IKBKG Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma|This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 8517)
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Genes

354 genes differentially expressed following the IKBKG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLA Src-like-adaptor 2.7227
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.7227
FNDC7 fibronectin type III domain containing 7 2.7227
TPPP2 tubulin polymerization-promoting protein family member 2 2.7227
OXER1 oxoeicosanoid (OXE) receptor 1 2.7227
TSLP thymic stromal lymphopoietin 2.7227
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.7227
HHATL hedgehog acyltransferase-like 2.7227
SIRPB2 signal-regulatory protein beta 2 2.7227
GCSAM germinal center-associated, signaling and motility 2.7227
FBP1 fructose-1,6-bisphosphatase 1 2.7227
TBX10 T-box 10 2.7227
WNT9B wingless-type MMTV integration site family, member 9B 2.7227
SLC46A3 solute carrier family 46, member 3 2.7227
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.7227
BFSP2 beaded filament structural protein 2, phakinin 2.7227
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.7227
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.7227
DNAH10 dynein, axonemal, heavy chain 10 2.7227
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.7227
FPR2 formyl peptide receptor 2 2.70684
RLBP1 retinaldehyde binding protein 1 2.70684
GPR75 G protein-coupled receptor 75 2.70684
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.70684
SCG2 secretogranin II 2.70684
PRB4 proline-rich protein BstNI subfamily 4 2.70684
USP26 ubiquitin specific peptidase 26 2.70684
RAET1G retinoic acid early transcript 1G 2.70684
ZNF99 zinc finger protein 99 2.70684
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.70684
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.70684
ZNF503 zinc finger protein 503 2.70684
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.70684
MAP3K7CL MAP3K7 C-terminal like 2.70684
IL11RA interleukin 11 receptor, alpha 2.70684
SIX6 SIX homeobox 6 2.70684
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.70684
KNG1 kininogen 1 2.70684
GFRA3 GDNF family receptor alpha 3 2.70684
TMEM71 transmembrane protein 71 2.70684
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.70684
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.70684
LGI1 leucine-rich, glioma inactivated 1 2.70684
GMNC geminin coiled-coil domain containing 2.70684
PNOC prepronociceptin 2.70684
WNT8B wingless-type MMTV integration site family, member 8B 2.70684
MUC20 mucin 20, cell surface associated 2.70684
CRYGC crystallin, gamma C 2.70684
TAS2R19 taste receptor, type 2, member 19 2.70684
C3ORF22 chromosome 3 open reading frame 22 2.70684
CXCL2 chemokine (C-X-C motif) ligand 2 2.70684
OTUD6A OTU deubiquitinase 6A 2.70684
SLC35G5 solute carrier family 35, member G5 2.70684
PGBDF plakoglobin binding and degradation factor 2.70684
FFAR4 free fatty acid receptor 4 2.70684
PAX8 paired box 8 2.70684
PAX3 paired box 3 2.70684
GDNF glial cell derived neurotrophic factor 2.70684
GPR26 G protein-coupled receptor 26 2.70684
MYOM3 myomesin 3 2.70684
PECAM1 platelet/endothelial cell adhesion molecule 1 2.70684
TRIM77 tripartite motif containing 77 2.70684
MYO16 myosin XVI 2.70684
PTPRH protein tyrosine phosphatase, receptor type, H 2.70684
SPMIP11 sperm microtubule inner protein 11 2.70684
NTAQ1 N-terminal glutamine amidase 1 2.70684
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.70684
PTH1R parathyroid hormone 1 receptor 2.70684
GBP6 guanylate binding protein family, member 6 2.70684
C3AR1 complement component 3a receptor 1 2.70684
ROPN1L rhophilin associated tail protein 1-like 2.70684
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.70684
SIM1 single-minded family bHLH transcription factor 1 2.70684
KRT83 keratin 83, type II 2.70684
TMPRSS7 transmembrane protease, serine 7 2.70684
LOC124900192 uncharacterized LOC124900192 2.70684
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.70684
RTL5 retrotransposon Gag like 5 2.70684
TEKTL1 tektin like 1 2.70684
CIMIP4 ciliary microtubule inner protein 4 2.70684
ANKRD42-DT ANKRD42 divergent transcript 2.70684
C17ORF113 chromosome 17 open reading frame 113 2.70684
TMA7B translation machinery associated 7 homolog B 2.70684
SMIM31 small integral membrane protein 31 2.70684
MYMK myomaker, myoblast fusion factor 2.70684
PEAK3 PEAK family member 3 2.70684
GSTT4 glutathione S-transferase theta 4 2.70684
SOFU1 sperm-oocyte fusion factor 1 2.70684
TMPRSS4 transmembrane protease, serine 4 2.70684
DOK7 docking protein 7 2.70684
MYL10 myosin, light chain 10, regulatory 2.70684
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.70684
GLP2R glucagon-like peptide 2 receptor 2.70684
C1QL2 complement component 1, q subcomponent-like 2 2.70684
HAPLN2 hyaluronan and proteoglycan link protein 2 2.70684
DNASE2B deoxyribonuclease II beta 2.70684
MSX1 msh homeobox 1 2.70684
TMEM235 transmembrane protein 235 2.70684
GOLGA6L4 golgin A6 family-like 4 2.70684
SCN10A sodium channel, voltage gated, type X alpha subunit 2.70684
IL31RA interleukin 31 receptor A 2.70684
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.70684
EXOC3L1 exocyst complex component 3-like 1 2.70684
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.70684
TSPAN1 tetraspanin 1 2.70684
KHDC1L KH homology domain containing 1-like 2.70684
ZNF705D zinc finger protein 705D 2.70684
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.70684
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 2.70684
ASIC3 acid sensing (proton gated) ion channel 3 2.70684
ASIC4 acid sensing (proton gated) ion channel family member 4 2.70684
IL7R interleukin 7 receptor 2.70684
GTSF1 gametocyte specific factor 1 2.70684
SBSN suprabasin 2.70684
CFAP99 cilia and flagella associated protein 99 2.70684
LGALS4 lectin, galactoside-binding, soluble, 4 2.70684
MC5R melanocortin 5 receptor 2.70684
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.70684
GAGE10 G antigen 10 2.70684
CLIC5 chloride intracellular channel 5 2.70684
HAMP hepcidin antimicrobial peptide 2.70684
EXTL1 exostosin-like glycosyltransferase 1 2.70684
ZNF541 zinc finger protein 541 2.70684
TUBB tubulin, beta class I 2.70684
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.70684
TRIM50 tripartite motif containing 50 2.70684
EBF2 early B-cell factor 2 2.70684
NPPA natriuretic peptide A 2.70684
S100A12 S100 calcium binding protein A12 2.70684
ALOX15B arachidonate 15-lipoxygenase, type B 2.70684
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.70684
TRIM29 tripartite motif containing 29 2.70684
KIF4B kinesin family member 4B 2.70684
PRSS55 protease, serine, 55 2.70684
ZNF679 zinc finger protein 679 2.70684
ELANE elastase, neutrophil expressed 2.70684
MAGEB17 melanoma antigen family B17 2.70684
SMYD1 SET and MYND domain containing 1 2.70684
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.70684
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.70684
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.70684
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.70684
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.70684
OTP orthopedia homeobox 2.70684
GBX2 gastrulation brain homeobox 2 2.70684
C22ORF31 chromosome 22 open reading frame 31 2.70684
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.70684
NICN1 nicolin 1 2.70684
TRIML1 tripartite motif family-like 1 2.70684
GPR150 G protein-coupled receptor 150 2.70684
MYADML2 myeloid-associated differentiation marker-like 2 2.70684
NKX6-2 NK6 homeobox 2 2.70684
EVPLL envoplakin-like 2.70684
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.70684
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.70684
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.70684
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.70684
KLK7 kallikrein-related peptidase 7 2.70684
ANKRD55 ankyrin repeat domain 55 2.70684
NT5C1B 5'-nucleotidase, cytosolic IB 2.70684
CDH22 cadherin 22, type 2 2.70684
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.70684
ERP29 endoplasmic reticulum protein 29 2.70684
SLITRK6 SLIT and NTRK-like family, member 6 2.70684
LGALS9 lectin, galactoside-binding, soluble, 9 2.70684
FXYD2 FXYD domain containing ion transport regulator 2 2.70684
NELL1 NEL-like 1 (chicken) 2.70684
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.70684
CD3D CD3d molecule, delta (CD3-TCR complex) 2.70684
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.70684
ANKRD30A ankyrin repeat domain 30A 2.70684
PADI1 peptidyl arginine deiminase, type I 2.70684
TAS2R40 taste receptor, type 2, member 40 2.70684
SPATC1L spermatogenesis and centriole associated 1-like 2.70684
NLRP5 NLR family, pyrin domain containing 5 2.70684
CHRDL2 chordin-like 2 2.70684
LEP leptin 2.70684
MAGEA12 melanoma antigen family A12 2.70684
FGF7 fibroblast growth factor 7 2.70684
SLITRK1 SLIT and NTRK-like family, member 1 2.70684
POTEJ POTE ankyrin domain family, member J 2.70684
HHIPL2 HHIP-like 2 2.70684
APOL6 apolipoprotein L, 6 2.70684
BTBD16 BTB (POZ) domain containing 16 2.70684
ITPKA inositol-trisphosphate 3-kinase A 2.70684
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.70684
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.70684
MSLN mesothelin 2.70684
GRM6 glutamate receptor, metabotropic 6 2.70684
CIB4 calcium and integrin binding family member 4 2.70684
USP11 ubiquitin specific peptidase 11 2.69969
ZBTB33 zinc finger and BTB domain containing 33 2.67504
HMMR hyaluronan-mediated motility receptor (RHAMM) 2.66116
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M 2.63943
RIMKLB ribosomal modification protein rimK-like family member B 2.63943
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 2.58122
SV2C synaptic vesicle glycoprotein 2C 2.55766
AADACL3 arylacetamide deacetylase-like 3 2.55766
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.55766
RASGRP4 RAS guanyl releasing protein 4 2.53457
GANC glucosidase, alpha; neutral C 2.50906
NKD2 naked cuticle homolog 2 (Drosophila) 2.49075
MTPN myotrophin 2.48508
ICAM5 intercellular adhesion molecule 5, telencephalin 2.37957
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2.37844
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.37844
CCDC184 coiled-coil domain containing 184 2.37844
SPATA32 spermatogenesis associated 32 2.37844
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 2.36146
TMED3 transmembrane emp24 protein transport domain containing 3 2.33119
RAPSN receptor-associated protein of the synapse 2.31026
BMP1 bone morphogenetic protein 1 2.31026
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.2847
SULT4A1 sulfotransferase family 4A, member 1 2.25831
TYW2 tRNA wybutosine-synthesizing protein 2 2.24486
NPY1R neuropeptide Y receptor Y1 2.24486
LRRC20 leucine rich repeat containing 20 2.24412
H2BC14 H2B clustered histone 14 2.23646
BCL2L1 BCL2-like 1 2.23178
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 2.22639
F12 coagulation factor XII (Hageman factor) 2.20782
CROT carnitine O-octanoyltransferase 2.2006
PTP4A2 protein tyrosine phosphatase type IVA, member 2 2.1711
DOCK10 dedicator of cytokinesis 10 2.17092
TPR translocated promoter region, nuclear basket protein 2.15398
UBR1 ubiquitin protein ligase E3 component n-recognin 1 2.15388
KLHL13 kelch-like family member 13 2.13965
SNAI1 snail family zinc finger 1 2.12671
SIGMAR1 sigma non-opioid intracellular receptor 1 2.11477
FAM217A family with sequence similarity 217, member A 2.1052
PCNX3 pecanex 3 2.10293
SPAG5 sperm associated antigen 5 2.0885
DERL3 derlin 3 2.0564
ATG7 autophagy related 7 2.04578
RPS2 ribosomal protein S2 2.04248
NSF N-ethylmaleimide-sensitive factor 2.0423
SSH3 slingshot protein phosphatase 3 2.03378
GDF11 growth differentiation factor 11 2.02667
RTN2 reticulon 2 2.01417
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A 2.00749

decreased expression

Symbol Name Standardized Value
MORN2 MORN repeat containing 2 -2.7227
ADGRE2 adhesion G protein-coupled receptor E2 -2.7227
SACK1B scaffolding CK1 anchoring protein B -2.7227
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.7227
AZU1 azurocidin 1 -2.7227
FAM186B family with sequence similarity 186, member B -2.7227
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -2.70684
VAMP5 vesicle-associated membrane protein 5 -2.70684
LYNX1 Ly6/neurotoxin 1 -2.70684
CELF6 CUGBP, Elav-like family member 6 -2.70684
OVCH2 ovochymase 2 (gene/pseudogene) -2.70684
MST1 macrophage stimulating 1 -2.70684
ETV5 ets variant 5 -2.70684
SLC51B solute carrier family 51, beta subunit -2.70684
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 -2.70684
NR4A3 nuclear receptor subfamily 4, group A, member 3 -2.70684
PCDHGA12 protocadherin gamma subfamily A, 12 -2.70684
DUSP13B dual specificity phosphatase 13B -2.70684
PDZD8 PDZ domain containing 8 -2.70684
H2BC8 H2B clustered histone 8 -2.70684
CFAP73 cilia and flagella associated protein 73 -2.70684
GPAT3 glycerol-3-phosphate acyltransferase 3 -2.70684
XKRX XK, Kell blood group complex subunit-related, X-linked -2.70684
SCRT1 scratch family zinc finger 1 -2.70684
ZBTB10 zinc finger and BTB domain containing 10 -2.70684
SCRG1 stimulator of chondrogenesis 1 -2.70684
ZNF285 zinc finger protein 285 -2.70684
PI15 peptidase inhibitor 15 -2.70684
ADGRE3 adhesion G protein-coupled receptor E3 -2.70684
KALRN kalirin, RhoGEF kinase -2.70684
HGD homogentisate 1,2-dioxygenase -2.70684
PKLR pyruvate kinase, liver and RBC -2.70684
EFCAB8 EF-hand calcium binding domain 8 -2.70684
FJX1 four jointed box 1 (Drosophila) -2.70684
PTN pleiotrophin -2.70684
NOX3 NADPH oxidase 3 -2.70684
OAZ3 ornithine decarboxylase antizyme 3 -2.70684
PF4 platelet factor 4 -2.70684
SPEF1 sperm flagellar 1 -2.70684
GOLGA6C golgin A6 family, member C -2.70684
FBXL22 F-box and leucine-rich repeat protein 22 -2.70684
FAM50B family with sequence similarity 50, member B -2.70684
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -2.70684
XIRP2 xin actin binding repeat containing 2 -2.70684
CISH cytokine inducible SH2-containing protein -2.70684
ACTA1 actin, alpha 1, skeletal muscle -2.66116
ICAM1 intercellular adhesion molecule 1 -2.66116
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 -2.62171
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -2.61723
PPP1R12A protein phosphatase 1, regulatory subunit 12A -2.55766
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -2.55665
SCUBE3 signal peptide, CUB domain, EGF-like 3 -2.52791
TEDC1 tubulin epsilon and delta complex 1 -2.52791
DXO decapping exoribonuclease -2.49513
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -2.49469
ADGRD2 adhesion G protein-coupled receptor D2 -2.48298
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -2.45558
DDHD1 DDHD domain containing 1 -2.45445
DEK DEK proto-oncogene -2.45195
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -2.4313
CAMK1D calcium/calmodulin-dependent protein kinase ID -2.42339
RPL41 ribosomal protein L41 -2.42339
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.42339
ERVV-2 endogenous retrovirus group V, member 2 -2.42339
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -2.41747
ESYT2 extended synaptotagmin-like protein 2 -2.41577
NEIL2 nei endonuclease VIII-like 2 (E. coli) -2.41153
FAM156A family with sequence similarity 156, member A -2.34797
ZFP2 ZFP2 zinc finger protein -2.34797
SCMH1 sex comb on midleg homolog 1 (Drosophila) -2.34797
DAGLB diacylglycerol lipase, beta -2.33119
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.27205
TIAM1 T-cell lymphoma invasion and metastasis 1 -2.27015
PEX7 peroxisomal biogenesis factor 7 -2.26519
SLC45A1 solute carrier family 45, member 1 -2.25831
PDPR pyruvate dehydrogenase phosphatase regulatory subunit -2.25831
LIAT1 ligand of ATE1 -2.25831
COPS8 COP9 signalosome subunit 8 -2.25597
INIP INTS3 and NABP interacting protein -2.25009
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.24913
DCAF7 DDB1 and CUL4 associated factor 7 -2.24574
DET1 de-etiolated homolog 1 (Arabidopsis) -2.24486
C2CD3 C2 calcium-dependent domain containing 3 -2.24412
STX6 syntaxin 6 -2.24107
COG2 component of oligomeric golgi complex 2 -2.23651
ZNF500 zinc finger protein 500 -2.23255
GPX8 glutathione peroxidase 8 (putative) -2.22967
DNASE1 deoxyribonuclease I -2.21124
ACHE acetylcholinesterase (Yt blood group) -2.20334
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -2.2006
STYK1 serine/threonine/tyrosine kinase 1 -2.19105
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 -2.18411
FBP2 fructose-1,6-bisphosphatase 2 -2.16132
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -2.16132
SARM1 sterile alpha and TIR motif containing 1 -2.13493
C1ORF50 chromosome 1 open reading frame 50 -2.12957
FHOD1 formin homology 2 domain containing 1 -2.11118
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -2.09206
TRAPPC2L trafficking protein particle complex 2-like -2.09206
H3C7 H3 clustered histone 7 -2.0885
VASP vasodilator-stimulated phosphoprotein -2.0885
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -2.0823
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.0823
XPC xeroderma pigmentosum, complementation group C -2.0807
ZC2HC1C zinc finger, C2HC-type containing 1C -2.05715
PRKN parkin RBR E3 ubiquitin protein ligase -2.05715
CIART circadian associated repressor of transcription -2.0564
WRN Werner syndrome, RecQ helicase-like -2.04985
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 -2.04578
CRYZ crystallin, zeta (quinone reductase) -2.04578
ZNF84 zinc finger protein 84 -2.02667
N4BP3 NEDD4 binding protein 3 -2.01253
FGF14 fibroblast growth factor 14 -2.01169
CYB561 cytochrome b561 -2.00774