| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | interleukin 2|The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3558) |
| External Link | https://ncbi.nlm.nih.gov/gene/3558 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the IL2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0179136 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | 0.0176646 |
| WDR7 | WD repeat domain 7 | 0.0159036 |
| MAP7 | microtubule-associated protein 7 | 0.0145021 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0134354 |
| HOPX | HOP homeobox | 0.0128402 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.0115004 |
| CA2 | carbonic anhydrase II | 0.0112436 |
| ARG1 | arginase 1 | 0.0112173 |
| CLU | clusterin | 0.0111452 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0109639 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0103468 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.0101553 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.010091 |
| RNF167 | ring finger protein 167 | 0.0100433 |
| NPY | neuropeptide Y | 0.00995699 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.00995328 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | 0.00956061 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00947443 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.00942929 |
| RPA3 | replication protein A3, 14kDa | 0.00929104 |
| PLK1 | polo-like kinase 1 | 0.00925679 |
| RGS5 | regulator of G-protein signaling 5 | 0.00920849 |
| DNASE1L3 | deoxyribonuclease I-like 3 | 0.00916021 |
| DCK | deoxycytidine kinase | 0.00915641 |
| CST7 | cystatin F (leukocystatin) | 0.00890851 |
| EPHB2 | EPH receptor B2 | 0.00885965 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.00870263 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.00868746 |
| FAM162A | family with sequence similarity 162, member A | 0.00866783 |
| CLEC2B | C-type lectin domain family 2, member B | 0.00864115 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00858165 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.00852005 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.0084398 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.00843281 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00833256 |
| CLC | Charcot-Leyden crystal galectin | 0.00819966 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00816239 |
| TMSB15A | thymosin beta 15a | 0.00815894 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.00812885 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0081046 |
| S100A12 | S100 calcium binding protein A12 | 0.00809912 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00805492 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.00803721 |
| TXNL4A | thioredoxin-like 4A | 0.00799881 |
| TMEM14A | transmembrane protein 14A | 0.00795159 |
| OLFM1 | olfactomedin 1 | 0.00792283 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.007876 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.00786598 |
| EAPP | E2F-associated phosphoprotein | 0.0077661 |
| PFKL | phosphofructokinase, liver | 0.00770526 |
| ANOS1 | anosmin 1 | 0.00765909 |
| FGL2 | fibrinogen-like 2 | 0.00764581 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00764315 |
| NKG7 | natural killer cell granule protein 7 | 0.00761369 |
| PODXL | podocalyxin-like | 0.00760827 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0076041 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 0.00754841 |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | 0.0074607 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 0.00738077 |
| CD69 | CD69 molecule | 0.00730588 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00729854 |
| SRGN | serglycin | 0.00728335 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00724412 |
| NSF | N-ethylmaleimide-sensitive factor | 0.00724137 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.00715126 |
| IL2RB | interleukin 2 receptor, beta | 0.0071398 |
| TXNL1 | thioredoxin-like 1 | 0.00711885 |
| S100A9 | S100 calcium binding protein A9 | 0.00702906 |
| RHOB | ras homolog family member B | 0.00702119 |
| TARP | TCR gamma alternate reading frame protein | 0.00686843 |
| CRYM | crystallin, mu | 0.00679378 |
| PPP1R16B | protein phosphatase 1, regulatory subunit 16B | 0.00676776 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 0.00676193 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 0.00673662 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.00673595 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | 0.00671571 |
| ARPP21 | cAMP-regulated phosphoprotein, 21kDa | 0.00669712 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.00669566 |
| MMP9 | matrix metallopeptidase 9 | 0.0066812 |
| COMMD10 | COMM domain containing 10 | 0.00666097 |
| S100P | S100 calcium binding protein P | 0.00665198 |
| FOXF1 | forkhead box F1 | 0.00662716 |
| ECI2 | enoyl-CoA delta isomerase 2 | 0.00662634 |
| GADD45G | growth arrest and DNA-damage-inducible, gamma | 0.00662169 |
| CHN2 | chimerin 2 | 0.00662126 |
| INSIG1 | insulin induced gene 1 | 0.00661509 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | 0.00659957 |
| MCM6 | minichromosome maintenance complex component 6 | 0.00658725 |
| CCNA2 | cyclin A2 | 0.00658722 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00658226 |
| CPE | carboxypeptidase E | 0.00657723 |
| LYPLA1 | lysophospholipase I | 0.00654963 |
| ETNPPL | ethanolamine-phosphate phospho-lyase | 0.0065411 |
| RGS1 | regulator of G-protein signaling 1 | 0.00652235 |
| FASN | fatty acid synthase | 0.00644224 |
| RAPSN | receptor-associated protein of the synapse | 0.00643742 |
| C7 | complement component 7 | 0.00640493 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.0063603 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.00635921 |
| EAF2 | ELL associated factor 2 | 0.00633933 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | 0.00633625 |
| LDB2 | LIM domain binding 2 | 0.00632771 |
| RIDA | reactive intermediate imine deaminase A homolog | 0.00628595 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | 0.00626382 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 0.00626103 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.00625893 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00625885 |
| CMC2 | C-x(9)-C motif containing 2 | 0.00624194 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.00623601 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | 0.00623181 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 0.00620646 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.00620019 |
| DDN | dendrin | 0.00619771 |
| PTK2 | protein tyrosine kinase 2 | 0.00617708 |
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.00615354 |
| CCNB2 | cyclin B2 | 0.00614508 |
| DSG1 | desmoglein 1 | 0.00612364 |
| TMEM106C | transmembrane protein 106C | 0.00612078 |
| MECOM | MDS1 and EVI1 complex locus | 0.00610843 |
| CLDND1 | claudin domain containing 1 | 0.00610323 |
| GUCY1B3 | guanylate cyclase 1, soluble, beta 3 | 0.00608821 |
| CTSC | cathepsin C | 0.00608582 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 0.00608474 |
| C12ORF29 | chromosome 12 open reading frame 29 | 0.00607387 |
| GSTO1 | glutathione S-transferase omega 1 | 0.0060531 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.00604021 |
| TRAPPC2L | trafficking protein particle complex 2-like | 0.0060351 |
| RPRD1A | regulation of nuclear pre-mRNA domain containing 1A | 0.00603196 |
| PCLAF | PCNA clamp associated factor | 0.00603125 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.00600971 |
| TPM4 | tropomyosin 4 | 0.00600508 |
| ASNSD1 | asparagine synthetase domain containing 1 | 0.00600032 |
| MGST2 | microsomal glutathione S-transferase 2 | 0.00599126 |
| PPA2 | pyrophosphatase (inorganic) 2 | 0.00597734 |
| UQCRC1 | ubiquinol-cytochrome c reductase core protein I | 0.00596603 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00596358 |
| NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | 0.0059634 |
| ADH1C | alcohol dehydrogenase 1C (class I), gamma polypeptide | 0.005951 |
| KIFAP3 | kinesin-associated protein 3 | 0.00594699 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.00593704 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | 0.0059215 |
| MOCS2 | molybdenum cofactor synthesis 2 | 0.00591691 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.00591648 |
| GPR171 | G protein-coupled receptor 171 | 0.00591474 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.005911 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.00588654 |
| TMEM38B | transmembrane protein 38B | 0.00584687 |
| COMMD8 | COMM domain containing 8 | 0.0058433 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00583855 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00583604 |
| ENG | endoglin | 0.00582137 |
| SELENOW | selenoprotein W | 0.00581696 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.00581324 |
| GYG1 | glycogenin 1 | 0.00581152 |
| VBP1 | von Hippel-Lindau binding protein 1 | 0.00579197 |
| MRPL13 | mitochondrial ribosomal protein L13 | 0.00578816 |
| SRP9 | signal recognition particle 9kDa | 0.00577442 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.00575596 |
| SLAMF7 | SLAM family member 7 | 0.00574077 |
| CDK1 | cyclin-dependent kinase 1 | 0.00573281 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.00569822 |
| CLEC4A | C-type lectin domain family 4, member A | 0.00569725 |
| COPS4 | COP9 signalosome subunit 4 | 0.00569679 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00567412 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | 0.00566907 |
| TRAPPC10 | trafficking protein particle complex 10 | 0.0056663 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.00565684 |
| PHACTR2 | phosphatase and actin regulator 2 | 0.00565301 |
| LOR | loricrin | 0.00564171 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | 0.00564028 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | 0.00563922 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.00561605 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.00560776 |
| SKP1 | S-phase kinase-associated protein 1 | 0.00560313 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00559157 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.00558742 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | 0.00558607 |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.0055763 |
| RPS5 | ribosomal protein S5 | 0.00556013 |
| THY1 | Thy-1 cell surface antigen | 0.00555048 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.00553075 |
| SUMO3 | small ubiquitin-like modifier 3 | 0.00552648 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00551814 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.00551758 |
| CD8A | CD8a molecule | 0.00547833 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00547478 |
| EREG | epiregulin | 0.00547214 |
| ABHD10 | abhydrolase domain containing 10 | 0.00546829 |
| LIMA1 | LIM domain and actin binding 1 | 0.00545279 |
| PLP1 | proteolipid protein 1 | 0.00544887 |
| SCG5 | secretogranin V | 0.00542001 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.00540707 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | 0.00540314 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.00539596 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.00539571 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00538024 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.00537586 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.00536928 |
| ACKR3 | atypical chemokine receptor 3 | 0.00536899 |
| RAB33A | RAB33A, member RAS oncogene family | 0.00536085 |
| LTF | lactotransferrin | 0.00534913 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.00534312 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 0.00534229 |
| LXN | latexin | 0.00534033 |
| SNX7 | sorting nexin 7 | 0.00533714 |
| ZG16 | zymogen granule protein 16 | 0.00533286 |
| C1QB | complement component 1, q subcomponent, B chain | 0.00529182 |
| NDRG1 | N-myc downstream regulated 1 | 0.00528886 |
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 0.00528098 |
| GPR65 | G protein-coupled receptor 65 | 0.00526727 |
| COX7B | cytochrome c oxidase subunit VIIb | 0.00526458 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | 0.00525841 |
| LST1 | leukocyte specific transcript 1 | 0.00524454 |
| HPF1 | histone PARylation factor 1 | 0.00524308 |
| LMAN1 | lectin, mannose-binding, 1 | 0.00522298 |
| CWH43 | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) | 0.00521756 |
| TSPAN13 | tetraspanin 13 | 0.00519473 |
| PIGN | phosphatidylinositol glycan anchor biosynthesis, class N | 0.00519102 |
| OTULINL | OTU deubiquitinase with linear linkage specificity like | 0.00519027 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | 0.00518701 |
| ADCY7 | adenylate cyclase 7 | 0.00518532 |
| CLCA1 | chloride channel accessory 1 | 0.00518377 |
| PPP2R2B | protein phosphatase 2, regulatory subunit B, beta | 0.00518363 |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 | 0.00516776 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00515663 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.00515238 |
| KIAA0125 | KIAA0125 | 0.00514834 |
| DEFB4A | defensin, beta 4A | 0.00513865 |
| TECR | trans-2,3-enoyl-CoA reductase | 0.00513485 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00512956 |
| RNASEH2A | ribonuclease H2, subunit A | 0.005123 |
| SEC24A | SEC24 family member A | 0.00511607 |
| MCM2 | minichromosome maintenance complex component 2 | 0.00511332 |
| VPS26C | VPS26 endosomal protein sorting factor C | 0.00510791 |
| HSPA13 | heat shock protein 70kDa family, member 13 | 0.0051053 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | 0.00510283 |
| AIF1 | allograft inflammatory factor 1 | 0.00509755 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00509459 |
| POLB | polymerase (DNA directed), beta | 0.00509226 |
| CXCR3 | chemokine (C-X-C motif) receptor 3 | 0.00508721 |
| WDR61 | WD repeat domain 61 | 0.00508395 |
| CLIC2 | chloride intracellular channel 2 | 0.00508352 |
| FAM107A | family with sequence similarity 107, member A | 0.00507429 |
| CST3 | cystatin C | 0.00507305 |
| GABARAPL2 | GABA(A) receptor-associated protein-like 2 | 0.00506244 |
| CD34 | CD34 molecule | 0.00506221 |
| CRYL1 | crystallin, lambda 1 | 0.00506153 |
| TCF21 | transcription factor 21 | 0.00506111 |
| SMAD4 | SMAD family member 4 | 0.00504171 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RRAGA | Ras-related GTP binding A | -0.0211233 |
| XIC | X chromosome inactivation center | -0.0179027 |
| MMP7 | matrix metallopeptidase 7 | -0.0171381 |
| APOD | apolipoprotein D | -0.0152731 |
| TXLNA | taxilin alpha | -0.0138977 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.0133345 |
| MAGEA3 | melanoma antigen family A3 | -0.0131098 |
| SPON2 | spondin 2, extracellular matrix protein | -0.0129178 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.0128194 |
| PCDH9 | protocadherin 9 | -0.0120806 |
| OSR2 | odd-skipped related transciption factor 2 | -0.0119146 |
| KRT19 | keratin 19, type I | -0.01186 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.0117543 |
| SYNM | synemin, intermediate filament protein | -0.0115917 |
| KRT15 | keratin 15, type I | -0.0114671 |
| ANXA1 | annexin A1 | -0.0111972 |
| PRAME | preferentially expressed antigen in melanoma | -0.0111477 |
| ASS1 | argininosuccinate synthase 1 | -0.010873 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.010834 |
| MAGEA12 | melanoma antigen family A12 | -0.0106618 |
| NLRP2 | NLR family, pyrin domain containing 2 | -0.0105211 |
| EMP1 | epithelial membrane protein 1 | -0.0104076 |
| CFD | complement factor D (adipsin) | -0.0103022 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | -0.0101548 |
| TSPYL5 | TSPY-like 5 | -0.0100329 |
| IRS2 | insulin receptor substrate 2 | -0.00999276 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.00992071 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.0098936 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00987164 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -0.00986235 |
| JAG1 | jagged 1 | -0.00986165 |
| MX1 | MX dynamin-like GTPase 1 | -0.00984295 |
| DSP | desmoplakin | -0.00982792 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00974028 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00969406 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00963256 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00949521 |
| PERP | PERP, TP53 apoptosis effector | -0.00939973 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00926941 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00924766 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.00922687 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.00917842 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | -0.0091542 |
| IER5 | immediate early response 5 | -0.00913024 |
| AREG | amphiregulin | -0.00902109 |
| YBX3 | Y box binding protein 3 | -0.00893488 |
| POSTN | periostin, osteoblast specific factor | -0.00893454 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.00888711 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00885797 |
| LOXL1 | lysyl oxidase-like 1 | -0.00884843 |
| ALOX5 | arachidonate 5-lipoxygenase | -0.00879048 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.00876527 |
| PDLIM4 | PDZ and LIM domain 4 | -0.00873908 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00860108 |
| NOTCH2NL | notch 2 N-terminal like | -0.00858545 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00857142 |
| RND3 | Rho family GTPase 3 | -0.00851338 |
| G0S2 | G0/G1 switch 2 | -0.00850979 |
| OAT | ornithine aminotransferase | -0.00848137 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00834447 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00831574 |
| RNASET2 | ribonuclease T2 | -0.00830335 |
| C3 | complement component 3 | -0.00826917 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.0082141 |
| RRAGD | Ras-related GTP binding D | -0.00820394 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.00819254 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.00817219 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00810269 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00800588 |
| VCL | vinculin | -0.00795885 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.00794343 |
| MME | membrane metallo-endopeptidase | -0.00793887 |
| GAS1 | growth arrest-specific 1 | -0.00792141 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00790863 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.00789833 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.00787932 |
| SSX1 | synovial sarcoma, X breakpoint 1 | -0.00780539 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00779835 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.00778997 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00769497 |
| TES | testin LIM domain protein | -0.00762582 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0076229 |
| PNMA8A | PNMA family member 8A | -0.00762181 |
| CAV2 | caveolin 2 | -0.00757892 |
| OPHN1 | oligophrenin 1 | -0.00757385 |
| HIST1H2BK | histone cluster 1, H2bk | -0.0075143 |
| COL6A1 | collagen, type VI, alpha 1 | -0.00743739 |
| TRIM29 | tripartite motif containing 29 | -0.00742127 |
| ENAH | enabled homolog (Drosophila) | -0.00741592 |
| TGFA | transforming growth factor, alpha | -0.00739971 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | -0.00738233 |
| EIF6 | eukaryotic translation initiation factor 6 | -0.00736152 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00734214 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00732533 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.00730916 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00730324 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.00729991 |
| KRT7 | keratin 7, type II | -0.00729808 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | -0.00729623 |
| ZMAT3 | zinc finger, matrin-type 3 | -0.00729355 |
| LAMA4 | laminin, alpha 4 | -0.00729235 |
| GNAS | GNAS complex locus | -0.00727704 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00725629 |
| FADS3 | fatty acid desaturase 3 | -0.00723788 |
| MAGEA4 | melanoma antigen family A4 | -0.00723187 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00722247 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00719384 |
| MGP | matrix Gla protein | -0.00719128 |
| FOXF2 | forkhead box F2 | -0.00716505 |
| IRS1 | insulin receptor substrate 1 | -0.00706919 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.00706722 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.00705633 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.0070285 |
| MXRA5 | matrix-remodelling associated 5 | -0.0069994 |
| PSG5 | pregnancy specific beta-1-glycoprotein 5 | -0.00697624 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00695862 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.00693998 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.00692186 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -0.00689891 |
| OXTR | oxytocin receptor | -0.00685619 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00682227 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.00681667 |
| FHL1 | four and a half LIM domains 1 | -0.00675851 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00675642 |
| ELOVL2 | ELOVL fatty acid elongase 2 | -0.00675274 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.00675085 |
| RIN2 | Ras and Rab interactor 2 | -0.00673434 |
| TUBB2B | tubulin, beta 2B class IIb | -0.00672919 |
| PLIN2 | perilipin 2 | -0.00672098 |
| TRIM38 | tripartite motif containing 38 | -0.00669854 |
| NID2 | nidogen 2 (osteonidogen) | -0.00665491 |
| MAGEA1 | melanoma antigen family A1 | -0.00665153 |
| LOC283683 | uncharacterized LOC283683 | -0.00665017 |
| S100A10 | S100 calcium binding protein A10 | -0.00664558 |
| RTCA | RNA 3'-terminal phosphate cyclase | -0.0066413 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.00663047 |
| APBA2 | amyloid beta (A4) precursor protein-binding, family A, member 2 | -0.00661949 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00661634 |
| SSPN | sarcospan | -0.00652236 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.00649192 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.00648339 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00644349 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00643422 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.00642286 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00640576 |
| LAMB3 | laminin, beta 3 | -0.00640343 |
| RANBP6 | RAN binding protein 6 | -0.00634139 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.00633635 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00633236 |
| BMP7 | bone morphogenetic protein 7 | -0.00631823 |
| DCT | dopachrome tautomerase | -0.00631429 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | -0.00630237 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | -0.00629041 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.00628794 |
| NINL | ninein-like | -0.00628145 |
| NOTCH2 | notch 2 | -0.00626672 |
| DUSP5 | dual specificity phosphatase 5 | -0.00626467 |
| GLDC | glycine dehydrogenase (decarboxylating) | -0.00626044 |
| THBS4 | thrombospondin 4 | -0.00625518 |
| PRPF4 | pre-mRNA processing factor 4 | -0.00624427 |
| LBH | limb bud and heart development | -0.00624126 |
| EPN2 | epsin 2 | -0.00622598 |
| TMEM43 | transmembrane protein 43 | -0.00622138 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.00621971 |
| DGKA | diacylglycerol kinase, alpha 80kDa | -0.0062191 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00620958 |
| NLGN1 | neuroligin 1 | -0.00620952 |
| TUFT1 | tuftelin 1 | -0.00619815 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 | -0.0061846 |
| LAMA2 | laminin, alpha 2 | -0.00617203 |
| BTG2 | BTG family, member 2 | -0.00616378 |
| KLK11 | kallikrein-related peptidase 11 | -0.00616283 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0061526 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -0.00613242 |
| CLGN | calmegin | -0.0061251 |
| CES3 | carboxylesterase 3 | -0.00611916 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.00611402 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00611362 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00611239 |
| CITED1 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | -0.00609187 |
| JAK1 | Janus kinase 1 | -0.00608236 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00607636 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00606631 |
| ARG2 | arginase 2 | -0.00605984 |
| GDF15 | growth differentiation factor 15 | -0.00604966 |
| SPATA20 | spermatogenesis associated 20 | -0.00604951 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.00604311 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | -0.00603756 |
| FBLN2 | fibulin 2 | -0.00602692 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.00602501 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0060178 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | -0.00599838 |
| USP3 | ubiquitin specific peptidase 3 | -0.00599573 |
| KRT5 | keratin 5, type II | -0.00598912 |
| TRAF3IP2 | TRAF3 interacting protein 2 | -0.00598659 |
| AEBP1 | AE binding protein 1 | -0.0059794 |
| FDX1 | ferredoxin 1 | -0.00596944 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00596199 |
| HIST1H2BD | histone cluster 1, H2bd | -0.00595869 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | -0.00594901 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00594608 |
| PUM3 | pumilio RNA binding family member 3 | -0.00594156 |
| MLXIP | MLX interacting protein | -0.00593815 |
| CD1E | CD1e molecule | -0.00591925 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00589558 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.00589398 |
| MID1 | midline 1 | -0.00588948 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.00588174 |
| NFIB | nuclear factor I/B | -0.00587254 |
| PEG10 | paternally expressed 10 | -0.00583528 |
| STC1 | stanniocalcin 1 | -0.0058148 |
| HMOX1 | heme oxygenase 1 | -0.00580457 |
| CTSK | cathepsin K | -0.00580302 |
| LHFP | lipoma HMGIC fusion partner | -0.00579508 |
| DNM1L | dynamin 1-like | -0.00578334 |
| SCPEP1 | serine carboxypeptidase 1 | -0.0057812 |
| GSDME | gasdermin E | -0.0057517 |
| PXDC1 | PX domain containing 1 | -0.0057463 |
| MAGEB2 | melanoma antigen family B2 | -0.00573603 |
| BMP4 | bone morphogenetic protein 4 | -0.00573359 |
| UXS1 | UDP-glucuronate decarboxylase 1 | -0.00573264 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00571283 |
| ATF3 | activating transcription factor 3 | -0.00570761 |
| HIP1R | huntingtin interacting protein 1 related | -0.00570187 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.00568944 |
| CCN2 | cellular communication network factor 2 | -0.00567961 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00566447 |
| PRKCA | protein kinase C, alpha | -0.00566145 |
| INSR | insulin receptor | -0.00566023 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.00565504 |
| STX4 | syntaxin 4 | -0.00563156 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.00561866 |
| TRIM16 | tripartite motif containing 16 | -0.00560967 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.00560477 |
| TPD52L1 | tumor protein D52-like 1 | -0.00560214 |
| PLXNB2 | plexin B2 | -0.00560183 |
| PITX3 | paired-like homeodomain 3 | -0.0055546 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0055471 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.00554282 |
| PTN | pleiotrophin | -0.00554125 |
| CCNG2 | cyclin G2 | -0.00552562 |
| DENND4C | DENN/MADD domain containing 4C | -0.00552544 |
| SOHLH2 | spermatogenesis and oogenesis specific basic helix-loop-helix 2 | -0.00550236 |
| PLXNA1 | plexin A1 | -0.00550111 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00549891 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00547931 |
| KRT8 | keratin 8, type II | -0.0054793 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00547296 |
| FJX1 | four jointed box 1 (Drosophila) | -0.00546688 |
