IKZF3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description IKAROS family zinc finger 3 (Aiolos)|This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 22806)
External Link http://www.ncbi.nlm.nih.gov/gene/22806
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Genes

46 interacting proteins for IKZF3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BCL2L1 BCL2-like 1
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
CRBN cereblon
CTBP1 C-terminal binding protein 1
DGCR6 DiGeorge syndrome critical region gene 6
DOK2 docking protein 2, 56kDa
FOXP3 forkhead box P3
GAB2 GRB2-associated binding protein 2
GRB2 growth factor receptor-bound protein 2
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HRAS Harvey rat sarcoma viral oncogene homolog
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF2 IKAROS family zinc finger 2 (Helios)
IKZF4 IKAROS family zinc finger 4 (Eos)
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
JAK1 Janus kinase 1
JAK3 Janus kinase 3
LCK LCK proto-oncogene, Src family tyrosine kinase
LDOC1 leucine zipper, down-regulated in cancer 1
MAGOHB mago-nashi homolog B (Drosophila)
NOTCH1 notch 1
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBBP8 retinoblastoma binding protein 8
RCOR3 REST corepressor 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIN3A SIN3 transcription regulator family member A
SIN3B SIN3 transcription regulator family member B
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
TCAF1 TRPM8 channel-associated factor 1
TEKT4 tektin 4
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I