IL11 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interleukin 11|The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012] (NCBI Entrez Gene Database, 3589)
External Link http://www.ncbi.nlm.nih.gov/gene/3589
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Genes

12 interacting proteins for IL11 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
IL11RA interleukin 11 receptor, alpha
IL6ST interleukin 6 signal transducer
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK3 Janus kinase 3
MAGEA11 melanoma antigen family A11
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLA2 Src-like-adaptor 2
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)