IKBKE Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon|IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] (NCBI Entrez Gene Database, 9641)
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Genes

308 genes differentially expressed following the IKBKE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.59561
HINT2 histidine triad nucleotide binding protein 2 2.59561
BSX brain-specific homeobox 2.59561
RTN4RL1 reticulon 4 receptor-like 1 2.59561
CNTN6 contactin 6 2.59561
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.59561
STARD6 StAR-related lipid transfer (START) domain containing 6 2.59561
CHRM4 cholinergic receptor, muscarinic 4 2.59561
CLRN2 clarin 2 2.59561
CEP295NL CEP295 N-terminal like 2.59561
TSPAN8 tetraspanin 8 2.59561
POU3F2 POU class 3 homeobox 2 2.59561
SACK1D scaffolding CK1 anchoring protein D 2.59561
SLPI secretory leukocyte peptidase inhibitor 2.59561
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.59561
PRR22 proline rich 22 2.59561
FGD2 FYVE, RhoGEF and PH domain containing 2 2.59561
TEX13C TEX13 family member C 2.59561
FNDC11 fibronectin type III domain containing 11 2.59561
RTL5 retrotransposon Gag like 5 2.59561
FAM81B family with sequence similarity 81, member B 2.59561
GBP4 guanylate binding protein 4 2.59561
NMUR1 neuromedin U receptor 1 2.59561
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.59534
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.47456
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.47456
GPR52 G protein-coupled receptor 52 2.47456
NPAP1 nuclear pore associated protein 1 2.47456
RRAD Ras-related associated with diabetes 2.47456
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.47456
MGAM2 maltase-glucoamylase 2 (putative) 2.47456
PCDHGB3 protocadherin gamma subfamily B, 3 2.47456
NCF1 neutrophil cytosolic factor 1 2.47456
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.47456
CD300LB CD300 molecule-like family member b 2.47456
OLIG2 oligodendrocyte lineage transcription factor 2 2.47456
CORO2B coronin, actin binding protein, 2B 2.47456
MRC1 mannose receptor, C type 1 2.47456
LGALS4 lectin, galactoside-binding, soluble, 4 2.47456
SIK2 salt-inducible kinase 2 2.47456
PRDM12 PR domain containing 12 2.47456
BHMT2 betaine--homocysteine S-methyltransferase 2 2.47456
MYH4 myosin, heavy chain 4, skeletal muscle 2.47456
CCNE2 cyclin E2 2.47456
GMFG glia maturation factor, gamma 2.47456
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.47456
SPRR1B small proline-rich protein 1B 2.47456
ALPK2 alpha-kinase 2 2.47456
MYOM3 myomesin 3 2.47456
TLX2 T-cell leukemia homeobox 2 2.47456
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.47456
UCN urocortin 2.47456
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.47456
CNGA3 cyclic nucleotide gated channel alpha 3 2.47456
KL klotho 2.47456
IMPG1 interphotoreceptor matrix proteoglycan 1 2.47456
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.47456
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.47456
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.47456
SMLR1 small leucine-rich protein 1 2.47456
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.47456
FMOD fibromodulin 2.47456
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 2.47456
HOXC13 homeobox C13 2.47456
HTD2 hydroxyacyl-thioester dehydratase type 2 2.47456
H3C13 H3 clustered histone 13 2.47456
CFAP97D2 CFAP97 domain containing 2 2.47456
REELD1 reeler domain containing 1 2.47456
OR56B2 olfactory receptor family 56 subfamily B member 2 2.47456
GPR132 G protein-coupled receptor 132 2.47456
PGA5 pepsinogen 5, group I (pepsinogen A) 2.47456
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.47456
ZACN zinc activated ligand-gated ion channel 2.47456
LURAP1L leucine rich adaptor protein 1-like 2.47456
RNF17 ring finger protein 17 2.47456
OR5P3 olfactory receptor, family 5, subfamily P, member 3 2.47456
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.47456
RGS9BP regulator of G protein signaling 9 binding protein 2.47456
ATP13A5 ATPase type 13A5 2.47456
FOXD4 forkhead box D4 2.47456
VIT vitrin 2.47456
MAGEB1 melanoma antigen family B1 2.47456
IRF5 interferon regulatory factor 5 2.47456
RUNDC1 RUN domain containing 1 2.47456
LIX1 Lix1 homolog (chicken) 2.47456
TLR6 toll-like receptor 6 2.47456
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.47456
PGC progastricsin (pepsinogen C) 2.47456
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.47456
DRC5 dynein regulatory complex subunit 5 2.47456
DRD5 dopamine receptor D5 2.47456
NT5C1A 5'-nucleotidase, cytosolic IA 2.47456
CSTA cystatin A (stefin A) 2.47456
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.47456
ERICH4 glutamate-rich 4 2.47456
HOXA7 homeobox A7 2.47456
CH25H cholesterol 25-hydroxylase 2.47456
SLC38A8 solute carrier family 38, member 8 2.47456
PCDHGB5 protocadherin gamma subfamily B, 5 2.47456
SMIM22 small integral membrane protein 22 2.47456
PSG3 pregnancy specific beta-1-glycoprotein 3 2.47456
TBPL2 TATA box binding protein like 2 2.47456
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 2.47456
TCF21 transcription factor 21 2.47456
TESPA1 thymocyte expressed, positive selection associated 1 2.47456
PATE4 prostate and testis expressed 4 2.47456
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 2.47456
KCTD20 potassium channel tetramerization domain containing 20 2.47456
POU2AF1 POU class 2 associating factor 1 2.47456
TRIM50 tripartite motif containing 50 2.47456
PAGE4 P antigen family, member 4 (prostate associated) 2.47456
MCCD1 mitochondrial coiled-coil domain 1 2.47456
ERICH6B glutamate-rich 6B 2.47456
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.47456
RNASE13 ribonuclease, RNase A family, 13 (non-active) 2.47456
KLF1 Kruppel-like factor 1 (erythroid) 2.47456
CYSLTR1 cysteinyl leukotriene receptor 1 2.47456
DQX1 DEAQ box RNA-dependent ATPase 1 2.47456
DAPK1 death-associated protein kinase 1 2.47456
RGS8 regulator of G-protein signaling 8 2.47456
MYLK2 myosin light chain kinase 2 2.47456
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.47456
CHRM1 cholinergic receptor, muscarinic 1 2.47456
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.47456
GLT6D1 glycosyltransferase 6 domain containing 1 2.47456
FOXP3 forkhead box P3 2.47456
CCNA1 cyclin A1 2.47456
LYZL2 lysozyme-like 2 2.47456
TGM1 transglutaminase 1 2.47456
CD226 CD226 molecule 2.47456
MRGPRX3 MAS-related GPR, member X3 2.47456
LMX1B LIM homeobox transcription factor 1, beta 2.47456
SFTA2 surfactant associated 2 2.47456
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.47456
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.47456
WDR17 WD repeat domain 17 2.47456
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.47456
SLC7A4 solute carrier family 7, member 4 2.47456
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.47456
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.47456
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.47456
REG1A regenerating islet-derived 1 alpha 2.47456
CARD9 caspase recruitment domain family, member 9 2.47456
C13ORF42 chromosome 13 open reading frame 42 2.46782
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.4561
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 2.44118
CASS4 Cas scaffolding protein family member 4 2.43485
HLA-DOB major histocompatibility complex, class II, DO beta 2.43485
ZNF81 zinc finger protein 81 2.40356
C1ORF202 chromosome 1 open reading frame 202 2.40014
RGPD2 RANBP2-like and GRIP domain containing 2 2.39789
TCEA1 transcription elongation factor A (SII), 1 2.3719
CCDC25 coiled-coil domain containing 25 2.3719
ZWINT ZW10 interacting kinetochore protein 2.35783
APOLTP apolipoprotein lipid transfer particle homolog 2.34292
RELL2 RELT-like 2 2.34147
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.33567
CPLX1 complexin 1 2.33567
TAS1R1 taste receptor, type 1, member 1 2.33567
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.33567
TYW5 tRNA-yW synthesizing protein 5 2.33054
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.31652
CDK3 cyclin-dependent kinase 3 2.30844
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 2.30509
ODAD1 outer dynein arm docking complex subunit 1 2.30386
ZNF684 zinc finger protein 684 2.29975
FZD8 frizzled class receptor 8 2.29353
ULK3 unc-51 like kinase 3 2.28826
SHISA4 shisa family member 4 2.28409
PIERCE2 piercer of microtubule wall 2 2.27862
TARBP1 TAR (HIV-1) RNA binding protein 1 2.2543
ZNF625 zinc finger protein 625 2.25072
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.24877
PDS5A PDS5 cohesin associated factor A 2.24371
SPMIP11 sperm microtubule inner protein 11 2.23935
LONP2 lon peptidase 2, peroxisomal 2.21935
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.21781
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 2.20648
TBX19 T-box 19 2.20575
MBNL1 muscleblind-like splicing regulator 1 2.20332
TMEM234 transmembrane protein 234 2.19661
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.19257
EMID1 EMI domain containing 1 2.13301
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.10568
MAML1 mastermind-like 1 (Drosophila) 2.10385
AK1 adenylate kinase 1 2.09052
KLC2 kinesin light chain 2 2.09024
SV2B synaptic vesicle glycoprotein 2B 2.04175
TTYH2 tweety family member 2 2.0326
ZNF488 zinc finger protein 488 2.02661
MPG N-methylpurine-DNA glycosylase 2.02014
TRAPPC10 trafficking protein particle complex 10 2.02014
GEMIN8 gem (nuclear organelle) associated protein 8 2.00998
STYXL1 serine/threonine/tyrosine interacting-like 1 2.0093
TBCK TBC1 domain containing kinase 2.00213

decreased expression

Symbol Name Standardized Value
RFX8 RFX family member 8, lacking RFX DNA binding domain -2.59561
TMEM190 transmembrane protein 190 -2.59561
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.59561
RPL7A ribosomal protein L7a -2.59534
OVGP1 oviductal glycoprotein 1, 120kDa -2.59534
TCAP titin-cap -2.59534
ASMT acetylserotonin O-methyltransferase -2.59534
MLIP muscular LMNA-interacting protein -2.59534
USHBP1 Usher syndrome 1C binding protein 1 -2.59534
PNPLA1 patatin-like phospholipase domain containing 1 -2.47456
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -2.47456
MUC20 mucin 20, cell surface associated -2.47456
TICAM2 toll-like receptor adaptor molecule 2 -2.47456
CHAD chondroadherin -2.47456
AQP1 aquaporin 1 (Colton blood group) -2.47456
VTCN1 V-set domain containing T cell activation inhibitor 1 -2.47456
CARD6 caspase recruitment domain family, member 6 -2.47456
DMTN dematin actin binding protein -2.47456
WFDC11 WAP four-disulfide core domain 11 -2.47456
IZUMO4 IZUMO family member 4 -2.47456
FETUB fetuin B -2.47456
SLC25A41 solute carrier family 25, member 41 -2.47456
MFAP4 microfibrillar-associated protein 4 -2.47456
TRIM74 tripartite motif containing 74 -2.47456
DNASE2 deoxyribonuclease II, lysosomal -2.47456
HOMER2 homer scaffolding protein 2 -2.47456
CILP2 cartilage intermediate layer protein 2 -2.47456
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.47456
LMO1 LIM domain only 1 (rhombotin 1) -2.47456
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -2.47456
PRSS21 protease, serine, 21 (testisin) -2.47456
ROR2 receptor tyrosine kinase-like orphan receptor 2 -2.47456
DLK2 delta-like 2 homolog (Drosophila) -2.47456
VAV1 vav 1 guanine nucleotide exchange factor -2.47456
MINDY4B MINDY family member 4B -2.47456
GTF2A1L general transcription factor IIA, 1-like -2.47456
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 -2.47456
TMEM238L transmembrane protein 238 like -2.47456
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.47456
CLDN14 claudin 14 -2.47456
N4BP2L2 NEDD4 binding protein 2-like 2 -2.47456
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.47456
ACTN1 actinin, alpha 1 -2.47456
KLF4 Kruppel-like factor 4 (gut) -2.47456
ADCY4 adenylate cyclase 4 -2.47456
PCDHB11 protocadherin beta 11 -2.47456
MAP1A microtubule-associated protein 1A -2.47456
SYT15 synaptotagmin XV -2.47456
SMIM41 small integral membrane protein 41 -2.47456
MUC12 mucin 12, cell surface associated -2.46812
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -2.4649
CEP152 centrosomal protein 152kDa -2.43485
TRIM27 tripartite motif containing 27 -2.37075
FAM184B family with sequence similarity 184, member B -2.35704
TADA3 transcriptional adaptor 3 -2.35704
FAM124B family with sequence similarity 124B -2.35704
CASD1 CAS1 domain containing 1 -2.34292
ZFAND4 zinc finger, AN1-type domain 4 -2.33054
MEF2B myocyte enhancer factor 2B -2.31206
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -2.30836
METTL26 methyltransferase like 26 -2.3051
HAS2 hyaluronan synthase 2 -2.27862
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 -2.24019
URM1 ubiquitin related modifier 1 -2.23672
TP73 tumor protein p73 -2.22868
PHGDH phosphoglycerate dehydrogenase -2.21935
CEP95 centrosomal protein 95kDa -2.21935
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.21935
GOLGA6L10 golgin A6 family-like 10 -2.21839
RPAIN RPA interacting protein -2.21781
RGPD6 RANBP2-like and GRIP domain containing 6 -2.19661
H4C11 H4 clustered histone 11 -2.19661
RSKR ribosomal protein S6 kinase related -2.19661
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.19661
GUCA1B guanylate cyclase activator 1B (retina) -2.17371
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -2.1724
CTCFL CCCTC-binding factor (zinc finger protein)-like -2.1715
TXNDC11 thioredoxin domain containing 11 -2.15442
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -2.14193
RPS27A ribosomal protein S27a -2.13853
ZFP91 ZFP91 zinc finger protein -2.13301
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) -2.13247
ONECUT2 one cut homeobox 2 -2.12418
RER1 retention in endoplasmic reticulum sorting receptor 1 -2.12257
MARCHF7 membrane associated ring-CH-type finger 7 -2.1216
RAB42 RAB42, member RAS oncogene family -2.11508
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.10385
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.10385
MEX3D mex-3 RNA binding family member D -2.10109
ETV4 ets variant 4 -2.09352
MTCH2 mitochondrial carrier 2 -2.0912
IL32 interleukin 32 -2.07704
XG Xg blood group -2.07704
TCF15 transcription factor 15 (basic helix-loop-helix) -2.07416
TGFBR1 transforming growth factor, beta receptor 1 -2.07266
IWS1 IWS1 homolog (S. cerevisiae) -2.06762
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -2.0638
LMCD1 LIM and cysteine-rich domains 1 -2.0638
ARMC12 armadillo repeat containing 12 -2.05697
ZNF454 zinc finger protein 454 -2.05413
SARNP SAP domain containing ribonucleoprotein -2.05401
SH3YL1 SH3 and SYLF domain containing 1 -2.04839
CNGA4 cyclic nucleotide gated channel alpha 4 -2.04512
ADPGK ADP-dependent glucokinase -2.04357
ZNF791 zinc finger protein 791 -2.04357
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -2.04357
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa -2.04175
GMNN geminin, DNA replication inhibitor -2.04175
ATG12 autophagy related 12 -2.0328
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -2.01131
PRKCH protein kinase C, eta -2.0072
OSBPL11 oxysterol binding protein-like 11 -2.00505
CDKN2AIP CDKN2A interacting protein -2.00213