IL2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interleukin 2|The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3558)
External Link http://www.ncbi.nlm.nih.gov/gene/3558
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Genes

93 interacting proteins for IL2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ADAP1 ArfGAP with dual PH domains 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
APC adenomatous polyposis coli
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARF6 ADP-ribosylation factor 6
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
B2M beta-2-microglobulin
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTK Bruton agammaglobulinemia tyrosine kinase
CD247 CD247 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD53 CD53 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CISH cytokine inducible SH2-containing protein
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
CYTH2 cytohesin 2
CYTH3 cytohesin 3
DGKA diacylglycerol kinase, alpha 80kDa
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
EPS8 epidermal growth factor receptor pathway substrate 8
FOXK2 forkhead box K2
GAB1 GRB2-associated binding protein 1
GRAP GRB2-related adaptor protein
GSN gelsolin
HLA-A major histocompatibility complex, class I, A
HRAS Harvey rat sarcoma viral oncogene homolog
IFNA1 interferon, alpha 1
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL21R interleukin 21 receptor
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
JAK3 Janus kinase 3
KHSRP KH-type splicing regulatory protein
KRAS Kirsten rat sarcoma viral oncogene homolog
LCK LCK proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCKAP1 NCK-associated protein 1
NGFR nerve growth factor receptor
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PTGES3 prostaglandin E synthase 3 (cytosolic)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SGK1 serum/glucocorticoid regulated kinase 1
SGMS1 sphingomyelin synthase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLA2 Src-like-adaptor 2
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
TERT telomerase reverse transcriptase
UGCG UDP-glucose ceramide glucosyltransferase
VAV2 vav 2 guanine nucleotide exchange factor
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2