IGFBP3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description insulin-like growth factor binding protein 3|This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3486)
External Link http://www.ncbi.nlm.nih.gov/gene/3486
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Genes

37 interacting proteins for IGFBP3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
CAV1 caveolin 1, caveolae protein, 22kDa
CD44 CD44 molecule (Indian blood group)
COL1A1 collagen, type I, alpha 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTSD cathepsin D
CTSG cathepsin G
EGFR epidermal growth factor receptor
F2 coagulation factor II (thrombin)
FN1 fibronectin 1
GPI glucose-6-phosphate isomerase
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
KLK1 kallikrein 1
KLK13 kallikrein-related peptidase 13
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KLKB1 kallikrein B, plasma (Fletcher factor) 1
KPNB1 karyopherin (importin) beta 1
LTBP1 latent transforming growth factor beta binding protein 1
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
NRF1 nuclear respiratory factor 1
PAPPA2 pappalysin 2
PLG plasminogen
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RXRA retinoid X receptor, alpha
TF transferrin
VTN vitronectin