| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | IKAROS family zinc finger 1 (Ikaros)|This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 10320) |
| External Link | https://ncbi.nlm.nih.gov/gene/10320 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the IKZF1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GNAS | GNAS complex locus | 0.0107296 |
| XIC | X chromosome inactivation center | 0.00925574 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00919161 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00899813 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00826498 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00819783 |
| LTF | lactotransferrin | 0.00790894 |
| S100P | S100 calcium binding protein P | 0.00774129 |
| C8ORF4 | chromosome 8 open reading frame 4 | 0.00745676 |
| GATA3 | GATA binding protein 3 | 0.00738113 |
| S100A10 | S100 calcium binding protein A10 | 0.00725174 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00707927 |
| KRT15 | keratin 15, type I | 0.00701716 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0069708 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.00691561 |
| TFF1 | trefoil factor 1 | 0.00691212 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00670668 |
| BMP2 | bone morphogenetic protein 2 | 0.00664627 |
| INHBA | inhibin, beta A | 0.00653255 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.00651093 |
| NRCAM | neuronal cell adhesion molecule | 0.00637967 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0063452 |
| RBM34 | RNA binding motif protein 34 | 0.00626744 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00626403 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00619192 |
| MAGEA12 | melanoma antigen family A12 | 0.00616896 |
| FN1 | fibronectin 1 | 0.00603511 |
| GPM6B | glycoprotein M6B | 0.00603159 |
| RCAN1 | regulator of calcineurin 1 | 0.00600081 |
| KRT13 | keratin 13, type I | 0.00598661 |
| ATF3 | activating transcription factor 3 | 0.00591002 |
| LXN | latexin | 0.00587656 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00583095 |
| PALLD | palladin, cytoskeletal associated protein | 0.0058269 |
| AEBP1 | AE binding protein 1 | 0.00576779 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0057573 |
| PMP2 | peripheral myelin protein 2 | 0.00575581 |
| YBX3 | Y box binding protein 3 | 0.00573986 |
| CNPY3 | canopy FGF signaling regulator 3 | 0.00573821 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00571432 |
| LAMC2 | laminin, gamma 2 | 0.0057116 |
| SIK1 | salt-inducible kinase 1 | 0.00568223 |
| MAGEA3 | melanoma antigen family A3 | 0.00566938 |
| LUM | lumican | 0.00563557 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00556714 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.00550987 |
| C1S | complement component 1, s subcomponent | 0.00549582 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00545264 |
| NAV2 | neuron navigator 2 | 0.00536933 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00536085 |
| LIPG | lipase, endothelial | 0.00536059 |
| DTNA | dystrobrevin, alpha | 0.00534515 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 0.00533165 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.00532638 |
| RGS4 | regulator of G-protein signaling 4 | 0.00527593 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.0052224 |
| IL1RN | interleukin 1 receptor antagonist | 0.00520951 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00517256 |
| CLTB | clathrin, light chain B | 0.0051137 |
| KRT19 | keratin 19, type I | 0.00507839 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.00503911 |
| CAPN3 | calpain 3, (p94) | 0.00502548 |
| RRAGD | Ras-related GTP binding D | 0.00500723 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 0.00495765 |
| PTCH1 | patched 1 | 0.0049385 |
| HSPB8 | heat shock 22kDa protein 8 | 0.00491391 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.00489726 |
| GPER1 | G protein-coupled estrogen receptor 1 | 0.00489264 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00487392 |
| MAGEA1 | melanoma antigen family A1 | 0.00487269 |
| TNC | tenascin C | 0.00487176 |
| ADM | adrenomedullin | 0.00484425 |
| TBX3 | T-box 3 | 0.00482249 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00481933 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00476171 |
| ITGAV | integrin, alpha V | 0.00475005 |
| SFTPB | surfactant protein B | 0.00474497 |
| KRT6A | keratin 6A, type II | 0.00473999 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.00473711 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0047171 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00469849 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.00467637 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.00466708 |
| CHGB | chromogranin B | 0.00465094 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.00464008 |
| MREG | melanoregulin | 0.00462653 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00462557 |
| POU4F1 | POU class 4 homeobox 1 | 0.00462518 |
| MXRA5 | matrix-remodelling associated 5 | 0.00460887 |
| COL11A1 | collagen, type XI, alpha 1 | 0.00460628 |
| TNNC1 | troponin C type 1 (slow) | 0.00460207 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | 0.00457528 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00457497 |
| CD163 | CD163 molecule | 0.00453937 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | 0.00449788 |
| SULF1 | sulfatase 1 | 0.00449524 |
| FAM120A | family with sequence similarity 120A | 0.00449423 |
| MAPK1IP1L | mitogen-activated protein kinase 1 interacting protein 1-like | 0.00447808 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 0.00447348 |
| NEBL | nebulette | 0.00446754 |
| PITX1 | paired-like homeodomain 1 | 0.00444321 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00439939 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0043729 |
| POSTN | periostin, osteoblast specific factor | 0.0043658 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00435356 |
| BMP4 | bone morphogenetic protein 4 | 0.00435089 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 0.00434596 |
| CTSE | cathepsin E | 0.00433242 |
| CYB5R2 | cytochrome b5 reductase 2 | 0.00431661 |
| FASTKD5 | FAST kinase domains 5 | 0.00429927 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | 0.00428579 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.00427059 |
| YBX1 | Y box binding protein 1 | 0.00426683 |
| SPRR3 | small proline-rich protein 3 | 0.00425872 |
| ACKR3 | atypical chemokine receptor 3 | 0.00425867 |
| THBS2 | thrombospondin 2 | 0.00425805 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00425789 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.00424544 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0042262 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.00422453 |
| FOXE1 | forkhead box E1 | 0.00422373 |
| HK2 | hexokinase 2 | 0.00421343 |
| STOM | stomatin | 0.00418932 |
| CADM1 | cell adhesion molecule 1 | 0.00418566 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.00418291 |
| TLCD3A | TLC domain containing 3A | 0.00417312 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00416047 |
| COL4A5 | collagen, type IV, alpha 5 | 0.00414714 |
| MYO1B | myosin IB | 0.004122 |
| PKP1 | plakophilin 1 | 0.00410149 |
| TMPRSS11E | transmembrane protease, serine 11E | 0.0040994 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.00407486 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.00406783 |
| FABP7 | fatty acid binding protein 7, brain | 0.00406719 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00406566 |
| HTRA1 | HtrA serine peptidase 1 | 0.00406531 |
| PLAT | plasminogen activator, tissue | 0.00406417 |
| CKAP4 | cytoskeleton-associated protein 4 | 0.00406192 |
| LYST | lysosomal trafficking regulator | 0.00405311 |
| STC2 | stanniocalcin 2 | 0.00404759 |
| ADAM23 | ADAM metallopeptidase domain 23 | 0.0040401 |
| GRIK2 | glutamate receptor, ionotropic, kainate 2 | 0.00401809 |
| CTSB | cathepsin B | 0.00401146 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | 0.00401087 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.00399778 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | 0.00399628 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00399589 |
| CAPRIN2 | caprin family member 2 | 0.00398708 |
| PLP1 | proteolipid protein 1 | 0.00398128 |
| RTCA | RNA 3'-terminal phosphate cyclase | 0.00398125 |
| ASPN | asporin | 0.00397879 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00397826 |
| CALCA | calcitonin-related polypeptide alpha | 0.00397513 |
| ENAH | enabled homolog (Drosophila) | 0.00395349 |
| NOL8 | nucleolar protein 8 | 0.00393635 |
| COG7 | component of oligomeric golgi complex 7 | 0.0039213 |
| DSP | desmoplakin | 0.00392033 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00391967 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00390364 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00387832 |
| COMP | cartilage oligomeric matrix protein | 0.00387267 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.00386587 |
| SYCP2 | synaptonemal complex protein 2 | 0.00386308 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.00385731 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 0.00385723 |
| STAG3 | stromal antigen 3 | 0.00385683 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.00384565 |
| SIRT3 | sirtuin 3 | 0.00384512 |
| PSAP | prosaposin | 0.00383567 |
| COL4A6 | collagen, type IV, alpha 6 | 0.00381287 |
| SCPEP1 | serine carboxypeptidase 1 | 0.00380873 |
| CLCA4 | chloride channel accessory 4 | 0.00380854 |
| MORF4L2 | mortality factor 4 like 2 | 0.00380274 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.0037992 |
| AKAP8L | A kinase (PRKA) anchor protein 8-like | 0.0037976 |
| NOP56 | NOP56 ribonucleoprotein | 0.00379525 |
| VCAN | versican | 0.00378769 |
| ASS1 | argininosuccinate synthase 1 | 0.00377878 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0037725 |
| SVIL | supervillin | 0.00375798 |
| MINK1 | misshapen-like kinase 1 | 0.00375695 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00375351 |
| DUOX2 | dual oxidase 2 | 0.00374809 |
| CD14 | CD14 molecule | 0.00373863 |
| SLC16A4 | solute carrier family 16, member 4 | 0.00373697 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.00372793 |
| MAP9 | microtubule-associated protein 9 | 0.0036938 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.0036893 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.00368772 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | 0.0036831 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.00368239 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 | 0.00368011 |
| KLK11 | kallikrein-related peptidase 11 | 0.00366856 |
| TMEM110 | transmembrane protein 110 | 0.00366838 |
| CENPE | centromere protein E, 312kDa | 0.00366432 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 0.00365453 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.00365324 |
| CST7 | cystatin F (leukocystatin) | 0.00364791 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.00363779 |
| CKM | creatine kinase, muscle | 0.0036346 |
| KCNK12 | potassium channel, two pore domain subfamily K, member 12 | 0.00362916 |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.00362892 |
| NNMT | nicotinamide N-methyltransferase | 0.00361902 |
| SALL1 | spalt-like transcription factor 1 | 0.00361824 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0036095 |
| COQ8A | coenzyme Q8A | 0.00359902 |
| RFX5 | regulatory factor X, 5 (influences HLA class II expression) | 0.00359492 |
| MMP8 | matrix metallopeptidase 8 | 0.00359444 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.00358877 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.00358758 |
| IFT20 | intraflagellar transport 20 | 0.00358708 |
| LRRN3 | leucine rich repeat neuronal 3 | 0.00358297 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.00357217 |
| RADX | RPA1 related single stranded DNA binding protein, X-linked | 0.0035588 |
| GYG1 | glycogenin 1 | 0.00355185 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00354857 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.00354327 |
| GPR87 | G protein-coupled receptor 87 | 0.00352965 |
| KLHL41 | kelch-like family member 41 | 0.00352655 |
| CTTN | cortactin | 0.00352244 |
| KRT16 | keratin 16, type I | 0.00351117 |
| CSTB | cystatin B (stefin B) | 0.0035018 |
| SPP1 | secreted phosphoprotein 1 | 0.00349932 |
| AIM2 | absent in melanoma 2 | 0.00349377 |
| CAPN9 | calpain 9 | 0.00349291 |
| CD1E | CD1e molecule | 0.00349139 |
| FERMT1 | fermitin family member 1 | 0.00348119 |
| NPIPA1 | nuclear pore complex interacting protein family, member A1 | 0.00346738 |
| MLPH | melanophilin | 0.00346657 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | 0.00346322 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.00345896 |
| DUSP10 | dual specificity phosphatase 10 | 0.00345615 |
| MALL | mal, T-cell differentiation protein-like | 0.00344725 |
| NKX2-1 | NK2 homeobox 1 | 0.003445 |
| TMEM255A | transmembrane protein 255A | 0.00343602 |
| PFKP | phosphofructokinase, platelet | 0.00342415 |
| CAPG | capping protein (actin filament), gelsolin-like | 0.00342028 |
| SFTPA2 | surfactant protein A2 | 0.00341345 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.00340972 |
| RHOB | ras homolog family member B | 0.00340881 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.00340641 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.00340484 |
| PLXND1 | plexin D1 | 0.00339438 |
| TAGLN | transgelin | 0.00339226 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 0.00338833 |
| TJP2 | tight junction protein 2 | 0.00338757 |
| ETNPPL | ethanolamine-phosphate phospho-lyase | 0.00338489 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.00338342 |
| HSPE1 | heat shock 10kDa protein 1 | 0.00338309 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0111372 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.0102703 |
| TMSB15A | thymosin beta 15a | -0.00952978 |
| DEFB1 | defensin, beta 1 | -0.00917542 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00893746 |
| EMX2 | empty spiracles homeobox 2 | -0.0073402 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00732514 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00730273 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0068762 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00687045 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00641242 |
| SCAND1 | SCAN domain containing 1 | -0.0063276 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00632734 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0063155 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.00631232 |
| PDGFD | platelet derived growth factor D | -0.00605634 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.00600945 |
| CRYM | crystallin, mu | -0.00591487 |
| HSPA13 | heat shock protein 70kDa family, member 13 | -0.00584522 |
| KRT23 | keratin 23, type I | -0.00581491 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00579586 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -0.00576854 |
| C3ORF14 | chromosome 3 open reading frame 14 | -0.00574237 |
| NPTX2 | neuronal pentraxin II | -0.00561711 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00558752 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00547971 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00547868 |
| CFH | complement factor H | -0.00547558 |
| TXNDC9 | thioredoxin domain containing 9 | -0.00542733 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00542366 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00536774 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00532607 |
| GPR183 | G protein-coupled receptor 183 | -0.00528329 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00527019 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.00521913 |
| TUBB6 | tubulin, beta 6 class V | -0.00521488 |
| C1ORF115 | chromosome 1 open reading frame 115 | -0.00518211 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00517852 |
| PDGFC | platelet derived growth factor C | -0.00511616 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.00511275 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | -0.00510469 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00504465 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | -0.00500758 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.00499654 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00498601 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | -0.00497765 |
| MRTFB | myocardin related transcription factor B | -0.00492745 |
| EPHB2 | EPH receptor B2 | -0.00492521 |
| RIPOR2 | RHO family interacting cell polarization regulator 2 | -0.00492342 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | -0.00488854 |
| CLU | clusterin | -0.00487274 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00486265 |
| DCXR | dicarbonyl/L-xylulose reductase | -0.00484612 |
| CCL21 | chemokine (C-C motif) ligand 21 | -0.00482788 |
| HNMT | histamine N-methyltransferase | -0.00481291 |
| FKBP14 | FK506 binding protein 14, 22 kDa | -0.00480867 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00480377 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00479313 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -0.00478974 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00478656 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.00478406 |
| TRIB2 | tribbles pseudokinase 2 | -0.0047687 |
| TARP | TCR gamma alternate reading frame protein | -0.00476713 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00475595 |
| RPA3 | replication protein A3, 14kDa | -0.0047386 |
| SDC2 | syndecan 2 | -0.00473516 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -0.00471328 |
| MGLL | monoglyceride lipase | -0.00469355 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.00468828 |
| ZNF217 | zinc finger protein 217 | -0.00461469 |
| FAM3C | family with sequence similarity 3, member C | -0.00459699 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.00457065 |
| ALPL | alkaline phosphatase, liver/bone/kidney | -0.00456963 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | -0.00450842 |
| COL9A3 | collagen, type IX, alpha 3 | -0.00449728 |
| ASRGL1 | asparaginase like 1 | -0.00448038 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | -0.0044786 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.00445474 |
| CRIP2 | cysteine-rich protein 2 | -0.00444935 |
| GSS | glutathione synthetase | -0.00439685 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.00438659 |
| WWOX | WW domain containing oxidoreductase | -0.00436723 |
| STK17A | serine/threonine kinase 17a | -0.00436289 |
| DPEP1 | dipeptidase 1 (renal) | -0.00436284 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00436201 |
| MT1E | metallothionein 1E | -0.00434804 |
| KRCC1 | lysine-rich coiled-coil 1 | -0.00433562 |
| SEPTIN10 | septin 10 | -0.00432181 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.00429439 |
| DLD | dihydrolipoamide dehydrogenase | -0.00429265 |
| ACAD8 | acyl-CoA dehydrogenase family, member 8 | -0.00425909 |
| TOX3 | TOX high mobility group box family member 3 | -0.0042573 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.00424645 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.00423268 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0042187 |
| CCR7 | chemokine (C-C motif) receptor 7 | -0.00417736 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00417633 |
| MDFIC | MyoD family inhibitor domain containing | -0.00417106 |
| LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 | -0.00416887 |
| TDO2 | tryptophan 2,3-dioxygenase | -0.00416728 |
| SIVA1 | SIVA1, apoptosis-inducing factor | -0.00415145 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | -0.00414878 |
| KLK5 | kallikrein-related peptidase 5 | -0.00414848 |
| CDCA4 | cell division cycle associated 4 | -0.00412187 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | -0.00412052 |
| COMMD10 | COMM domain containing 10 | -0.00411164 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00409018 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.00408412 |
| NTS | neurotensin | -0.00407291 |
| CNN3 | calponin 3, acidic | -0.00406693 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -0.00405971 |
| FASN | fatty acid synthase | -0.00405246 |
| CPNE1 | copine I | -0.00404078 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | -0.00403056 |
| PPL | periplakin | -0.00402959 |
| PEX3 | peroxisomal biogenesis factor 3 | -0.00402385 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.00401821 |
| BIN1 | bridging integrator 1 | -0.00400728 |
| KLK8 | kallikrein-related peptidase 8 | -0.00398853 |
| SH3BP4 | SH3-domain binding protein 4 | -0.00398712 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | -0.00398231 |
| ZNF91 | zinc finger protein 91 | -0.00396355 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.00395909 |
| EREG | epiregulin | -0.00395193 |
| HMGB3 | high mobility group box 3 | -0.00394948 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | -0.00391622 |
| RAB32 | RAB32, member RAS oncogene family | -0.00391092 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.0038989 |
| BICC1 | BicC family RNA binding protein 1 | -0.00388828 |
| SYNJ2 | synaptojanin 2 | -0.00388472 |
| TEX30 | testis expressed 30 | -0.00388317 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | -0.00388022 |
| CEP170B | centrosomal protein 170B | -0.00385367 |
| IDE | insulin-degrading enzyme | -0.00385313 |
| MCOLN1 | mucolipin 1 | -0.00385099 |
| FBL | fibrillarin | -0.00384242 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00381513 |
| FANCG | Fanconi anemia, complementation group G | -0.00381239 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.00380358 |
| DACH1 | dachshund family transcription factor 1 | -0.00379543 |
| CLDN3 | claudin 3 | -0.00378543 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | -0.00377815 |
| ISYNA1 | inositol-3-phosphate synthase 1 | -0.00377591 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.00377461 |
| SEC61G | Sec61 gamma subunit | -0.00377428 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | -0.00377289 |
| ADIRF | adipogenesis regulatory factor | -0.00376459 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.00375815 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.0037518 |
| ZNF395 | zinc finger protein 395 | -0.00375025 |
| PHF20 | PHD finger protein 20 | -0.00374367 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.00373509 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00373338 |
| XYLT1 | xylosyltransferase I | -0.00373237 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00372437 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.00372225 |
| EPCAM | epithelial cell adhesion molecule | -0.00371765 |
| SPART | spartin | -0.003707 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00370544 |
| SASH1 | SAM and SH3 domain containing 1 | -0.00369858 |
| AOX1 | aldehyde oxidase 1 | -0.00369604 |
| RAB11FIP2 | RAB11 family interacting protein 2 (class I) | -0.00369031 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00368629 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | -0.00368527 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00367659 |
| NAV3 | neuron navigator 3 | -0.0036607 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00364823 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -0.00364169 |
| NUDCD3 | NudC domain containing 3 | -0.00364045 |
| ERGIC3 | ERGIC and golgi 3 | -0.00363793 |
| NDUFA6 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa | -0.00363062 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | -0.00362699 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | -0.00362503 |
| NYNRIN | NYN domain and retroviral integrase containing | -0.00362487 |
| NBEA | neurobeachin | -0.00361722 |
| CIB2 | calcium and integrin binding family member 2 | -0.0036169 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.0036092 |
| BEX1 | brain expressed, X-linked 1 | -0.00359594 |
| CES1 | carboxylesterase 1 | -0.00359294 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00359136 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.00358845 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | -0.00357745 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | -0.00357715 |
| RDX | radixin | -0.00357359 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.00357098 |
| RGS1 | regulator of G-protein signaling 1 | -0.00356363 |
| MPHOSPH6 | M-phase phosphoprotein 6 | -0.00355614 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.00354193 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.00353113 |
| ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 | -0.00352891 |
| TMEM106C | transmembrane protein 106C | -0.00350121 |
| DAPK1 | death-associated protein kinase 1 | -0.00349468 |
| HOXB2 | homeobox B2 | -0.00348858 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.00348788 |
| ACYP1 | acylphosphatase 1, erythrocyte (common) type | -0.00348585 |
| RGL1 | ral guanine nucleotide dissociation stimulator-like 1 | -0.00348418 |
| PSMA2 | proteasome (prosome, macropain) subunit, alpha type, 2 | -0.00348031 |
| ETV5 | ets variant 5 | -0.00347912 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00347621 |
| CENPX | centromere protein X | -0.00346872 |
| WDTC1 | WD and tetratricopeptide repeats 1 | -0.00345928 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | -0.00345865 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.00345827 |
| FCGRT | Fc fragment of IgG, receptor, transporter, alpha | -0.00345371 |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | -0.00345371 |
| FSCN1 | fascin actin-bundling protein 1 | -0.00345359 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00345014 |
| VIM | vimentin | -0.00344164 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | -0.00344139 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.00343307 |
| MAST2 | microtubule associated serine/threonine kinase 2 | -0.00342034 |
| CP | ceruloplasmin (ferroxidase) | -0.00341667 |
| HSD17B4 | hydroxysteroid (17-beta) dehydrogenase 4 | -0.00341497 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.00341393 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | -0.00341302 |
| APOC1 | apolipoprotein C-I | -0.00339912 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.00339866 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | -0.00339818 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00339708 |
| MSH2 | mutS homolog 2 | -0.0033934 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | -0.00338047 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | -0.00337285 |
| MAMLD1 | mastermind-like domain containing 1 | -0.0033701 |
| MX2 | MX dynamin-like GTPase 2 | -0.00335776 |
| STOML2 | stomatin (EPB72)-like 2 | -0.00335687 |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | -0.00335534 |
| KYAT3 | kynurenine aminotransferase 3 | -0.00335485 |
| OSMR | oncostatin M receptor | -0.00334821 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.00334626 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00334503 |
| DHCR24 | 24-dehydrocholesterol reductase | -0.00333681 |
| WT1 | Wilms tumor 1 | -0.0033345 |
| AZI2 | 5-azacytidine induced 2 | -0.00333204 |
| EFNB3 | ephrin-B3 | -0.00333109 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.00333016 |
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | -0.00332443 |
| RUNX3 | runt-related transcription factor 3 | -0.00331684 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.00331307 |
| RXYLT1 | ribitol xylosyltransferase 1 | -0.00330816 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00329926 |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | -0.00329888 |
| TST | thiosulfate sulfurtransferase (rhodanese) | -0.00329801 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00327674 |
| ST6GALNAC5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | -0.00327013 |
| CTSG | cathepsin G | -0.00326654 |
| IFI44 | interferon-induced protein 44 | -0.00326488 |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | -0.00326197 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.003261 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.00325731 |
| CLDN10 | claudin 10 | -0.00325665 |
