -1.53429
ZNF367 zinc finger protein 367 -1.52729
NRIP1 nuclear receptor interacting protein 1 -1.52593
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -1.52305
MMP17 matrix metallopeptidase 17 (membrane-inserted) -1.52207
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -1.51684
SELPLG selectin P ligand -1.50274
HIST1H2BF histone cluster 1, H2bf -1.49665
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 -1.49393
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -1.48779
TSPAN2 tetraspanin 2 -1.48635
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -1.48417
PARK7 parkinson protein 7 -1.47536
TM6SF1 transmembrane 6 superfamily member 1 -1.47288
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -1.46669
KMT2C lysine (K)-specific methyltransferase 2C -1.45297
DPY30 dpy-30 homolog (C. elegans) -1.44733
MANF mesencephalic astrocyte-derived neurotrophic factor -1.43975
PLCL2 phospholipase C-like 2 -1.43596
RNASEH2C ribonuclease H2, subunit C -1.43381
TDP2 tyrosyl-DNA phosphodiesterase 2 -1.42455
RBBP4 retinoblastoma binding protein 4 -1.41854
UEVLD UEV and lactate/malate dehyrogenase domains -1.41744
HDAC1 histone deacetylase 1 -1.41437
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -1.41375
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -1.40996
PBX3 pre-B-cell leukemia homeobox 3 -1.40843
ZBTB22 zinc finger and BTB domain containing 22 -1.40399
RELL1 RELT-like 1 -1.39681
TIMELESS timeless circadian clock -1.39477
PAQR8 progestin and adipoQ receptor family member VIII -1.39324
ANKRD11 ankyrin repeat domain 11 -1.39163
CKS2 CDC28 protein kinase regulatory subunit 2 -1.3903
KCMF1 potassium channel modulatory factor 1 -1.38338
EPN1 epsin 1 -1.37788
BTG2 BTG family, member 2 -1.37636
ISM1 isthmin 1, angiogenesis inhibitor -1.37529
DAP death-associated protein -1.36903
STAG1 stromal antigen 1 -1.36539
GAS2L3 growth arrest-specific 2 like 3 -1.36458
ACOT7 acyl-CoA thioesterase 7 -1.35887
LRR1 leucine rich repeat protein 1 -1.35647
GLTP glycolipid transfer protein -1.35553
TPI1 triosephosphate isomerase 1 -1.35479
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -1.35305
BAG4 BCL2-associated athanogene 4 -1.34976
MTL5 metallothionein-like 5, testis-specific (tesmin) -1.34973
IGSF3 immunoglobulin superfamily, member 3 -1.34361
RNF157 ring finger protein 157 -1.34229
UBQLN1 ubiquilin 1 -1.33991
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -1.33323
NRL neural retina leucine zipper -1.33015
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -1.32809
EPS8 epidermal growth factor receptor pathway substrate 8 -1.3214
AMHR2 anti-Mullerian hormone receptor, type II -1.31605
SFXN1 sideroflexin 1 -1.31181
BUD13 BUD13 homolog (S. cerevisiae) -1.31043
OGG1 8-oxoguanine DNA glycosylase -1.31005
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) -1.30518
NEK7 NIMA-related kinase 7 -1.29365
NANS N-acetylneuraminic acid synthase -1.29052
C17ORF53 chromosome 17 open reading frame 53 -1.28823
FBXO34 F-box protein 34 -1.28663
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -1.28535
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -1.28416
SP1 Sp1 transcription factor -1.28215
MKI67 marker of proliferation Ki-67 -1.28185
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -1.27763
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -1.27753
PGLYRP2 peptidoglycan recognition protein 2 -1.27725
SYNDIG1L synapse differentiation inducing 1-like -1.27427
PSEN1 presenilin 1 -1.2731
SLC35G1 solute carrier family 35, member G1 -1.27098
RRM2 ribonucleotide reductase M2 -1.26988
TLE3 transducin-like enhancer of split 3 -1.26982
METTL9 methyltransferase like 9 -1.26914
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -1.2677
PTDSS1 phosphatidylserine synthase 1 -1.261
STMN1 stathmin 1 -1.25972
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -1.25872
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -1.25588
APOC2 apolipoprotein C-II -1.25303
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -1.24761
PTPRE protein tyrosine phosphatase, receptor type, E -1.24654
AGO2 argonaute RISC catalytic component 2 -1.24499
ZNF280B zinc finger protein 280B -1.24393
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -1.24205
CLEC11A C-type lectin domain family 11, member A -1.23749
MCM3 minichromosome maintenance complex component 3 -1.23514
RPL5 ribosomal protein L5 -1.2269
PSAT1 phosphoserine aminotransferase 1 -1.22199
CAST calpastatin -1.2213
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -1.221
GPX1 glutathione peroxidase 1 -1.22065
POLD2 polymerase (DNA directed), delta 2, accessory subunit -1.21728
MRPS36 mitochondrial ribosomal protein S36 -1.21725
ZNF362 zinc finger protein 362 -1.21225
EME1 essential meiotic structure-specific endonuclease 1 -1.20994
TRIM16 tripartite motif containing 16 -1.20943
CELA1 chymotrypsin-like elastase family, member 1 -1.20662
RPL23 ribosomal protein L23 -1.20492
GPSM2 G-protein signaling modulator 2 -1.20487
EMD emerin -1.20273
RAD54B RAD54 homolog B (S. cerevisiae) -1.20004
RPS28 ribosomal protein S28 -1.19999
PRDX1 peroxiredoxin 1 -1.19533
RANGAP1 Ran GTPase activating protein 1 -1.19533
RBBP7 retinoblastoma binding protein 7 -1.19504
SASS6 spindle assembly 6 homolog (C. elegans) -1.19198
PHF10 PHD finger protein 10 -1.19124
NAP1L1 nucleosome assembly protein 1-like 1 -1.19086
AES amino-terminal enhancer of split -1.19054
MROH1 maestro heat-like repeat family member 1 -1.18462
DPY19L1 dpy-19-like 1 (C. elegans) -1.18072
NOP10 NOP10 ribonucleoprotein -1.18066
SALL4 spalt-like transcription factor 4 -1.17682
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -1.17553
TBC1D16 TBC1 domain family, member 16 -1.17323
HMGN1 high mobility group nucleosome binding domain 1 -1.16773
C9ORF89 chromosome 9 open reading frame 89 -1.1648
UHRF1 ubiquitin-like with PHD and ring finger domains 1 -1.16286
GAP43 growth associated protein 43 -1.16076
KLHL6 kelch-like family member 6 -1.16056
MMS22L MMS22-like, DNA repair protein -1.1601
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) -1.15918
CMC2 C-x(9)-C motif containing 2 -1.15904
PCNA proliferating cell nuclear antigen -1.15893
RPL28 ribosomal protein L28 -1.15849
H2AFZ H2A histone family, member Z -1.15748
YY1 YY1 transcription factor -1.14969
TGFBR3 transforming growth factor, beta receptor III -1.14816
MYH9 myosin, heavy chain 9, non-muscle -1.14743
SGOL1 shugoshin-like 1 (S. pombe) -1.14724
CD9 CD9 molecule -1.14625
MAPK8 mitogen-activated protein kinase 8 -1.14587
CRLF3 cytokine receptor-like factor 3 -1.14531
ZXDC ZXD family zinc finger C -1.13783
ATP11A ATPase, class VI, type 11A -1.13635
GMNN geminin, DNA replication inhibitor -1.13616
FGFR1OP FGFR1 oncogene partner -1.13287
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -1.1282
LMTK2 lemur tyrosine kinase 2 -1.12789
CDC7 cell division cycle 7 -1.12679
PF4 platelet factor 4 -1.12545
ASXL1 additional sex combs like transcriptional regulator 1 -1.12209
TCF19 transcription factor 19 -1.12118
C5ORF24 chromosome 5 open reading frame 24 -1.11895
HAT1 histone acetyltransferase 1 -1.11791
LIG3 ligase III, DNA, ATP-dependent -1.11694
NEK2 NIMA-related kinase 2 -1.11589
HMGB2 high mobility group box 2 -1.11425
RBM22 RNA binding motif protein 22 -1.11285
NCAPG2 non-SMC condensin II complex, subunit G2 -1.11214
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.11129
H1F0 H1 histone family, member 0 -1.10833
S100A4 S100 calcium binding protein A4 -1.10703
NUCB1 nucleobindin 1 -1.10397
CBX6 chromobox homolog 6 -1.10179
PRKCH protein kinase C, eta -1.10174
RFC5 replication factor C (activator 1) 5, 36.5kDa -1.10171
DGKA diacylglycerol kinase, alpha 80kDa -1.10138
ISCA1 iron-sulfur cluster assembly 1 -1.10126
ORC6 origin recognition complex, subunit 6 -1.10056
FBXO5 F-box protein 5 -1.0988
HDLBP high density lipoprotein binding protein -1.09529
VRK1 vaccinia related kinase 1 -1.09117
ACTL6A actin-like 6A -1.09105
NDE1 nudE neurodevelopment protein 1 -1.09041
ALAD aminolevulinate dehydratase -1.08925
BLMH bleomycin hydrolase -1.08694
KRTAP3-1 keratin associated protein 3-1 -1.08615
DEF6 differentially expressed in FDCP 6 homolog (mouse) -1.0842
LMO4 LIM domain only 4 -1.07764
CDCA5 cell division cycle associated 5 -1.07734
FLOT1 flotillin 1 -1.07718
JAK1 Janus kinase 1 -1.07701
TRIB3 tribbles pseudokinase 3 -1.07581
ZCCHC6 zinc finger, CCHC domain containing 6 -1.07492
EGLN3 egl-9 family hypoxia-inducible factor 3 -1.07012
SLBP stem-loop binding protein -1.06617
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -1.06489
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -1.06452
PTRH2 peptidyl-tRNA hydrolase 2 -1.06158
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -1.05897
SRSF4 serine/arginine-rich splicing factor 4 -1.0584
KIF2C kinesin family member 2C -1.05826
RAD1 RAD1 checkpoint DNA exonuclease -1.05754