IKBKB Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta|The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 3551)
External Link http://www.ncbi.nlm.nih.gov/gene/3551
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Genes

26 substrates of the kinase IKBKB from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
BBC3 BCL2 binding component 3
BCL10 B-cell CLL/lymphoma 10
CDKN2A cyclin-dependent kinase inhibitor 2A
CYLD cylindromatosis (turban tumor syndrome)
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO3 forkhead box O3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRS1 insulin receptor substrate 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OPTN optineurin
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS3 ribosomal protein S3
SNAP23 synaptosomal-associated protein, 23kDa
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP63 tumor protein p63
TSC1 tuberous sclerosis 1
ZC3H12A zinc finger CCCH-type containing 12A