IGFBP3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description insulin-like growth factor binding protein 3|This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3486)
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Genes

321 genes differentially expressed following the IGFBP3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.0882
NFE2 nuclear factor, erythroid 2 3.0882
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.0882
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.0882
UPK3B uroplakin 3B 3.0882
NKPD1 NTPase, KAP family P-loop domain containing 1 3.0882
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.0882
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.0882
VWA7 von Willebrand factor A domain containing 7 3.0882
STAB1 stabilin 1 3.0882
WNT7B wingless-type MMTV integration site family, member 7B 3.0882
APOH apolipoprotein H (beta-2-glycoprotein I) 3.0882
LGALS2 lectin, galactoside-binding, soluble, 2 3.0882
CFAP73 cilia and flagella associated protein 73 3.0882
RDH16 retinol dehydrogenase 16 (all-trans) 3.0882
TPTE transmembrane phosphatase with tensin homology 3.0882
INSYN1 inhibitory synaptic factor 1 3.0882
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.0882
HSPB6 heat shock protein, alpha-crystallin-related, B6 3.0882
LY6L lymphocyte antigen 6 family member L 3.0882
ASCL5 achaete-scute family bHLH transcription factor 5 3.0882
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.0882
SLC22A10 solute carrier family 22, member 10 3.0882
MYO1G myosin IG 3.0311
IKZF3 IKAROS family zinc finger 3 (Aiolos) 3.0311
TSPO2 translocator protein 2 3.0311
DIO3 deiodinase, iodothyronine, type III 3.0311
PTK6 protein tyrosine kinase 6 3.0311
CRYGB crystallin, gamma B 3.0311
CCDC38 coiled-coil domain containing 38 3.0311
GPR22 G protein-coupled receptor 22 3.0311
DPPA3 developmental pluripotency associated 3 3.0311
AFMID arylformamidase 3.0311
PITX2 paired-like homeodomain 2 3.0311
PROX2 prospero homeobox 2 3.0311
GYS2 glycogen synthase 2 (liver) 3.0311
WNK4 WNK lysine deficient protein kinase 4 3.0311
LKAAEAR1 LKAAEAR motif containing 1 3.0311
KRTAP13-2 keratin associated protein 13-2 3.0311
GRM2 glutamate receptor, metabotropic 2 3.0311
REP15 RAB15 effector protein 3.0311
EMCN endomucin 3.0311
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 3.0311
ASCL2 achaete-scute family bHLH transcription factor 2 3.0311
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.0311
TDO2 tryptophan 2,3-dioxygenase 3.0311
TSPAN8 tetraspanin 8 3.0311
RAB7B RAB7B, member RAS oncogene family 3.0311
GATA6 GATA binding protein 6 3.0311
SYT15 synaptotagmin XV 3.0311
UBA7 ubiquitin-like modifier activating enzyme 7 3.0311
OTUD6A OTU deubiquitinase 6A 3.0311
COL19A1 collagen, type XIX, alpha 1 3.0311
TBX3 T-box 3 3.0311
HBA2 hemoglobin, alpha 2 3.0311
MTNR1B melatonin receptor 1B 3.0311
PCDHB11 protocadherin beta 11 3.0311
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.0311
BBS5 Bardet-Biedl syndrome 5 3.0311
GOLGA6L4 golgin A6 family-like 4 3.0311
CD79A CD79a molecule, immunoglobulin-associated alpha 3.0311
IDO2 indoleamine 2,3-dioxygenase 2 3.0311
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.0311
C10ORF67 chromosome 10 open reading frame 67 3.0311
CCDC92 coiled-coil domain containing 92 3.0311
IL5 interleukin 5 3.0311
GJD2 gap junction protein, delta 2, 36kDa 3.0311
GZMM granzyme M (lymphocyte met-ase 1) 3.0311
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 3.0311
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.0311
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 3.0311
RFPL2 ret finger protein-like 2 3.0311
FBLN7 fibulin 7 3.0311
TGFB3 transforming growth factor, beta 3 3.0311
MTMR8 myotubularin related protein 8 3.0311
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.0311
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.0311
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.0311
MUSK muscle, skeletal, receptor tyrosine kinase 3.0311
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.0311
AIM2 absent in melanoma 2 3.0311
SLC25A41 solute carrier family 25, member 41 3.0311
MYBPC3 myosin binding protein C, cardiac 3.0311
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.0311
PDYN prodynorphin 3.0311
LTB lymphotoxin beta (TNF superfamily, member 3) 3.0311
SAMD15 sterile alpha motif domain containing 15 3.0311
MYH15 myosin, heavy chain 15 3.0311
PGM5 phosphoglucomutase 5 3.0311
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.0311
VAV1 vav 1 guanine nucleotide exchange factor 3.0311
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.0311
OR2B11 olfactory receptor, family 2, subfamily B, member 11 3.0311
ITGA11 integrin, alpha 11 3.0311
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.0311
SPATA9 spermatogenesis associated 9 3.0311
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.0311
CTXND1 cortexin domain containing 1 3.0311
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.0311
PCDHGA3 protocadherin gamma subfamily A, 3 3.0311
C2CD4B C2 calcium-dependent domain containing 4B 3.0311
SNX31 sorting nexin 31 3.0311
C20ORF204 chromosome 20 open reading frame 204 3.0311
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 3.0311
PLET1 placenta expressed transcript 1 3.0311
FAM163A family with sequence similarity 163, member A 3.0311
PRH2 proline-rich protein HaeIII subfamily 2 3.0311
CTSO cathepsin O 3.0311
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 3.0311
FAM237A family with sequence similarity 237 member A 3.0311
NPY2R neuropeptide Y receptor Y2 3.0311
CEND1 cell cycle exit and neuronal differentiation 1 3.0311
GNG5B G protein subunit gamma 5B 3.0311
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.0311
FAIM2 Fas apoptotic inhibitory molecule 2 3.0311
TSPAN19 tetraspanin 19 3.0311
EFCAB12 EF-hand calcium binding domain 12 3.0311
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.0311
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.0311
CCNI2 cyclin I family, member 2 3.0311
CYTH4 cytohesin 4 3.0311
SLC38A3 solute carrier family 38, member 3 3.0311
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.0311
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.0311
SOSTDC1 sclerostin domain containing 1 3.0311
CDHR5 cadherin-related family member 5 3.0311
RHEX regulator of hemoglobinization and erythroid cell expansion 3.0311
POU5F2 POU domain class 5, transcription factor 2 3.0311
SUN3 Sad1 and UNC84 domain containing 3 3.0311
SPI1 Spi-1 proto-oncogene 3.0311
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.0311
PRSS55 protease, serine, 55 3.0311
TCF21 transcription factor 21 3.0311
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.0311
KRT17 keratin 17, type I 3.0311
ERMN ermin, ERM-like protein 3.0311
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.0311
RNF224 ring finger protein 224 3.0311
KLB klotho beta 3.0311
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.0311
C10ORF90 chromosome 10 open reading frame 90 3.0311
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.0311
RNF148 ring finger protein 148 3.0311
MAGEA10 melanoma antigen family A10 3.0311
DUOXA1 dual oxidase maturation factor 1 3.0311
TSKS testis-specific serine kinase substrate 3.0311
MORC1 MORC family CW-type zinc finger 1 3.0311
FAM237B family with sequence similarity 237 member B 3.0311
DNAAF6 dynein axonemal assembly factor 6 3.0311
NXNL1 nucleoredoxin-like 1 3.0311
CLDN34 claudin 34 3.0311
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 3.0311
AQP3 aquaporin 3 (Gill blood group) 3.0311
OTC ornithine carbamoyltransferase 3.0311
CT55 cancer/testis antigen 55 3.0311
LRRC43 leucine rich repeat containing 43 3.0311
GAL3ST2 galactose-3-O-sulfotransferase 2 3.0311
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.0311
SMIM35 small integral membrane protein 35 3.0311
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.0311
RPL30 ribosomal protein L30 3.01228
SCRIB scribbled planar cell polarity protein 2.99562
MTM1 myotubularin 1 2.93217
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 2.81862
L1CAM L1 cell adhesion molecule 2.81053
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.71853
MATK megakaryocyte-associated tyrosine kinase 2.63855
RANBP6 RAN binding protein 6 2.58273
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 2.53914
PBX1 pre-B-cell leukemia homeobox 1 2.50564
PRDM6 PR domain containing 6 2.43746
RAB4B RAB4B, member RAS oncogene family 2.41974
MRPL42 mitochondrial ribosomal protein L42 2.40179
HNRNPF heterogeneous nuclear ribonucleoprotein F 2.38957
TMCO1 transmembrane and coiled-coil domains 1 2.34485
MYL12B myosin, light chain 12B, regulatory 2.33193
HOMER1 homer scaffolding protein 1 2.31099
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.29037
SLC16A14 solute carrier family 16, member 14 2.28776
FH fumarate hydratase 2.28667
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 2.28654
ISG20 interferon stimulated exonuclease gene 20kDa 2.27397
NCKAP5 NCK-associated protein 5 2.27303
TRMT9B tRNA methyltransferase 9B (putative) 2.22525
ATP13A1 ATPase type 13A1 2.2149
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.18671
TPRG1 tumor protein p63 regulated 1 2.17759
BRI3BP BRI3 binding protein 2.1759
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 2.16975
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 2.14504
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.13175
ARL16 ADP-ribosylation factor-like 16 2.13175
TANGO6 transport and golgi organization 6 homolog (Drosophila) 2.08537
BASP1 brain abundant, membrane attached signal protein 1 2.08537
MAK16 MAK16 homolog (S. cerevisiae) 2.06956
ECRG4 ECRG4 augurin precursor 2.06328
DRC2 dynein regulatory complex subunit 2 2.05416
UNKL unkempt family zinc finger-like 2.0451
TULP2 tubby like protein 2 2.04107
SYT15B synaptotagmin 15B 2.04107
SYT4 synaptotagmin IV 2.04107
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.04107
MANSC4 MANSC domain containing 4 2.04107
LYG1 lysozyme G-like 1 2.04107
NLRC5 NLR family, CARD domain containing 5 2.04107
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.04107
TBC1D2B TBC1 domain family, member 2B 2.04107
GPAT3 glycerol-3-phosphate acyltransferase 3 2.04107
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2.04107
PMM1 phosphomannomutase 1 2.02852
PAIP2 poly(A) binding protein interacting protein 2 2.02478
RBM45 RNA binding motif protein 45 2.02438
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 2.01668
NAP1L2 nucleosome assembly protein 1-like 2 2.01668
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 2.01268
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.00804

decreased expression

Symbol Name Standardized Value
VAMP4 vesicle-associated membrane protein 4 -3.0882
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha -3.07663
ANKRD37 ankyrin repeat domain 37 -3.0311
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -3.0311
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -3.0311
C1QL3 complement component 1, q subcomponent-like 3 -3.02264
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -3.02264
FAM216B family with sequence similarity 216, member B -3.02264
TMC2 transmembrane channel-like 2 -3.02264
SPN sialophorin -3.02264
CSNK2A3 casein kinase 2, alpha 3 polypeptide -3.02264
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -3.02264
SPON2 spondin 2, extracellular matrix protein -3.02264
CFAP53 cilia and flagella associated protein 53 -3.02264
RBP2 retinol binding protein 2, cellular -3.02264
NELL1 NEL-like 1 (chicken) -3.02264
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -3.02264
TRAM1L1 translocation associated membrane protein 1-like 1 -3.02264
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -3.02264
CPB2 carboxypeptidase B2 (plasma) -3.02264
FBXW12 F-box and WD repeat domain containing 12 -3.02264
CKM creatine kinase, muscle -3.02264
PCDHA5 protocadherin alpha 5 -3.02264
ZNF436 zinc finger protein 436 -3.02264
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -3.02264
LOC124902694 uncharacterized LOC124902694 -3.02264
HES3 hes family bHLH transcription factor 3 -3.02264
SH2D7 SH2 domain containing 7 -3.02264
MSC musculin -3.02264
ASB12 ankyrin repeat and SOCS box containing 12 -3.02264
DLK1 delta-like 1 homolog (Drosophila) -3.02264
C1ORF146 chromosome 1 open reading frame 146 -3.02264
H2BC8 H2B clustered histone 8 -3.02264
BATF2 basic leucine zipper transcription factor, ATF-like 2 -3.02264
VWF von Willebrand factor -3.02264
FAM151A family with sequence similarity 151, member A -3.02264
LAMB3 laminin, beta 3 -3.02264
C6ORF163 chromosome 6 open reading frame 163 -3.02264
AQP4 aquaporin 4 -3.02264
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 -3.02264
ACOX2 acyl-CoA oxidase 2, branched chain -3.02264
EPHA5 EPH receptor A5 -3.02264
ACADSB acyl-CoA dehydrogenase, short/branched chain -3.02264
RAD9B RAD9 homolog B (S. pombe) -3.02264
LSMEM2 leucine-rich single-pass membrane protein 2 -3.02264
TRAPPC13 trafficking protein particle complex 13 -3.01534
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -2.9818
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.9818
SNTG1 syntrophin, gamma 1 -2.88752
PHEX phosphate regulating endopeptidase homolog, X-linked -2.86243
RAB9B RAB9B, member RAS oncogene family -2.86243
NCK2 NCK adaptor protein 2 -2.86243
EAPP E2F-associated phosphoprotein -2.8377
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.79829
RBM47 RNA binding motif protein 47 -2.70284
FAM89B family with sequence similarity 89, member B -2.69992
NOXRED1 NADP-dependent oxidoreductase domain containing 1 -2.69992
SORT1 sortilin 1 -2.6981
NEK9 NIMA-related kinase 9 -2.65046
ZNF521 zinc finger protein 521 -2.62946
SHOX short stature homeobox -2.58273
PROK2 prokineticin 2 -2.58273
TMEM165 transmembrane protein 165 -2.58273
RBM42 RNA binding motif protein 42 -2.58273
CFAP54 cilia and flagella associated 54 -2.58273
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.58273
ZNF764 zinc finger protein 764 -2.49141
KYAT1 kynurenine aminotransferase 1 -2.45834
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.38957
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.38957
SMAD6 SMAD family member 6 -2.38957
SENP6 SUMO1/sentrin specific peptidase 6 -2.36616
MOG myelin oligodendrocyte glycoprotein -2.33122
PITPNM3 PITPNM family member 3 -2.33122
PTPN9 protein tyrosine phosphatase, non-receptor type 9 -2.33122
IL17RC interleukin 17 receptor C -2.33122
PCDHGB6 protocadherin gamma subfamily B, 6 -2.26041
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -2.23753
DHRS11 dehydrogenase/reductase (SDR family) member 11 -2.22525
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa -2.19794
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.18888
API5 apoptosis inhibitor 5 -2.18888
IQCH IQ motif containing H -2.16975
MTBP MDM2 binding protein -2.15356
INIP INTS3 and NABP interacting protein -2.14582
SORBS3 sorbin and SH3 domain containing 3 -2.14504
ARHGAP8 Rho GTPase activating protein 8 -2.14504
TM2D3 TM2 domain containing 3 -2.13175
ARMC3 armadillo repeat containing 3 -2.10839
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -2.09373
MEPCE methylphosphate capping enzyme -2.09364
UBXN11 UBX domain protein 11 -2.09099
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 -2.08039
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.06053
FBXO30 F-box protein 30 -2.05416
WASHC5 WASH complex subunit 5 -2.04107
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.04107
TMEM17 transmembrane protein 17 -2.04107
TMEM116 transmembrane protein 116 -2.04107
ZNF140 zinc finger protein 140 -2.03962
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -2.02852
IKBIP IKBKB interacting protein -2.02484
MED9 mediator complex subunit 9 -2.01668
DAD1 defender against cell death 1 -2.01234
ZNF148 zinc finger protein 148 -2.01034