IKBKE Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon|IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] (NCBI Entrez Gene Database, 9641)
External Link http://www.ncbi.nlm.nih.gov/gene/9641
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Genes

17 substrates of the kinase IKBKE from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CYLD cylindromatosis (turban tumor syndrome)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
ESR1 estrogen receptor 1
FOXO3 forkhead box O3
GSK3A glycogen synthase kinase 3 alpha
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PELI1 pellino E3 ubiquitin protein ligase 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
STAT1 signal transducer and activator of transcription 1, 91kDa
TRAF3IP2 TRAF3 interacting protein 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase