IKZF1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description IKAROS family zinc finger 1 (Ikaros)|This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 10320)
External Link http://www.ncbi.nlm.nih.gov/gene/10320
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243 interacting proteins for IKZF1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACIN1 apoptotic chromatin condensation inducer 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADNP activity-dependent neuroprotector homeobox
AGPS alkylglycerone phosphate synthase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKAP8 A kinase (PRKA) anchor protein 8
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD11 ankyrin repeat domain 11
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARID4A AT rich interactive domain 4A (RBP1-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATAD2 ATPase family, AAA domain containing 2
ATG2B autophagy related 2B
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAG2 BCL2-associated athanogene 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BBX bobby sox homolog (Drosophila)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEND3 BEN domain containing 3
BRMS1 breast cancer metastasis suppressor 1
BRMS1L breast cancer metastasis-suppressor 1-like
BTK Bruton agammaglobulinemia tyrosine kinase
C11ORF30 chromosome 11 open reading frame 30
C2ORF47 chromosome 2 open reading frame 47
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALU calumenin
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDYL chromodomain protein, Y-like
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
CIRH1A cirrhosis, autosomal recessive 1A (cirhin)
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CPT1A carnitine palmitoyltransferase 1A (liver)
CRBN cereblon
CSNK1G1 casein kinase 1, gamma 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
DCX doublecortin
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
DICER1 dicer 1, ribonuclease type III
DKC1 dyskeratosis congenita 1, dyskerin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EBNA1BP2 EBNA1 binding protein 2
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
ERLIN2 ER lipid raft associated 2
ESD esterase D
ETV5 ets variant 5
FAM214B family with sequence similarity 214, member B
FAM50B family with sequence similarity 50, member B
FAM60A family with sequence similarity 60, member A
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATAD1 GATA zinc finger domain containing 1
GATAD2A GATA zinc finger domain containing 2A
GATAD2B GATA zinc finger domain containing 2B
GCFC2 GC-rich sequence DNA-binding factor 2
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GEMIN2 gem (nuclear organelle) associated protein 2
GEMIN4 gem (nuclear organelle) associated protein 4
GSE1 Gse1 coiled-coil protein
GTF2B general transcription factor IIB
H1FX H1 histone family, member X
HDAC1 histone deacetylase 1
HDAC11 histone deacetylase 11
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HDIP1 HDAC and MIER1 interacting protein 1
HEATR1 HEAT repeat containing 1
HHIP hedgehog interacting protein
HIST1H3B histone cluster 1, H3b
HJURP Holliday junction recognition protein
HMG20A high mobility group 20A
HMG20B high mobility group 20B
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IK IK cytokine, down-regulator of HLA II
IKZF2 IKAROS family zinc finger 2 (Helios)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IKZF4 IKAROS family zinc finger 4 (Eos)
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
KDM1A lysine (K)-specific demethylase 1A
KDM5A lysine (K)-specific demethylase 5A
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA3 karyopherin alpha 3 (importin alpha 4)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KPNA6 karyopherin alpha 6 (importin alpha 7)
MBD2 methyl-CpG binding domain protein 2
MBD3 methyl-CpG binding domain protein 3
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MDN1 MDN1, midasin homolog (yeast)
MIER1 mesoderm induction early response 1, transcriptional regulator
MIER2 mesoderm induction early response 1, family member 2
MIER3 mesoderm induction early response 1, family member 3
MLF2 myeloid leukemia factor 2
MPPED2 metallophosphoesterase domain containing 2
MSH6 mutS homolog 6
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTA3 metastasis associated 1 family, member 3
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NCOR2 nuclear receptor corepressor 2
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NOTCH1 notch 1
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUP133 nucleoporin 133kDa
NUP153 nucleoporin 153kDa
NUP85 nucleoporin 85kDa
NUP93 nucleoporin 93kDa
NUP98 nucleoporin 98kDa
PAXBP1 PAX3 and PAX7 binding protein 1
PDCD11 programmed cell death 11
PES1 pescadillo ribosomal biogenesis factor 1
PFDN2 prefoldin subunit 2
PFDN5 prefoldin subunit 5
PFDN6 prefoldin subunit 6
PHF12 PHD finger protein 12
PHF21A PHD finger protein 21A
PHIP pleckstrin homology domain interacting protein
PML promyelocytic leukemia
PNN pinin, desmosome associated protein
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
PPAN peter pan homolog (Drosophila)
PPP6R1 protein phosphatase 6, regulatory subunit 1
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF6 pre-mRNA processing factor 6
PWWP2A PWWP domain containing 2A
RAD51D RAD51 paralog D
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RBBP8 retinoblastoma binding protein 8
RBM12B-AS1 RBM12B antisense RNA 1
RBM14 RNA binding motif protein 14
RBM22 RNA binding motif protein 22
RBM28 RNA binding motif protein 28
RBM34 RNA binding motif protein 34
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RCOR1 REST corepressor 1
RCOR2 REST corepressor 2
RCOR3 REST corepressor 3
RERE arginine-glutamic acid dipeptide (RE) repeats
RIF1 replication timing regulatory factor 1
RNF219 ring finger protein 219
RREB1 ras responsive element binding protein 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
RWDD2B RWD domain containing 2B
SAP130 Sin3A-associated protein, 130kDa
SAP18 Sin3A-associated protein, 18kDa
SAP30 Sin3A-associated protein, 30kDa
SAP30L SAP30-like
SEC16A SEC16 homolog A (S. cerevisiae)
SF3A1 splicing factor 3a, subunit 1, 120kDa
SF3B2 splicing factor 3b, subunit 2, 145kDa
SIN3A SIN3 transcription regulator family member A
SIN3B SIN3 transcription regulator family member B
SLC25A42 solute carrier family 25, member 42
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SMN2 survival of motor neuron 2, centromeric
SNW1 SNW domain containing 1
SON SON DNA binding protein
SRRM2 serine/arginine repetitive matrix 2
STAG1 stromal antigen 1
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SYK spleen tyrosine kinase
SYNE2 spectrin repeat containing, nuclear envelope 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBP TATA box binding protein
TDG thymine-DNA glycosylase
TFIP11 tuftelin interacting protein 11
THRAP3 thyroid hormone receptor associated protein 3
TNRC18 trinucleotide repeat containing 18
TRERF1 transcriptional regulating factor 1
TRMT61A tRNA methyltransferase 61A
TTC27 tetratricopeptide repeat domain 27
TTF2 transcription termination factor, RNA polymerase II
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
VBP1 von Hippel-Lindau binding protein 1
WDR33 WD repeat domain 33
WDR36 WD repeat domain 36
WDR5 WD repeat domain 5
WDR74 WD repeat domain 74
WRNIP1 Werner helicase interacting protein 1
XAB2 XPA binding protein 2
YBX2 Y box binding protein 2
YBX3 Y box binding protein 3
YLPM1 YLP motif containing 1
ZBTB2 zinc finger and BTB domain containing 2
ZFR zinc finger RNA binding protein
ZMYM2 zinc finger, MYM-type 2
ZMYM3 zinc finger, MYM-type 3
ZMYND8 zinc finger, MYND-type containing 8
ZNF217 zinc finger protein 217
ZNF326 zinc finger protein 326
ZNF512B zinc finger protein 512B
ZNF516 zinc finger protein 516
ZNF521 zinc finger protein 521
ZNF592 zinc finger protein 592
ZNF609 zinc finger protein 609
ZNF687 zinc finger protein 687
ZNF827 zinc finger protein 827